General solid-phase synthesis approach to prepare mechanism-based aspartyl protease inhibitor libraries. Identification of potent cathepsin D inhibitors

Journal of the American Chemical Society

Volumn 120, Issue 38, 1998, Pages 9735-9747

  Lee, Christina E ^a   Kick, Ellen K ^a   Ellman, Jonathan A ^b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b BRISTOL MYERS SQUIBB   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ASPARTYL PROTEINASE INHIBITOR; CATHEPSIN D; PROTEINASE INHIBITOR; REAGENT; UNCLASSIFIED DRUG;

ARTICLE; CHEMICAL REACTION; ENZYME INHIBITION; REACTION ANALYSIS; SCREENING; SYNTHESIS;

EID: 0032582003     PISSN: 00027863     EISSN: None     Source Type: Journal    
DOI: 10.1021/ja981812m     Document Type: Article

References (3)

1. Babine, R. E.; Bender, S. L. Chem. Reu. 1997, 97, 1359-1472.
2. Dunn, B. M. In Structure and Function of the Aspartic Proteinases: Genetics, Structures, and Mechanisms; Plenum Press: New York, 1991; Vol. 306, xviii, 585 pp.
3. Takahashi, K. In Aspartic Proteinases: Structure, Function, Biology, and Biomedical Implications; Plenum Press: New York, 1995.