General solid-phase method to prepare novel cyclic ketone inhibitors of the cysteine protease cruzain

Bioorganic and Medicinal Chemistry Letters

Volumn 12, Issue 20, 2002, Pages 2993-2996

  Huang, Lily ^a   Ellman, Jonathan A ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CATHEPSIN B; CATHEPSIN L; CRUZIPAIN; CYSTEINE PROTEINASE; PROTEINASE INHIBITOR;

ARTICLE; CHAGAS DISEASE; COMBINATORIAL CHEMISTRY; DRUG ACTIVITY; DRUG POTENCY; DRUG SELECTIVITY; DRUG SYNTHESIS; SOLID; TECHNIQUE;

CATHEPSIN B; CATHEPSINS; CHEMISTRY, PHYSICAL; CYSTEINE ENDOPEPTIDASES; CYSTEINE PROTEINASE INHIBITORS; DRUG DESIGN; HUMANS; KETONES; KINETICS; MOLECULAR CONFORMATION; PROTOZOAN PROTEINS; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0037152496     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(02)00619-4     Document Type: Article

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