Identification of genes contributing to the obese yellow Avy phenotype: Caloric restriction, genotype, diet X genotype interactions

Physiological Genomics

Volumn 18, Issue , 2004, Pages 316-324

  Kaput, Jim ^a,b,f   Klein, Karin G ^b   Reyes, Eric J ^b   Kibbe, Warren A ^b   Cooney, Craig A ^c   Jovanovic, Borko ^b   Visek, Willard J ^d   Wolff, George L ^e  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b NORTHWESTERN UNIVERSITY   (United States)

^c UNIVERSITY OF ARKANSAS FOR MEDICAL SCIENCES   (United States)

^d UNIVERSITY OF ILLINOIS AT URBANA CHAMPAIGN   (United States)

^e NATIONAL CENTER FOR TOXICOLOGICAL RESEARCH   (United States)

^f NutraGenomics   (United States)

Author keywords

Diabesity; Diabetes; Expression; Gene regulation; Obesity; Quantitative trait locus

Indexed keywords

AGOUTI PROTEIN;

ANIMAL TISSUE; ARTICLE; BALANCE DISORDER; CALORIC INTAKE; CALORIC RESTRICTION; CONTROLLED STUDY; DIET; DISEASE COURSE; DYSLIPIDEMIA; FEMALE; GENE EXPRESSION; GENE IDENTIFICATION; GENOTYPE; HYPERGLYCEMIA; HYPERINSULINEMIA; INFLAMMATION; INSULIN RESISTANCE; LIVER; MALE; MOUSE; MOUSE STRAIN; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; OBESITY; PHENOTYPE; PRIORITY JOURNAL; QUANTITATIVE TRAIT LOCUS;

ANIMALS; BREEDING; CALORIC RESTRICTION; CHROMOSOME MAPPING; DIET; ENERGY INTAKE; FEMALE; GENE EXPRESSION REGULATION; GENES; GENETIC MARKERS; GENOTYPE; LINKAGE (GENETICS); MALE; MICE; MICE, INBRED BALB C; MICE, INBRED C3H; MICE, INBRED STRAINS; MICE, OBESE; OBESITY; QUANTITATIVE TRAIT LOCI; WEIGHT GAIN;

AGOUTI; ANIMALIA; EUKARYOTA;

EID: 4844230290     PISSN: 15312267     EISSN: None     Source Type: Journal    
DOI: 10.1152/physiolgenomics.00065.2003     Document Type: Article

References (108)

1. Aizawa K, Suzuki T, Kada N, Ishihara A, Kawai-Kowase K, Matsumura T, Sasaki K, Munemasa Y, Manabe I, Kurabayashi M, Collins T, and Nagai R. Regulation of platelet-derived growth factor-A chain by Kruppel-like factor 5: new pathway of cooperative activation with nuclear factor-κB. J Biol Chem 279: 70-76, 2004.
2. Belfiore F, Romeo F, Napoli E, and Lo Vecchio L. Enzymes of glucose metabolism in liver of subjects with adult-onset diabetes. Diabetes 23: 293-301, 1974.
3. Beranger F, Mejean C, Moniot B, Berta P, and Vandromme M. Muscle differentiation is antagonized by SOX15, a new member of the sox protein family. J Biol Chem 275: 16103-16109, 2000.
4. Biedi C, Panetta D, Segat D, Cordera R, and Maggi D. Specificity of insulin-like growth factor I and insulin on Shc phosphorylation and Grb2 recruitment in caveolae. Endocrinology 144: 5497-5503, 2003.
5. Boden G. Pathogenesis of type 2 diabetes. Insulin resistance. Endocrinol Metab Clin North Am 30: 801-815, 2001.
6. Brockmann GA and Bevova MR. Using mouse models to dissect the genetics of obesity. Trends Genet 18: 367-76, 2002.
7. Bultman SJ, Michaud EJ, and Woychik RP. Molecular characterization of the mouse agouti locus. Cell 71: 1195-1204, 1992.
8. Busch CP and Hegele RA. Genetic determinants of type 2 diabetes mellitus. Clin Genet 60: 243-254, 2001.
9. Cao SX, Dhahbi JM, Mote PL, and Spindler SR. Genomic profiling of short- and long-term caloric restriction effects in the liver of aging mice. Proc Natl Acad Sci USA 98: 10630-10635, 2001.
10. Chawla A, Repa JJ, Evans RM, and Mangelsdorf DJ. Nuclear receptors and lipid physiology: opening the x-files. Science 294: 1866-1870, 2001.
11. Coleman DL, Kuzava JE, and Leiter EH. Effect of diet on incidence of diabetes in nonobese diabetic mice. Diabetes 39: 432-436, 1990.
12. Collins FS, Guyer MS, and Charkravarti A. Variations on a theme: cataloging human DNA sequence variation. Science 278: 1580-1581, 1997.
13. Cooney CA, Dave AA, and Wolff GL. Maternal methyl supplements in mice affect epigenetic variation and DNA methylation of offspring. J Nutr 132. Suppl: 2393S-2400S, 2002.
14. Dauncey MJ, White P, Burton KA, and Katsumata M. Nutrition-hormone receptor-gene interactions: implications for development and disease. Proc Nutr Soc 60: 63-72, 2001.
15. de Valk HW. Magnesium in diabetes mellitus. Neth J Med 54: 139-146, 1999.
16. Dhahbi JM, Mote PL, Wingo J, Tillman JB, Walford RL, and Spindler SR. Calories and aging alter gene expression for gluconeogenic, glycolytic, and nitrogen-metabolizing enzymes. Am J Physiol Endocrinol Metab 277: E352-E360, 1999.
17. Doble BW and Woodgett JR. GSK-3: tricks of the trade for a multitasking kinase. J Cell Sci 116: 1175-1186, 2003.
18. 0-ATPase subunit e gene isolated in a screen for diet regulated genes. Biochem Biophys Res Commun 190: 167-174, 1993.
19. Evans JL, Goldfine ID, Maddux BA, and Grodsky GM. Oxidative stress and stress-activated signaling pathways: a unifying hypothesis of type 2 diabetes. Endocr Rev 23: 599-622, 2002.
20. Feng L, Novak EK, Hartnell LM, Bonifacino JS, Collinson LM, and Swank RT. The Hermansky-Pudlak syndrome 1 (HPS1) and HPS2 genes independently contribute to the production and function of platelet dense granules, melanosomes, and lysosomes. Blood 99: 1651-1658, 2002.
21. Ferre P. Regulation of gene expression by glucose. Proc Nutr Soc 58: 621-623, 1999.
22. Flint J and Mott R. Finding the molecular basis of quantitative traits: Successes and pitfalls. Nat Rev Genet 2: 437-445, 2001.
23. Florez JC, Hirschhorn J, and Altshuler D. The inherited basis of diabetes mellitus: implications for the genetic analysis of complex traits. Annu Rev Genomics Hum Genet 4: 257-291, 2003.
24. Francis GA, Fayard E, Picard F, and Auwerx J. Nuclear receptors and the control of metabolism. Annu Rev Physiol 65: 261-311, 2002.
25. Fucini RV, Chen JL, Sharma C, Kessels MM, and Stamnes M. Golgi vesicle proteins are linked to the assembly of an actin complex defined by MAPBI. Mol Biol Cell 13: 621-631, 2002.
26. Furumura M, Potterf SB, Toyofuku K, Matsunaga J, Muller J, and Hearing VJ. Involvement of ITF2 in the transcriptional regulation of melanogenic genes. J Biol Chem 276: 28147-28154, 2001.
27. Furumura M, Sakai C, Potterf SB, Vieira WD, Barsh GS, and Hearing VJ. Characterization of genes modulated during pheomelanogenesis using differential display. Proc Natl Acad Sci USA 95: 7374-7378, 1998.
28. Gabriel SB, Schaffner SF, Nguyen H, Moore JM, Roy J, Blumenstiel B, Higgins J, DeFelice M, Lochner A, Faggart M, Liu-Cordero SN, Rotimi C, Adeyemo A, Cooper R, Ward R, Lander ES, Daly MJ, and Altshuler D. The structure of haplotype blocks in the human genome. Science 296: 2225-2229, 2002.
29. Gasser SM and Cockell MM. The molecular biology of the sir proteins. Gene 279: 1-16, 2001.
30. Gurnell M. PPARγ and metabolism: insights from the study of human genetic variants. Clin Endocrinol (Oxf) 59: 267-277, 2003.
31. Hanada M, Ninomiya-Tsuji J, Komaki K, Ohnishi M, Katsura K, Kanamaru R, Matsumoto K, and Tamura S. Regulation of the TAK1 signaling pathway by protein phosphatase 2c. J Biol Chem 276: 5753-5759, 2001.
32. Hansen L. Candidate genes and late-onset type 2 diabetes mellitus. Susceptibility genes or common polymorphisms? Dan Med Bull 50: 320-346, 2003.
33. He HJ, Kole S, Kwon YK, Crow MT, and Bernier M. Interaction of Filamin a with the insulin receptor alters insulin-dependent activation of the mitogen-activated protein kinase pathway. J Biol Chem 278: 27096-27104, 2003.
34. Henras A, Henry Y, Bousquet-Antonelli C, Noaillac-Depeyre J, Gelugne JP, and Caizergues-Ferrer M. NHP2p and NOP10p are essential for the function of H/ACA SnoRNPs. EMBO J 17: 7078-7090, 1998.
35. Hildebrand JD and Soriano P. Shroom, a pdz domain-containing actin-binding protein, is required for neural tube morphogenesis in mice. Cell 99: 485-497, 1999.
36. Hilf N, Singh-Jasuja H, and Schild H. The heat shock protein GP96 links innate and specific immunity. Int J Hyperthermia 18: 521-533, 2002.
37. Holt RI, Simpson HL, and Sonksen PH. The role of the growth hormone-insulin-like growth factor axis in glucose homeostasis. Diabet Med 20: 3-15, 2003.
38. Hribal ML, Oriente F, and Accili D. Mouse models of insulin resistance. Am J Physiol Endocrinol Metab 282: E977-E981, 2002.
39. Imae M, Inoue Y, Fu Z, Kato H, and Noguchi T. Gene expression of the three members of hepatocyte nuclear factor-3 is differentially regulated by nutritional and hormonal factors. J Endocrinol 167: R1-R5, 2000.
40. Jacobs MN and Lewis DF. Steroid hormone receptors and dietary ligands: a selected review. Proc Nutr Soc 61: 105-122, 2002.
41. Kaidanovich O and Eldar-Finkelman H. The role of glycogen synthase kinase-3 in insulin resistance and type 2 diabetes. Expert Opin Ther Targets 6: 555-561, 2002.
42. Kaput J. Diet-disease gene interactions. Nutrition 20: 26-31, 2004.
43. Kaput J and Rodriguez R. Nutritional genomics: the next frontier in the post-genomic era. Physiol Genomics 16: 166-177, 2004: 10.1152/physiolgenomics. 00107.2003.
44. Kaput J, Swartz D, Paisley E, Mangian H, Daniel WL, and Visek WJ. Diet-disease interactions at the molecular level: an experimental paradigm. J Nutr 124, Suppl: 1296S-1305S, 1994.
45. Kato T, Satoh S, Okabe H, Kitahara O, Ono K, Kihara C, Tanaka T, Tsunoda T, Yamaoka Y, Nakamura Y, and Furukawa Y. Isolation of a novel human gene, MARKL1, homologous to MARK3 and its involvement in hepatocellular carcinogenesis. Neoplasia 3: 4-9, 2001.
46. Kayed H, Kleeff J, Keleg S, Buchler MW, and Friess H. Distribution of Indian hedgehog and its receptors patched and smoothened in human chronic pancreatitis. J Endocrinol 178: 467-478, 2003.
47. Kessels MM, Engqvist-Goldstein AE, and Drubin DG. Association of mouse actin-binding protein 1 (MAPB1/SH3p7), an SRC kinase target, with dynamic regions of the cortical actin cytoskeleton in response to RAC1 activation. Mol Biol Cell 11: 393-412, 2000.
48. Khan AH and Pessin JE. Insulin regulation of glucose uptake: a complex interplay of intracellular signaling pathways. Diabetologia 45: 1475-1483, 2002.
49. Krueger DA, Warner EA, and Dowd DR. Involvement of thyrotroph embryonic factor in calcium-mediated regulation of gene expression. J Biol Chem 275: 14524-14531, 2000.
50. Lan H, Rabaglia ME, Stoehr JP, Nadler ST, Schueler KL, Zou F, Yandell BS, and Attie AD. Gene expression profiles of nondiabetic and diabetic obese mice suggest a role of hepatic lipogenic capacity in diabetes susceptibility. Diabetes 52: 688-700, 2003.
51. Lander ES. The new genomics: global views of biology. Science 274: 536-539, 1996.
52. Lang J, Fukuda M, Zhang H, Mikoshiba K, and Wollheim CB. The first c2 domain of synaptotagmin is required for exocytosis of insulin from pancreatic beta-cells: action of synaptotagmin at low micromolar calcium. EMBO J 16: 5837-5846, 1997.
53. Lee CK, Allison DB, Brand J, Weindruch R, and Prolla TA. Transcriptional profiles associated with aging and middle age-onset caloric restriction in mouse hearts. Proc Natl Acad Sci USA 99: 14988-14993, 2002.
54. Lee CK, Klopp RG, Weindruch R, and Prolla TA. Gene expression profile of aging and its retardation by caloric restriction. Science 285: 1390-1393, 1999.
55. Lee CK, Weindruch R, and Prolla TA. Gene-expression profile of the ageing brain in mice. Nat Genet 25: 294-297, 2000.
56. Lee J, Mira-Arbibe L, and Ulevitch RJ. TAK1 regulates multiple protein kinase cascades activated by bacterial lipopolysaccharide. J Leukoc Biol 68: 909-915, 2000.
57. Leiter EH and Chapman HD. Obesity-induced diabetes (diabesity) in C57BL/KSJ mice produces aberrant trans-regulation of sex steroid sulfotransferase genes. J Clin Invest 93: 2007-2013, 1994.
58. Lin SJ, Defossez PA, and Guarente L. Requirement of NAD and SIR2 for life-span extension by calorie restriction in Saccharomyces cerevisiae. Science 289: 2126-2128, 2000.
59. Lin SJ, Kaeberlein M, Andalis AA, Sturtz LA, Defossez PA, Culotta VC, Fink GR, and Guarente L. Calorie restriction extends Saccharomyces cerevisiae lifespan by increasing respiration. Nature 418: 344-348, 2002.
60. Lin Y, Nadler ST, Lan H, Attie AD, Yandell BS. Adaptive gene picking with microarray data: Detecting important low abundance signals. In: The Analyses of Gene Expression Data: Methods and Software, edited by Parmigiani G, Garrett ES, Irizarry RA, and Zeger SL. Heidelberg: Springer, 2003, p. 291-312.
61. Lioubinski O, Muller M, Wegner M, and Sander M. Expression of SOX transcription factors in the developing mouse pancreas. Dev Dyn 227: 402-408, 2003.
62. Moazed D. Enzymatic activities of SIR2 and chromatin silencing. Curr Opin Cell Biol 13: 232-238, 2001.
63. Mokdad AH, Bowman BA, Ford ES, Vinicor F, Marks JS, and Koplan JP. The continuing epidemics of obesity and diabetes in the United States. JAMA 286: 1195-1200, 2001.
64. Moussa NM and Claycombe KJ. The yellow mouse obesity syndrome and mechanisms of agouti-induced obesity. Obes Res 7: 506-514, 1999.
65. Muller M and Kersten S. Nutrigenomics: goals and strategies. Nat Rev Genet 4: 315-322, 2003.
66. Nosjean O and Boutin JA. Natural ligands of PPARγ: are prostaglandin j(2) derivatives really playing the part? Cell Signal 14: 573-583, 2002.
67. O'Neill TJ, Zhu Y, and Gustafson TA. Interaction of MAD2 with the carboxyl terminus of the insulin receptor but not with the IGFIR. Evidence for release from the insulin receptor after activation. J Biol Chem 272: 10035-10040, 1997.
68. Paisley EA, Park EI, Swartz DA, Mangian HJ, Visek WJ, and Kaput J. Temporal-regulation of serum lipids and stearoyl CoA desaturase and lipoprotein lipase mRNA in BALB/cHnn mice. J Nutr 126: 2730-2737, 1996.
69. Park EI, Paisley EA, Mangian HJ, Swartz DA, Wu MX, O'Morchoe PJ, Behr SR, Visek WJ, and Kaput J. Lipid level and type alter stearoyl CoA desaturase mRNA abundance differently in mice with distinct susceptibilities to diet-influenced diseases. J Nutr 127: 566-573, 1997.
70. Paterson A, Damon S, Hewitt JD, Zamir D, Rabinowitch HD, Lincoln SE, Lander ES, and Tanksley SD. Mendelian factors underlying quantitative traits in tomato: comparison across species, generations, and environments. Genetics 127: 181-197, 1991.
71. Patti ME, Butte AJ, Crunkhorn S, Cusi K, Berria R, Kashyap S, Miyazaki Y, Kohane I, Costello M, Saccone R, Landaker EJ, Goldfine AB, Mun E, DeFronzo R, Finlayson J, Kahn CR, and Mandarino LJ. Coordinated reduction of genes of oxidative metabolism in humans with insulin resistance and diabetes: potential role of PGC1 and NRF1. Proc Natl Acad Sci USA 100: 8466-8471, 2003.
72. Pomp D. Genetic dissection of obesity in polygenic animal models. Behav Genet 27: 285-306, 1997.
73. Raile K, Berthold A, Banning U, Horn F, Pfeiffer G, and Kiess W. IGFS, basic FGF, and glucose modulate proliferation and apoptosis induced by IFNγ but not by IL-1β in rat INS-1e β-cells. Horm Metab Res 35: 407-414, 2003.
74. Ramachandran C and Kennedy BP. Protein tyrosine phosphatase 1b: a novel target for type 2 diabetes and obesity. Curr Top Med Chem 3: 749-757, 2003.
75. Reifsnyder PC, Churchill G, and Leiter EH. Maternal environment and genotype interact to establish diabesity in mice. Genome Res 10: 1568-1578, 2000.
76. Reifsnyder PC and Leiter EH. Deconstructing and reconstructing obesity-induced diabetes (diabesity) in mice. Diabetes 51: 825-832, 2002.
77. Ritzel RA and Butler PC. Replication increases β-cell vulnerability to human islet amyloid polypeptide-induced apoptosis. Diabetes 52: 1701-1708, 2003.
78. Roig J, Mikhailov A, Belham C, and Avruch J. Nercc1, a mammalian NIMA-family kinase, binds the RAN GTPase and regulates mitotic progression. Genes Dev 16: 1640-1658, 2002.
79. Sakanaka C, Sun TQ, and Williams LT. New steps in the WNT/β-catenin signal transduction pathway. Recent Prog Horm Res 55: 225-236, 2000.
80. Salehi A, Henningsson R, Mosen H, Ostenson CG, Efendic S, and Lundquist I. Dysfunction of the islet lysosomal system conveys impairment of glucose-induced insulin release in the diabetic GK rat. Endocrinology 140: 3045-3053, 1999.
81. Sciacchitano S, Orecchio A, Lavra L, Misiti S, Giacchini A, Zani M, Danese D, Gurtner A, Soddu S, Di Mario U, and Andreoli M. Cloning of the mouse insulin receptor substrate-3 (MIRS-3) promoter, and its regulation by p53. Mol Endocrinol 16: 1577-1589, 2002.
82. Shoelson SE, Lee J, and Yuan M. Inflammation and the IKKβ/IκB/ NF-κB axis in obesity- and diet-induced insulin resistance. Int J Obes Relat Metab Disord 27, Suppl 3: S49-S52, 2003.
83. Skerjanc IS, Truong J, Filion P, and McBurney MW. A splice variant of the ITF-2 transcript encodes a transcription factor that inhibits MYOd activity. J Biol Chem 271: 3555-3561, 1996.
84. Spiegelman BM and Flier JS. Obesity and the regulation of energy balance. Cell 104: 531-43, 2001.
85. Sul HS, Latasa MJ, Moon Y, and Kim KH. Regulation of the fatty acid synthase promoter by insulin. J Nutr 130, Suppl: 315S-320S, 2000.
86. 0-ATP synthase. Genomic sequence, chromosomal mapping, and diet regulation. J Biol Chem 271: 20942-20948, 1996.
87. Tetsuka T, Uranishi H, Imai H, Ono T, Sonta S, Takahashi N, Asamitsu K, and Okamoto T. Inhibition of nuclear factor-κB-mediated transcription by association with the amino-terminal enhancer of split, a Groucho-related protein lacking WD40 repeats. J Biol Chem 275: 4383-4390, 2000.
88. Thelander M, Fredriksson D, Schouten J, Hoge JH, and Ronne H. Cloning by pathway activation in yeast: identification of an Arabidopsis thaliana F-box protein that can turn on glucose repression. Plant Mol Biol 49: 69-79, 2002.
89. Thirone AC, Scarlett JA, Gasparetti AL, Araujo EP, Lima MH, Carvalho CR, Velloso LA, and Saad MJ. Modulation of growth hormone signal transduction in kidneys of streptozotocin-induced diabetic animals: effect of a growth hormone receptor antagonist. Diabetes 51: 2270-2281, 2002.
90. Thomas MK, Rastalsky N, Lee JH, and Habener JF. Hedgehog signaling regulation of insulin production by pancreatic beta-cells. Diabetes 49: 2039-2047, 2000.
91. Tobe K, Asai S, Matuoka K, Yamamoto T, Chida K, Kaburagi Y, Akanuma Y, Kuroki T, Takenawa T, Kimura S, Nagai R, and Kadowaki T. Cytoskeletal reorganization induced by insulin: involvement of GRB2/ASH, RAS and phosphatidylinositol 3-kinase signaling. Genes Cells 8: 29-40, 2003.
92. Turturro A, Blank K, Murasko D, and Hart R. Mechanisms of caloric restriction affecting aging and disease. Ann NY Acad Sci 719: 159-170, 1994.
93. Voisey J and van Daal A. Agouti: from mouse to man, from skin to fat. Pigment Cell Res 15: 10-18, 2002.
94. Wade CM, Kulbokas EJ III, Kirby AW, Zody MC, Mullikin JC, Lander ES, Lindblad-Toh K, and Daly MJ. The mosaic structure of variation in the laboratory mouse genome. Nature 420: 574-578, 2002.
95. Weindruch R, Kayo T, Lee CK, and Prolla TA. Gene expression profiling of aging using DNA microarrays. Mech Ageing Dev 123: 177-193, 2002.
96. Weindruch R, Keenan KP, Carney JM, Fernandes G, Feuers RJ, Floyd RA, Halter JB, Ramsey JJ, Richardson A, Roth GS, and Spindler SR. Caloric restriction mimetics: metabolic interventions. J Gerontol A Biol Sci Med Sci 56 (spec no 1): 20-33, 2001.
97. Willett W. Isocaloric diets are of primary interest in experimental and epidemiological studies. Im J Epidemiol 31: 694-695, 2002.
98. Willett WC. Balancing life-style and genomics research for disease prevention. Science 296: 695-698, 2002.
99. Wolff GL. Body weight and cancer. Am J Clin Nutr 45, Suppl: 168-180, 1987.
100. Wolff GL. Obesity as a pleiotropic effect of gene action. J Nutr 127: 1897S-1901S, 1997.
101. 1 hybrid mice. J Toxicol Environ Health 10: 131-142, 1982.
102. Wolff GL, Kodell RL, Kaput JA, and Visek WJ. Caloric restriction abolishes enhanced metabolic efficiency induced by ectopic agouti protein in yellow mice. Proc Soc Exp Biol Med 221: 99-104, 1999.
103. Wolff GL, Roberts DW, and Mountjoy KG. Physiological consequences of ectopic agouti gene expression: The yellow obese mouse syndrome. Physiol Genomics 1: 151-163, 1999.
104. Wolfrum C, Borrmann CM, Borchers T, and Spener F. Fatty acids and hypolipidemic drugs regulate peroxisome proliferator-activated receptors alpha- and gamma-mediated gene expression via liver fatty acid binding protein: a signaling path to the nucleus. Proc Natl Acad Sci USA 98: 2323-2328, 2001.
105. Wrede CE, Dickson LM, Lingohr MK, Briaud I, and Rhodes CJ. Protein kinase b/AKT prevents fatty acid-induced apoptosis in pancreatic beta-cells (INS-1). J Biol Chem 277: 49676-49684, 2002.
106. Yan H, Yuan W, Velculescu VE, Vogelstein B, and Kinzler KW. Allelic variation in human gene expression. Science 297: 1143, 2002.
107. Zemel MB. Regulation of adiposity and obesity risk by dietary calcium: mechanisms and implications. J Am Coll Nutr 21: 146S-151S, 2002.
108. Zhu Y, Kan L, Qi C, Kanwar YS, Yeldandi AV, Rao MS, and Reddy JK. Isolation and characterization of peroxisome proliferator-activated receptor (PPAR) interacting protein (PR1P) as a coactivator for PPAR. J Biol Chem 275: 13510-13516, 2000.