Depletion of BRCA1 impairs differentiation but enhances proliferation of mammary epithelial cells

Proceedings of the National Academy of Sciences of the United States of America

Volumn 102, Issue 26, 2005, Pages 9176-9181

  Furuta, Saori ^a   Jiang, Xianzhi ^a   Gu, Bingnan ^a   Cheng, Eric ^a   Chen, Phang Lang ^a   Lee, Wen Hwa ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

3D culture; Breast cancer; Matrix gel; Tumor suppressor

Indexed keywords

BRCA1 PROTEIN; MUTANT PROTEIN; RAD50 PROTEIN;

ACINAR CELL; ARTICLE; AUTOCRINE EFFECT; BREAST CANCER; BREAST CARCINOGENESIS; BREAST EPITHELIUM; CARBOXY TERMINAL SEQUENCE; CELL CULTURE; CELL CYCLE; CELL DIFFERENTIATION; CELL PROLIFERATION; CONTROLLED STUDY; CULTURE MEDIUM; DNA REPAIR; EXTRACELLULAR MATRIX; GENE EXPRESSION; GENE EXPRESSION REGULATION; GENOMIC INSTABILITY; HUMAN; HUMAN CELL; NUCLEOTIDE SEQUENCE; ONCOGENE; PARACRINE SIGNALING; PHENOTYPE; PRIORITY JOURNAL; PROTEIN DEPLETION; PROTEIN DOMAIN; RNA INTERFERENCE; THREE DIMENSIONAL CELL CULTURE;

ADENOVIRIDAE; BASE SEQUENCE; BRCA1 PROTEIN; BREAST NEOPLASMS; CELL CULTURE TECHNIQUES; CELL DIFFERENTIATION; CELL LINE, TUMOR; CELL PROLIFERATION; CULTURE MEDIA, CONDITIONED; DOWN-REGULATION; EPITHELIAL CELLS; EXTRACELLULAR MATRIX; GENE EXPRESSION REGULATION, NEOPLASTIC; GENES, BRCA1; GENETIC VECTORS; HUMANS; IMAGING, THREE-DIMENSIONAL; MAMMARY GLANDS, HUMAN; MICROSCOPY, FLUORESCENCE; MODELS, GENETIC; MOLECULAR SEQUENCE DATA; MUTATION; PHENOTYPE; PLASMIDS; POINT MUTATION; PROTEIN STRUCTURE, TERTIARY; RETINOBLASTOMA PROTEIN; RNA; RNA INTERFERENCE; UP-REGULATION;

EID: 21544480554     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.0503793102     Document Type: Article

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