Human BRCA1 gene rescues the embryonic lethality of BRCA1 mutant mice

Genesis

Volumn 29, Issue 2, 2001, Pages 72-77

  Chandler, Jennifer ^a   Hohenstein, Peter ^b   Swing, Deborah A ^a   Tessarollo, Lino ^b   Sharan, Shyam K ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

^b LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

Bacterial artificial chromosome; BRCA1; Functional complementation; Humanized mice; Transgenic mice

Indexed keywords

RNA POLYMERASE;

AMINO ACID SEQUENCE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BACTERIAL ARTIFICIAL CHROMOSOME; BREAST CANCER; EMBRYO DEVELOPMENT; FAMILIAL DISEASE; GENE EXPRESSION; GENE MAPPING; GENE MUTATION; GENE SEQUENCE; HETEROZYGOSITY; HUMAN; HUMAN CELL; HUMAN TISSUE; IN SITU HYBRIDIZATION; KNOCKOUT MOUSE; LETHAL MUTANT; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; ONCOGENE; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SEQUENCE ANALYSIS; TRANSGENE;

ANIMALS; BLOTTING, SOUTHERN; BRCA1 PROTEIN; DISEASE MODELS, ANIMAL; DNA PRIMERS; EMBRYO LOSS; GENE DOSAGE; GENE TRANSFER TECHNIQUES; GENETIC VECTORS; GENOMIC LIBRARY; GENOTYPE; HOMOZYGOTE; HUMANS; IN SITU HYBRIDIZATION; MICE; MICE, TRANSGENIC; PHENOTYPE; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION;

ANIMALIA; BACTERIA (MICROORGANISMS); MURINAE; MUS MUSCULUS;

EID: 0035101934     PISSN: 1526954X     EISSN: None     Source Type: Journal    
DOI: 10.1002/1526-968X(200102)29:2<72::AID-GENE1007>3.0.CO;2-B     Document Type: Article

References (16)

1. Divergent hTAFII31-binding motifs hidden in activation domains
2. Genetic linkage analysis in familial breast and ovarian cancer: Results from 214 families. The Breast Cancer Linkage Consortium
3. Genetic heterogeneity and penetrance analysis of the BRCA1 and BRCA2 genes in breast cancer families
4. Developmental studies of Brca1 and Brca2 knock-out mice
5. Functional assay for BRCA1: Mutagenesis of the COOH-terminal region reveals critical residues for transcription activation
6. Embryonic lethality but no proliferation block in mice with a 3′ Brca1 mutation
7. Gene replacement with the human BRCA1 locus: Tissue specific expression and rescue of embryonic lethality in mice
8. Novel cis-acting element controlling the rat CYP2D5 gene and requiring cooperativity between C/EBP beta and an Spl factor
9. The developmental pattern of Brca1 expression implies a role in differentiation of the breast and other tissues
10. A strong candidate for the breast and ovarian cancer susceptibility gene BRCA1
11. Genetic analysis of BRCA1 function in a defined tumor cell line
12. Murine Brca1: Sequence and significance for human missense mutations
13. BRCA1 and BRCA2 gene mutation analysis: Visit to the Breast Cancer Information Core (BIC)
14. In situ hybridization
15. Complex regulation of the BRCA1 gene
16. Conditional mutation of Brca1 in mammary epithelial cells results in blunted ductal morphogenesis and tumour formation