α-Lipoic acid prevents the development of glucose-induced insulin resistance in 3T3-L1 adipocytes and accelerates the decline in immunoreactive insulin during cell incubation

Metabolism: Clinical and Experimental

Volumn 50, Issue 9, 2001, Pages 1063-1069

  Greene, E L ^a   Nelson, B A ^a   Robinson, K A ^a   Buse, M G ^a  

^a MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLCYSTEINE; ANTIOXIDANT; DIHYDROLIPOATE; GLUCOSE; INSULIN; THIOCTIC ACID;

ADIPOCYTE; ANIMAL CELL; ARTICLE; CELL COMPARTMENTALIZATION; CELL STRAIN 3T3; COMPARATIVE STUDY; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; CULTURE MEDIUM; DISEASE COURSE; DOWN REGULATION; DRUG EFFECT; DRUG SCREENING; EXPOSURE; GLUCOSE TRANSPORT; IMMUNOREACTIVITY; INSULIN RESISTANCE; INSULIN SENSITIVITY; MOUSE; NONHUMAN; OXIDATION REDUCTION STATE; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTECTION; RADIOIMMUNOASSAY; STIMULATION;

EID: 0034788565     PISSN: 00260495     EISSN: None     Source Type: Journal    
DOI: 10.1053/meta.2001.25601     Document Type: Article

References (41)

1. Glucose toxicity
2. Hyperglycemia decreases glucose uptake in type I diabetes
3. Prevention by protein kinase C inhibitors of glucose-induced insulin receptor tyrosine kinase resistance in rat fat cells
4. Glucose induced translocation of protein kinase C isoforms in rat-1 fibroblasts is paralleled by inhibition of the insulin receptor tyrosine kinase
5. Troglitazone prevents hyperglycemia-induced but not glucosamine-induced insulin resistance
6. Discovery of a metabolic pathway mediating glucose-induced desensitization of the glucose transport system
7. The tissue concentration of UDP-N-acetylglucosamine modulates the stimulatory effect of insulin on skeletal muscle glucose uptake
8. Mechanism of hexosamine-induced insulin resistance in transgenic mice overexpressing glutamine:fructose-6-phosphate aminotransferase: Decreased glucose transporter GLUT-4 translocation and reversal by treatment with thiazolidinedione
9. Role of oxidative stress in the development of complications of diabetes mellitus
10. Oxidative stress and insulin action: Is there a relationship?
11. Prevention of glucose toxicity in HIT-T15 cells and Zucker diabetic fatty rats by antioxidants
12. Glucose and insulin co-regulate the glucose transport system in primary cultured adipocytes: A new mechanism of insulin resistance
13. Sublines of mouse 3T3 cells that accumulate lipid
14. Development of insulin resistance in 3T3-LI adipocytes
15. High glucose and glucosamine induce insulin resistance via different mechanisms in 3T3-L1 adipocytes
16. Alpha-lipoic acid as a biological antioxidant
17. Lipoic acid protects against oxidative stress induced impairment in insulin stimulation of protein kinase B and glucose transport in 3T3-L1 adipocytes
18. What is oxidative stress?
19. Oxidative stress and glycemic regulation
20. Clinical relevance of the oxidative stress concept
21. Glucose transporters of muscles cells in culture. Developmental regulation and modulation by lipoic acid, an anti-hyperglycemic agent
22. Stimulation of glucose uptake by the natural coenzyme α-lipoic acid/thioctic acid. Participation of elements of the insulin signaling pathway
23. The antioxidant α-lipoic acid enhances insulin stimulated glucose metabolism in insulin resistant rat skeletal muscle
24. Oxidative stress disrupts insulin-induced cellular redistribution of insulin receptor substrate-1 and phosphatidylinositol 3-kinase in 3T3-L1 adipocytes
25. N-acetyl-cysteine-promoted survival of PC-12 cells is glutathione independent but transcription-dependent
26. 2 for platelet-derived growth factor signal transduction
27. Mitogenic signaling mediated by oxidants in Ras-transformed fibroblasts
28. Using lipoate enantiomers and thioredoxin to study the mechanism of the 2-oxoacid-dependent dihydrolipoate production by the 2-oxoacid dehydrogenase complexes
29. Reversible change in thiol redox status of the insulin receptor α-subunit
30. α-Lipoic acid increases intracellular glutathione in a human T-lymphocyte Jurkat cell line
31. Differential effects of lipoic acid stereoisomers on glucose metabolism in insulin-resistant skeletal muscle
32. Engagement of the insulin-sensitive pathway in the stimulation of glucose transport by α-lipoic acid in 3T3-L1 adipocytes
33. Glutathione reductase and lipoamide dehydrogenase have opposite stereospecificities for α-lipoic acid enantiomers
34. Oral administration of rac-lipoic acid modulates insulin sensitivity in patients with type-2 diabetes mellitus. A placebo-controlled pilot trial
35. α-Lipoic acid in the treatment of diabetic peripheral and cardiac autonomic neuropathy
36. α-Lipoic acid treatment decreases serum lactate and pyruvate concentrations and improves glucose effectiveness in lean and obese patients with type 2 diabetes
37. Enantioselective pharmacokinetics and bioavailability of different racemic α-lipoic acid formulations in healthy volunteers
38. TNF-α-induced insulin resistance in vivo and its prevention by troglitazone
39. Molecular cloning and expression of human tumor necrosis factor and comparison with mouse tumor necrosis factor
40. Effects of DL-α-lipoic acid on peripheral nerve conduction, blood flow, energy metabolism, and oxidative stress in experimental diabetic neuropathy
41. Dihydrolipoic acid - A universal antioxidant both in the membrane and in the aqueous phase. Reduction of peroxyl, ascorbyl and chromanoxyl radicals