Six-month outcome of critically ill patients given glutamine- supplemented parenteral nutrition

Nutrition

Volumn 13, Issue 4, 1997, Pages 295-302

  Griffiths, Richard D ^a   Jones, Christina ^a   Palmer, T E Allan ^a  

^a UNIVERSITY OF LIVERPOOL   (United Kingdom)

Author keywords

costs; critically ill; glutamine; intensive care; nutrition; outcome; parenteral nutrition

Indexed keywords

AMINO ACID; ELECTROLYTE; GLUCOSE; GLUTAMINE; LIPID; TRACE ELEMENT;

ADULT; AGED; ARTICLE; CALORIC INTAKE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CRITICAL ILLNESS; DIET SUPPLEMENTATION; DOUBLE BLIND PROCEDURE; FEMALE; HOSPITAL COST; HOSPITALIZATION; HUMAN; INTENSIVE CARE; MAJOR CLINICAL STUDY; MALE; NUTRITIONAL SUPPORT; PARENTERAL NUTRITION; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; TREATMENT OUTCOME;

ADULT; AGED; AGED, 80 AND OVER; CRITICAL ILLNESS; DOUBLE-BLIND METHOD; FEMALE; GLUTAMINE; HEALTH CARE COSTS; HUMANS; INTENSIVE CARE; LENGTH OF STAY; MALE; MIDDLE AGED; PARENTERAL NUTRITION; PROSPECTIVE STUDIES; TREATMENT OUTCOME;

EID: 0030904577     PISSN: 08999007     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0899-9007(97)00017-8     Document Type: Article

References (41)

1. Palmer TEA, Jones C, Griffiths RD. Measuring the consequences of sepsis. In: Rennie M, ed. Intensive care Britain. 1993. London: Greycoat Publishing, 1993:85
2. Bone RC. Sepsis, the sepsis syndrome, multi-organ failure: a plea for comparable definitions. Ann Intern Med 1991;114:332
3. Apelgren K, Rombeau JL, Twomey PL, Miller RA. Comparison of nutritional indices and outcome in critically ill patients. Crit Care Med 1982;10:305
4. Streat SJ, Beddoe AH, Hill GL. Aggressive nutritional support does not prevent protein loss despite fat gain in septic intensive care patients. J Trauma 1987;27:262
5. Heyland DK, Cook DJ, Guyatt GH. Enteral nutrition in the critically ill patient: a critical review of the evidence. Intensive Care Med 1993;19:435
6. Shiell AM, Griffiths RD, Short AIK, Spiby J. An evaluation of the costs and outcome of adult intensive care in two units in the UK. Clinical Intensive Care 1990;1:256
7. Bergstrom J, Furst P, Noree L-O, Vinnars. Intracellular free amino acid concentration in human muscle tissue. J Appl Physiol 1974;36:693
8. Deutz NEP, Reijven PLM, Athanasas G, Soeters PB. Post-operative changes in hepatic, intestinal, splenic and muscle fluxes of amino acids and ammonia in pigs. Clin Sci 1992;83:607
9. Slazman NP, Eagle H, Sebring ED. The utilisation of glutamine, glutamic acid, and ammonia for the biosynthesis of nucleic acid bases in mammalian cell cultures. J Biol Chem 1958;230:1001
10. Wernerman J, von der Decken A, Vinnars E. Protein synthesis in skeletal muscle in relation to nitrogen balance after abdominal surgery: the effect of total parenteral nutrition. JPEN 1986;10:578
11. Wernerman J, Hammarqvist F, Ali MR, Vinnars E. Glutamine and ornithine-alpha-ketoglutarate but not branched-chain amino acids reduce the loss of muscle glutamine after surgical trauma. Metabolism 1989;38(8 suppl. 1):63
12. Stehle P, Zander J, Mertes N, et al. Effect of parenteral glutamine peptide supplements on muscle glutamine loss and nitrogen balance after major surgery. Lancet 1989;1(8632):231
13. Petersson B, Waller S-O, Vinnars E, Wernerman J. Long-term effect of glycyl-glutamine after elective surgery on free amino acids in muscle. JPEN 1994;18:320
14. Ziegler TR, Young LS, Benfell K, et al. Clinical and metabolic efficacy of glutamine-supplemented parenteral nutrition after bone marrow transplantation. Ann Intern Med 1992;116:821
15. Knaus WA, Draper EA, Wagner DP, Zimmerman JE. APACHE II: a severity of disease classification. Crit Care Med 1985;13:818
16. Hardy G, Wiggins D, McElroy B, Thompson GR. Formulation of a glutamine-containing total parenteral nutrition mixture for clinical use. Proc Nutr Soc 1992;51:136A
17. Green CJ, Campbell IT, McClelland P, et al. Energy and nitrogen balance and changes in midupper-arm circumference with multiple organ failure. Nutrition 1995;11:739
18. Knaus WA, Draper EA, Wagner DP, Zimmerman JE. Prognosis in acute organ-system failure. Ann Surg 1985;202:685
19. Keen AR, Cullen DJ. Therapeutic Intervention Score System: Update 1983. Crit Care Med 1983;11:1
20. Marshall J, Sweeney D. Microbial infection and the septic response in critical surgical illness. Arch Surg 1990;125:17
21. Jones C, Hussey RM, Griffiths RD. A tool to measure the change in health status of selected adult patients before and after intensive care. Clinical Intensive Care 1993;4:160
22. Lund P. L-glutamine and L-glutamate: UV-method with glutaminase and glutamate dehydrogenase. In: Bergmeyer HU, Grassl M, eds. Methods of enzymatic analysis. Verlag Chemie, Basel, Switzerland 1983:357
23. Bergner M, Bobbitt RA, Carter WB, Gilson BS. The sickness impact profile: development and final revision of a health status measure. Medical Care 1981;19:789
24. Cullen DJ, Civetta JM, Briggs BA, Ferrara LC. Therapeutic intervention scoring system: a method for quantitative comparison of patient care. Crit Care Med 1974;2:57
25. Heymsfield SB, McManus C, Stevens V, Smith J. Muscle mass: reliable indicator of protein-energy malnutrition severity and outcome. Am J Clin Nutr 1982;35:1192
26. Cederholm T, Jagren C, Hellstrom K. Outcome of protein-energy malnutrition in elderly medical patients. Am J Med 1995;98:67
27. Giner M, Laviano A, Meguid MM, Gleason JR. In 1995 a correlation between malnutrition and poor outcome in critically ill patients still exists. Nutrition 1996;12:23
28. Lexell J, Taylor CC, Sjostrom M. What is the cause of the ageing atrophy? Total number, size and proportion of different fiber types studied in whole vastus lateralis muscle from 15- to 83-year-old men. J Neurol Sci 1988;84:275
29. Finn PJ, Plank LD, Clark MA, Connolly AB, Hill GL. Progressive cellular dehydration and proteolysis in critically-ill patients. Lancet 1996;347:654
30. Griffiths RD. Muscle mass, survival, and the elderly ICU patient. Nutrition 1996;12(6):456
31. Hammarqvist F, Wernerman J, Ali R, von der Decken A, Vinnars E. Addition of glutamine to total parenteral nutrition after elective abdominal surgery spares free glutamine in muscle, counteracts the fall in muscle protein synthesis, and improves nitrogen balance. Ann Surg 1989;209:455
32. Palmer TEA, Griffiths RD, Jones C. Effect of parenteral 1-glutamine on muscle in the very severely ill. Nutrition 1996;12:316
33. Wilmore DW, Smith RJ, O'Dwyer ST, Jacobs DO, Ziegler TR, Wang XD. The gut: a central organ after surgical stress. Surgery 1988;104:917
34. Windmueller HO, Spaeth AE. Uptake and metabolism of plasma glutamine by the small intestine. J Biol Chem 1974;249:5070
35. Harris CE, Griffiths RD, Freestone N, Billington D, Atherton ST, Macmillan RR. Intestinal permeability in the critically ill. Intensive Care Med 1992;18:38
36. Van der Hulst RR, van Kreel BK, Von Meyenfeldt MF, Brummer RJ, Arends JW, Deutz NE, Soeters PB. Glutamine and the preservation of gut integrity. Lancet 1993;341:1363
37. Newsholme EA, Crabtree B, Ardawi MSM. Glutamine metabolism in lymphocytes, its biochemical, physiological and clinical importance. Q J Exp Physiol 1985;70:473
38. Parry-Billings M, Evans J, Calder PC, Newsholme EA. Does glutamine contribute to immunosuppression after burns? Lancet 1990;336:523
39. Hong RW, Rounds JD, Helton WS, Robinson MK, Wilmore DW. Glutamine preserves liver glutathione after lethal hepatic injury. Ann Surg 1992;215:114
40. Harward TR, Coe D, Souba WW, Klingman N, Seeger JM. Glutamine preserves gut glutathione levels during intestinal ischaemia/ reperfusion. J Surg Res 1994;56:351
41. O'Riordain MG, Fearon KCH, Ross JA, Rogers P, Falconer JS, Bartolo DCC, Garden OJ, Carter DC. Glutamine-supplemented total parenteral nutrition enhances T-lymphocyte response in surgical patients undergoing colorectal resection. Ann Surg 1994;220:212