Use of exogenous arginine in multiple organ dysfunction syndrome and sepsis

Critical Care Medicine

Volumn 35, Issue 9 SUPPL., 2007, Pages

  Barbul, Adrian ^a   Uliyargoli, Ajith ^a  

^a DEPARTMENT OF PATHOLOGY   (United States)

Author keywords

Arginine; Multiple organ dysfunction syndrome; Sepsis

Indexed keywords

ARGININE; NITRIC OXIDE;

AMINO ACID METABOLISM; CONFERENCE PAPER; CRITICALLY ILL PATIENT; DRUG EFFECT; ENZYME BLOOD LEVEL; HUMAN; IMMUNE RESPONSE; IMMUNE SYSTEM; MONOTHERAPY; MULTIPLE ORGAN FAILURE; NONHUMAN; NUTRITION; NUTRITIONAL ASSESSMENT; PRIORITY JOURNAL; SEPSIS; SUPPLEMENTATION; WOUND HEALING;

ANIMALS; ARGININE; HOMEOSTASIS; HUMANS; IMMUNE SYSTEM; MULTIPLE ORGAN FAILURE; NUTRITIONAL SUPPORT; SEPSIS; WOUND HEALING;

EID: 34548175761     PISSN: 00903493     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.CCM.0000279188.97421.FE     Document Type: Conference Paper

References (33)

1. Barbul A: Arginine: Biochemistry, physiology, and therapeutic implications. JPEN J Parenter Enteral Nutr 1986; 10:227-238
2. Wu G, Morris SM Jr: Arginine metabolism: Nitric oxide and beyond. Biochem J 1998; 336:1-17
3. Luiking YC, Poeze M, Dejong CH, et al: Sepsis: An arginine deficiency state? Crit Care Med 2004; 32:2135-2145
4. Satriano J: Agmatine: At the crossroads of arginine pathways. Ann NY Acad Sci 2003; 1009:34-43
5. Freund H, Atamian S, Holroyde J, et al: Plasma amino acids as predictors of the severity and outcome of sepsis. Ann Surg 1979; 190:571-576
6. Gardiner KR, Gardiner RE, Barbul A: Reduced intestinal absorption of arginine during sepsis. Crit Care Med 1995; 23:1227-1232
7. Argaman Z, Young VR, Noviski N, et al: Arginine and nitric oxide metabolism in critically ill septic pediatric patients. Crit Care Med 2003; 31:591-597
8. Nijveldt RJ, Teerlink T, Van Der Hoven B, et al: Asymmetrical dimethylarginine (ADMA) in critically ill patients: High plasma ADMA concentration is an independent risk factor of ICU mortality. Clin Nutr 2003; 22:23-30
9. O'Dwyer MJ, Dempsey F, Crowley V, et al: Septic shock is correlated with asymmetrical dimethyl arginine levels, which may be in-fluenced by a polymorphism in the dimethylarginine dimethylhydrolase II gene: A prospective observational study. Crit Care 2006; 10:1-7
10. de Jonge WJ, Marescau B, D'Hooge R, et al: Overexpression of arginase I alters circulating and tissue amino acids and guanidine compounds and affects neuromotor behavior in mice. J Nutr 1994; 131:2732-2740
11. Rodriguez PC, Zea AH, Culotta KS, et al: Regulation of T cell receptor CD3+ chain expression by L-arginine. J Biol Chem 2002; 227:21123-21129
12. Brittenden J, Heys SD, Ros J, et al: Nutritional pharmacology. Effects of L-arginine on host defenses, response to trauma, and tumor growth. Clin Sci 1994; 86:123-132
13. Efron D, Kirk SJ, Regan MC, et al: Nitric oxide generation from L-arginine is required for optimal peripheral blood lymphocyte DNA synthesis. Surgery 1991; 110:327-334
14. Munder M, Eichmann K, Modolell M: Alternative metabolic states in murine macrophages reflected by the nitric oxide synthase/arginase balance: Competitive regulation of CD4+ T cells correlates with Th1/Th2 phenotype. J Immunol 1998; 160:5347-5354
15. Bernard AC, Mistry SK, Morris SM, et al: Alterations in arginine metabolic enzymes in trauma. Shock 2001; 15:215-219
16. Caraway MS, Piantadosi CA, Jenkinson CP, et al: Differential expression of arginase and iNOS in the lung in sepsis. Exp Lung Res 1998; 24:253-268
17. Kirk SJ, Regan MC, Wasserkrug HL, et al: Arginine enhances T cell responses in athymic nude mice. JPEN J Parenter Enteral Nutr 1992; 16:429-432
18. Bernstein LH: The impact of immunonutrition. Gastroenterology 1996; 110:1677-1678
19. Daly J, Reynolds J, Thom A, et al: Immune and metabolic effects of arginine in the surgical patient. Ann Surg 1988; 208:512-523
20. Abumrad NN, Barbul A: The use of arginine in clinical practice. In: Amino Acid Metabolism and Therapy in Health and Nutritional Diseases. Cynober L (Ed). Boca Raton, FL, CRC Press, 2003, pp 595-611
21. De-Souza DA, Greene LJ: Pharmacological nutrition after burn injury. J Nutr 1998; 128:797-803
22. Witte MB, Barbul A: Arginine physiology and its implication for wound healing. Wound Repair Regen 2003; 11:419-423
23. Shi HP, Most D, Efron DT, et al: Supplemental L-arginine enhances wound healing in diabetic rats. Wound Repair Regen 2003; 11:198-203
24. Kirk SJ, Hurson M, Regan MC, et al: Arginine stimulates wound healing and immune function in aged humans. Surgery 1993; 114:155-160
25. Regan MC, Barbul A: The role of the immune system in the regulation of wound repair. Clin Mater 1991; 8:197-201
26. Witte MB, Barbul A: Role of nitric oxide in repair processes. Am J Surg 2002; 183:406-412
27. Thornton FJ, Schäffer MR, Witte MB, et al: Enhanced collagen accumulation following direct transfection of the inducible nitric oxide synthase gene in cutaneous wounds. Biochem Biophys Res Commun 1998; 246:654-659
28. Madden HP, Breslin RJ, Wasserkrug HL, et al: Stimulation of T cell immunity enhances survival in peritonitis. J Surg Res 1988; 44:658-663
29. Yeh CL, Yeh SL, Lin MT, et al: Effects of arginine-enriched total parenteral nutrition on inflammatory-related mediator and T-cell population in septic rats. Nutrition 2002; 18:631-635
30. Kalil AC, Sevransky JE, Meyers DE, et al: Preclinical trial of l-arginine monotherapy alone or with N-acetylcysteine in septic shock. Crit Care Med 2006; 34:2719-2728
31. Bushinsky DA, Gennari FJ: Life-threatening hyperkalemia induced by arginine. Ann Intern Med 1978; 89:632-634
32. Heyland DK, Frantisek N, Drover JW, et al: Should immunonutrition become routine in critically ill patients? A systematic review of the evidence. JAMA 2001; 286:944-953
33. Heyland DK, Dhaliwal R, Drover JW, et al: Canadian clinical practice guidelines for nutritional support in mechanically ventilated, critically ill adult patients. JPEN J Parenter Enteral Nutr 2003; 27:355-373