-
1
-
-
0032707765
-
Structural and functional studies of UDP-glucuronosyltransferases
-
Radominska-Pandya A, Czernik PJ, Little JM. Structural and functional studies of UDP-glucuronosyltransferases. Drug Metab Rev 1999; 31: 817-899.
-
(1999)
Drug Metab Rev
, vol.31
, pp. 817-899
-
-
Radominska-Pandya, A.1
Czernik, P.J.2
Little, J.M.3
-
2
-
-
0035115599
-
Genetic multiplicity of the human UDP-glucuronosyltransferases and regulation in the gastrointestinal tract
-
Tukey RH, Strassburg CP. Genetic multiplicity of the human UDP-glucuronosyltransferases and regulation in the gastrointestinal tract. Mol Pharmacol 2001; 59: 405-414.
-
(2001)
Mol Pharmacol
, vol.59
, pp. 405-414
-
-
Tukey, R.H.1
Strassburg, C.P.2
-
3
-
-
0034966656
-
Thirteen UDPglucuronosyltransferase genes are encoded at the human UGT1 gene complex locus
-
Gong QH, Cho JW, Huang T, Potter C, Gholami N, Basu NK et al. Thirteen UDPglucuronosyltransferase genes are encoded at the human UGT1 gene complex locus. Pharmacogenetics 2001; 11: 357-368.
-
(2001)
Pharmacogenetics
, vol.11
, pp. 357-368
-
-
Gong, Q.H.1
Cho, J.W.2
Huang, T.3
Potter, C.4
Gholami, N.5
Basu, N.K.6
-
4
-
-
0032489465
-
Transcriptional activation of the UDP-glucuronosyltransferase 1A7 gene in rat liver by aryl hydrocarbon receptor ligands and oltipraz
-
Metz RP, Ritter JK. Transcriptional activation of the UDP-glucuronosyltransferase 1A7 gene in rat liver by aryl hydrocarbon receptor ligands and oltipraz. J Biol Chem 1998; 273: 5607-5614.
-
(1998)
J Biol Chem
, vol.273
, pp. 5607-5614
-
-
Metz, R.P.1
Ritter, J.K.2
-
5
-
-
0037819284
-
Pharmacogenomics of human UDP-glucuronosyltransferase enzymes
-
Guillemette C. Pharmacogenomics of human UDP-glucuronosyltransferase enzymes. Pharmacogenomics J 2003; 3: 136-158.
-
(2003)
Pharmacogenomics J
, vol.3
, pp. 136-158
-
-
Guillemette, C.1
-
6
-
-
0033789766
-
Structural heterogeneity at the UDP-glucuronosyltransferase 1 locus: Functional consequences of three novel missense mutations in the human UGT1A7 gene
-
Guillemette C, Ritter JK, Auyeung DJ, Kessler FK, Housman DE. Structural heterogeneity at the UDP-glucuronosyltransferase 1 locus: Functional consequences of three novel missense mutations in the human UGT1A7 gene. Pharmacogenetics 2000; 10: 629-644.
-
(2000)
Pharmacogenetics
, vol.10
, pp. 629-644
-
-
Guillemette, C.1
Ritter, J.K.2
Auyeung, D.J.3
Kessler, F.K.4
Housman, D.E.5
-
7
-
-
0036765309
-
Common human UGT1A polymorphisms and the altered metabolism of irinotecan active metabolite 7-ethyl-10-hydroxycamptothecin (SN-38)
-
Gagne JF, Montminy V, Belanger P, Journault K, Gaucher G, Guillemette C. Common human UGT1A polymorphisms and the altered metabolism of irinotecan active metabolite 7-ethyl-10-hydroxycamptothecin (SN-38). Mol Pharmacol 2002; 62: 608-617.
-
(2002)
Mol Pharmacol
, vol.62
, pp. 608-617
-
-
Gagne, J.F.1
Montminy, V.2
Belanger, P.3
Journault, K.4
Gaucher, G.5
Guillemette, C.6
-
8
-
-
0036016310
-
Identification and functional characterization of UDP-glucuronosyltransferases UGT1A8*1, UGT1A8*2 and UGT1A8*3
-
Huang YH, Galijatovic A, Nguyen N, Geske D, Beaton D, Green J et al. Identification and functional characterization of UDP-glucuronosyltransferases UGT1A8*1, UGT1A8*2 and UGT1A8*3. Pharmacogenetics 2002; 12: 287-297.
-
(2002)
Pharmacogenetics
, vol.12
, pp. 287-297
-
-
Huang, Y.H.1
Galijatovic, A.2
Nguyen, N.3
Geske, D.4
Beaton, D.5
Green, J.6
-
9
-
-
0042071532
-
Detection of UGT1A10 polymorphisms and their association with orolaryngeal carcinoma risk
-
Elahi A, Bendaly J, Zheng Z, Muscat JE, Richie Jr JP, Schantz SP et al. Detection of UGT1A10 polymorphisms and their association with orolaryngeal carcinoma risk. Cancer 2003; 98: 872-880.
-
(2003)
Cancer
, vol.98
, pp. 872-880
-
-
Elahi, A.1
Bendaly, J.2
Zheng, Z.3
Muscat, J.E.4
Richie Jr., J.P.5
Schantz, S.P.6
-
10
-
-
0037960948
-
Functional characterization of human UDP-glucuronosyltransferase 1A9 variant, D256N, found in Japanese cancer patients
-
Jinno H, Saeki M, Saito Y, Tanaka-Kagawa T, Hanioka N, Sai K et al. Functional characterization of human UDP-glucuronosyltransferase 1A9 variant, D256N, found in Japanese cancer patients. J Pharmacol Exp Ther 2003; 306: 688-693.
-
(2003)
J Pharmacol Exp Ther
, vol.306
, pp. 688-693
-
-
Jinno, H.1
Saeki, M.2
Saito, Y.3
Tanaka-Kagawa, T.4
Hanioka, N.5
Sai, K.6
-
11
-
-
0037403403
-
Functional characterization of wild-type and variant (T2021 and M591) human UDP-glucuronosyltransferase 1A10
-
Jinno H, Saeki M, Tanaka-Kagawa T, Hanioka N, Saito Y, Ozawa S et al. Functional characterization of wild-type and variant (T2021 and M591) human UDP-glucuronosyltransferase 1A10. Drug Metab Dispos 2003; 31: 528-532.
-
(2003)
Drug Metab Dispos
, vol.31
, pp. 528-532
-
-
Jinno, H.1
Saeki, M.2
Tanaka-Kagawa, T.3
Hanioka, N.4
Saito, Y.5
Ozawa, S.6
-
12
-
-
0141519502
-
Novel functional polymorphisms in the UGT1A7 and UGT1A9 glucuronidating enzymes in Caucasian and African-American subjects and their impact on the metabolism of 7-ethyl-10-hydroxycamptothecin and flavopiridol anticancer drugs
-
Villeneuve L, Girard H, Fortier LC, Gagne JF, Guillemette C. Novel functional polymorphisms in the UGT1A7 and UGT1A9 glucuronidating enzymes in Caucasian and African-American subjects and their impact on the metabolism of 7-ethyl-10-hydroxycamptothecin and flavopiridol anticancer drugs. J Pharmacol Exp Ther 2003; 307: 117-128.
-
(2003)
J Pharmacol Exp Ther
, vol.307
, pp. 117-128
-
-
Villeneuve, L.1
Girard, H.2
Fortier, L.C.3
Gagne, J.F.4
Guillemette, C.5
-
13
-
-
1842532189
-
Variation of hepatic glucuronidation: Novel functional polymorphisms of the UDP-glucuronosyltransferase UGT1A4
-
Ehmer U, Vogel A, Schutte JK, Krone B, Manns MP, Strassburg CP. Variation of hepatic glucuronidation: Novel functional polymorphisms of the UDP-glucuronosyltransferase UGT1A4. Hepatology 2004; 39: 970-977.
-
(2004)
Hepatology
, vol.39
, pp. 970-977
-
-
Ehmer, U.1
Vogel, A.2
Schutte, J.K.3
Krone, B.4
Manns, M.P.5
Strassburg, C.P.6
-
14
-
-
4143100168
-
Human UGT1A6 pharmacogenetics: Identification of a novel SNP, characterization of allele frequencies and functional analysis of recombinant allozymes in human liver tissue and in cultured cells
-
Nagar S, Zalatoris JJ, Blanchard RL. Human UGT1A6 pharmacogenetics: identification of a novel SNP, characterization of allele frequencies and functional analysis of recombinant allozymes in human liver tissue and in cultured cells. Pharmacogenetics 2004; 14: 487-499.
-
(2004)
Pharmacogenetics
, vol.14
, pp. 487-499
-
-
Nagar, S.1
Zalatoris, J.J.2
Blanchard, R.L.3
-
15
-
-
0038275905
-
Glucuronidation of 7-ethyl-10-hydroxycamptothecin (SN-38), an active metabolite of irinotecan (CPT-11), by human UGT1A1 variants, G71R, P229Q, and Y486D
-
Jinno H, Tanaka-Kagawa T, Hanioka N, Saeki M, Ishida S, Nishimura T et al. Glucuronidation of 7-ethyl-10-hydroxycamptothecin (SN-38), an active metabolite of irinotecan (CPT-11), by human UGT1A1 variants, G71R, P229Q, and Y486D. Drug Metab Dispos 2003; 31: 108-113.
-
(2003)
Drug Metab Dispos
, vol.31
, pp. 108-113
-
-
Jinno, H.1
Tanaka-Kagawa, T.2
Hanioka, N.3
Saeki, M.4
Ishida, S.5
Nishimura, T.6
-
17
-
-
17044450136
-
Frequent co-occurrence of the TATA box mutation associated with Gilbert's syndrome (UGT1A1*28) with other polymorphisms of the UDP-glucuronosyltransferase-1 locus (UGT1A6*2 and UGT1A7*3) in Caucasians and Egyptians
-
Kohle C, Mohrle B, Munzel PA, Schwab M, Wernet D, Badary OA et al. Frequent co-occurrence of the TATA box mutation associated with Gilbert's syndrome (UGT1A1*28) with other polymorphisms of the UDP-glucuronosyltransferase-1 locus (UGT1A6*2 and UGT1A7*3) in Caucasians and Egyptians. Biochem Pharmacol 2003; 65: 1521-1527.
-
(2003)
Biochem Pharmacol
, vol.65
, pp. 1521-1527
-
-
Kohle, C.1
Mohrle, B.2
Munzel, P.A.3
Schwab, M.4
Wernet, D.5
Badary, O.A.6
-
18
-
-
12944329893
-
UGT1A7 and UGT1A9 polymorphisms predict response and toxicity in colorectal cancer patients treated with capecitabine/irinotecan
-
Carlini LE, Meropol NJ, Bever J, Andria ML, Hill T, Gold P et al. UGT1A7 and UGT1A9 polymorphisms predict response and toxicity in colorectal cancer patients treated with capecitabine/irinotecan. Clin Cancer Res 2005; 11: 1226-1236.
-
(2005)
Clin Cancer Res
, vol.11
, pp. 1226-1236
-
-
Carlini, L.E.1
Meropol, N.J.2
Bever, J.3
Andria, M.L.4
Hill, T.5
Gold, P.6
-
19
-
-
2942527225
-
UGT1A1 Haplotypes associated with reduced glucuronidation and increased serum bilirubin in irinotecan-administered Japanese cancer patients
-
Sai K, Saeki M, Saito Y, Ozawa S, Katori N, Jinno H et al. UGT1A1 Haplotypes associated with reduced glucuronidation and increased serum bilirubin in irinotecan-administered Japanese cancer patients. Clin Pharmacol Ther 2004; 75: 501-515.
-
(2004)
Clin Pharmacol Ther
, vol.75
, pp. 501-515
-
-
Sai, K.1
Saeki, M.2
Saito, Y.3
Ozawa, S.4
Katori, N.5
Jinno, H.6
-
20
-
-
24144483508
-
Genetic polymorphisms of UGT1A6 in a Japanese population
-
Saeki M, Saito Y, Jinno H, Sai K, Kaniwa N, Ozawa S et al. Genetic polymorphisms of UGT1A6 in a Japanese population. Drug Metab Pharmacokinet 2005; 20: 85-90.
-
(2005)
Drug Metab Pharmacokinet
, vol.20
, pp. 85-90
-
-
Saeki, M.1
Saito, Y.2
Jinno, H.3
Sai, K.4
Kaniwa, N.5
Ozawa, S.6
-
21
-
-
21444439973
-
Genetic variations and haplotypes of UGT1A4 in a Japanese population
-
Saeki M, Saito Y, Jinno H, Sai K, Hachisuka A, Kaniwa N et al. Genetic variations and haplotypes of UGT1A4 in a Japanese population. Drug Metab Pharmacokinet 2005; 20: 144-151.
-
(2005)
Drug Metab Pharmacokinet
, vol.20
, pp. 144-151
-
-
Saeki, M.1
Saito, Y.2
Jinno, H.3
Sai, K.4
Hachisuka, A.5
Kaniwa, N.6
-
22
-
-
1942424750
-
Six novel UDP-glucuronosyltransferase (UGT1A3) polymorphisms with varying activity
-
Iwai M, Maruo Y, Ito M, Yamamoto K, Sato H, Takeuchi Y. Six novel UDP-glucuronosyltransferase (UGT1A3) polymorphisms with varying activity. J Hum Genet 2004; 49: 123-128.
-
(2004)
J Hum Genet
, vol.49
, pp. 123-128
-
-
Iwai, M.1
Maruo, Y.2
Ito, M.3
Yamamoto, K.4
Sato, H.5
Takeuchi, Y.6
-
23
-
-
0031010944
-
Recognition of AUG and alternative initiator codons is augmented by G in position +4 but is not generally affected by the nucleotides in positions +5 and +6
-
Kozak M. Recognition of AUG and alternative initiator codons is augmented by G in position +4 but is not generally affected by the nucleotides in positions +5 and +6. EMBO J 1997; 16: 2482-2492.
-
(1997)
EMBO J
, vol.16
, pp. 2482-2492
-
-
Kozak, M.1
-
24
-
-
2442547653
-
A novel polymorphism in the promoter region of human UGT1A9 gene (UGT1A9*22) and its effects on the transcriptional activity
-
Yamanaka H, Nakajima M, Katoh M, Hara Y, Tachibana O, Yamashita J et al. A novel polymorphism in the promoter region of human UGT1A9 gene (UGT1A9*22) and its effects on the transcriptional activity. Pharmacogenetics 2004; 14: 329-332.
-
(2004)
Pharmacogenetics
, vol.14
, pp. 329-332
-
-
Yamanaka, H.1
Nakajima, M.2
Katoh, M.3
Hara, Y.4
Tachibana, O.5
Yamashita, J.6
-
25
-
-
17844410900
-
Identification and characterization of a functional TATA box polymorphism of the UDP glucuronosyltransferase 1A7 gene
-
Lankisch TO, Vogel A, Eilermann S, Fiebeler A, Krone B, Barut A et al. Identification and characterization of a functional TATA box polymorphism of the UDP glucuronosyltransferase 1A7 gene. Mol Pharmacol 2005; 67: 1732-1739.
-
(2005)
Mol Pharmacol
, vol.67
, pp. 1732-1739
-
-
Lankisch, T.O.1
Vogel, A.2
Eilermann, S.3
Fiebeler, A.4
Krone, B.5
Barut, A.6
-
26
-
-
0036313887
-
Genetic polymorphisms of the UDP-glucuronosyltransferase 1A7 gene and irinotecan toxicity in Japanese cancer patients
-
Ando M, Ando Y, Sekido Y, Ando M, Shimokata K, Hasegawa Y. Genetic polymorphisms of the UDP-glucuronosyltransferase 1A7 gene and irinotecan toxicity in Japanese cancer patients. Jpn J Cancer Res 2002; 93: 591-597.
-
(2002)
Jpn J Cancer Res
, vol.93
, pp. 591-597
-
-
Ando, M.1
Ando, Y.2
Sekido, Y.3
Ando, M.4
Shimokata, K.5
Hasegawa, Y.6
-
27
-
-
14544300089
-
Polymorphisms of uridine-diphosphoglucuronosyltransferase 1A7 gene in Taiwan Chinese
-
Huang MJ, Yang SS, Lin MS, Huang CS. Polymorphisms of uridine-diphosphoglucuronosyltransferase 1A7 gene in Taiwan Chinese. World J Gastroenterol 2005; 11: 797-802.
-
(2005)
World J Gastroenterol
, vol.11
, pp. 797-802
-
-
Huang, M.J.1
Yang, S.S.2
Lin, M.S.3
Huang, C.S.4
-
28
-
-
18744373338
-
Haplotypes of variants in the UDP-glucuronosyltransferase1A9 and 1A1 genes
-
Innocenti F, Liu W, Chen P, Desai AA, Das S, Ratain MJ. Haplotypes of variants in the UDP-glucuronosyltransferase1A9 and 1A1 genes. Pharmacogenet Genomics 2005; 15: 295-301.
-
(2005)
Pharmacogenet Genomics
, vol.15
, pp. 295-301
-
-
Innocenti, F.1
Liu, W.2
Chen, P.3
Desai, A.A.4
Das, S.5
Ratain, M.J.6
-
29
-
-
0033600191
-
Glucuronidation of 7-ethyl-10-hydroxycamptothecin (SN-38) by the human UDP-glucuronosyltransferases encoded at the UGT1 locus
-
Ciotti M, Basu N, Brangi M, Owens IS. Glucuronidation of 7-ethyl-10-hydroxycamptothecin (SN-38) by the human UDP-glucuronosyltransferases encoded at the UGT1 locus. Biochem Biophys Res Commun 1999; 260: 199-202.
-
(1999)
Biochem Biophys Res Commun
, vol.260
, pp. 199-202
-
-
Ciotti, M.1
Basu, N.2
Brangi, M.3
Owens, I.S.4
-
30
-
-
6344248683
-
Specificity and regioselectivity of the conjugation of estradiol, estrone, and their catecholestrogen and methoxyestrogen metabolites by human uridine diphospho-glucuronosyltransferases expressed in endometrium
-
Lepine J, Bernard O, Plante M, Tetu B, Pelletier G, Labrie F et al. Specificity and regioselectivity of the conjugation of estradiol, estrone, and their catecholestrogen and methoxyestrogen metabolites by human uridine diphospho-glucuronosyltransferases expressed in endometrium. J Clin Endocrinol Metab 2004; 89: 5222-5232.
-
(2004)
J Clin Endocrinol Metab
, vol.89
, pp. 5222-5232
-
-
Lepine, J.1
Bernard, O.2
Plante, M.3
Tetu, B.4
Pelletier, G.5
Labrie, F.6
-
31
-
-
3142652041
-
Gastrointestinally distributed UDP-glucuronosyltransferase 1A10, which metabolizes estrogens and nonsteroidal anti-inflammatory drugs, depends upon phosphorylation
-
Basu NK, Kubota S, Meselhy MR, Ciotti M, Chowdhury B, Hartori M et al. Gastrointestinally distributed UDP-glucuronosyltransferase 1A10, which metabolizes estrogens and nonsteroidal anti-inflammatory drugs, depends upon phosphorylation. J Biol Chem 2004; 279: 28320-28329.
-
(2004)
J Biol Chem
, vol.279
, pp. 28320-28329
-
-
Basu, N.K.1
Kubota, S.2
Meselhy, M.R.3
Ciotti, M.4
Chowdhury, B.5
Hartori, M.6
-
32
-
-
0142074253
-
Glucuronidation of arachidonic and linoleic acid metabolites by human UDP-glucuronosyltransferases
-
Turgeon D, Chouinard S, Belanger P, Picard S, Labbe JF, Borgeat P et al. Glucuronidation of arachidonic and linoleic acid metabolites by human UDP-glucuronosyltransferases. J Lipid Res 2003; 44: 1182-1191.
-
(2003)
J Lipid Res
, vol.44
, pp. 1182-1191
-
-
Turgeon, D.1
Chouinard, S.2
Belanger, P.3
Picard, S.4
Labbe, J.F.5
Borgeat, P.6
-
33
-
-
4644315738
-
Glucuronidation of oxidized fatty acids and prostaglandins B1 and E2 by human hepatic and recombinant UDP-glucuronosyltransferases
-
Little JM, Kurkela M, Sonka J, Jantti S, Ketola R, Bratton S et al. Glucuronidation of oxidized fatty acids and prostaglandins B1 and E2 by human hepatic and recombinant UDP-glucuronosyltransferases. J Lipid Res 2004; 45: 1694-1703.
-
(2004)
J Lipid Res
, vol.45
, pp. 1694-1703
-
-
Little, J.M.1
Kurkela, M.2
Sonka, J.3
Jantti, S.4
Ketola, R.5
Bratton, S.6
-
34
-
-
0032493441
-
Racial variability in the UDP-glucuronosyltransferase 1 (UGT1A1) promoter: A balanced polymorphism for regulation of bilirubin metabolism?
-
Beutler E, Gelbart T, Demina A. Racial variability in the UDP-glucuronosyltransferase 1 (UGT1A1) promoter: A balanced polymorphism for regulation of bilirubin metabolism? Proc Natl Acad Sci USA 1998; 95: 8170-8174.
-
(1998)
Proc Natl Acad Sci USA
, vol.95
, pp. 8170-8174
-
-
Beutler, E.1
Gelbart, T.2
Demina, A.3
-
35
-
-
18444399926
-
Identification of a defect in the UGT1A1 gene promoter and its association with hyperbilirubinemia
-
Sugatani J, Yamakawa K, Yoshinari K, Machida T, Takagi H, Mori M et al. Identification of a defect in the UGT1A1 gene promoter and its association with hyperbilirubinemia. Biochem Biophys Res Commun 2002; 292: 492-497.
-
(2002)
Biochem Biophys Res Commun
, vol.292
, pp. 492-497
-
-
Sugatani, J.1
Yamakawa, K.2
Yoshinari, K.3
Machida, T.4
Takagi, H.5
Mori, M.6
-
36
-
-
6444220151
-
UGT1A10 is responsible for SN-38 glucuronidation and its expression in human lung cancers
-
Oguri T, Takahashi T, Miyazaki M, Isobe T, Kohno N, Mackenzie PI et al. UGT1A10 is responsible for SN-38 glucuronidation and its expression in human lung cancers. Anticancer Res 2004; 24: 2893-2896.
-
(2004)
Anticancer Res
, vol.24
, pp. 2893-2896
-
-
Oguri, T.1
Takahashi, T.2
Miyazaki, M.3
Isobe, T.4
Kohno, N.5
Mackenzie, P.I.6
-
37
-
-
0013029439
-
Three novel single nucleotide polymorphisms in UGT1A10
-
Saeki M, Ozawa S, Saito Y, Jinno H, Hamaguchi T, Nokihara H et al. Three novel single nucleotide polymorphisms in UGT1A10. Drug Metab Pharmacokinet 2002; 17: 488-490.
-
(2002)
Drug Metab Pharmacokinet
, vol.17
, pp. 488-490
-
-
Saeki, M.1
Ozawa, S.2
Saito, Y.3
Jinno, H.4
Hamaguchi, T.5
Nokihara, H.6
-
38
-
-
2442506227
-
Three novel single nucleotide polymorphisms in UGT1A9
-
Saeki M, Saito Y, Jinno H, Sai K, Komamura K, Ueno K et al. Three novel single nucleotide polymorphisms in UGT1A9. Drug Metab Pharmacokinet 2003; 18: 146-149.
-
(2003)
Drug Metab Pharmacokinet
, vol.18
, pp. 146-149
-
-
Saeki, M.1
Saito, Y.2
Jinno, H.3
Sai, K.4
Komamura, K.5
Ueno, K.6
-
39
-
-
0038271981
-
Comprehensive UGT1A1 genotyping in a Japanese population by pyrosequencing
-
Saeki M, Saito Y, Jinno H, Tohkin M, Kurose K, Kaniwa N et al. Comprehensive UGT1A1 genotyping in a Japanese population by pyrosequencing. Clin Chem 2003; 49: 1182-1185.
-
(2003)
Clin Chem
, vol.49
, pp. 1182-1185
-
-
Saeki, M.1
Saito, Y.2
Jinno, H.3
Tohkin, M.4
Kurose, K.5
Kaniwa, N.6
-
40
-
-
0036562879
-
Determination of probability distribution of diplotype configuration (diplotype distribution) for each subject from genotypic data using the EM algorithm
-
Kitamura Y, Moriguchi M, Kaneko H, Morisaki H, Morisaki T, Toyama K et al. Determination of probability distribution of diplotype configuration (diplotype distribution) for each subject from genotypic data using the EM algorithm. Ann Hum Genet 2002; 66: 183-193.
-
(2002)
Ann Hum Genet
, vol.66
, pp. 183-193
-
-
Kitamura, Y.1
Moriguchi, M.2
Kaneko, H.3
Morisaki, H.4
Morisaki, T.5
Toyama, K.6
|