Gene expression profiles of nondiabetic and diabetic obese mice suggest a role of hepatic lipogenic capacity in diabetes susceptibility

Diabetes

Volumn 52, Issue 3, 2003, Pages 688-700

  Lan, Hong ^a   Rabaglia, Mary E ^a   Stoehr, Jonathan P ^a   Nadler, Samuel T ^a   Schueler, Kathryn L ^a   Zou, Fei ^b   Yandell, Brian S ^c   Attie, Alan D ^a  

^a UNIVERSITY OF WISCONSIN MADISON   (United States)

^b IL   (United States)

^c University of Wisconsin Madison   (United States)

Author keywords

ACO, Acyl CoA oxidase; CT, threshold cycle; DChip, DNA Chip analyzer; IL, interleukin; PEPCK, phosphoenopyruvate caxboxykinase; PPAR , peroxisome proliferator activator receptors ; SREBP, sterol regulatory element binding protein

Indexed keywords

ADIPOSE TISSUE; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; DIABETES MELLITUS; DNA MICROARRAY; GENE EXPRESSION; GENE REPRESSION; GLUCONEOGENESIS; LIPOGENESIS; LIVER; MOUSE; MOUSE STRAIN; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; OBESITY; PANCREAS ISLET; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RISK FACTOR; SKELETAL MUSCLE; UNINDEXED SEQUENCE;

ADIPOSE TISSUE; ANIMALS; DIABETES MELLITUS; DIABETES MELLITUS, TYPE 2; FATTY LIVER; FEMALE; GENE EXPRESSION PROFILING; GENETIC PREDISPOSITION TO DISEASE; GLUCONEOGENESIS; ISLETS OF LANGERHANS; LIPIDS; LIVER; MICE; MICE, INBRED C57BL; MICE, OBESE; MUSCLE, SKELETAL; OBESITY; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; TRIGLYCERIDES;

EID: 0037342152     PISSN: 00121797     EISSN: None     Source Type: Journal    
DOI: 10.2337/diabetes.52.3.688     Document Type: Article

References (41)

1. Coleman DL, Hummel KP: The influence of genetic background on the expression of the obese (Ob) gene in the mouse. Diabetologia 9:287-293, 1973
2. Stoehr JP, Nadler ST, Schueler KL, Rabaglia ME, Yandell BS, Metz SA, Attie AD: Genetic obesity unmasks nonlinear interactions between murine type 2 diabetes susceptibility loci. Diabetes 49:1946-1954, 2000
3. Ranheim T, Dumke C, Schueler KL, Cartee GD, Attie AD: Interaction between BTBR and C57BL/6J genomes produces an insulin resistance syndrome in (BTBR x C57BL/6J) F1 mice. Arterioscler Thromb Vasc Biol 17:3286-3293, 1997
4. Soukas A, Cohen P, Socci ND, Friedman JM: Leptin-specific patterns of gene expression in white adipose tissue. Genes Dev 14:963-980, 2000
5. Nadler ST, Stoehr JP, Schueler KL, Tanimoto G, Yandell BS, Attie AD: The expression of adipogenic genes is decreased in obesity and diabetes mellitus. Proc Natl Acad Sci U S A 97:11371-11376, 2000
6. Ducluzeau PH, Perretti N, Laville M, Andreelli F, Vega N, Riou JP, Vidal H: Regulation by insulin of gene expression in human skeletal muscle and adipose tissue: evidence for specific defects in type 2 diabetes, Diabetes 50:1134-1142, 2001
7. Kolehmainen M, Vidal H, Alhava E, Uusitupa MI: Sterol regulatory element binding protein 1c (SREBP-1c) expression in human obesity. Obes Res 9:706-712, 2001
8. Diraison F, Dusserre E, Vidal H, Sothier M, Beylot M: Increased hepatic lipogenesis but decreased expression of lipogenic gene in adipose tissue in human obesity. Am J Physiol Endocrinol Metab 282:E46-E51, 2002
9. Sewter C, Berger D, Considine RV, Medina G, Rochford J, Ciaraldi T, Henry R, Dohm L, Flier JS, O'Rahilly S, Vidal-Puig AJ: Human obesity and type 2 diabetes are associated with alterations in SREBP1 isoform expression that are reproduced ex'vivo by tumor necrosis factor-alpha. Diabetes 51:1035-1041, 2002
10. Shimomura I, Bashmakov Y, Horton JD: Increased levels of nuclear SREBP-1c associated with fatty livers in two mouse models of diabetes mellitus. J Biol Chem 274:30028-30032, 1990
11. Nadler ST, Attie AD: Please pass the chips: genomic insights into obesity and diabetes. J Nutr 131:2078-2081, 2001
12. Li C, Wong WH: Model-based analysis of oligonucleotide arrays: expression index computation and outlier detection. Proc Natl Acad Sci U S A 98:31-36, 2001
13. Lin Y, Nadler ST, Lan H, Attie AD, Yandell BS: Adaptive gene picking with microarray data: detecting important low abundance signals. In The Analysis of Gene Expression Data: Methods and Software. Parmigiani ES, Garrett RA, Irizarry SL, Eds. New York, Springer-Verlag, 2002
14. Briaud I, Harmon JS, Kelpe CL, Segu VB, Poitout V: Lipotoxicity of the pancreatic beta-cell is associated with glucose-dependent esterification of fatty acids into neutral lipids. Diabetes 50:315-321, 2001
15. Newton MA, Kendziorski CM, Richmond CS, Blattner FR, Tsui KW: On differential variability of expression ratios: improving statistical inference about gene expression changes from microarray data. J Comput Biol 8:37-52, 2001
16. Cook KS, Min HY, Johnson D, Chaplinsky RJ, Flier JS, Hunt CR, Spiegelman BM: Adipsin: a circulating serine protease homolog secreted by adipose tissue and sciatic nerve. Science 237:402-405, 1987
17. Peterfy M, Phan J, Xu P, Reue K: Lipodystrophy in the fld mouse results from mutation of a new gene encoding a nuclear protein, lipin. Nat Genet 27:121-124, 2001
18. Borriello F, Krauter KS: Multiple murine alpha 1-protease inhibitor genes show unusual evolutionary divergence. Proc Natl Acad Sci U S A 88:9417-9421, 1991
19. Tardiff J, Krauter KS: Divergent expression of alpha1-protease inhibitor genes in mouse and human. Nucleic Acids Res 26:3794-3799, 1998
20. Fruhbeck G, Gomez-Ambrosi J, Muruzabal FJ, Burrell MA: The adipocyte: a model for integration of endocrine and metabolic signaling in energy metabolism regulation. Am J Physiol Endocrinol Metab 280:E827-E847, 2001
21. Coppack SW: Pro-inflammatory cytokines and adipose tissue. Proc Nutr Soc 60:349-356, 2001
22. Kern PA, Ranganathan S, Li C, Wood L, Ranganathan G: Adipose tissue tumor necrosis factor and interleukin-6 expression in human obesity and insulin resistance. Am J Physiol Endocrinol Metab 280:E745-E751, 2001
23. Steppan CM, Bailey ST, Bhat S, Brown EJ, Banerjee RR, Wright CM, Patel HR, Ahima RS, Lazar MA: The hormone resistin links obesity to diabetes. Nature 409:307-312, 2001
24. Holcomb IN, Kabakoff RC, Chan B, Baker TW, Gurney A, Henzel W, Nelson C, Lowman HB, Wright BD, Skelton NJ, Frantz GD, Tumas DB, Peale FV Jr, Shelton DL, Hebert CC: FIZZ1, a novel cysteine-rich secreted protein associated with pulmonary inflammation, defines a new gene family. Embo J 19:4046-4055, 2000
25. Way JM, Harrington WW, Brown KK, Gottschalk WK, Sundseth SS, Mansfield TA, Ramachandran RK, Willson TM, Kliewer SA: Comprehensive messenger ribonucleic acid profiling reveals that peroxisome proliferator-activated receptor gamma activation has coordinate effects on gene expression in multiple insulin-sensitive tissues. Endocrinology 142:1269-1277, 2001
26. Suzuki A, Yasuno T, Kojo H, Hirosumi J, Mutoh S, Notsu Y: Alteration in expression profiles of a series of diabetes-related genes in db/db mice following treatment with thiazolidinediones. Jpn J Pharmacol 84:113-123, 2000
27. Bedoucha M, Atzpodien E, Boelsterli UA: Diabetic KKAy mice exhibit increased hepatic PPARgammal gene expression and develop hepatic steatosis upon chronic treatment with antidiabetic thiazolidinediones. J Hepatol 35:17-23, 2001
28. Chao L, Marcus-Samuels B, Mason MM, Moitra J, Vinson C, Arioglu E, Gavrilova O, Reitman ML: Adipose tissue is required for the antidiabetic, but not for the hypolipidemic, effect of thiazolidinediones. J Clin Invest 106:1221-1228, 2000
29. Yahagi N, Shimano H, Hasty AH, Matsuzaka T, Ide T, Yoshikawa T, Amemiya-Kudo M, Tomita S, Okazaki H, Tamura Y, Iizuka Y, Ohashi K, Osuga J, Harada K, Gotoda T, Nagai R, Ishibashi S, Yamada N: Absence of sterol regulatory element-binding protein-1 (SREBP-1) ameliorates fatty livers but not obesity or insulin resistance in Lep(ob)/Lep(ob) mice. J Biol Chem 277:19353-19357, 2002
30. Boelsterli UA, Bedoucha M: Toxicological consequences of altered peroxisome proliferator-activated receptor gamma (PPARgamma) expression in the liver: insights from models of obesity and type 2 diabetes. Biochem Pharmacol 63:1-10, 2002
31. Moitra J, Mason MM, Olive M, Krylov D, Gavrilova O, Marcus-Samuels B, Feigenbaum L, Lee E, Aoyama T, Eckhaus M, Reitman ML, Vinson C: Life without white fat: a transgenic mouse. Genes Dev 12:3168-3181, 1998
32. Colombo C, Haluzik M, Cutson JJ, Dietz KR, Marcus-Samuels B, Vinson C, Gavrilova O, Reitman ML: Opposite effects of background genotype on muscle and liver insulin sensitivity of lipoatrophic mice: role of triglyceride clearance. J Biol Chem. In press
33. Becard D, Hainault I, Azzout-Marniche D, Bertry-Marniche D, Bertry-Coussot L, Ferre P, Foufelle F: Adenovirus-mediated overexpression of sterol regulatory element binding protein-1c mimics insulin effects on hepatic gene expression and glucose homeostasis in diabetic mice. Diabetes 50:2425-2430, 2001
34. Cao G, Liang Y, Broderick CL, Oldham BA, Beyer TP, Schmidt RJ, Zhang Y, Stayrook KR, Suen C, Otto KA, Miller AR, Dai J, Foxworthy P, Gao H, Ryan TP, Jiang XC, Burris TP, Eacho PI, Etgen GJ: Antidiabetic action of a liver X receptor agonist mediated by inhibition of hepatic gluconeogenesis. J Biol Chem 278:1131-1136, 2003
35. Kelley DE, Goodpaster BH: Skeletal muscle triglyceride: an aspect of regional adiposity and insulin resistance (Review). Diabetes Care 24:933-941, 2001
36. McGarry JD: Banting Lecture 2001: Dysregulation of fatty acid metabolism in the etiology of type 2 diabetes. Diabetes 51:7-18, 2002
37. Yu C, Chen Y, Zong H, Wang Y, Bergeron R, Kim JK, Cline GW, Cushman SW, Cooney GJ, Atcheson B, White MF, Kraegen EW, Shulman GI: Mechanism by which fatty acids inhibit insulin activation of insuli receptor substrate-1 (IRS-I)-associated phosphatidylinositol 3-kinase activity in muscle. J Biol Chem 277:50230-50236, 2002
38. Kim JK, Fillmore JJ, Chen Y, Yu C, Moore IK, Pypaert M, Lutz EP, Kako Y, Velez-Carrasco W, Goldberg IJ, Breslow JL, Shulman GI: Tissue-specific overexpression of lipoprotein lipase causes tissue-specific insulin resistance. Proc Natl Acad Sci U S A 98:7522-7527, 2001
39. Unger RH: Lipotoxic diseases. Ann Rev Med 53:319-336, 2002
40. Unger RH, Zhou YT, Orci L: Regulation of fatty acid homeostasis in cells: novel role of leptin. Proc Natl Acad Sci U S A 96:2327-2332, 1999
41. Busch AK, Cordery D, Denyer GS, Biden TJ: Expression profiling of palmitate- and oleate-regulated genes provides novel insights into the effects of chronic lipid exposure on pancreatic β-cell function. Diabetes 51:977-987, 2002