Family 1 uridine-5′-diphosphate glucuronosyltransferases (UGT1A): From Gilbert's syndrome to genetic organization and variability

Archives of Toxicology

Volumn 82, Issue 7, 2008, Pages 415-433

  Strassburg, Christian P ^a   Lankisch, Tim O ^a   Manns, Michael P ^a   Ehmer, Ursula ^a  

^a HANNOVER MEDICAL SCHOOL   (Germany)

Author keywords

Carcinogenesis; Drug safety; Gilbert's syndrome; Glucuronidation; Pharmacogenetics; UGT1A7

Indexed keywords

2 HYDROXYESTRONE; 7 ETHYL 10 HYDROXYCAMPTOTHECIN; ATAZANAVIR; ATORVASTATIN; BILIRUBIN; BUPRENORPHINE; CARCINOGEN; CERIVASTATIN; ESTRADIOL; ETHINYLESTRADIOL; EZETIMIBE; FLURBIPROFEN; GEMFIBROZIL; GLUCURONOSYLTRANSFERASE 1A1; GLUCURONOSYLTRANSFERASE 1A10; GLUCURONOSYLTRANSFERASE 1A3; GLUCURONOSYLTRANSFERASE 1A6; GLUCURONOSYLTRANSFERASE 1A7; GLUCURONOSYLTRANSFERASE 1A8; GLUCURONOSYLTRANSFERASE 1A9; GLYCOSYLTRANSFERASE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; IBUPROFEN; INDINAVIR; IRINOTECAN; KETOPROFEN; NONSTEROID ANTIINFLAMMATORY AGENT; SIMVASTATIN; UNINDEXED DRUG; XENOBIOTIC AGENT;

ALLELE; BILIRUBIN METABOLISM; CANCER RISK; CATALYSIS; COLORECTAL CANCER; DETOXIFICATION; DIARRHEA; DRUG DISPOSITION; DRUG DOSE REDUCTION; DRUG GLUCURONIDATION; DRUG WITHDRAWAL; ENZYME SPECIFICITY; GASTROINTESTINAL SYMPTOM; GENE LOCUS; GENETIC ORGANIZATION; GENETIC VARIABILITY; GILBERT DISEASE; HAPLOTYPE; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; HYPERBILIRUBINEMIA; JAUNDICE; LEUKOPENIA; LIVER CELL CARCINOMA; NEUTROPENIA; NOMENCLATURE; NONHUMAN; PANCREAS CANCER; PHARMACOGENETICS; PREDICTION; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FAMILY; REVIEW; RISK ASSESSMENT; RISK FACTOR; THROMBOCYTOPENIA; UNSPECIFIED SIDE EFFECT;

ANTINEOPLASTIC AGENTS, PHYTOGENIC; BILIRUBIN; CAMPTOTHECIN; GILBERT DISEASE; GLUCURONOSYLTRANSFERASE; HIV PROTEASE INHIBITORS; HUMANS; ISOENZYMES; JAUNDICE; NEOPLASMS; OLIGOPEPTIDES; PHARMACOGENETICS; PYRIDINES; RISK FACTORS; TERMINOLOGY AS TOPIC; VARIATION (GENETICS);

EID: 45849134870     PISSN: 03405761     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00204-008-0314-x     Document Type: Review

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