The first C2 domain of synaptotagmin is required for exocytosis of insulin from pancreatic β-cells: Action of synaptotagmin at low micromolar calcium

EMBO Journal

Volumn 16, Issue 19, 1997, Pages 5837-5846

  Lang, Jochen ^a   Fukuda, Mitsunori ^b,c   Zhang, Hui ^a   Mikoshiba, Katsuhiko ^b,c   Wollheim, Claes B ^a  

^a UNIVERSITY OF GENEVA MEDICAL SCHOOL   (Switzerland)

^b RIKEN   (Japan)

^c UNIVERSITY OF TOKYO   (Japan)

Author keywords

C2 domain; Cytosolic Ca2+; GTP; Insulin exocytosis; Synaptotagmin

Indexed keywords

ANTIBODY; CALCIUM ION; GUANOSINE 5' O (3 THIOTRIPHOSPHATE); IMMUNOGLOBULIN F(AB) FRAGMENT; INSULIN; PHOSPHOLIPID; SYNAPTOTAGMIN; CALCIUM; CALCIUM BINDING PROTEIN; MEMBRANE PROTEIN; NERVE PROTEIN; SYNAPTOTAGMIN I;

ANIMAL CELL; ARTICLE; BINDING SITE; CELL FRACTIONATION; CELL LINE; CONFOCAL MICROSCOPY; CONTROLLED STUDY; EXOCYTOSIS; IMMUNOBLOTTING; INSULIN RELEASE; NONHUMAN; NORTHERN BLOTTING; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; PROTEIN DOMAIN; RAT; SECRETORY GRANULE; SYNAPSE VESICLE; ANIMAL; CELL GRANULE; CELL MEMBRANE PERMEABILITY; CHEMISTRY; METABOLISM; PANCREAS ISLET; PHYSIOLOGY; WESTERN BLOTTING;

ANIMALIA;

ANIMALS; BLOTTING, WESTERN; CALCIUM; CALCIUM-BINDING PROTEINS; CELL LINE; CELL MEMBRANE PERMEABILITY; CYTOPLASMIC GRANULES; EXOCYTOSIS; GUANOSINE 5'-O-(3-THIOTRIPHOSPHATE); INSULIN; ISLETS OF LANGERHANS; MEMBRANE GLYCOPROTEINS; NERVE TISSUE PROTEINS; PHOSPHOLIPIDS; SYNAPTOTAGMIN I; SYNAPTOTAGMINS;

EID: 0030868429     PISSN: 02614189     EISSN: None     Source Type: Journal    
DOI: 10.1093/emboj/16.19.5837     Document Type: Article

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