Enzymatic activities of Sir2 and chromatin silencing

Current Opinion in Cell Biology

Volumn 13, Issue 2, 2001, Pages 232-238

  Moazed, D ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLADENOSINE DIPHOSPHATE RIBOSE; ADENOSINE DIPHOSPHATE RIBOSE; HISTONE DEACETYLASE; REGULATOR PROTEIN; SILENT INFORMATION REGULATOR PROTEIN 2; STRUCTURAL PROTEIN; UNCLASSIFIED DRUG;

ACETYLATION; CHROMATIN STRUCTURE; DNA HISTONE INTERACTION; ENZYME ACTIVITY; NONHUMAN; PRIORITY JOURNAL; REGULATORY MECHANISM; REVIEW; SILENCER GENE; YEAST;

EUKARYOTA;

EID: 0035313756     PISSN: 09550674     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0955-0674(00)00202-7     Document Type: Review

References (53)

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2. Heterochromatin protein 1 is required for correct chromosome segregation in Drosophila embryos
3. Position effect variegation at fission yeast centromeres
4. Fission yeast mutants that alleviate transcriptional silencing in centromeric flanking repeats and disrupt chromosome segregation
5. Mating-type determination and mating-type interconversion in Saccharomyces cerevisiae
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9. The Sir proteins of Saccharomyces cerevisiae: Mediators of transcriptional silencing and much more
10. Characterization of five human cDNAs with homology to the yeast SIR2 gene: Sir2-like proteins (sirtuins) metabolize NAD and may have protein ADP-ribosyltransferase activity
11. An enzymatic activity in the yeast Sir2 protein that is essential for gene silencing
12. Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase
13. The silencing protein SIR2 and its homologs are NAD-dependent protein deacetylases
14. A phylogenetically conserved NAD+-dependent protein deacetylase activity in the Sir2 protein family
15. MAR1 - A regulator of HMa and HMα loci in Saccharomyces cerevisiae
16. Four genes responsible for a position effect on expression from HML and HMR in Saccharomyces cerevisiae
17. Modifiers of position effect are shared between telomeric and silent mating-type loci in S. cerevisiae
18. Transcriptional silencing of Ty1 elements in the RDN1 locus of yeast
19. An unusual form of transcriptional silencing in yeast ribosomal DNA
20. A deubiquitinating enzyme interacts with SIR4 and regulates silencing in S. cerevisiae
21. Silent information regulator protein complexes in Saccharomyces cerevisiae: A SIR2/SIR4 complex and evidence for a regulatory domain in SIR4 that inhibits its interaction with SIR3
22. SIR2 and SIR4 interactions differ in core and extended telomeric heterochromatin in yeast
23. Net1, a Sir2-associated nucleolar protein required for rDNA silencing and nucleolar integrity
24. The termination of telophase is triggered by Tem1-dependent release of the protein phosphatase Cdc14 from the nucleolar RENT complex
25. Locus specificity determinants in the multifunctional yeast silencing protein Sir2
26. Extrachromosomal rDNA circles - A cause of aging in yeast
27. The SIR2/3/4 complex and SIR2 alone promote longevity in Saccharomyces cerevisiae by two different mechanisms
28. Extremely conserved histone H4 N terminus is dispensable for growth but essential for repressing the silent mating loci in yeast
29. Genetic evidence for an interaction between SIR3 and histone H4 in the repression of the silent mating loci in Saccharomyces cerevisiae
30. Histone H3 amino terminus is required for telomeric and silent mating locus repression in yeast
31. Efficient transcriptional silencing in Saccharomyces cerevisiae requires a heterochromatin histone acetylation pattern
32. Histone H3 and H4 N-termini interact with SIR3 and SIR4 proteins: A molecular model for the formation of heterochromatin in yeast
33. The SIR2 gene family, conserved from bacteria to humans, functions in silencing, cell cycle progression, and chromosome stability
34. Phylogenetic classification of prokaryotic and eukaryotic Sir2-like proteins
35. The Schizosaccharomyces pombe hst4(+) gene is a SIR2 homologue with silencing and centromeric functions
36. Sum1 and Hst1 repress middle sporulation-specific gene expression during mitosis in Saccharomyces cerevisiae
37. CobB, a new member of the SIR2 family of eucaryotic regulatory proteins, is required to compensate for the lack of nicotinate mononucleotide: 5,6-dimethylbenzimidazole phosphoribosyltransferase activity in cobT mutants during cobalamin biosynthesis in Salmonella typhimurium LT2
38. Transcriptional silencing in yeast is associated with reduced nucleosome acetylation
39. + in the deacetylation activity of SIR2-like proteins
40. Coupling of histone deacetylation to NAD breakdown by the yeast silencing prtoein Sir2: Evidence for acetyl transfer from substrate to an NAD breakdown product
41. Silent information regulator 2 family of NAD-dependent histone/protein deacetylases generates a unique product, 1-O-acetyl-ADP-ribose
42. The phosphorolysis of nicotinamide riboside
43. Histone acetylation in chromatin structure and transcription
44. Roles of histone acetyltransferases and deacetylases in gene regulation
45. The histone deacetylase RPD3 counteracts genomic silencing in Drosophila and yeast
46. HDA1 and RPD3 are members of distinct yeast histone deacetylase complexes that regulate silencing and transcription
47. A general requirement for the Sin3-Rpd3 histone deacetylase complex in regulating silencing in Saccharomyces cerevisiae
48. Type B histone acetyltransferase Hat1p participates in telomeric silencing
49. Yeast SAS silencing genes and hman genes associated with AML and HIV-1 Tat interactions are homolgous with acetyltransferases
50. SAS4 and SAS5 locus-specific regulators of silencing in Saccharomyces cerevisiae
51. Molecular model for telomeric heterochromatin in yeast
52. Silencing and heritable domains of gene expression