Identification of potent inhibitors of Plasmodium falciparum plasmepsin II from an encoded statine combinatorial library

Bioorganic and Medicinal Chemistry Letters

Volumn 8, Issue 17, 1998, Pages 2315-2320

  Carroll, Carolyn Dilanni ^a   Patel, Hitesh ^a   Johnson, Theodore O ^a   Guo, Tao ^a   Orlowski, Marc ^a   He, Zhen Min ^a   Cavallaro, Cullen L ^a   Guo, Joan ^a   Oksman, Anna ^b   Gluzman, Ilya Y ^b   Connelly, James ^a   Chelsky, Daniel ^a   Goldberg, Daniel E ^b   Dolle, Roland E ^a  

^a PHARMACOPEIA INC   (United States)

^b WASHINGTON UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACID; ASPARTIC PROTEINASE; ASPARTIC PROTEINASE INHIBITOR; CATHEPSIN D; HEMOGLOBIN; HYDROXYL GROUP; PLASMEPSIN II; STATINE; UNCLASSIFIED DRUG;

ARTICLE; DRUG POTENCY; ENZYME INHIBITION; ENZYME SUBSTRATE; MALARIA; METABOLISM; NONHUMAN; PLASMODIUM FALCIPARUM; STEREOCHEMISTRY; STRUCTURE ACTIVITY RELATION;

AMINO ACIDS; ANIMALS; ANTIMALARIALS; ASPARTIC ENDOPEPTIDASES; CLONING, MOLECULAR; DATABASES; DRUG DESIGN; HEMOGLOBINS; HUMANS; MOLECULAR STRUCTURE; OLIGOPEPTIDES; PEPTIDE LIBRARY; PLASMODIUM FALCIPARUM; PROTEASE INHIBITORS; RECOMBINANT PROTEINS; STRUCTURE-ACTIVITY RELATIONSHIP; SUBSTRATE SPECIFICITY;

PLASMODIUM FALCIPARUM;

EID: 0032497354     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(98)00419-3     Document Type: Article

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