Review: Nutrition therapy in critically ill infants and children

Journal of Parenteral and Enteral Nutrition

Volumn 32, Issue 5, 2008, Pages 520-534

  Skillman, Heather E ^a   Wischmeyer, Paul E ^b  

^a CHILDREN S HOSPITAL COLORADO   (United States)

^b UNIVERSITY OF COLORADO   (United States)

Author keywords

Clinical practice guidelines; Critically ill infants and children; Enteral nutrition; Funding; Nutrition therapy; Parenteral nutrition; Research

Indexed keywords

5,8,11,14,17 ICOSAPENTAENOIC ACID; ARGININE; ASCORBIC ACID; GAMMA LINOLENIC ACID; GLUCOSE; GLUTAMINE; INSULIN; LIPID; OXANDROLONE; PROBIOTIC AGENT; SELENIUM;

ADULT RESPIRATORY DISTRESS SYNDROME; BURN; CALORIMETRY; CLINICAL ASSESSMENT; CRITICAL ILLNESS; CRITICALLY ILL PATIENT; DIET THERAPY; DIETITIAN; ENTERIC FEEDING; FISTULA; HUMAN; INTENSIVE CARE; INTENSIVE CARE UNIT; INTERVENTION STUDY; MALNUTRITION; MONITORING; NECROTIZING ENTEROCOLITIS; NUTRITION; NUTRITIONAL DEFICIENCY; OBESITY; OUTCOME ASSESSMENT; OVERNUTRITION; PARENTERAL NUTRITION; PEDIATRICS; PNEUMATOSIS INTESTINALIS; PNEUMONIA; PRACTICE GUIDELINE; PREDICTION; PRIORITY JOURNAL; RESPIRATORY FAILURE; REVIEW; RISK; SEPSIS; SMALL INTESTINE; SUPPLEMENTATION; TRAUMATIC BRAIN INJURY; VOMITING; WOUND INFECTION; CHILD; GLUCOSE BLOOD LEVEL; INFANT; METABOLISM; METHODOLOGY; NUTRITIONAL STATUS;

BLOOD GLUCOSE; CHILD; CRITICAL ILLNESS; ENTERAL NUTRITION; HUMANS; INFANT; MALNUTRITION; NUTRITION THERAPY; NUTRITIONAL STATUS; OVERNUTRITION; PARENTERAL NUTRITION; PROBIOTICS;

EID: 50049099514     PISSN: 01486071     EISSN: None     Source Type: Journal    
DOI: 10.1177/0148607108322398     Document Type: Review

References (231)

1. Forbes GB, Bruining GJ Urinary creatinine excretion and lean body mass. Am J Clin Nutr. 1976 ; 29: 1359-1366.
2. Fomon SJ, Haschke F., Ziegler EE, Nelson SE Body composition of reference children from birth to age 10 years. Am J Clin Nutr. 1982 ; 35: 1169-1175.
3. Schofield WN Predicting basal metabolic rate, new standards and review of previous work. Hum Nutr Clin Nutr. 1985 ; 39 (suppl 1). 5-41.
4. Coss-Bu JA, Klish WJ, Walding D., Stein F., Smith EO, Jefferson LS Energy metabolism, nitrogen balance, and substrate utilization in critically ill children. Am J Clin Nutr. 2001 ; 74: 664-669.
5. Powis MR, Smith K., Rennie M., Halliday D., Pierro A. Effect of major abdominal operations on energy and protein metabolism in infants and children. J Pediatr Surg. 1998 ; 33: 49-53.
6. Cunningham JJ Body composition and nutrition support in pediatrics: what to defend and how soon to begin. Nutr Clin Pract. 1995 ; 10: 177-182.
7. Long CL, Kinney JM, Geiger JW Nonsuppressability of gluconeogenesis by glucose in septic patients. Metabolism. 1976 ; 25: 193-201.
8. Hulst J., Joosten K., Zimmermann L., et al. Malnutrition in critically ill children: from admission to 6 months after discharge. Clin Nutr. 2004 ; 23: 223-232.
9. Littlewood RA, Wotten M., Trocki O., Shepherd RW, Shepherd K. Reduced body cell mass following severe head injury in children: implications for rehabilitation. Pediatr Rehabil. 1999 ; 3: 95-99.
10. Varan B., Tokel K., Yilmaz G. Malnutrition and growth failure in cyanotic and acyanotic congenital heart disease with and without pulmonary hypertension. Arch Dis Child. 1999 ; 81: 49-52.
11. Norris MK, Hill CS Nutritional issues in infants and children with congenital heart disease. Crit Care Nurs Clin North Am. 1994 ; 6: 153-163.
12. Kelleher DK, Laussen P., Teixeira-Pinto A., Duggan C. Growth and correlates of nutritional status among infants with hypoplastic left heart syndrome (HLHS) after stage 1 Norwood procedure. Nutrition. 2006 ; 22: 237-244.
13. Pollack MM, Wiley JS, Holbrook PR Early nutritional depletion in critically ill children. Crit Care Med. 1981 ; 9: 580-583.
14. Pollack MM, Wiley JS, Kanter R., Holbrook PR Malnutrition in critically ill infants and children. JPEN J Parenter Enteral Nutr. 1982 ; 6: 20-24.
15. Briassoulis G., Zavras N., Hatzis T. Malnutrition, nutritional indices, and early enteral feeding in critically ill children. Nutrition. 2001 ; 17: 548-557.
16. Pollack MM, Ruttimann UE, Wiley JS Nutritional depletions in critically ill children: associations with physiologic instability and increased quantity of care. JPEN J Parenter Enteral Nutr. 1985 ; 9: 309-313.
17. Ogden CL, Flegal KM, Carroll MD, Johnson CL Prevalence and trends in overweight among US children and adolescents, 1999-2000. JAMA. 2002 ; 288: 1728-1732.
18. Krebs NF, Himes JH, Jacobson D., Nicklas TA, Guilday P., Styne D. Assessment of child and adolescent overweight and obesity. Pediatrics. 2007 ; 120 (suppl 4). S193 - S228.
19. Hedley AA, Ogden CL, Johnson CL, Carroll MD, Curtin LR, Flegal KM Prevalence of overweight and obesity among US children, adolescents, and adults, 1999-2002. JAMA. 2004 ; 291: 2847-2850.
20. Brown CV, Neville AL, Salim A., Rhee P., Cologne K., Demetriades D. The impact of obesity on severely injured children and adolescents. J Pediatr Surg. 2006 ; 41: 88-91.
21. Karlsson M., Marild S., Brandberg J., Lonn L., Friberg P., Strandvik B. Serum phospholipid fatty acids, adipose tissue, and metabolic markers in obese adolescents. Obesity (Silver Spring). 2006 ; 14: 1931-1939.
22. Heyland DK, Dhaliwal R., Drover JW, Gramlich L., Dodek P. Canadian clinical practice guidelines for nutrition support in mechanically ventilated, critically ill adult patients. JPEN J Parenter Enteral Nutr. 2003 ; 27: 355-373.
23. Jones NE, Suurdt J., Ouelette-Kuntz H., Heyland DK Implementation of the Canadian Clinical Practice Guidelines for Nutrition Support: a multiple case study of barriers and enablers. Nutr Clin Pract. 2007 ; 22: 449-457.
24. Wernerman J. Guidelines for nutritional support in intensive care unit patients: a critical analysis. Curr Opin Clin Nutr Metab Care. 2005 ; 8: 171-175.
25. Heyland DK, Dhaliwal R., Day A., Jain M., Drover J. Validation of the Canadian clinical practice guidelines for nutrition support in mechanically ventilated, critically ill adult patients: results of a prospective observational study. Crit Care Med. 2004 ; 32: 2260-2266.
26. Jain MK, Heyland D., Dhaliwal R., et al. Dissemination of the Canadian clinical practice guidelines for nutrition support: results of a cluster randomized controlled trial. Crit Care Med. 2006 ; 34: 2362-2369.
27. Martin CM, Doig GS, Heyland DK, Morrison T., Sibbald WJ Multicentre, cluster-randomized clinical trial of algorithms for critical-care enteral and parenteral therapy (ACCEPT). CMAJ. 2004 ; 170: 197-204.
28. Sweet D., Bevilacqua G., Carnielli V., et al. European consensus guidelines on the management of neonatal respiratory distress syndrome. J Perinat Med. 2007 ; 35: 175-186.
29. Adelson PD, Bratton SL, Carney NA, et al. Guidelines for the acute medical management of severe traumatic brain injury in infants, children, and adolescents: chapter 18: nutritional support. Pediatr Crit Care Med. 2003 ; 4 (3 Suppl). S68 - S71.
30. Phillips R., Ott L., Young B., Walsh J. Nutritional support and measured energy expenditure of the child and adolescent with head injury. J Neurosurg. 1987 ; 67: 846-851.
31. Moore R., Najarian MP, Konvolinka CW Measured energy expenditure in severe head trauma. J Trauma. 1989 ; 29: 1633-1636.
32. A.S.P.E.N. Board of Directors and the Clinical Guidelines Task Force. Guidelines for the use of parenteral and enteral nutrition in adult and pediatric patients. [erratum published in JPEN 2002;26(2):144] JPEN J Parenter Enteral Nutr. 2002 ; 26: 1SA - 138SA.
33. Ista E., Joosten K. Nutritional assessment and enteral support of critically ill children. Crit Care Nurs Clin North Am. 2005 ; 17: 385-393, x.
34. Wessel J., Balint J., Crill C., Klotz K. Standards for specialized nutrition support: hospitalized pediatric patients. Nutr Clin Pract. 2005 ; 20: 103-116.
35. Hulst JM, van Goudoever JB, Zimmermann LJ, et al. Adequate feeding and the usefulness of the respiratory quotient in critically ill children. Nutrition. 2005 ; 21: 192-198.
36. Gottschlich MM, Jenkins M., Mayes T., Khoury J., Kagan R., Warden GD Lack of effect of sleep on energy expenditure and physiologic measures in critically ill burn patients. J Am Diet Assoc. 1997 ; 97: 131-139.
37. White MS, Shepherd RW, McEniery JA Energy expenditure measurements in ventilated critically ill children: within- and between-day variability. JPEN J Parenter Enteral Nutr. 1999 ; 23: 300-304.
38. Joosten KF, Verhoeven JJ, Hop WC, Hazelzet JA Indirect calorimetry in mechanically ventilated infants and children: accuracy of total daily energy expenditure with 2 hour measurements. Clin Nutr. 1999 ; 18: 149-152.
39. Framson CM, LeLeiko NS, Dallal GE, Roubenoff R., Snelling LK, Dwyer JT Energy expenditure in critically ill children. Pediatr Crit Care Med. 2007 ; 8: 264-267.
40. Oosterveld MJ, Van Der Kuip M., De Meer K., De Greef HJ, Gemke RJ Energy expenditure and balance following pediatric intensive care unit admission: a longitudinal study of critically ill children. Pediatr Crit Care Med. 2006 ; 7: 147-153.
41. de Klerk G., Hop WC, de Hoog M., Joosten KF Serial measurements of energy expenditure in critically ill children: useful in optimizing nutritional therapy ? Intensive Care Med. 2002 ; 28: 1781-1785.
42. Coss-Bu JA, Jefferson LS, Walding D., David Y., Smith EO, Klish WJ Resting energy expenditure and nitrogen balance in critically ill pediatric patients on mechanical ventilation. Nutrition. 1998 ; 14: 649-652.
43. Suman OE, Mlcak RP, Chinkes DL, Herndon DN Resting energy expenditure in severely burned children: analysis of agreement between indirect calorimetry and prediction equations using the Bland-Altman method. Burns. 2006 ; 32: 335-342.
44. Littlewood RA, Trocki O., Shepherd RW, Shepherd K. Resting energy expenditure of children attending a rehabilitation programme following head injury. Pediatr Rehabil. 2000 ; 4: 51-55.
45. Matthews DS, Aynsley-Green A., Matthews JN, Bullock RE, Cooper BG, Eyre JA The effect of severe head injury on whole body energy expenditure and its possible hormonal mediators in children. Pediatr Res. 1995 ; 37: 409-417.
46. Liusuwan RA, Palmieri TL, Kinoshita L., Greenhalgh DG Comparison of measured resting energy expenditure versus predictive equations in pediatric burn patients. J Burn Care Rehabil. 2005 ; 26: 464-470.
47. Taylor RM, Cheeseman P., Preedy V., Baker AJ, Grimble G. Can energy expenditure be predicted in critically ill children ? Pediatr Crit Care Med. 2003 ; 4: 176-180.
48. Vazquez Martinez JL, Martinez-Romillo PD, Diez Sebastian J., Ruza Tarrio F. Predicted versus measured energy expenditure by continuous, online indirect calorimetry in ventilated, critically ill children during the early postinjury period. Pediatr Crit Care Med. 2004 ; 5: 19-27.
49. Briassoulis G., Venkataraman S., Thompson AE Energy expenditure in critically ill children. Crit Care Med. 2000 ; 28: 1166-1172.
50. Turi RA, Petros AJ, Eaton S., et al. Energy metabolism of infants and children with systemic inflammatory response syndrome and sepsis. Ann Surg. 2001 ; 233: 581-587.
51. Vernon DD, Witte MK Effect of neuromuscular blockade on oxygen consumption and energy expenditure in sedated, mechanically ventilated children. Crit Care Med. 2000 ; 28: 1569-1571.
52. White MS, Shepherd RW, McEniery JA Energy expenditure in 100 ventilated, critically ill children: improving the accuracy of predictive equations. Crit Care Med. 2000 ; 28: 2307-2312.
53. Chwals WJ, Lally KP, Woolley MM, Mahour GH Measured energy expenditure in critically ill infants and young children. J Surg Res. 1988 ; 44: 467-472.
54. Chwals WJ Overfeeding the critically ill child: fact or fantasy ? New Horiz. 1994 ; 2: 147-155.
55. Letton RW, Chwals WJ, Jamie A., Charles B. Early postoperative alterations in infant energy use increase the risk of overfeeding. J Pediatr Surg. 1995 ; 30: 988-992 ; discussion 992-993.
56. Hart DW, Wolf SE, Herndon DN, et al. Energy expenditure and caloric balance after burn: increased feeding leads to fat rather than lean mass accretion. Ann Surg. 2002 ; 235: 152-161.
57. Chwals WJ, Letton RW, Jamie A., Charles B. Stratification of injury severity using energy expenditure response in surgical infants. J Pediatr Surg. 1995 ; 30: 1161-1164.
58. Steinhorn DM, Green TP Severity of illness correlates with alterations in energy metabolism in the pediatric intensive care unit. Crit Care Med. 1991 ; 19: 1503-1509.
59. Winthrop AL, Wesson DE, Pencharz PB, Jacobs DG, Heim T., Filler RM Injury severity, whole body protein turnover, and energy expenditure in pediatric trauma. J Pediatr Surg. 1987 ; 22: 534-537.
60. Havalad S., Quaid MA, Sapiega V. Energy expenditure in children with severe head injury: lack of agreement between measured and estimated energy expenditure. Nutr Clin Pract. 2006 ; 21: 175-181.
61. Selby AM, McCauley JC, Schell DN, O'Connell A., Gillis J., Gaskin KJ Indirect calorimetry in mechanically ventilated children: a new technique that overcomes the problem of endotracheal tube leak. Crit Care Med. 1995 ; 23: 365-370.
62. Chwals WJ, Lally KP, Woolley MM Indirect calorimetry in mechanically ventilated infants and children: measurement accuracy with absence of audible airleak. Crit Care Med. 1992 ; 20: 768-770.
63. Haugen HA, Chan LN, Li F. Indirect calorimetry: a practical guide for clinicians. Nutr Clin Pract. 2007 ; 22: 377-388.
64. van der Kuip M., Oosterveld MJ, van Bokhorst-de van der Schueren MA, de Meer K., Lafeber HN, Gemke RJ Nutritional support in 111 pediatric intensive care units: a European survey. Intensive Care Med. 2004 ; 30: 1807-1813.
65. Talbot F. Basal metabolism standards for children. Am J Dis Child. 1938 ; 55: 455-459.
66. Energy and protein requirements: report of a joint FAO/WHO/UNU expert consultation. World Health Organ Tech Rep Ser. 1985 ; 724: 1-206.
67. Hardy CM, Dwyer J., Snelling LK, Dallal GE, Adelson JW Pitfalls in predicting resting energy requirements in critically ill children: a comparison of predictive methods to indirect calorimetry. Nutr Clin Pract. 2002 ; 17: 182-189.
68. Verhoeven JJ, Hazelzet JA, van der Voort E., Joosten KF Comparison of measured and predicted energy expenditure in mechanically ventilated children. Intensive Care Med. 1998 ; 24: 464-468.
69. Prelack K., Cunningham JJ, Sheridan RL, Tompkins RG Energy and protein provisions for thermally injured children revisited: an outcome-based approach for determining requirements. J Burn Care Rehabil. 1997 ; 18: 177-181 ; discussion 176.
70. Letton RW, Chwals WJ, Jamie A., Charles B. Neonatal lipid utilization increases with injury severity: recombinant human growth hormone versus placebo. J Pediatr Surg. 1996 ; 31: 1068-1072 ; discussion 1072-1074.
71. Alaedeen DI, Walsh MC, Chwals WJ Total parenteral nutrition-associated hyperglycemia correlates with prolonged mechanical ventilation and hospital stay in septic infants. J Pediatr Surg. 2006 ; 41: 239-244.
72. de Oliveira Iglesias SB, Leite HP, Santana e Meneses JF, de Carvalho WB Enteral nutrition in critically ill children: are prescription and delivery according to their energy requirements? Nutr Clin Pract. 2007 ; 22: 233-239.
73. Lambe C., Hubert P., Jouvet P., Cosnes J., Colomb V. A nutritional support team in the pediatric intensive care unit: changes and factors impeding appropriate nutrition. Clin Nutr. 2007 ; 26: 355-363.
74. Taylor RM, Preedy VR, Baker AJ, Grimble G. Nutritional support in critically ill children. Clin Nutr. 2003 ; 22: 365-369.
75. Rogers EJ, Gilbertson HR, Heine RG, Henning R. Barriers to adequate nutrition in critically ill children. Nutrition. 2003 ; 19: 865-868.
76. Villet S., Chiolero RL, Bollmann MD, et al. Negative impact of hypocaloric feeding and energy balance on clinical outcome in ICU patients. Clin Nutr. 2005 ; 24: 502-509.
77. Hulst JM, van Goudoever JB, Zimmermann LJ, et al. The effect of cumulative energy and protein deficiency on anthropometric parameters in a pediatric ICU population. Clin Nutr. 2004 ; 23: 1381-1389.
78. Hulst JM, Joosten KF, Tibboel D., van Goudoever JB Causes and consequences of inadequate substrate supply to pediatric ICU patients. Curr Opin Clin Nutr Metab Care. 2006 ; 9: 297-303.
79. Simpson F., Doig GS Parenteral vs. enteral nutrition in the critically ill patient: a meta-analysis of trials using the intention to treat principle. Intensive Care Med. 2005 ; 31: 12-23.
80. Pettignano R., Heard M., Davis R., Labuz M., Hart M. Total enteral nutrition versus total parenteral nutrition during pediatric extracorporeal membrane oxygenation. Crit Care Med. 1998 ; 26: 358-363.
81. Wertheim HF, Albers MJ, Piena-Spoel M., Tibboel D. The incidence of septic complications in newborns on extracorporeal membrane oxygenation is not affected by feeding route. J Pediatr Surg. 2001 ; 36: 1485-1489.
82. Chellis MJ, Sanders SV, Webster H., Dean JM, Jackson D. Early enteral feeding in the pediatric intensive care unit. JPEN J Parenter Enteral Nutr. 1996 ; 20: 71-73.
83. Sanchez C., Lopez-Herce J., Carrillo A., Mencia S., Vigil D. Early transpyloric enteral nutrition in critically ill children. Nutrition. 2007 ; 23: 16-22.
84. Venter M., Rode H., Sive A., Visser M. Enteral resuscitation and early enteral feeding in children with major burns-effect on McFarlane response to stress. Burns. 2007 ; 33: 464-471.
85. King W., Petrillo T., Pettignano R. Enteral nutrition and cardiovascular medications in the pediatric intensive care unit. JPEN J Parenter Enteral Nutr. 2004 ; 28: 334-338.
86. Briassoulis GC, Zavras NJ, Hatzis MT Effectiveness and safety of a protocol for promotion of early intragastric feeding in critically ill children. Pediatr Crit Care Med. 2001 ; 2: 113-121.
87. Leite HP, Fantozzi G. Metabolic assessment and enteral tube feeding usage in children with acute neurological diseases. Sao Paulo Med J. 1998 ; 116: 1858-1865.
88. Sanchez C., Lopez-Herce J., Carrillo A., Bustinza A., Sancho L., Vigil D. Transpyloric enteral feeding in the postoperative of cardiac surgery in children. J Pediatr Surg. 2006 ; 41: 1096-1102.
89. Briassoulis G., Tsorva A., Zavras N., Hatzis T. Influence of an aggressive early enteral nutrition protocol on nitrogen balance in critically ill children. J Nutr Biochem. 2002 ; 13: 560.
90. Hart DW, Wolf SE, Chinkes DL, et al. Effects of early excision and aggressive enteral feeding on hypermetabolism, catabolism, and sepsis after severe burn. J Trauma. 2003 ; 54: 755-761.
91. Gottschlich MM, Jenkins ME, Mayes T., Khoury J., Kagan RJ, Warden GD The 2002 Clinical Research Award: an evaluation of the safety of early vs delayed enteral support and effects on clinical, nutritional, and endocrine outcomes after severe burns. J Burn Care Rehabil. 2002 ; 23: 401-415.
92. Willis L., Kaufman J., Wymore E., Thureen P., Skillman H., da Cruz E. Enteral feeding in prostaglandin-dependent neonates: is it a safe practice? J Pediatr. In press.
93. Petrillo-Albarano T., Pettignano R., Asfaw M., Easley K. Use of a feeding protocol to improve nutritional support through early, aggressive, enteral nutrition in the pediatric intensive care unit. Pediatr Crit Care Med. 2006 ; 7: 340-344.
94. Tofil NM, Benner KW, Faro SJ, Winkler MK The use of enteral naloxone to treat opioid-induced constipation in a pediatric intensive care unit. Pediatr Crit Care Med. 2006 ; 7: 252-254.
95. Thakkar K., Kien CL, Rosenblatt JI, Herndon DN Diarrhea in severely burned children. JPEN J Parenter Enteral Nutr. 2005 ; 29: 8-11.
96. Wolf SE, Jeschke MG, Rose JK, Desai MH, Herndon DN Enteral feeding intolerance: an indicator of sepsis-associated mortality in burned children. Arch Surg. 1997 ; 132: 1310-1313 ; discussion 1313-1314.
97. Horn D., Chaboyer W., Schluter PJ Gastric residual volumes in critically ill paediatric patients: a comparison of feeding regimens. Aust Crit Care. 2004 ; 17: 98-100, 102-103.
98. McClave SA, Snider HL Clinical use of gastric residual volumes as a monitor for patients on enteral tube feeding. JPEN J Parenter Enteral Nutr. 2002 ; 26 (6 Suppl). S43 - S48 ; discussion S49 - S50.
99. McClave SA, Lukan JK, Stefater JA, et al. Poor validity of residual volumes as a marker for risk of aspiration in critically ill patients. Crit Care Med. 2005 ; 33: 324-330.
100. Landzinski J., Kiser TH, Fish DN, Wischmeyer PE, Maclaren R. Gastric motility function in critically ill patients tolerant vs intolerant to gastric nutrition. JPEN J Parenter Enteral Nutr. 2008 ; 32: 45-50.
101. Weckwerth JA Monitoring enteral nutrition support tolerance in infants and children. Nutr Clin Pract. 2004 ; 19: 496-503.
102. Lopez-Herce J., Sanchez C., Carrillo A., et al. Transpyloric enteral nutrition in the critically ill child with renal failure. Intensive Care Med. 2006 ; 32: 1599-1605.
103. Lopez-Herce J., Santiago MJ, Sanchez C., Mencia S., Carrillo A., Vigil D. Risk factors for gastrointestinal complications in critically ill children with transpyloric enteral nutrition. Eur J Clin Nutr. 2008 ; 62: 395-400.
104. Kurbegov AC, Sondheimer JM Pneumatosis intestinalis in non-neonatal pediatric patients. Pediatrics. 2001 ; 108: 402-406.
105. Lin PW, Stoll BJ Necrotising enterocolitis. Lancet. 2006 ; 368: 1271-1283.
106. Babbitt C. Transpyloric feeding in the pediatric intensive care unit. J Pediatr Gastroenterol Nutr. 2007 ; 44: 646-649.
107. Ostlie DJ, Spilde TL, St Peter SD, et al. Necrotizing enterocolitis in full-term infants. J Pediatr Surg. 2003 ; 38: 1039-1042.
108. McElhinney DB, Hedrick HL, Bush DM, et al. Necrotizing enterocolitis in neonates with congenital heart disease: risk factors and outcomes. Pediatrics. 2000 ; 106: 1080-1087.
109. McClave SA, DeMeo MT, DeLegge MH, et al. North American Summit on Aspiration in the Critically Ill Patient: consensus statement. JPEN J Parenter Enteral Nutr. 2002 ; 26 (Suppl): S80 - S85.
110. Strauss D., Kastner T., Ashwal S., White J. Tubefeeding and mortality in children with severe disabilities and mental retardation. Pediatrics. 1997 ; 99: 358-362.
111. Foglia E., Meier MD, Elward A. Ventilator-associated pneumonia in neonatal and pediatric intensive care unit patients. Clin Microbiol Rev. 2007 ; 20: 409-425.
112. Mehall JR, Kite CA, Saltzman DA, Wallett T., Jackson RJ, Smith SD Prospective study of the incidence and complications of bacterial contamination of enteral feeding in neonates. J Pediatr Surg. 2002 ; 37: 1177-1182.
113. Bowen AB, Braden CR Invasive Enterobacter sakazakii disease in infants. Emerg Infect Dis. 2006 ; 12: 1185-1189.
114. From the Centers for Disease Control and Prevention. Enterobacter sakazakii infections associated with the use of powdered infant formula-Tennessee, 2001. JAMA. 2002 ; 287: 2204-2205.
115. Neely AN, Mayes T., Gardner J., Kagan RJ, Gottschlich MM A microbiologic study of enteral feeding hang time in a burn hospital: can feeding costs be reduced without compromising patient safety ? Nutr Clin Pract. 2006 ; 21: 610-616.
116. Bott L., Husson MO, Guimber D., et al. Contamination of gastrostomy feeding systems in children in a home-based enteral nutrition program. J Pediatr Gastroenterol Nutr. 2001 ; 33: 266-270.
117. Bourgault AM, Heyland DK, Drover JW, Keefe L., Newman P., Day AG Prophylactic pancreatic enzymes to reduce feeding tube occlusions. Nutr Clin Pract. 2003 ; 18: 398-401.
118. Ellett ML, Maahs J., Forsee S. Prevalence of feeding tube placement errors and associated risk factors in children. MCN Am J Matern Child Nurs. 1998 ; 23: 234-239.
119. Creel AM, Winkler MK Oral and nasal enteral tube placement errors and complications in a pediatric intensive care unit. Pediatr Crit Care Med. 2007 ; 8: 161-164.
120. Meert KL, Daphtary KM, Metheny NA Gastric vs small-bowel feeding in critically ill children receiving mechanical ventilation: a randomized controlled trial. Chest. 2004 ; 126: 872-878.
121. Lyons KA, Brilli RJ, Wieman RA, Jacobs BR Continuation of transpyloric feeding during weaning of mechanical ventilation and tracheal extubation in children: a randomized controlled trial. JPEN J Parenter Enteral Nutr. 2002 ; 26: 209-213.
122. de Lucas C., Moreno M., Lopez-Herce J., Ruiz F., Perez-Palencia M., Carrillo A. Transpyloric enteral nutrition reduces the complication rate and cost in the critically ill child. J Pediatr Gastroenterol Nutr. 2000 ; 30: 175-180.
123. Poindexter BB, Ehrenkranz RA, Stoll BJ, et al. Parenteral glutamine supplementation does not reduce the risk of mortality or late-onset sepsis in extremely low birth weight infants. Pediatrics. 2004 ; 113: 1209-1215.
124. Gore DC, Jahoor F. Deficiency in peripheral glutamine production in pediatric patients with burns. J Burn Care Rehabil. 2000 ; 21: 171 ; discussion 172-177.
125. Wischmeyer PE Glutamine: mode of action in critical illness. Crit Care Med. 2007 ; 35: S541 - S544.
126. Windle EM Glutamine supplementation in critical illness: evidence, recommendations, and implications for clinical practice in burn care. J Burn Care Res. 2006 ; 27: 764-772.
127. Griffiths RD, Jones C., Palmer TE Six-month outcome of critically ill patients given glutamine-supplemented parenteral nutrition. Nutrition. 1997 ; 13: 295-302.
128. Wischmeyer PE, Lynch J., Liedel J., et al. Glutamine administration reduces Gram-negative bacteremia in severely burned patients: a prospective, randomized, double-blind trial versus isonitrogenous control. Crit Care Med. 2001 ; 29: 2075-2080.
129. Dechelotte P., Hasselmann M., Cynober L., et al. L-alanyl-L-glutamine dipeptide-supplemented total parenteral nutrition reduces infectious complications and glucose intolerance in critically ill patients: the French controlled, randomized, double-blind, multicenter study. Crit Care Med. 2006 ; 34: 598-604.
130. Bakalar B., Duska F., Pachl J., et al. Parenterally administered dipeptide alanyl-glutamine prevents worsening of insulin sensitivity in multiple-trauma patients. Crit Care Med. 2006 ; 34: 381-386.
131. De-Souza DA, Greene LJ Intestinal permeability and systemic infections in critically ill patients: effect of glutamine. Crit Care Med. 2005 ; 33: 1125-1135.
132. Conejero R., Bonet A., Grau T., et al. Effect of a glutamine-enriched enteral diet on intestinal permeability and infectious morbidity at 28 days in critically ill patients with systemic inflammatory response syndrome: a randomized, single-blind, prospective, multicenter study. Nutrition. 2002 ; 18: 716-721.
133. Garrel D., Patenaude J., Nedelec B., et al. Decreased mortality and infectious morbidity in adult burn patients given enteral glutamine supplements: a prospective, controlled, randomized clinical trial. Crit Care Med. 2003 ; 31: 2444-2449.
134. Tubman TR, Thompson SW, McGuire W. Glutamine supplementation to prevent morbidity and mortality in preterm infants. Cochrane Database Syst Rev. 2005 :CD001457.
135. Grover Z., Tubman R., McGuire W. Glutamine supplementation for young infants with severe gastrointestinal disease. Cochrane Database Syst Rev. 2007 :CD005947.
136. Albers MJ, Steyerberg EW, Hazebroek FW, et al. Glutamine supplementation of parenteral nutrition does not improve intestinal permeability, nitrogen balance, or outcome in newborns and infants undergoing digestive-tract surgery: results from a double-blind, randomized, controlled trial. Ann Surg. 2005 ; 241: 599-606.
137. Williams EA, Elia M., Lunn PG A double-blind, placebo-controlled, glutamine-supplementation trial in growth-faltering Gambian infants. Am J Clin Nutr. 2007 ; 86: 421-427.
138. Lima NL, Soares AM, Mota RM, Monteiro HS, Guerrant RL, Lima AA Wasting and intestinal barrier function in children taking alanyl-glutamine-supplemented enteral formula. J Pediatr Gastroenterol Nutr. 2007 ; 44: 365-374.
139. Lima AA, Brito LF, Ribeiro HB, et al. Intestinal barrier function and weight gain in malnourished children taking glutamine supplemented enteral formula. J Pediatr Gastroenterol Nutr. 2005 ; 40: 28-35.
140. Yalcin SS, Yurdakok K., Tezcan I., Oner L. Effect of glutamine supplementation on diarrhea, interleukin-8 and secretory immunoglobulin A in children with acute diarrhea. J Pediatr Gastroenterol Nutr. 2004 ; 38: 494-501.
141. Aquino VM, Harvey AR, Garvin JH, et al. A double-blind randomized placebo-controlled study of oral glutamine in the prevention of mucositis in children undergoing hematopoietic stem cell transplantation: a pediatric blood and marrow transplant consortium study. Bone Marrow Transplant. 2005 ; 36: 611-616.
142. Mok E., Eleouet-Da Violante C., Daubrosse C., et al. Oral glutamine and amino acid supplementation inhibit whole-body protein degradation in children with Duchenne muscular dystrophy. Am J Clin Nutr. 2006 ; 83: 823-828.
143. Williams R., Olivi S., Li CS, et al. Oral glutamine supplementation decreases resting energy expenditure in children and adolescents with sickle cell anemia. J Pediatr Hematol Oncol. 2004 ; 26: 619-625.
144. Sheridan RL, Prelack K., Yu YM, et al. Short-term enteral glutamine does not enhance protein accretion in burned children: a stable isotope study. Surgery. 2004 ; 135: 671-678.
145. Ligthart-Melis GC, van de Poll MC, Dejong CH, Boelens PG, Deutz NE, van Leeuwen PA The route of administration (enteral or parenteral) affects the conversion of isotopically labeled L-[2-15N]glutamine into citrulline and arginine in humans. JPEN J Parenter Enteral Nutr. 2007 ; 31: 343-348 ; discussion 349-350.
146. Vermeulen MA, van de Poll MC, Ligthart-Melis GC, et al. Specific amino acids in the critically ill patient-exogenous glutamine/ arginine: a common denominator? Crit Care Med. 2007 ; 35 (9 Suppl). S568 - S576.
147. Barbul A., Uliyargoli A. Use of exogenous arginine in multiple organ dysfunction syndrome and sepsis. Crit Care Med. 2007 ; 35 (9 Suppl). S564 - S567.
148. Amin HJ, Zamora SA, McMillan DD, et al. Arginine supplementation prevents necrotizing enterocolitis in the premature infant. J Pediatr. 2002 ; 140: 425-431.
149. van Waardenburg DA, de Betue CT, Luiking YC, Engel M., Deutz NE Plasma arginine and citrulline concentrations in critically ill children: strong relation with inflammation. Am J Clin Nutr. 2007 ; 86: 1438-1444.
150. Yu YM, Sheridan RL, Burke JF, Chapman TE, Tompkins RG, Young VR Kinetics of plasma arginine and leucine in pediatric burn patients. Am J Clin Nutr. 1996 ; 64: 60-66.
151. Yu YM, Ryan CM, Castillo L., et al. Arginine and ornithine kinetics in severely burned patients: increased rate of arginine disposal. Am J Physiol Endocrinol Metab. 2001 ; 280: E509 - E517.
152. Argaman Z., Young VR, Noviski N., et al. Arginine and nitric oxide metabolism in critically ill septic pediatric patients. Crit Care Med. 2003 ; 31: 591-597.
153. Marin VB, Rodriguez-Osiac L., Schlessinger L., Villegas J., Lopez M., Castillo-Duran C. Controlled study of enteral arginine supplementation in burned children: impact on immunologic and metabolic status. Nutrition. 2006 ; 22: 705-712.
154. Jeschke MG, Finnerty CC, Suman OE, Kulp G., Mlcak RP, Herndon DN The effect of oxandrolone on the endocrinologic, inflammatory, and hypermetabolic responses during the acute phase postburn. Ann Surg. 2007 ; 246: 351-360 ; discussion 360-362.
155. Hart DW, Wolf SE, Ramzy PI, et al. Anabolic effects of oxandrolone after severe burn. Ann Surg. 2001 ; 233: 556-564.
156. Wolf SE, Thomas SJ, Dasu MR, et al. Improved net protein balance, lean mass, and gene expression changes with oxandrolone treatment in the severely burned. Ann Surg. 2003 ; 237: 801-810.
157. Murphy KD, Thomas S., Mlcak RP, Chinkes DL, Klein GL, Herndon DN Effects of long-term oxandrolone administration in severely burned children. Surgery. 2004 ; 136: 219-224.
158. Przkora R., Jeschke MG, Barrow RE, et al. Metabolic and hormonal changes of severely burned children receiving long-term oxandrolone treatment. Ann Surg. 2005 ; 242: 384-389, discussion 390-391.
159. Thomas S., Wolf SE, Murphy KD, Chinkes DL, Herndon DN The long-term effect of oxandrolone on hepatic acute phase proteins in severely burned children. J Trauma. 2004 ; 56: 37-44.
160. Mlcak RP, Suman OE, Murphy K., Herndon DN Effects of growth hormone on anthropometric measurements and cardiac function in children with thermal injury. Burns. 2005 ; 31: 60-66.
161. Gilpin DA, Barrow RE, Rutan RL, Broemeling L., Herndon DN Recombinant human growth hormone accelerates wound healing in children with large cutaneous burns. Ann Surg. 1994 ; 220: 19-24.
162. Thomas SJ, Morimoto K., Herndon DN, et al. The effect of prolonged euglycemic hyperinsulinemia on lean body mass after severe burn. Surgery. 2002 ; 132: 341-347.
163. Wu X., Thomas SJ, Herndon DN, Sanford AP, Wolf SE Insulin decreases hepatic acute phase protein levels in severely burned children. Surgery. 2004 ; 135: 196-202.
164. Jeschke MG, Klein D., Herndon DN Insulin treatment improves the systemic inflammatory reaction to severe trauma. Ann Surg. 2004 ; 239: 553-560.
165. Abiles J., de la Cruz AP, Castano J., et al. Oxidative stress is increased in critically ill patients according to antioxidant vitamins intake, independent of severity: a cohort study. Crit Care. 2006 ; 10: R146.
166. Lyons J., Rauh-Pfeiffer A., Ming-Yu Y., et al. Cysteine metabolism and whole blood glutathione synthesis in septic pediatric patients. Crit Care Med. 2001 ; 29: 870-877.
167. Seear M., Lockitch G., Jacobson B., Quigley G., MacNab A. Thiamine, riboflavin, and pyridoxine deficiencies in a population of critically ill children. J Pediatr. 1992 ; 121: 533-538.
168. Voruganti VS, Klein GL, Lu HX, Thomas S., Freeland-Graves JH, Herndon DN Impaired zinc and copper status in children with burn injuries: need to reassess nutritional requirements. Burns. 2005 ; 31: 711-716.
169. Gottschlich MM, Mayes T., Khoury J., Warden GD Hypovitaminosis D in acutely injured pediatric burn patients. J Am Diet Assoc. 2004 ; 104: 931-941, quiz 1031.
170. Berger MM, Chiolero RL Antioxidant supplementation in sepsis and systemic inflammatory response syndrome. Crit Care Med. 2007 ; 35 (9 Suppl). S584 - S590.
171. Biesalski HK, McGregor GP Antioxidant therapy in critical care-is the microcirculation the primary target? Crit Care Med. 2007 ; 35 (9 Suppl). S577 - S583.
172. Ramstack M., Listernick R. Safety and efficacy of a new pediatric enteral product in the young child. JPEN J Parenter Enteral Nutr. 1991 ; 15: 89-92.
173. Alexander JW, MacMillan BG, Stinnett JD, et al. Beneficial effects of aggressive protein feeding in severely burned children. Ann Surg. 1980 ; 192: 505-517.
174. Hart DW, Wolf SE, Zhang XJ, et al. Efficacy of a high-carbohydrate diet in catabolic illness. Crit Care Med. 2001 ; 29: 1318-1324.
175. Meredith JW, Ditesheim JA, Zaloga GP Visceral protein levels in trauma patients are greater with peptide diet than with intact protein diet. J Trauma. 1990 ; 30: 825-828 ; discussion 828-829.
176. Ziegler F., Ollivier JM, Cynober L., et al. Efficiency of enteral nitrogen support in surgical patients: small peptides v non-degraded proteins. Gut. 1990 ; 31: 1277-1283.
177. Brinson RR, Kolts BE Diarrhea associated with severe hypoalbuminemia: a comparison of a peptide-based chemically defined diet and standard enteral alimentation. Crit Care Med. 1988 ; 16: 130-136.
178. Khoshoo V., Zembo M., King A., Dhar M., Reifen R., Pencharz P. Incidence of gastroesophageal reflux with whey- and casein-based formulas in infants and in children with severe neurological impairment. J Pediatr Gastroenterol Nutr. 1996 ; 22: 48-55.
179. Fried MD, Khoshoo V., Secker DJ, Gilday DL, Ash JM, Pencharz PB Decrease in gastric emptying time and episodes of regurgitation in children with spastic quadriplegia fed a whey-based formula. J Pediatr. 1992 ; 120: 569-572.
180. Gadek JE, DeMichele SJ, Karlstad MD, et al. Effect of enteral feeding with eicosapentaenoic acid, gamma-linolenic acid, and antioxidants in patients with acute respiratory distress syndrome. Enteral Nutrition in ARDS Study Group. Crit Care Med. 1999 ; 27: 1409-1420.
181. Pontes-Arruda A., Aragao AM, Albuquerque JD Effects of enteral feeding with eicosapentaenoic acid, gamma-linolenic acid, and antioxidants in mechanically ventilated patients with severe sepsis and septic shock. Crit Care Med. 2006 ; 34: 2325-2333.
182. Nadkarni V., DeMichele S., Goldstein B., Checchia P., Ayad O., Jacobs BR Safety of an enteral formula enriched with eicosapentaenoic and gamma-linolenic acids in critically ill children with acute lung injury [abstract]. Crit Care Med. 2005 ; 33: A99.
183. Mayes T., Gottschlich M., Carman B., Kagan R. An evaluation of the safety of an anti-inflammatory, pulmonary enteral formula in the treatment of pediatric burn patients with respiratory failure [abstract]. Nutr Clin Pract. 2005 ; 20: A130.
184. Heyland DK, Novak F., Drover JW, Jain M., Su X., Suchner U. Should immunonutrition become routine in critically ill patients? A systematic review of the evidence. JAMA. 2001 ; 286: 944-953.
185. Gottschlich MM, Jenkins M., Warden GD, et al. Differential effects of three enteral dietary regimens on selected outcome variables in burn patients. JPEN J Parenter Enteral Nutr. 1990 ; 14: 225-236.
186. Saffle JR, Wiebke G., Jennings K., Morris SE, Barton RG Randomized trial of immune-enhancing enteral nutrition in burn patients. J Trauma. 1997 ; 42: 793-800.
187. Briassoulis G., Filippou O., Hatzi E., Papassotiriou I., Hatzis T. Early enteral administration of immunonutrition in critically ill children: results of a blinded randomized controlled clinical trial. Nutrition. 2005 ; 21: 799-807.
188. Briassoulis G., Filippou O., Kanariou M., Hatzis T. Comparative effects of early randomized immune or non-immune-enhancing enteral nutrition on cytokine production in children with septic shock. Intensive Care Med. 2005 ; 31: 851-858.
189. Briassoulis G., Filippou O., Kanariou M., Papassotiriou I., Hatzis T. Temporal nutritional and inflammatory changes in children with severe head injury fed a regular or an immune-enhancing diet: a randomized, controlled trial. Pediatr Crit Care Med. 2006 ; 7: 56-62.
190. Saavedra JM Use of probiotics in pediatrics: rationale, mechanisms of action, and practical aspects. Nutr Clin Pract. 2007 ; 22: 351-365.
191. Lemberg DA, Ooi CY, Day AS Probiotics in paediatric gastrointestinal diseases. J Paediatr Child Health. 2007 ; 43: 331-336.
192. Johnston BC, Supina AL, Ospina M., Vohra S. Probiotics for the prevention of pediatric antibiotic-associated diarrhea. Cochrane Database Syst Rev. 2007 :CD004827.
193. Deshpande G., Rao S., Patole S. Probiotics for prevention of necrotising enterocolitis in preterm neonates with very low birth-weight: a systematic review of randomised controlled trials. Lancet. 2007 ; 369: 1614-1620.
194. Honeycutt TC, El Khashab M., Wardrop RM III, et al. Probiotic administration and the incidence of nosocomial infection in pediatric intensive care: a randomized placebo-controlled trial. Pediatr Crit Care Med. 2007 ; 8: 452-458 ; quiz 464.
195. Srinivasan R., Meyer R., Padmanabhan R., Britto J. Clinical safety of Lactobacillus casei shirota as a probiotic in critically ill children. J Pediatr Gastroenterol Nutr. 2006 ; 42: 171-173.
196. Duggan C., Rizzo C., Cooper A., et al. Effectiveness of a clinical practice guideline for parenteral nutrition: a 5-year follow-up study in a pediatric teaching hospital. JPEN J Parenter Enteral Nutr. 2002 ; 26: 377-381.
197. Heird WC Amino acids in pediatric and neonatal nutrition. Curr Opin Clin Nutr Metab Care. 1998 ; 1: 73-78.
198. Shulman RJ, Phillips S. Parenteral nutrition in infants and children. J Pediatr Gastroenterol Nutr. 2003 ; 36: 587-607.
199. Koletzko B., Goulet O., Hunt J., Krohn K., Shamir R. 1. Guidelines on paediatric parenteral nutrition of the European Society of Paediatric Gastroenterology, Hepatology and Nutrition (ESPGHAN) and the European Society for Clinical Nutrition and Metabolism (ESPEN), supported by the European Society of Paediatric Research (ESPR). J Pediatr Gastroenterol Nutr. 2005 ; 41 (suppl 2). S1 - S87.
200. Thureen PJ, Melara D., Fennessey PV, Hay WW Jr. Effect of low versus high intravenous amino acid intake on very low birth weight infants in the early neonatal period. Pediatr Res. 2003 ; 53: 24-32.
201. Moore FA Caution: use fat emulsions judiciously in intensive care patients. Crit Care Med. 2001 ; 29: 1644-1645.
202. Bresson JL, Narcy P., Putet G., Ricour C., Sachs C., Rey J. Energy substrate utilization in infants receiving total parenteral nutrition with different glucose to fat ratios. Pediatr Res. 1989 ; 25: 645-648.
203. Van Aerde JE, Sauer PJ, Pencharz PB, Smith JM, Heim T., Swyer PR Metabolic consequences of increasing energy intake by adding lipid to parenteral nutrition in full-term infants. Am J Clin Nutr. 1994 ; 59: 659-662.
204. Li X., Ying J., Zeng S., et al. The effects of a short-term long-chain-triglyceride infusion on the postoperative immune function of pediatric patients receiving a gastrointestinal surgical procedure. JPEN J Parenter Enteral Nutr. 2008 ; 32: 72-77.
205. Donnell SC, Lloyd DA, Eaton S., Pierro A. The metabolic response to intravenous medium-chain triglycerides in infants after surgery. J Pediatr. 2002 ; 141: 689-694.
206. Lehner F., Demmelmair H., Roschinger W., et al. Metabolic effects of intravenous LCT or MCT/LCT lipid emulsions in preterm infants. J Lipid Res. 2006 ; 47: 404-411.
207. Liet JM, Piloquet H., Marchini JS, et al. Leucine metabolism in preterm infants receiving parenteral nutrition with medium-chain compared with long-chain triacylglycerol emulsions. Am J Clin Nutr. 1999 ; 69: 539-543.
208. Gura KM, Lee S., Valim C., et al. Safety and efficacy of a fish-oil-based fat emulsion in the treatment of parenteral nutrition-associated liver disease. Pediatrics. 2008 ; 121: e678 - e686.
209. Heller AR, Rossler S., Litz RJ, et al. Omega-3 fatty acids improve the diagnosis-related clinical outcome. Crit Care Med. 2006 ; 34: 972-979.
210. Gilio AE, Stape A., Pereira CR, Cardoso MF, Silva CV, Troster EJ Risk factors for nosocomial infections in a critically ill pediatric population: a 25-month prospective cohort study. Infect Control Hosp Epidemiol. 2000 ; 21: 340-342.
211. Sheridan RL, Weber JM Mechanical and infectious complications of central venous cannulation in children: lessons learned from a 10-year experience placing more than 1000 catheters. J Burn Care Res. 2006 ; 27: 713-718.
212. Kumpf VJ Parenteral nutrition-associated liver disease in adult and pediatric patients. Nutr Clin Pract. 2006 ; 21: 279-290.
213. Hulst JM, van Goudoever JB, Zimmermann LJ, Tibboel D., Joosten KF The role of initial monitoring of routine biochemical nutritional markers in critically ill children. J Nutr Biochem. 2006 ; 17: 57-62.
214. Sheridan RL, Yu YM, Prelack K., Young VR, Burke JF, Tompkins RG Maximal parenteral glucose oxidation in hypermetabolic young children: a stable isotope study. JPEN J Parenter Enteral Nutr. 1998 ; 22: 212-216.
215. Devos P., Preiser JC Current controversies around tight glucose control in critically ill patients. Curr Opin Clin Nutr Metab Care. 2007 ; 10: 206-209.
216. Wintergerst KA, Buckingham B., Gandrud L., Wong BJ, Kache S., Wilson DM Association of hypoglycemia, hyperglycemia, and glucose variability with morbidity and death in the pediatric intensive care unit. Pediatrics. 2006 ; 118: 173-179.
217. Srinivasan V., Spinella PC, Drott HR, Roth CL, Helfaer MA, Nadkarni V. Association of timing, duration, and intensity of hyperglycemia with intensive care unit mortality in critically ill children. Pediatr Crit Care Med. 2004 ; 5: 329-336.
218. Faustino EV, Apkon M. Persistent hyperglycemia in critically ill children. J Pediatr. 2005 ; 146: 30-34.
219. Klein GW, Hojsak JM, Rapaport R. Hyperglycemia in the pediatric intensive care unit. Curr Opin Clin Nutr Metab Care. 2007 ; 10: 187-192.
220. Pham TN, Warren AJ, Phan HH, Molitor F., Greenhalgh DG, Palmieri TL Impact of tight glycemic control in severely burned children. J Trauma. 2005 ; 59: 1148-1154.
221. Piper HG, Alexander JL, Shukla A., et al. Real-time continuous glucose monitoring in pediatric patients during and after cardiac surgery. Pediatrics. 2006 ; 118: 1176-1184.
222. Wintergerst KA, Deiss D., Buckingham B., et al. Glucose control in pediatric intensive care unit patients using an insulin-glucose algorithm. Diabetes Technol Ther. 2007 ; 9: 211-222.
223. van den Berghe G. KU Leuven Intensive Insulin Study in Pediatric Intensive Care Patients. Available at: http://clinicaltrials.gov/ct2/show/ NCT00214916. Accessed May 14, 2008.
224. Dunn RL, Stettler N., Mascarenhas MR Refeeding syndrome in hospitalized pediatric patients. Nutr Clin Pract. 2003 ; 18: 327-332.
225. Gardelis JG, Hatzis TD, Stamogiannou LN, et al. Activity of the growth hormone/insulin-like growth factor-I axis in critically ill children. J Pediatr Endocrinol Metab. 2005 ; 18: 363-372.
226. Moshage H. Cytokines and the hepatic acute phase response. J Pathol. 1997 ; 181: 257-266.
227. Leite HP, Fisberg M., de Carvalho WB, de Camargo Carvalho AC Serum albumin and clinical outcome in pediatric cardiac surgery. Nutrition. 2005 ; 21: 553-558.
228. Gottschlich MM, Baumer T., Jenkins M., Khoury J., Warden GD The prognostic value of nutritional and inflammatory indices in patients with burns. J Burn Care Rehabil. 1992 ; 13: 105-113.
229. Chwals WJ, Fernandez ME, Jamie AC, Charles BJ Relationship of metabolic indexes to postoperative mortality in surgical infants. J Pediatr Surg. 1993 ; 28: 819-822.
230. Pons Leite H., Gilberto Henriques Vieira J., Brunow De Carvalho W., Chwals WJ The role of insulin-like growth factor I, growth hormone, and plasma proteins in surgical outcome of children with congenital heart disease. Pediatr Crit Care Med. 2001 ; 2: 29-35.
231. Prelack K., Washek M., Sheridan RL Pre-albumin and C-reactive protein are predictive of nutritional adequacy in burned children [abstract]. J Burn Care Rehabil. 2001 ; 23: s126.