Human UDP-glucuronosyltransferase 1A1 is the primary enzyme responsible for the N-glucuronidation of N-hydroxy-PhIP in vitro

Chemical Research in Toxicology

Volumn 17, Issue 8, 2004, Pages 1137-1144

  Malfatti, Michael A ^a   Felton, James S ^a  

^a LAWRENCE LIVERMORE NATIONAL LABORATORY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 AMINO 1 METHYL 6 PHENYLIMIDAZO[4,5 B]PYRIDINE; CARCINOGEN; CYTOCHROME P450 1A2; GLUCURONIDE; GLUCURONOSYLTRANSFERASE; GLUCURONOSYLTRANSFERASE 1A1; GLUCURONOSYLTRANSFERASE 1A10; GLUCURONOSYLTRANSFERASE 1A3; GLUCURONOSYLTRANSFERASE 1A4; GLUCURONOSYLTRANSFERASE 1A6; GLUCURONOSYLTRANSFERASE 1A7; GLUCURONOSYLTRANSFERASE 1A8; GLUCURONOSYLTRANSFERASE 1A9; HETEROCYCLIC AMINE; ISOENZYME; N HYDROXY 2 AMINO 1 METHYL 6 PHENYLIMIDAZO[4,5 B]PYRIDINE N2 GLUCURONIDE; N HYDROXY 2 AMINO 1 METHYL 6 PHENYLIMIDAZO[4,5 B]PYRIDINE N3 GLUCURONIDE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; BACULOVIRUS; BIOTRANSFORMATION; CATALYSIS; CONCENTRATION RESPONSE; CONTROLLED STUDY; COOKING; DETOXIFICATION; ENZYME ACTIVITY; ENZYME SPECIFICITY; GLUCURONIDATION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HYDROXYLATION; IN VITRO STUDY; INSECT CELL; MEAT; MICHAELIS CONSTANT; MICROSOME; NONHUMAN; PROTEIN EXPRESSION; XENOBIOTIC METABOLISM;

BIOTRANSFORMATION; CARCINOGENS; GLUCURONIDES; GLUCURONOSYLTRANSFERASE; HUMANS; HYDROGEN-ION CONCENTRATION; IMIDAZOLES; KINETICS; MICROSOMES; PYRIDINES; TIME FACTORS;

ANIMALIA; INSECTA; UNIDENTIFIED BACULOVIRUS;

EID: 4243182634     PISSN: 0893228X     EISSN: None     Source Type: Journal    
DOI: 10.1021/tx049898m     Document Type: Article

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