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Volumn 617, Issue , 2008, Pages 99-108

Functional significance of aurora kinase a in centrosome amplification and genomic instability

Author keywords

[No Author keywords available]

Indexed keywords

AURORA A KINASE; AURKA PROTEIN, HUMAN; PROTEIN SERINE THREONINE KINASE;

EID: 46749088707     PISSN: 00652598     EISSN: None     Source Type: Book Series    
DOI: 10.1007/978-0-387-69080-3_9     Document Type: Conference Paper
Times cited : (16)

References (57)
  • 1
    • 0242551545 scopus 로고    scopus 로고
    • The cellular geography of Aurora kinases. Nat Rev of Mol
    • Carmena M, Earnshaw WC (2003) The cellular geography of Aurora kinases. Nat Rev of Mol Cell Biol 4:842-854.
    • (2003) Cell Biol , vol.4 , pp. 842-854
    • Carmena, M.1    Earnshaw, W.C.2
  • 2
    • 0038341158 scopus 로고    scopus 로고
    • The Aurora kinases: Role in cell transformation and tumorigenesis
    • Katayama H, Brinkley WR, Sen S (2003) The Aurora kinases: role in cell transformation and tumorigenesis. Cancer Metastasis Rev 22:451-464.
    • (2003) Cancer Metastasis Rev , vol.22 , pp. 451-464
    • Katayama, H.1    Brinkley, W.R.2    Sen, S.3
  • 3
    • 0031714080 scopus 로고    scopus 로고
    • Tumor amplified kinase STK 15/BTAK induces centrosome amplification, aneuploidy and transformation
    • Zhou H, Kuang J, Zhong L, et al. (1998) Tumor amplified kinase STK 15/BTAK induces centrosome amplification, aneuploidy and transformation. Nat Genet 20:189-193.
    • (1998) Nat Genet , vol.20 , pp. 189-193
    • Zhou, H.1    Kuang, J.2    Zhong, L.3
  • 4
    • 0032100685 scopus 로고
    • A homologue of Drosophilia aurora kinase is oncogenic and amplified in human colorectal cancers
    • Bischoff JR, Anderson L, Zhu Y, et al. (1988) A homologue of Drosophilia aurora kinase is oncogenic and amplified in human colorectal cancers. EMBO J 17:3052-3065.
    • (1988) EMBO J , vol.17 , pp. 3052-3065
    • Bischoff, J.R.1    Anderson, L.2    Zhu, Y.3
  • 5
    • 0033135640 scopus 로고    scopus 로고
    • Centrosomal kinase AIK1 is overexpressed in invasive ductal carcinoma of the breast
    • Tanaka T, Kimura M, Matsunga K, et al. (1999) Centrosomal kinase AIK1 is overexpressed in invasive ductal carcinoma of the breast. Cancer Res 59:2041-2044.
    • (1999) Cancer Res , vol.59 , pp. 2041-2044
    • Tanaka, T.1    Kimura, M.2    Matsunga, K.3
  • 6
    • 0037019736 scopus 로고    scopus 로고
    • Amplification/overexpression of a mitotic kinase gene in human bladder cancer
    • Sen S, Zhou H, Zhang RD, et al. (2002) Amplification/overexpression of a mitotic kinase gene in human bladder cancer. J Natl Cancer Inst 94:1320-1329.
    • (2002) J Natl Cancer Inst , vol.94 , pp. 1320-1329
    • Sen, S.1    Zhou, H.2    Zhang, R.D.3
  • 7
    • 0037343237 scopus 로고    scopus 로고
    • Overexpression of oncogenic STK15/BTAK/Aurora A kinase in human pancreatic cancer
    • Li D, Zhu J, Sen S, et al. (2003) Overexpression of oncogenic STK15/BTAK/Aurora A kinase in human pancreatic cancer. Clin Cancer Res 9:991-997.
    • (2003) Clin Cancer Res , vol.9 , pp. 991-997
    • Li, D.1    Zhu, J.2    Sen, S.3
  • 8
    • 16344361846 scopus 로고    scopus 로고
    • The clinical significance of Aurora-A/STK15/BTAK expression in human esophageal squamous cell carcinoma
    • Tanaka E, Hashimoto Y, Ito T, et al. (2005) The clinical significance of Aurora-A/STK15/BTAK expression in human esophageal squamous cell carcinoma. Clin Cancer Res 11:1827-1834.
    • (2005) Clin Cancer Res , vol.11 , pp. 1827-1834
    • Tanaka, E.1    Hashimoto, Y.2    Ito, T.3
  • 9
    • 0037099531 scopus 로고    scopus 로고
    • Centrosome amplification and overexpression of aurora A are early events in rat mammary carcinogenesis
    • Goepfert TM, Adigun YE, Zhong L, et al. (2002) Centrosome amplification and overexpression of aurora A are early events in rat mammary carcinogenesis. Cancer Res 62:4115-4122.
    • (2002) Cancer Res , vol.62 , pp. 4115-4122
    • Goepfert, T.M.1    Adigun, Y.E.2    Zhong, L.3
  • 10
    • 11144228109 scopus 로고    scopus 로고
    • Estrogen mediates Aurora-A overexpression, centrosome amplification, chromosomal instability, and breast cancer in female ACI rats
    • Li JJ, Weroha SJ, Lingle WL, et al. (2004) Estrogen mediates Aurora-A overexpression, centrosome amplification, chromosomal instability, and breast cancer in female ACI rats. Proc Natl Acad Sci USA 101:18123-18128.
    • (2004) Proc Natl Acad Sci USA , vol.101 , pp. 18123-18128
    • Li, J.J.1    Weroha, S.J.2    Lingle, W.L.3
  • 11
    • 33751085368 scopus 로고    scopus 로고
    • Overexpression of aurora kinase A in mouse mammary epithelium induces genetic instability preceding mammary tumor formation
    • online publication
    • Wang X, Zhou YX, Qiao W, et al. (2006) Overexpression of aurora kinase A in mouse mammary epithelium induces genetic instability preceding mammary tumor formation. Oncogene Adv (online publication).
    • (2006) Oncogene Adv
    • Wang, X.1    Zhou, Y.X.2    Qiao, W.3
  • 12
    • 0036142218 scopus 로고    scopus 로고
    • Mitotic phosphorylation of histone H3: Spatiotemporal regulation by mammalian Aurora kinases
    • Crosio C, Fimia GM, Sen S, et al. (2002) Mitotic phosphorylation of histone H3: spatiotemporal regulation by mammalian Aurora kinases. Mol Cell Biol 22:874-885.
    • (2002) Mol Cell Biol , vol.22 , pp. 874-885
    • Crosio, C.1    Fimia, G.M.2    Sen, S.3
  • 13
    • 0037048279 scopus 로고    scopus 로고
    • On the role of aurora-A in centrosome function
    • Dutertre S, Descamps S, Prigent C (2002) On the role of aurora-A in centrosome function. Oncogene 21:6175-6183.
    • (2002) Oncogene , vol.21 , pp. 6175-6183
    • Dutertre, S.1    Descamps, S.2    Prigent, C.3
  • 14
    • 0037180488 scopus 로고    scopus 로고
    • Identification of phosphorylated residues that affect the activity of the mitotic kinase Aurora-A
    • Littlepage LE, Wu H, Anderson T, et al. (2002) Identification of phosphorylated residues that affect the activity of the mitotic kinase Aurora-A. Proc Natl Acad Sci USA 99:15440-15445.
    • (2002) Proc Natl Acad Sci USA , vol.99 , pp. 15440-15445
    • Littlepage, L.E.1    Wu, H.2    Anderson, T.3
  • 15
    • 0034213929 scopus 로고    scopus 로고
    • Degradation of human Aurora2 protein kinase by the anaphase-promoting complex-ubiquitin-proteasome pathway
    • Honda K, Mihara H, Kato Y, et al. (2000) Degradation of human Aurora2 protein kinase by the anaphase-promoting complex-ubiquitin-proteasome pathway. Oncogene 19:2812-2819.
    • (2000) Oncogene , vol.19 , pp. 2812-2819
    • Honda, K.1    Mihara, H.2    Kato, Y.3
  • 16
    • 12244301635 scopus 로고    scopus 로고
    • The D box activating domain (DAD) is a new proteolysis signal that stimulates the silent D-box sequence of Aurora A
    • Castro A, Vigneron S, Bennis C, et al. (2002) The D box activating domain (DAD) is a new proteolysis signal that stimulates the silent D-box sequence of Aurora A. EMBO Rep 3:1209-1214.
    • (2002) EMBO Rep , vol.3 , pp. 1209-1214
    • Castro, A.1    Vigneron, S.2    Bennis, C.3
  • 17
    • 12344309497 scopus 로고    scopus 로고
    • Requirements of the destruction of human Aurora- A
    • Crane R, Kloepfer A, Ruderman JV (2004) Requirements of the destruction of human Aurora- A. J Cell Sci 117:5975-5983.
    • (2004) J Cell Sci , vol.117 , pp. 5975-5983
    • Crane, R.1    Kloepfer, A.2    Ruderman, J.V.3
  • 18
    • 0034609753 scopus 로고    scopus 로고
    • The mitotic serine/threonine kinase Aurora2/ AIK is regulated by phosphorylation and degradation
    • Walter AO, Seqhezzi W, Korner W, et al. (2002) The mitotic serine/threonine kinase Aurora2/ AIK is regulated by phosphorylation and degradation. Oncogene 19:4906-4916.
    • (2002) Oncogene , vol.19 , pp. 4906-4916
    • Walter, A.O.1    Seqhezzi, W.2    Korner, W.3
  • 19
    • 0037044846 scopus 로고    scopus 로고
    • Crystal structure of aurora-2, an oncogenic serine/threonine kinase
    • Cheetham GM, Knegtel RM, Coll JT, et al. (2002) Crystal structure of aurora-2, an oncogenic serine/threonine kinase. J Biol Chem 277:42419-42422.
    • (2002) J Biol Chem , vol.277 , pp. 42419-42422
    • Cheetham, G.M.1    Knegtel, R.M.2    Coll, J.T.3
  • 20
    • 0242330123 scopus 로고    scopus 로고
    • Structural basis of Aurora-A activation by TPX2 at the mitotic spindle
    • Bayliss R, Sardon T, Vernos I, et al. (2003) Structural basis of Aurora-A activation by TPX2 at the mitotic spindle. Mol Cell 12:851-862.
    • (2003) Mol Cell , vol.12 , pp. 851-862
    • Bayliss, R.1    Sardon, T.2    Vernos, I.3
  • 21
    • 0034949769 scopus 로고    scopus 로고
    • The non-catalytic domain of the Xenopus laevis aurora A kinase localises the protein to the centrosome
    • Giet R, Prigent C (2001) The non-catalytic domain of the Xenopus laevis aurora A kinase localises the protein to the centrosome. J Cell Sci 114:2095-2104.
    • (2001) J Cell Sci , vol.114 , pp. 2095-2104
    • Giet, R.1    Prigent, C.2
  • 22
    • 0038323936 scopus 로고    scopus 로고
    • Dynamic association of a tumor amplified kinase, aurora A, with the centrosome and mitotic spindle
    • Stenoien DL, Sen S, Mancini MA, et al. (2003) Dynamic association of a tumor amplified kinase, aurora A, with the centrosome and mitotic spindle. Cell Motil Cytoskeletin 55:134-146.
    • (2003) Cell Motil Cytoskeletin , vol.55 , pp. 134-146
    • Stenoien, D.L.1    Sen, S.2    Mancini, M.A.3
  • 23
    • 0035196659 scopus 로고    scopus 로고
    • GCP5 and GCP6: Two new members of the human gamma-tubulin complex
    • Murphy SM, Preble AM, Patel UK, et al. (2001) GCP5 and GCP6: Two new members of the human gamma-tubulin complex. Mol Biol Cell 12:3340-3352.
    • (2001) Mol Biol Cell , vol.12 , pp. 3340-3352
    • Murphy, S.M.1    Preble, A.M.2    Patel, U.K.3
  • 25
    • 0033055061 scopus 로고    scopus 로고
    • Cyclin-dependent kinase control of centrosome duplication
    • Lacey KR, Jackson PK, Stearns T (1999) Cyclin-dependent kinase control of centrosome duplication. Proc Natl Acad Sci USA 96:2817-2822.
    • (1999) Proc Natl Acad Sci USA , vol.96 , pp. 2817-2822
    • Lacey, K.R.1    Jackson, P.K.2    Stearns, T.3
  • 26
    • 7444229923 scopus 로고    scopus 로고
    • A centrosomal localization signal in cyclin E required for Cdk2-independent S phase entry
    • Matsumoto Y, Malles JL (2004) A centrosomal localization signal in cyclin E required for Cdk2-independent S phase entry. Science 306:885-888.
    • (2004) Science , vol.306 , pp. 885-888
    • Matsumoto, Y.1    Malles, J.L.2
  • 27
    • 0037084163 scopus 로고    scopus 로고
    • Aurora-A overexpression reveals tetraploidization as a major route to centrosome amplification in p53-/- cells
    • Meraldi P, Honda R, Nigg EA (2002) Aurora-A overexpression reveals tetraploidization as a major route to centrosome amplification in p53-/- cells. EMBO J 21:483-492.
    • (2002) EMBO J , vol.21 , pp. 483-492
    • Meraldi, P.1    Honda, R.2    Nigg, E.A.3
  • 28
    • 31144463968 scopus 로고    scopus 로고
    • The Polo kinase Plk4 functions in centriole duplication
    • Habedanck R, Stierhof YD, Wilkinson CJ, et al. (2005) The Polo kinase Plk4 functions in centriole duplication. Nat Cell Biol 7:1140-1146.
    • (2005) Nat Cell Biol , vol.7 , pp. 1140-1146
    • Habedanck, R.1    Stierhof, Y.D.2    Wilkinson, C.J.3
  • 29
    • 0037113949 scopus 로고    scopus 로고
    • Inhibitor-2 regulates protein phosphatase-1 complexed with NimA-related kinase to induce centrosome separation
    • Eto M, Elliott E, Prinkett TD, et al. (2002) Inhibitor-2 regulates protein phosphatase-1 complexed with NimA-related kinase to induce centrosome separation. J Biol Chem 277:44013-44020.
    • (2002) J Biol Chem , vol.277 , pp. 44013-44020
    • Eto, M.1    Elliott, E.2    Prinkett, T.D.3
  • 30
    • 0037672151 scopus 로고    scopus 로고
    • Polo-like kinase 1 regulates Nip, a centrosome protein involved in microtubule nucleation
    • Casenghi M, Meraldi P, Weinhart U, et al. (2003) Polo-like kinase 1 regulates Nip, a centrosome protein involved in microtubule nucleation. Dev Cell 5:113-125.
    • (2003) Dev Cell , vol.5 , pp. 113-125
    • Casenghi, M.1    Meraldi, P.2    Weinhart, U.3
  • 31
    • 0032578008 scopus 로고    scopus 로고
    • C-Nap1, a novel centrosomal coiled-coil protein and candidate substrate of the cell cycle-regulated protein kinase Nek2
    • Fry AM, Mayor T, Meraldi P, et al. (1998a) C-Nap1, a novel centrosomal coiled-coil protein and candidate substrate of the cell cycle-regulated protein kinase Nek2. J Cell Biol 141:1563-1574.
    • (1998) J Cell Biol , vol.141 , pp. 1563-1574
    • Fry, A.M.1    Mayor, T.2    Meraldi, P.3
  • 32
    • 0032518798 scopus 로고    scopus 로고
    • A centrosomal function for the human Nek2 protein kinase, a member of the NIMA family of cell cycle regulators
    • Fry AM, Meraldi P, Nigg EA (1998b) A centrosomal function for the human Nek2 protein kinase, a member of the NIMA family of cell cycle regulators. EMBO J 17:470-481.
    • (1998) EMBO J , vol.17 , pp. 470-481
    • Fry, A.M.1    Meraldi, P.2    Nigg, E.A.3
  • 33
    • 0035824660 scopus 로고    scopus 로고
    • Interaction and feedback regulation between STK15/ BTAK/Aurora-A kinase and protein phosphatase 1 through mitotic cell division cycle
    • Katayama H, Zhou H, Li Q, et al. (2001) Interaction and feedback regulation between STK15/ BTAK/Aurora-A kinase and protein phosphatase 1 through mitotic cell division cycle. J Biol Chem 276:46219-46224.
    • (2001) J Biol Chem , vol.276 , pp. 46219-46224
    • Katayama, H.1    Zhou, H.2    Li, Q.3
  • 34
    • 0034595292 scopus 로고    scopus 로고
    • Targeted disruption of Skp2 results in accumulation of cyclin E and p27(Kip1), polyploidy and centrosome overduplication
    • Nakayama K, Nagahama H, Minamishima YA, et al. (2000) Targeted disruption of Skp2 results in accumulation of cyclin E and p27(Kip1), polyploidy and centrosome overduplication. EMBO J 19:2069-2081.
    • (2000) EMBO J , vol.19 , pp. 2069-2081
    • Nakayama, K.1    Nagahama, H.2    Minamishima, Y.A.3
  • 35
    • 4544240599 scopus 로고    scopus 로고
    • BRCA1-dependent ubiquitination of gamma-tubulin regulates centrosome number
    • Sharita LM, Machida Y, Sankaran S, et al. (2004) BRCA1-dependent ubiquitination of gamma-tubulin regulates centrosome number. Mol Cell Biol 24:8457-8566.
    • (2004) Mol Cell Biol , vol.24 , pp. 8457-8566
    • Sharita, L.M.1    Machida, Y.2    Sankaran, S.3
  • 36
    • 0036095082 scopus 로고    scopus 로고
    • E2F-dependent accumulation of hEmi1 regulates S phase entry by inhibiting APC(Cdh1)
    • Hsu JY, Reimann JD, Sorensen CS, et al. (2002) E2F-dependent accumulation of hEmi1 regulates S phase entry by inhibiting APC(Cdh1). Nat Cell Biol 4:358-366.
    • (2002) Nat Cell Biol , vol.4 , pp. 358-366
    • Hsu, J.Y.1    Reimann, J.D.2    Sorensen, C.S.3
  • 37
    • 0033145516 scopus 로고    scopus 로고
    • Centrosome duplication in mammalian somatic cells requires E2F and Cdk2-cyclin A
    • Meraldi P, Lukas J, Fry AM, et al. (1999) Centrosome duplication in mammalian somatic cells requires E2F and Cdk2-cyclin A. Nat Cell Biol 1:88-93.
    • (1999) Nat Cell Biol , vol.1 , pp. 88-93
    • Meraldi, P.1    Lukas, J.2    Fry, A.M.3
  • 38
    • 2442584567 scopus 로고    scopus 로고
    • BRCA1 phosphorylation by Aurora-A in the regulation of G2 to M transition
    • Ouchi M, Fujiuchi N, Sasai K, et al. (2004) BRCA1 phosphorylation by Aurora-A in the regulation of G2 to M transition. J Biol Chem 279:19643-19648.
    • (2004) J Biol Chem , vol.279 , pp. 19643-19648
    • Ouchi, M.1    Fujiuchi, N.2    Sasai, K.3
  • 39
    • 0036714512 scopus 로고    scopus 로고
    • Identification of a new APC/C recognition domain, the A box, which is required for the Cdh1-dependent destruction of the kinase Aurora-A during mitotic exit
    • Littlepage LE, Rudeman JV (2002) Identification of a new APC/C recognition domain, the A box, which is required for the Cdh1-dependent destruction of the kinase Aurora-A during mitotic exit. Genes Dev 16:2272-2285.
    • (2002) Genes Dev , vol.16 , pp. 2272-2285
    • Littlepage, L.E.1    Rudeman, J.V.2
  • 40
    • 33747814420 scopus 로고    scopus 로고
    • Mechanism limiting centrosome duplication to once per cell cycle
    • Tsou MF, Stearns T (2006) Mechanism limiting centrosome duplication to once per cell cycle. Nature 442:947-951.
    • (2006) Nature , vol.442 , pp. 947-951
    • Tsou, M.F.1    Stearns, T.2
  • 41
    • 0347324949 scopus 로고    scopus 로고
    • Aurora-A kinase maintains the fidelity of early and late mitotic events in HeLa cells
    • Marumoto T, Honda S, Hara T, et al. (2003) Aurora-A kinase maintains the fidelity of early and late mitotic events in HeLa cells. J Biol Chem 278:51786-51795.
    • (2003) J Biol Chem , vol.278 , pp. 51786-51795
    • Marumoto, T.1    Honda, S.2    Hara, T.3
  • 42
    • 0141429171 scopus 로고    scopus 로고
    • Aurora-A and in interacting activator, the LIM protein Ajuba, are required in mitotic commitment in human cells
    • Hirota T, Kunitoku N, Sasayama T, et al. (2003) Aurora-A and in interacting activator, the LIM protein Ajuba, are required in mitotic commitment in human cells. Cell 114:585-598.
    • (2003) Cell , vol.114 , pp. 585-598
    • Hirota, T.1    Kunitoku, N.2    Sasayama, T.3
  • 43
    • 0035945342 scopus 로고    scopus 로고
    • Aurora-A kinase is required for centrosome maturation in Caenorhabditis elegans
    • Hannak E, Kirkham M, Hyman AA, et al. (2001) Aurora-A kinase is required for centrosome maturation in Caenorhabditis elegans. J Cell Biol 155:1109-1116.
    • (2001) J Cell Biol , vol.155 , pp. 1109-1116
    • Hannak, E.1    Kirkham, M.2    Hyman, A.A.3
  • 44
    • 0031938231 scopus 로고    scopus 로고
    • The Xenopus protein kinase pEg2 associates with the centrosome in a cell cycle-dependent manner, binds to the spindle microtubules and is involoved in bipolar mitotic spindle assembly
    • Roghi C, Geit R, Uzebekov R, et al. (1998) The Xenopus protein kinase pEg2 associates with the centrosome in a cell cycle-dependent manner, binds to the spindle microtubules and is involoved in bipolar mitotic spindle assembly. J Cell Sci 111:557-572.
    • (1998) J Cell Sci , vol.111 , pp. 557-572
    • Roghi, C.1    Geit, R.2    Uzebekov, R.3
  • 45
    • 0028938482 scopus 로고
    • Mutations in aurora prevent centrosome separation leading to the formation of monopolar spindles
    • Glover DM, Leibowitz MH, McLean DA, et al. (1995) Mutations in aurora prevent centrosome separation leading to the formation of monopolar spindles. Cell 81:95-105.
    • (1995) Cell , vol.81 , pp. 95-105
    • Glover, D.M.1    Leibowitz, M.H.2    McLean, D.A.3
  • 46
    • 0037017398 scopus 로고    scopus 로고
    • Drosophila Aurora A kinase is required to localize D-TACC to centrosomes and to regulate astral microtubules
    • Geit R, McLean D, Descamps S, et al. (2002) Drosophila Aurora A kinase is required to localize D-TACC to centrosomes and to regulate astral microtubules. J Cell Biol 156:437-451.
    • (2002) J Cell Biol , vol.156 , pp. 437-451
    • Geit, R.1    McLean, D.2    Descamps, S.3
  • 47
    • 3042734502 scopus 로고    scopus 로고
    • Phosphorylation of CDC25B by Aurora- A at the centrosome contributes to the G2-M transition
    • Dutertre S, Cazales M, Quaranta M, et al. (2004) Phosphorylation of CDC25B by Aurora- A at the centrosome contributes to the G2-M transition. J Cell Sci 117:2523-2531.
    • (2004) J Cell Sci , vol.117 , pp. 2523-2531
    • Dutertre, S.1    Cazales, M.2    Quaranta, M.3
  • 48
    • 27144495462 scopus 로고    scopus 로고
    • The focal adhesion scaffolding protein HEF1 regulates activation of the Aurora-A and Nek2 kinsases at the centrosome
    • Pugacheva EN, Golemis EA (2005) The focal adhesion scaffolding protein HEF1 regulates activation of the Aurora-A and Nek2 kinsases at the centrosome. Nat Cell Biol 7:937-946.
    • (2005) Nat Cell Biol , vol.7 , pp. 937-946
    • Pugacheva, E.N.1    Golemis, E.A.2
  • 49
    • 26944442735 scopus 로고    scopus 로고
    • The GIT associated kinase PAK target to the centrosome and regulates Aurora-A
    • Zhao ZS, Lim JP, Ng YW, et al. (2005) The GIT associated kinase PAK target to the centrosome and regulates Aurora-A. Mol Cell 20:237-249.
    • (2005) Mol Cell , vol.20 , pp. 237-249
    • Zhao, Z.S.1    Lim, J.P.2    Ng, Y.W.3
  • 50
    • 33746544622 scopus 로고    scopus 로고
    • Mitotic activation of the kinase Aurora- A requires its binding partner Bora
    • Hutterer A, Berdnik D, Weitz-Peitz F, et al. (2006) Mitotic activation of the kinase Aurora- A requires its binding partner Bora. Dev Cell 11:147-157.
    • (2006) Dev Cell , vol.11 , pp. 147-157
    • Hutterer, A.1    Berdnik, D.2    Weitz-Peitz, F.3
  • 51
    • 0037341906 scopus 로고    scopus 로고
    • A Ran signaling pathway mediated by the mediated by the mitotic kinase Aurora A in spindle assembly
    • Tsai MY, Wiese C, Cao K, et al. (2003) A Ran signaling pathway mediated by the mediated by the mitotic kinase Aurora A in spindle assembly. Nat Cell Biol 5:242-248.
    • (2003) Nat Cell Biol , vol.5 , pp. 242-248
    • Tsai, M.Y.1    Wiese, C.2    Cao, K.3
  • 52
    • 0037135979 scopus 로고    scopus 로고
    • Human TPX2 is required for targeting Aurora-A kinase to the spindle
    • Kufer TA, Sillje HH, Korner R, et al. (2002) Human TPX2 is required for targeting Aurora-A kinase to the spindle. J Cell Biol 158:617-623.
    • (2002) J Cell Biol , vol.158 , pp. 617-623
    • Kufer, T.A.1    Sillje, H.H.2    Korner, R.3
  • 53
    • 33646024346 scopus 로고    scopus 로고
    • HURP (Hepatocarcinoma-Upregulated) is part of a Ran-dependent complex involved in spindle formation
    • Koffa MD, Casanova CM, Santarella R, et al. (2006) HURP (Hepatocarcinoma-Upregulated) is part of a Ran-dependent complex involved in spindle formation. Curr Biol 16:743-754.
    • (2006) Curr Biol , vol.16 , pp. 743-754
    • Koffa, M.D.1    Casanova, C.M.2    Santarella, R.3
  • 54
    • 33646061361 scopus 로고    scopus 로고
    • HURP is a Ran-importin beta-regulated protein that stabilizes kinetochore microtubules in the vicinity of chromosomes
    • Sillje HH, Nagel S, Komer R, et al. (2006) HURP is a Ran-importin beta-regulated protein that stabilizes kinetochore microtubules in the vicinity of chromosomes. Curr Biol 16:731-742.
    • (2006) Curr Biol , vol.16 , pp. 731-742
    • Sillje, H.H.1    Nagel, S.2    Komer, R.3
  • 55
    • 10744225982 scopus 로고    scopus 로고
    • CENP-A phosphorylation by Aurora-A in prophase is required for enrichment of Aurora-B at inner centromeres and for kinetochore function
    • Kunitoku N, Sasayama T, Marumoto T, et al. (2003) CENP-A phosphorylation by Aurora-A in prophase is required for enrichment of Aurora-B at inner centromeres and for kinetochore function. Dev Cell 5:853-864.
    • (2003) Dev Cell , vol.5 , pp. 853-864
    • Kunitoku, N.1    Sasayama, T.2    Marumoto, T.3
  • 56
    • 9144251019 scopus 로고    scopus 로고
    • Phosphorylation by aurora kinase A induces Mdm2-mediated destabilization and inhibition of p53
    • Katayama H, Sasai K, Kawai H, et al. (2004) Phosphorylation by aurora kinase A induces Mdm2-mediated destabilization and inhibition of p53. Nat Genet 36:55-62.
    • (2004) Nat Genet , vol.36 , pp. 55-62
    • Katayama, H.1    Sasai, K.2    Kawai, H.3
  • 57
    • 33746905089 scopus 로고    scopus 로고
    • AURKA is one of the downstream targets of MAPK1/ERK2 in pancreatic cancer
    • online publication
    • Furukawa T, Kanai N, Shiwaker HO (2006) AURKA is one of the downstream targets of MAPK1/ERK2 in pancreatic cancer. Oncogene Adv (online publication).
    • (2006) Oncogene Adv
    • Furukawa, T.1    Kanai, N.2    Shiwaker, H.O.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.