Conformational change of the transmembrane helices II and IV of metabotropic glutamate receptor involved in G protein activation

Journal of Neurochemistry

Volumn 106, Issue 2, 2008, Pages 850-859

  Yamashita, Takahiro ^a   Terakita, Akihisa ^a,b   Kai, Toshihiro ^a   Shichida, Yoshinori ^a  

^a KYOTO UNIVERSITY   (Japan)

^b Osaka Prefecture University   (Japan)

Author keywords

Constitutively active mutation; G protein; G protein coupled receptor; Metabotropic glutamate receptor; Rho Dopsin

Indexed keywords

DISULFIDE; GUANINE NUCLEOTIDE BINDING PROTEIN; METABOTROPIC RECEPTOR 8; 2 AMINO 2 (2 CARBOXYCYCLOPROPYL) 3 (XANTHEN 9 YL)PROPIONIC ACID; 2 AMINO 4 PHOSPHONO PROPINATE; 2-AMINO-4-PHOSPHONO-PROPINATE; AMINO ACID; GUANOSINE 5' O (3 THIOTRIPHOSPHATE); METABOTROPIC GLUTAMATE RECEPTOR TYPE 1; METABOTROPIC RECEPTOR; PROPIONIC ACID DERIVATIVE; TRITIUM; XANTHENE DERIVATIVE;

ARTICLE; CHEMICAL INTERACTION; CONFORMATIONAL TRANSITION; CROSS LINKING; CYTOPLASM; HUMAN; HUMAN CELL; INHIBITION KINETICS; MUTANT; MUTATION; PRIORITY JOURNAL; PROTEIN STRUCTURE; CELL LINE; CHEMICAL STRUCTURE; DOSE RESPONSE; GENETIC TRANSFECTION; GENETICS; METABOLISM; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN SECONDARY STRUCTURE; SITE DIRECTED MUTAGENESIS; STRUCTURE ACTIVITY RELATION;

AMINO ACIDS; CELL LINE, TRANSFORMED; DOSE-RESPONSE RELATIONSHIP, DRUG; GUANOSINE 5'-O-(3-THIOTRIPHOSPHATE); HUMANS; MODELS, MOLECULAR; MUTAGENESIS, SITE-DIRECTED; PROPIONIC ACIDS; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN STRUCTURE, SECONDARY; RECEPTORS, METABOTROPIC GLUTAMATE; STRUCTURE-ACTIVITY RELATIONSHIP; TRANSFECTION; TRITIUM; XANTHENES;

EID: 51649102148     PISSN: 00223042     EISSN: 14714159     Source Type: Journal    
DOI: 10.1111/j.1471-4159.2008.05443.x     Document Type: Article

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