Considerations on the potentiometric log P determination

Pharmaceutical Research

Volumn 15, Issue 8, 1998, Pages 1310-1313

  Krämer, Stefanie D ^a   Gautier, Jean Claude ^a   Saudemon, Philippe ^a  

^a SANOFI   (France)

Author keywords

Amiodarone; Atenolol; Metoprolol; Potentiometric log P determination; Ramipril

Indexed keywords

AMIODARONE; ATENOLOL; METOPROLOL; RAMIPRIL;

ARTICLE; IONIZATION; LIPOPHILICITY; MATHEMATICAL ANALYSIS; PARTITION COEFFICIENT; POTENTIOMETRY; PRIORITY JOURNAL; THEORY; TITRIMETRY;

AMIODARONE; POTENTIOMETRY;

EID: 0031709544     PISSN: 07248741     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1011968630713     Document Type: Article

References (5)

1. W. Nernst. Verteilung eines Stoffes zwischen zwei Lösungsmitteln und zwischen Lösungsmittel und Dampfraum. Z. Phys. Chem. 8:110-139 (1891).
2. A. Avdeef. Refinement of partition coefficients and ionization constants of multiprotic substances. J. Pharm. Sci. 82:183-190 (1993).
3. F. H. Clarke and N. M. Cahoon. Ionization constants by curve fitting: determination of partition and distribution coefficients of acids and bases and their ions. J. Pharm. Sci. 76:611-620 (1987).
4. a determination of water-insoluble compounds. Validation Study in methanol/water mixtures. Int. J. Pharm. 151:235-248 (1997).
5. G. M. Pauletti. Partition coefficients in vitro: artificial membranes as a standardized distribution model. Dissertation ETH Zürich, Switzerland # 10266 (1993).