메뉴 건너뛰기




Volumn 7, Issue 17, 2008, Pages 2647-2653

Mouse models for BRCA1 associated tumorigenesis: From fundamental insights to preclinical utility

Author keywords

BRCA1; Breast cancer; Mouse models; Ovarian cancer; Tumor suppressor

Indexed keywords

BRCA1 PROTEIN; BRCA2 PROTEIN; EPIDERMAL GROWTH FACTOR RECEPTOR 2; ESTROGEN RECEPTOR; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE INHIBITOR; PROGESTERONE RECEPTOR;

EID: 50849091292     PISSN: 15384101     EISSN: 15514005     Source Type: Journal    
DOI: 10.4161/cc.7.17.6266     Document Type: Review
Times cited : (23)

References (69)
  • 2
    • 4944229642 scopus 로고    scopus 로고
    • Hallmarks of 'BRCAness' in sporadic cancers
    • Turner N, Tutt A, Ashworth A. Hallmarks of 'BRCAness' in sporadic cancers. Nat Rev Cancer 2004; 4:814-9.
    • (2004) Nat Rev Cancer , vol.4 , pp. 814-819
    • Turner, N.1    Tutt, A.2    Ashworth, A.3
  • 3
    • 1642451743 scopus 로고    scopus 로고
    • BRCA1 functions as a breast stem cell regulator
    • Foulkes WD. BRCA1 functions as a breast stem cell regulator. J Med Genet 2004; 41:1-5.
    • (2004) J Med Genet , vol.41 , pp. 1-5
    • Foulkes, W.D.1
  • 7
    • 33749007676 scopus 로고    scopus 로고
    • Mouse models of BRCA1 and BRCA2 deficiency: Past lessons, current understanding and future prospects
    • Evers B, Jonkers J. Mouse models of BRCA1 and BRCA2 deficiency: past lessons, current understanding and future prospects. Oncogene 2006; 25:5885-97.
    • (2006) Oncogene , vol.25 , pp. 5885-5897
    • Evers, B.1    Jonkers, J.2
  • 11
    • 21544480554 scopus 로고    scopus 로고
    • Depletion of BRCA1 impairs differentiation but enhances proliferation of mammary epithelial cells
    • Furuta S, Jiang X, Gu B, Cheng E, Chen PL, Lee WH. Depletion of BRCA1 impairs differentiation but enhances proliferation of mammary epithelial cells. Proc Natl Acad Sci USA 2005; 102:9176-81.
    • (2005) Proc Natl Acad Sci USA , vol.102 , pp. 9176-9181
    • Furuta, S.1    Jiang, X.2    Gu, B.3    Cheng, E.4    Chen, P.L.5    Lee, W.H.6
  • 13
    • 33846850422 scopus 로고    scopus 로고
    • Ten genes for inherited breast cancer
    • Walsh T, King MC. Ten genes for inherited breast cancer. Cancer Cell 2007; 11:103-5.
    • (2007) Cancer Cell , vol.11 , pp. 103-105
    • Walsh, T.1    King, M.C.2
  • 16
    • 0035065040 scopus 로고    scopus 로고
    • Apparent human BRCA1 knockout caused by mispriming during polymerase chain reaction: Implications for genetic testing
    • Kuschel B, Gayther SA, Easton DF, Ponder BA, Pharoah PD. Apparent human BRCA1 knockout caused by mispriming during polymerase chain reaction: implications for genetic testing. Genes Chromosomes Cancer 2001; 31:96-8.
    • (2001) Genes Chromosomes Cancer , vol.31 , pp. 96-98
    • Kuschel, B.1    Gayther, S.A.2    Easton, D.F.3    Ponder, B.A.4    Pharoah, P.D.5
  • 17
    • 0026935108 scopus 로고
    • Allele losses in the region 17q12[ndash]21 in familial breast and ovarian cancer involve the wild-type chromosome
    • Smith SA, Easton DF, Evans DG, Ponder BA. Allele losses in the region 17q12[ndash]21 in familial breast and ovarian cancer involve the wild-type chromosome. Nature Genet 1992; 2:128-31.
    • (1992) Nature Genet , vol.2 , pp. 128-131
    • Smith, S.A.1    Easton, D.F.2    Evans, D.G.3    Ponder, B.A.4
  • 20
    • 0035872462 scopus 로고    scopus 로고
    • TP53 mutations in breast cancer associated with BRCA1 or BRCA2 germ-line mutations: Distinctive spectrum and structural distribution
    • Greenblatt MS, Chappuis PO, Bond JP, Hamel N, Foulkes WP. TP53 mutations in breast cancer associated with BRCA1 or BRCA2 germ-line mutations: Distinctive spectrum and structural distribution. Cancer Res 2001; 61:4092-7.
    • (2001) Cancer Res , vol.61 , pp. 4092-4097
    • Greenblatt, M.S.1    Chappuis, P.O.2    Bond, J.P.3    Hamel, N.4    Foulkes, W.P.5
  • 22
    • 0142178215 scopus 로고    scopus 로고
    • Breast and ovarian cancer risks due to inherited mutations in BRCA1 and BRCA2
    • King MC, Marks JH, Mandell JB. Breast and ovarian cancer risks due to inherited mutations in BRCA1 and BRCA2. Science 2003; 302:643-6.
    • (2003) Science , vol.302 , pp. 643-646
    • King, M.C.1    Marks, J.H.2    Mandell, J.B.3
  • 23
    • 27144447689 scopus 로고    scopus 로고
    • BRCA1 and BRCA2 as ovarian cancer susceptibility genes
    • Sowter H, Ashworth A. BRCA1 and BRCA2 as ovarian cancer susceptibility genes. Carcinogenesis 2005.
    • (2005) Carcinogenesis
    • Sowter, H.1    Ashworth, A.2
  • 27
    • 0037130887 scopus 로고    scopus 로고
    • Cancer Incidence in BRCA1 mutation carriers
    • Thompson D, Easton DF. Cancer Incidence in BRCA1 mutation carriers. J Natl Cancer Inst 2002; 94:1358-65.
    • (2002) J Natl Cancer Inst , vol.94 , pp. 1358-1365
    • Thompson, D.1    Easton, D.F.2
  • 31
    • 0031569873 scopus 로고    scopus 로고
    • Developmental expression of Brca2 colocalizes with Brca1 and is associated with proliferation and differentiation in multiple tissues
    • Rajan JV, Marquis ST, Gardner HP, Chodosh LA. Developmental expression of Brca2 colocalizes with Brca1 and is associated with proliferation and differentiation in multiple tissues. Dev Biol 1997; 184:385-401.
    • (1997) Dev Biol , vol.184 , pp. 385-401
    • Rajan, J.V.1    Marquis, S.T.2    Gardner, H.P.3    Chodosh, L.A.4
  • 32
    • 0029822055 scopus 로고    scopus 로고
    • Brca2 is coordinately regulated with Brca1 during proliferation and differentiation in mammary epithelial cells
    • Rajan JV, Wang M, Marquis ST, Chodosh LA. Brca2 is coordinately regulated with Brca1 during proliferation and differentiation in mammary epithelial cells. Proc Natl Acad Sci USA 1996; 93:13078-83.
    • (1996) Proc Natl Acad Sci USA , vol.93 , pp. 13078-13083
    • Rajan, J.V.1    Wang, M.2    Marquis, S.T.3    Chodosh, L.A.4
  • 33
    • 0029784528 scopus 로고    scopus 로고
    • Inactivation of the mouse Brca1 gene leads to failure in the morphogenesis of the egg cylinder in early postimplantation development
    • Liu CY, Flesken-Nikitin A, Li S, Zeng Y, Lee WH. Inactivation of the mouse Brca1 gene leads to failure in the morphogenesis of the egg cylinder in early postimplantation development. Genes Dev 1996; 10:1835-43.
    • (1996) Genes Dev , vol.10 , pp. 1835-1843
    • Liu, C.Y.1    Flesken-Nikitin, A.2    Li, S.3    Zeng, Y.4    Lee, W.H.5
  • 35
    • 0030924656 scopus 로고    scopus 로고
    • Targeted mutations of breast cancer susceptibility gene homologs in mice: Lethal phenotypes of Brca1, Brca2, Brca1/ Brca2, Brca1/p53 and Brca2/p53 nullizygous embryos
    • Ludwig T, Chapman DL, Papaioannou VE, Efstratiadis A. Targeted mutations of breast cancer susceptibility gene homologs in mice: lethal phenotypes of Brca1, Brca2, Brca1/ Brca2, Brca1/p53 and Brca2/p53 nullizygous embryos. Genes Dev 1997; 11:1226-41.
    • (1997) Genes Dev , vol.11 , pp. 1226-1241
    • Ludwig, T.1    Chapman, D.L.2    Papaioannou, V.E.3    Efstratiadis, A.4
  • 36
    • 0030051903 scopus 로고    scopus 로고
    • Brca1 deficiency results in early embryonic lethality characterized by neuroepithelial abnormalities
    • Gowen LC, Johnson BL, Latour AM, Sulik KK, Koller BH. Brca1 deficiency results in early embryonic lethality characterized by neuroepithelial abnormalities. Nat Genet 1996; 12:191-4.
    • (1996) Nat Genet , vol.12 , pp. 191-194
    • Gowen, L.C.1    Johnson, B.L.2    Latour, A.M.3    Sulik, K.K.4    Koller, B.H.5
  • 37
    • 0032542216 scopus 로고    scopus 로고
    • A targeted disruption of the murine Brca1 gene causes gamma-irradiation hypersensitivity and genetic instability
    • Shen SX, Weaver Z, Xu X, Li C, Weinstein M, Chen L, Guan XY, Ried T, Deng CX. A targeted disruption of the murine Brca1 gene causes gamma-irradiation hypersensitivity and genetic instability. Oncogene 1998; 17:3115-24.
    • (1998) Oncogene , vol.17 , pp. 3115-3124
    • Shen, S.X.1    Weaver, Z.2    Xu, X.3    Li, C.4    Weinstein, M.5    Chen, L.6    Guan, X.Y.7    Ried, T.8    Deng, C.X.9
  • 38
    • 0034946638 scopus 로고    scopus 로고
    • Genetic interactions between tumor suppressors Brca1 and p53 in apoptosis, cell cycle and tumorigenesis
    • Xu X, Qiao W, Linke SP, Cao L, Li WM, Furth PA, Harris CC, Deng CX. Genetic interactions between tumor suppressors Brca1 and p53 in apoptosis, cell cycle and tumorigenesis. Nat Genet 2001; 28:266-71.
    • (2001) Nat Genet , vol.28 , pp. 266-271
    • Xu, X.1    Qiao, W.2    Linke, S.P.3    Cao, L.4    Li, W.M.5    Furth, P.A.6    Harris, C.C.7    Deng, C.X.8
  • 41
    • 0035829651 scopus 로고    scopus 로고
    • Multiple genetic changes are associated with mammary tumorigenesis in Brca1 conditional knockout mice
    • Brodie SG, Xu X, Qiao W, Li WM, Cao L, Deng CX. Multiple genetic changes are associated with mammary tumorigenesis in Brca1 conditional knockout mice. Oncogene 2001; 20:7514-23.
    • (2001) Oncogene , vol.20 , pp. 7514-7523
    • Brodie, S.G.1    Xu, X.2    Qiao, W.3    Li, W.M.4    Cao, L.5    Deng, C.X.6
  • 42
    • 36448996703 scopus 로고    scopus 로고
    • Breast cancer risk associated with BRCA1 and BRCA2 in diverse populations
    • Fackenthal JD, Olopade OI. Breast cancer risk associated with BRCA1 and BRCA2 in diverse populations. Nat Rev Cancer 2007; 7:937-48.
    • (2007) Nat Rev Cancer , vol.7 , pp. 937-948
    • Fackenthal, J.D.1    Olopade, O.I.2
  • 43
    • 0034946638 scopus 로고    scopus 로고
    • Genetic interactions between tumor suppressors Brca1 and p53 in apoptosis, cell cycle and tumorigenesis
    • Xu X, Qiao W, Linke SP, Cao L, Li WM, Furth PA, Harris CC, Deng CX. Genetic interactions between tumor suppressors Brca1 and p53 in apoptosis, cell cycle and tumorigenesis. Nat Genet 2001; 28:266-71.
    • (2001) Nat Genet , vol.28 , pp. 266-271
    • Xu, X.1    Qiao, W.2    Linke, S.P.3    Cao, L.4    Li, W.M.5    Furth, P.A.6    Harris, C.C.7    Deng, C.X.8
  • 45
    • 0014677426 scopus 로고
    • Relationship between previous reproductive history and chemically induced mammary cancer in rats
    • Moon RC. Relationship between previous reproductive history and chemically induced mammary cancer in rats. Int J Cancer 1969; 4:312-7.
    • (1969) Int J Cancer , vol.4 , pp. 312-317
    • Moon, R.C.1
  • 46
    • 0001575033 scopus 로고
    • Influence of pregnancy and lactation on the incidence of mammary carcinoma induced with methylcholanthrene in female mice of the "IF" strain
    • Marchant J. Influence of pregnancy and lactation on the incidence of mammary carcinoma induced with methylcholanthrene in female mice of the "IF" strain. J Pathol Bacteriol 1955; 70:415-8.
    • (1955) J Pathol Bacteriol , vol.70 , pp. 415-418
    • Marchant, J.1
  • 48
    • 0037152096 scopus 로고    scopus 로고
    • Evidence from randomised trials on the long-term effects of hormone replacement therapy
    • Beral V, Banks E, Reeves G. Evidence from randomised trials on the long-term effects of hormone replacement therapy. Lancet 2002; 360:942-4.
    • (2002) Lancet , vol.360 , pp. 942-944
    • Beral, V.1    Banks, E.2    Reeves, G.3
  • 49
    • 33845315093 scopus 로고    scopus 로고
    • Prevention of Brca1-mediated mammary tumorigenesis in mice by a progesterone antagonist
    • Poole AJ, Li Y, Kim Y, Lin SC, Lee WH, Lee EY. Prevention of Brca1-mediated mammary tumorigenesis in mice by a progesterone antagonist. Science 2006; 314:1467-70.
    • (2006) Science , vol.314 , pp. 1467-1470
    • Poole, A.J.1    Li, Y.2    Kim, Y.3    Lin, S.C.4    Lee, W.H.5    Lee, E.Y.6
  • 50
    • 2442701845 scopus 로고    scopus 로고
    • Lin SC, Lee KF, Nikitin AY, Hilsenbeck SG, Cardiff RD, Li A, Kang KW, Frank SA, Lee WH, Lee EY. Somatic mutation of p53 leads to estrogen receptor alpha-positive and -negative mouse mammary tumors with high frequency of metastasis. Cancer Res 2004; 64:3525-32.
    • Lin SC, Lee KF, Nikitin AY, Hilsenbeck SG, Cardiff RD, Li A, Kang KW, Frank SA, Lee WH, Lee EY. Somatic mutation of p53 leads to estrogen receptor alpha-positive and -negative mouse mammary tumors with high frequency of metastasis. Cancer Res 2004; 64:3525-32.
  • 51
    • 34547504504 scopus 로고    scopus 로고
    • Rottenberg S, Nygren AO, Pajic M, van Leeuwen FW, van der Heijden I, van de Wetering K, Liu X, de Visser KE, Gilhuijs KG, van TO, Schouten JP, Jonkers J, Borst P. Selective induction of chemotherapy resistance of mammary tumors in a conditional mouse model for hereditary breast cancer. Proc Natl Acad Sci USA 2007; 104:12117-22.
    • Rottenberg S, Nygren AO, Pajic M, van Leeuwen FW, van der Heijden I, van de Wetering K, Liu X, de Visser KE, Gilhuijs KG, van TO, Schouten JP, Jonkers J, Borst P. Selective induction of chemotherapy resistance of mammary tumors in a conditional mouse model for hereditary breast cancer. Proc Natl Acad Sci USA 2007; 104:12117-22.
  • 52
    • 37249061592 scopus 로고    scopus 로고
    • What makes tumors multidrug resistant?
    • Borst P, Jonkers J, Rottenberg S. What makes tumors multidrug resistant? Cell Cycle 2007; 6:2782-7.
    • (2007) Cell Cycle , vol.6 , pp. 2782-2787
    • Borst, P.1    Jonkers, J.2    Rottenberg, S.3
  • 53
    • 20144377943 scopus 로고    scopus 로고
    • Cell-nonautonomous induction of ovarian and uterine serous cystadenomas in mice lacking a functional Brca1 in ovarian granulosa cells
    • Chodankar R, Kwang S, Sangiorgi F, Hong H, Yen HY, Deng C, Pike MC, Shuler CF, Maxson R, Dubeau L. Cell-nonautonomous induction of ovarian and uterine serous cystadenomas in mice lacking a functional Brca1 in ovarian granulosa cells. Curr Biol 2005; 15:561-5.
    • (2005) Curr Biol , vol.15 , pp. 561-565
    • Chodankar, R.1    Kwang, S.2    Sangiorgi, F.3    Hong, H.4    Yen, H.Y.5    Deng, C.6    Pike, M.C.7    Shuler, C.F.8    Maxson, R.9    Dubeau, L.10
  • 54
    • 33845644738 scopus 로고    scopus 로고
    • Conditional inactivation of Brca1 in the mouse ovarian surface epithelium results in an increase in preneoplastic changes
    • Clark-Knowles KV, Garson K, Jonkers J, Vanderhyden BC. Conditional inactivation of Brca1 in the mouse ovarian surface epithelium results in an increase in preneoplastic changes. Exp Cell Res 2007; 313:133-45.
    • (2007) Exp Cell Res , vol.313 , pp. 133-145
    • Clark-Knowles, K.V.1    Garson, K.2    Jonkers, J.3    Vanderhyden, B.C.4
  • 55
    • 33749482498 scopus 로고    scopus 로고
    • A mouse model for the molecular characterization of brca1-associated ovarian carcinoma
    • Xing D, Orsulic S. A mouse model for the molecular characterization of brca1-associated ovarian carcinoma. Cancer Res 2006; 66:8949-53.
    • (2006) Cancer Res , vol.66 , pp. 8949-8953
    • Xing, D.1    Orsulic, S.2
  • 56
    • 33645780411 scopus 로고    scopus 로고
    • Dekker M, Brouwers C, Aarts M, van der Torre J, de Vries S, van de Vrugt H, te Riele H. Effective oligonucleotide-mediated gene disruption in ES cells lacking the mismatch repair protein MSH3. Gene Ther 2006; 13:686-94.
    • Dekker M, Brouwers C, Aarts M, van der Torre J, de Vries S, van de Vrugt H, te Riele H. Effective oligonucleotide-mediated gene disruption in ES cells lacking the mismatch repair protein MSH3. Gene Ther 2006; 13:686-94.
  • 57
    • 0037445212 scopus 로고    scopus 로고
    • Targeted gene modification in mismatch-repair-deficient embryonic stem cells by single-stranded DNA oligonucleotides
    • Dekker M, Brouwers C, te Riele H. Targeted gene modification in mismatch-repair-deficient embryonic stem cells by single-stranded DNA oligonucleotides. Nucleic Acids Res 2003; 31:27.
    • (2003) Nucleic Acids Res , vol.31 , pp. 27
    • Dekker, M.1    Brouwers, C.2    te Riele, H.3
  • 58
    • 33845676733 scopus 로고    scopus 로고
    • Aarts M, Dekker M, de Vries S, van der Wal A, te Riele H. Generation of a mouse mutant by oligonucleotide-mediated gene modification in ES cells. Nucleic Acids Res 2006; 34:147.
    • Aarts M, Dekker M, de Vries S, van der Wal A, te Riele H. Generation of a mouse mutant by oligonucleotide-mediated gene modification in ES cells. Nucleic Acids Res 2006; 34:147.
  • 59
    • 0034710541 scopus 로고    scopus 로고
    • Gene replacement with the human BRCA1 locus: Tissue specific expression and rescue of embryonic lethality in mice
    • Lane TF, Lin C, Brown MA, Solomon E, Leder P. Gene replacement with the human BRCA1 locus: tissue specific expression and rescue of embryonic lethality in mice. Oncogene 2000; 19:4085-90.
    • (2000) Oncogene , vol.19 , pp. 4085-4090
    • Lane, T.F.1    Lin, C.2    Brown, M.A.3    Solomon, E.4    Leder, P.5
  • 60
    • 0035101934 scopus 로고    scopus 로고
    • Chandler J, Hohenstein P, Swing DA, Tessarollo L, Sharan SK. Human BRCA1 gene rescues the embryonic lethality of Brca1 mutant mice. Genesis 2001; 29:72-7.
    • Chandler J, Hohenstein P, Swing DA, Tessarollo L, Sharan SK. Human BRCA1 gene rescues the embryonic lethality of Brca1 mutant mice. Genesis 2001; 29:72-7.
  • 63
    • 42349096328 scopus 로고    scopus 로고
    • Secondary BRCA1 mutations in BRCA1-mutated ovarian carcinomas with platinum resistance
    • Swisher EM, Sakai W, Karlan BY, Wurz K, Urban N, Taniguchi T. Secondary BRCA1 mutations in BRCA1-mutated ovarian carcinomas with platinum resistance. Cancer Res 2008; 68:2581-6.
    • (2008) Cancer Res , vol.68 , pp. 2581-2586
    • Swisher, E.M.1    Sakai, W.2    Karlan, B.Y.3    Wurz, K.4    Urban, N.5    Taniguchi, T.6
  • 64
    • 39849097680 scopus 로고    scopus 로고
    • Edwards SL, Brough R, Lord CJ, Natrajan R, Vatcheva R, Levine DA, Boyd J, Reis-Filho JS, Ashworth A. Resistance to therapy caused by intragenic deletion in BRCA2. Nature 2008.
    • Edwards SL, Brough R, Lord CJ, Natrajan R, Vatcheva R, Levine DA, Boyd J, Reis-Filho JS, Ashworth A. Resistance to therapy caused by intragenic deletion in BRCA2. Nature 2008.
  • 65
    • 45749108933 scopus 로고    scopus 로고
    • How do real tumors become resistant to cisplatin?
    • Borst P, Rottenberg S, Jonkers J. How do real tumors become resistant to cisplatin? Cell Cycle 2008; 7.
    • (2008) Cell Cycle , pp. 7
    • Borst, P.1    Rottenberg, S.2    Jonkers, J.3
  • 66
    • 33748641755 scopus 로고    scopus 로고
    • Hyperplasia and spontaneous tumor development in the gynecologic system in mice lacking the BRCA1-Delta11 isoform
    • Kim SS, Cao L, Lim SC, Li C, Wang RH, Xu X, Bachelier R, Deng CX. Hyperplasia and spontaneous tumor development in the gynecologic system in mice lacking the BRCA1-Delta11 isoform. Mol Cell Biol 2006; 26:6983-92.
    • (2006) Mol Cell Biol , vol.26 , pp. 6983-6992
    • Kim, S.S.1    Cao, L.2    Lim, S.C.3    Li, C.4    Wang, R.H.5    Xu, X.6    Bachelier, R.7    Deng, C.X.8
  • 67
    • 33646885230 scopus 로고    scopus 로고
    • Total-genome analysis of BRCA1/2-related invasive carcinomas of the breast identifies tumor stroma as potential landscaper for neoplastic initiation
    • Weber F, Shen L, Fukino K, Patocs A, Mutter GL, Caldes T, Eng C. Total-genome analysis of BRCA1/2-related invasive carcinomas of the breast identifies tumor stroma as potential landscaper for neoplastic initiation. Am J Hum Genet 2006; 78:961-72.
    • (2006) Am J Hum Genet , vol.78 , pp. 961-972
    • Weber, F.1    Shen, L.2    Fukino, K.3    Patocs, A.4    Mutter, G.L.5    Caldes, T.6    Eng, C.7


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.