The use of enteral naloxone to treat opioid-induced constipation in a pediatric intensive care unit

Pediatric Critical Care Medicine

Volumn 7, Issue 3, 2006, Pages 252-254

  Tofil, Nancy M ^a   Benner, Kim W ^b   Faro, Sarah Jane ^c   Winkler, Margaret K ^a  

^a University of Alabama at Birmingham   (United States)

^b SAMFORD UNIVERSITY   (United States)

^c Primary Children's ^*  (United States)

Author keywords

Constipation; Critical care; Naloxone; Opioids; Pediatrics; Side effects

Indexed keywords

BISACODYL; ENEMA; FENTANYL; GLYCEROL; LAXATIVE; MACROGOL 3350; METHADONE; MORPHINE; NALOXONE; NARCOTIC AGENT; NARCOTIC ANTAGONIST; NEUROMUSCULAR BLOCKING AGENT; OPIATE;

ADOLESCENT; AGITATION; CHILD; CLINICAL ARTICLE; CONSTIPATION; CONTROLLED STUDY; DRUG USE; DRUG WITHDRAWAL; FECES ANALYSIS; FEMALE; HUMAN; HYPERTENSION; INFANT; INTENSIVE CARE UNIT; LENGTH OF STAY; MALE; MEDICATION ERROR; NUTRITIONAL STATUS; PRIORITY JOURNAL; RESPIRATORY DISTRESS; RETROSPECTIVE STUDY; REVIEW; TACHYCARDIA; TREATMENT OUTCOME;

EID: 33646887970     PISSN: 15297535     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.PCC.0000216421.72002.09     Document Type: Article

References (10)

1. Manara L, Bianchetti A: The central and peripheral influences of opioids on gastrointestinal propulsion. Annu Rev Pharmacol Toxicol 1985; 25:249-273
2. Friedman JD, DelloBuono FA: Opioid antagonists in the treatment of opioid-induced constipation and pruritus. Ann Pharmacother 2001; 35:85-91
3. Berkowitz BA: The relationship of pharmacokinetics to pharmacologic activity: morphine, methadone and naloxone. Clin Pharmacokinet 1976; 1:219-229
4. Handal KA, Schauben JL, Salamone FR: Naloxone. Ann Emerg Med 1983; 12:936-942
5. Kreek MJ, Scheafer RA, Hahn EF, et al: Naloxone, a specific opioid antagonist, reverses chronic idiopathic constipation. Lancet 1983; 261-262
6. Culpepper-Morgan JA, Inturrisi CE, Portenoy RK, et al: Treatment of opioid-induced constipation with oral naloxone: A pilot study. Clin Pharmacol Ther 1992; 52:90-95
7. Liu M, Wittbrodt E: Low-dose oral naloxone reverses opioid-induced constipation and analgesia. J Pain Symptom Manage 2002; 23:48-53
8. Meissner W, Schmidt U, Hartman M, et al: Oral naloxone reverses opioid-induced constipation. Pain 2000; 84:105-109
9. Tobias JD, Rasmussen GE: Pain management and sedation in the pediatric intensive care unit. Pediatr Clin North Am 1994; 41:1269-1291
10. Gan TJ, Ginsberg B, Glass PJ, et al: Opioid-sparing effects of a low-dose infusion of naloxone in patient-administered morphine sulfate. Anesthesiology 1997; 87:1075-1081