Counting of apoptotic cells: A methodological study in invasive breast cancer

Journal of Clinical Pathology - Clinical Molecular Pathology

Volumn 49, Issue 4, 1996, Pages

  Van Anna Maria De Schepop, H ^a   De Jong, Johannes S ^a   Van Diest, Paul J ^a   Baak, Jan P A ^a  

^a VU UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

Apoptosis; Breast cancer; Reproducibility; Sampling

Indexed keywords

APOPTOSIS; ARTICLE; BREAST CARCINOMA; CANCER INVASION; CELL COUNT; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; HUMAN; HUMAN TISSUE; PRIORITY JOURNAL; PROGNOSIS;

EID: 0029783518     PISSN: 13552910     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (25)

1. Aaltomaa S, Lipponen P, Eskelinen M, Kosma VM, Marin S, Alhava E, er al. Prognostic factors in axillary lymph node-negative (pN-) breast carcinomas. EurJ Cancer 1991 ; 27:1555-9.
2. Baak JPA, Dop H van, Kurver PHJ, Hermans J. The value of morphometry to classic prognosticators in breast cancer. Cancer 1985;56:374-82.
3. Bouzubar N, Walker KJ, Griffiths K, Ellis IO, Elston CW, Robertson JFR, et al. Ki67 immunostaining in primary breast cancer: pathological and clinical associations. Br J Cancer 1989;59:943-7.
4. Clayton F. Pathologic correlates of survival in 378 lymph node-negative infiltrating ductal breast carcinomas. Mitotic count is the best single predictor. Cancer 1991; 68:1309-17.
5. Diest PJ van, Baak JPA. The morphometric multivariate prognostic index (MPI) is the strongest prognosticator in premenopausal lymph node negative and lymph node positive breast cancer patients. Hum Pathol 1992;22:47989.
6. Joensuu H, Toikkanen S, Klemi PJ. DNA index and S-phase fraction and their combination as prognostic factors in operable ductal breast carcinoma. Cancer 1990;66:33140.
7. Kamel OW, Franklin WA, Ringus JC, Meyes JS. Thymidine labeling index and Ki-67 growth fraction in lesions of the breast. wJPar/20/1989;134:107-13.
8. Linden JC van der, Baak JPA, Lindeman J, Hermans J, Meijer CJLM. Prospective evaluation of prognostic value of morphometry in patients with primary breast cancer. J Clin Pathol 1987;40:302-6.
9. Meyer JS, Friedman E, McCrate MM, Bauer WC. Prediction of early course of breast carcinoma by thymidine labeling. Cancer 1983;51:1879-86.
10. Sahin AA, Ro J, Ro JY, Thick MB, El-Nagger AK, Ordonez NG, et al. Ki67 immunostaining in node-negative stage I/II breast carcinoma. Significant correlation with prognosis. Cancer 1991 ;68:549-57.
11. Sigurdsson H, Baldetorp B, Borg A, Dalberg M, Ferno M, Killander D, et al. Indicators of prognosis in node-negative breast cancer. N Engl JMed 1990;322:1045-53.
12. Uyterlinde AM, Schipper NW, Baak JPA, Peterse H, Matze P. Limited prognostic value of cellular DNA content to classical and morphological parameters in invasive ductal breast cancer. Am J Clin Pathol 1988;89:301-7.
13. Weidner N, Moore DH, Ljung BM, Waldman FM, Goodson WH, Mayall B, et al. Correlation of bromodeoxyuridine (BrdU) labeling of breast carcinoma cells with mitotic figure content and tumor grade. Am J Si/rg Pathol 1993;17:987-94.
14. Moore JV. Death of cells and necrosis of tumours. In: Potten CS, ed. Perspectives on mammalian cell death. Oxford: Oxford University Press, 1987:305.
15. Sarraf CE, Bowen ID. Proportions of mitotic and apoptotic cells in a range of untreated experimental tumours. Cell Tissue Kinet 1988;21:45-9.
16. Wyllie AH. Apoptosis and the regulation of cell numbers in normal and neoplastic tissues; an overview. Cancer Metastasis Rev 1992;! 1:95-103.
17. Lipponen P, Aaltoma S, Kosma VM, Syrjanen K. Apoptosis in breast cancer as related to histopathological characteristics and prognosis. EitrJ Cancer 1994;30A:2068-73.
18. Afanasyev VN, Korol BA, Matylevich NP, Pechatnikow VA, Umansky SR. The use of flow cytometry for the investigation of cell death. Cytometry 1993;14:603-9.
19. Belloc F, Dumain P, Boisseau MR, Jalloustre C, Reiflers J, Bernard P, et al. A flow cytometric method using Hoechst 33342 and propidium iodide for simultaneous cell cycle analysis and apoptosis determination in unfixed cells. Cytometry 1994;17:59-65.
20. Nicoletti I, Migliorati G, Pagliacci MC, Grignani F, Riccardi C. A rapid and simple method for measuring thymocyte apoptosis by propidium iodide staining and flow cytometry. J Immimol Method 1991;139:271-9.
21. Swat W, Ignatowicz L, Kisielow P. Detection of apoptosis in immature CD4+8+ thymocytes by flow cytometry. J IniniHHolMethod l99l;l31:79-87.
22. Zamai L, Falcieri E, Zauli G, Cataldi A, Vitale M. Optimal detection of apoptosis by flow cytometry depends on cell morphology. Cytometry 1993;14:891-7.
23. Wijsman JH, Jonker RR, Keijzer R, Velde CJH van de, Cornelisse CJ, Dierendonck JH van. A new method to detect apoptosis in paraffin sections: in situ end labeling of fragmented DNA. JHistochem Cywchem 1993;41:7-12.
24. Fleege JC, Diest PJ van, Baak JPA. Computer assisted efficiency-testing of different sampling methods for selective nuclear graphic tablet morphometry. Lab Invest 1990;63:270-5.
25. Bursch W, Pane S, Putz B, Barthel G, Schuhe-Hermann R. Determination of the length of the histological stages of apoptosis in normal liver and in altered hepatic foci of rats. Carcmogenesis 1990; 11:847.