Application of combinatorial and parallel synthesis chemistry methodologies to antiparasitic drug discovery

Current Medicinal Chemistry

Volumn 11, Issue 19, 2004, Pages 2519-2533

  Musonda, Chitalu C ^a   Chibale, Kelly ^a  

^a UNIVERSITY OF CAPE TOWN   (South Africa)

Author keywords

Antimalarial; Antiparasitic drugs; Combinatorial chemistry; Parallel synthesis; Polyamine based derivatives; Solid phase organic synthesis; Trypanothione

Indexed keywords

1,4 NAPHTHOQUINONE DERIVATIVE; ADENOSINE DERIVATIVE; ANTIMALARIAL AGENT; ANTIPARASITIC AGENT; ANTIPROTOZOAL AGENT; ASPARTIC ACID; ASPARTIC PROTEINASE; ASPARTIC PROTEINASE INHIBITOR; CYSTEINE PROTEINASE; CYSTEINE PROTEINASE INHIBITOR; HOMOTRYPANOTHIONE DISULFIDE; IPRIFLAVONE; KUKOAMINE A; KUKOAMINE B; LUPEOL; MENADIONE; NORSPERMINE; NORTRYPANOTHIONE; PLASMEPSIN II; PLUMBAGIN; POLYAMINE DERIVATIVE; PROLYL ENDOPEPTIDASE INHIBITOR; QUINOLINE DERIVATIVE; SPERMIDINE; SPERMINE; SULFONAMIDE; TRITERPENE DERIVATIVE; TRYPANOTHIONE; TRYPANOTHIONE REDUCTASE; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ANTIMALARIAL ACTIVITY; ANTIPROTOZOAL ACTIVITY; COMBINATORIAL CHEMISTRY; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME SUBSTRATE; ENZYME SYNTHESIS; METHODOLOGY; NONHUMAN; PARALLEL DESIGN; PLASMODIUM FALCIPARUM; POLYMERIZATION; REVIEW; SOLID PHASE EXTRACTION; TRYPANOSOMA CRUZI;

EID: 4544357837     PISSN: 09298673     EISSN: None     Source Type: Journal    
DOI: 10.2174/0929867043364469     Document Type: Review

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