-
1
-
-
0022002912
-
Trypanothione: a novel bis(glutathionyl)spermidine co‐factor for glutathione reductase in trypanosomatids
-
1 Fairlamb, A. H., Blackburn, P., Ulrich, P., Chait, B. T. & Cerami, A. (1985) Trypanothione: a novel bis (glutathionyl)spermidine co‐factor for glutathione reductase in trypanosomatids, Science 227, 1485–1487.
-
(1985)
Science
, vol.227
, pp. 1485-1487
-
-
Fairlamb, A.H.1
Blackburn, P.2
Ulrich, P.3
Chait, B.T.4
Cerami, A.5
-
2
-
-
0026793462
-
Metabolism and functions of trypanothione in the Kinetoplastida
-
2 Fairlamb, A. H. & Cerami, A. (1992) Metabolism and functions of trypanothione in the Kinetoplastida, Annu. Rev. Microbiol. 46, 695–729.
-
(1992)
Annu. Rev. Microbiol.
, vol.46
, pp. 695-729
-
-
Fairlamb, A.H.1
Cerami, A.2
-
3
-
-
0025787080
-
Redox enzyme engineering: conversion of human glutathione reductase into a trypanothione reductase
-
3 Bradley, M., Bücheler, U. S. & Walsh, C. T. (1991) Redox enzyme engineering: conversion of human glutathione reductase into a trypanothione reductase, Biochemistry 30, 6124–6127.
-
(1991)
Biochemistry
, vol.30
, pp. 6124-6127
-
-
Bradley, M.1
Bücheler, U.S.2
Walsh, C.T.3
-
4
-
-
0026481561
-
Molecular studies on trypanothione reductase: an antiparasitic target enzyme
-
4 Walsh, C. T., Bradley, M. & Nadeau, K. (1992) Molecular studies on trypanothione reductase: an antiparasitic target enzyme, Curr. Top. Cell. Reg. 33, 409–417.
-
(1992)
Curr. Top. Cell. Reg.
, vol.33
, pp. 409-417
-
-
Walsh, C.T.1
Bradley, M.2
Nadeau, K.3
-
5
-
-
33748233963
-
Disulphide‐reductase inhibitors as chemotherapeutic agents: the design of drugs for trypanosomiasis and malaria
-
5 Schirmer, R. H., Muller, J. G. & Krauth‐Siegel, R. L. (1995) Disulphide‐reductase inhibitors as chemotherapeutic agents: the design of drugs for trypanosomiasis and malaria, Angew. Chem. Int. Ed. Engl. 34, 141–154.
-
(1995)
Angew. Chem. Int. Ed. Engl.
, vol.34
, pp. 141-154
-
-
Schirmer, R.H.1
Muller, J.G.2
Krauth‐Siegel, R.L.3
-
6
-
-
0026649526
-
Rationally designed selective inhibitors of trypanothione reductase
-
6 Benson, T. J., McKie, J. H., Garforth, J., Borges, A., Fairlamb, A. H. & Douglas, K. T. (1992) Rationally designed selective inhibitors of trypanothione reductase, Biochem. J. 286, 9–11.
-
(1992)
Biochem. J.
, vol.286
, pp. 9-11
-
-
Benson, T.J.1
McKie, J.H.2
Garforth, J.3
Borges, A.4
Fairlamb, A.H.5
Douglas, K.T.6
-
7
-
-
0028879059
-
Kukoamine A and other hydrophobic acylpolyamines–potent and selective inhibitors of Crithidia fasciculata trypanothione reductase
-
7 Ponasik, J. A., Strickland, C., Faerman, C., Savvides, S., Karplus, P. A. & Ganem, B. (1995) Kukoamine A and other hydrophobic acylpolyamines–potent and selective inhibitors of Crithidia fasciculata trypanothione reductase, Biochem. J. 311, 371–375.
-
(1995)
Biochem. J.
, vol.311
, pp. 371-375
-
-
Ponasik, J.A.1
Strickland, C.2
Faerman, C.3
Savvides, S.4
Karplus, P.A.5
Ganem, B.6
-
8
-
-
0024521456
-
Trypanothione reductase from Trypanosoma cruzi. Catalytic properties of the enzyme and inhibition studies with trypanocidal compounds
-
8 Jockers‐Scherübl, M. C., Schirmer, R. H. & Krauth‐Siegel, R. L. (1989) Trypanothione reductase from Trypanosoma cruzi. Catalytic properties of the enzyme and inhibition studies with trypanocidal compounds, Eur. J. Biochem. 180, 267–272.
-
(1989)
Eur. J. Biochem.
, vol.180
, pp. 267-272
-
-
Jockers‐Scherübl, M.C.1
Schirmer, R.H.2
Krauth‐Siegel, R.L.3
-
9
-
-
0028263005
-
Mechanism of inhibition of trypanothione reductase and glutathione reductase by trivalent organic arsenicals
-
9 Cunningham, M. L., Zvelebil, M. J. J. M. & Fairlamb, A. H. (1994) Mechanism of inhibition of trypanothione reductase and glutathione reductase by trivalent organic arsenicals, Eur. J. Biochem. 221, 285–295.
-
(1994)
Eur. J. Biochem.
, vol.221
, pp. 285-295
-
-
Cunningham, M.L.1
Zvelebil, M.J.J.M.2
Fairlamb, A.H.3
-
10
-
-
0027195053
-
Synthesis and anti‐trypanosomal evaluation of some thiazole‐containing amino acids and peptides
-
10 Van Bogaert, I., Haemers, A., Bollaert, W., Van Meirvenne, N., Brun, R., Smith, K. & Fairlamb, A. H. (1993) Synthesis and anti‐trypanosomal evaluation of some thiazole‐containing amino acids and peptides, Eur. J. Med. Chem. 28, 387–397.
-
(1993)
Eur. J. Med. Chem.
, vol.28
, pp. 387-397
-
-
Van Bogaert, I.1
Haemers, A.2
Bollaert, W.3
Van Meirvenne, N.4
Brun, R.5
Smith, K.6
Fairlamb, A.H.7
-
11
-
-
0023810590
-
‘Subversive’ substrates for the enzyme trypanothione disulfide reductase: alternative approach to chemotherapy of Chagas disease
-
11 Henderson, G. B., Ulrich, P., Fairlamb, A. H., Rosenberg, I., Pereira, M., Sela, M. & Cerami, A. (1988) ‘Subversive’ substrates for the enzyme trypanothione disulfide reductase: alternative approach to chemotherapy of Chagas disease, Proc. Natl Acad. Sci. USA 85, 5374–5378.
-
(1988)
Proc. Natl Acad. Sci. USA
, vol.85
, pp. 5374-5378
-
-
Henderson, G.B.1
Ulrich, P.2
Fairlamb, A.H.3
Rosenberg, I.4
Pereira, M.5
Sela, M.6
Cerami, A.7
-
12
-
-
0028357962
-
Rational design of peptide‐based inhibitors of trypanothione reductase as potential antitrypanosomal drugs
-
12 Garforth, J., McKie, J. H., Jaouhari, R., Benson, T. J., Fairlamb, A. H. & Douglas, K. T. (1994) Rational design of peptide‐based inhibitors of trypanothione reductase as potential antitrypanosomal drugs, Amino Acids (Vienna) 6, 295–299.
-
(1994)
Amino Acids (Vienna)
, vol.6
, pp. 295-299
-
-
Garforth, J.1
McKie, J.H.2
Jaouhari, R.3
Benson, T.J.4
Fairlamb, A.H.5
Douglas, K.T.6
-
13
-
-
0023051830
-
Purification and characterisation of trypanothione reductase from Crithidia fasciculata, a newly discovered member of the family of disulfide‐containing flavoprotein reductases
-
13 Shames, S. L., Fairlamb, A. H., Cerami, A. & Walsh, C. T. (1986) Purification and characterisation of trypanothione reductase from Crithidia fasciculata, a newly discovered member of the family of disulfide‐containing flavoprotein reductases, Biochemistry 25, 3519–3526.
-
(1986)
Biochemistry
, vol.25
, pp. 3519-3526
-
-
Shames, S.L.1
Fairlamb, A.H.2
Cerami, A.3
Walsh, C.T.4
-
14
-
-
0023808976
-
Trypanothione reductase of Trypanosoma congolense: gene isolation, primary sequence determination, and comparison to glutathione reductase
-
14 Shames, S. L., Kimmel, B. E., Peoples, O. P., Agabain, N. & Walsh, C. T. (1988) Trypanothione reductase of Trypanosoma congolense: gene isolation, primary sequence determination, and comparison to glutathione reductase, Biochemistry 27, 5014–5019.
-
(1988)
Biochemistry
, vol.27
, pp. 5014-5019
-
-
Shames, S.L.1
Kimmel, B.E.2
Peoples, O.P.3
Agabain, N.4
Walsh, C.T.5
-
15
-
-
0026098498
-
Cloning, sequencing, overproduction and purification of trypanothione reductase from Trypanosoma cruzi
-
15 Sullivan, F. X. & Walsh, C. T. (1991) Cloning, sequencing, overproduction and purification of trypanothione reductase from Trypanosoma cruzi, Mol. Biochem. Parasitol. 44, 145–147.
-
(1991)
Mol. Biochem. Parasitol.
, vol.44
, pp. 145-147
-
-
Sullivan, F.X.1
Walsh, C.T.2
-
16
-
-
0026567726
-
Cloning, sequencing, and demonstration of polymorphism in trypanothione reductase from Crithidia fasciculata
-
16 Field, H., Cerami, A. & Henderson, G. (1992) Cloning, sequencing, and demonstration of polymorphism in trypanothione reductase from Crithidia fasciculata, Mol. Biochem. Parasitol. 50, 47–56.
-
(1992)
Mol. Biochem. Parasitol.
, vol.50
, pp. 47-56
-
-
Field, H.1
Cerami, A.2
Henderson, G.3
-
17
-
-
0026591827
-
Molecular characterisation of the trypanothione reductase gene from Crithidia fasciculata and Trypanosoma brucei–comparison with other flavoprotein disulfide oxidoreductases with respect to substrate specificity and catalytic mechanism
-
17 Aboagye‐Kwarteng, T., Smith, K. & Fairlamb, A. H., (1992) Molecular characterisation of the trypanothione reductase gene from Crithidia fasciculata and Trypanosoma brucei–comparison with other flavoprotein disulfide oxidoreductases with respect to substrate specificity and catalytic mechanism, Mol. Microbiol. 6, 3089–3099.
-
(1992)
Mol. Microbiol.
, vol.6
, pp. 3089-3099
-
-
Aboagye‐Kwarteng, T.1
Smith, K.2
Fairlamb, A.H.3
-
18
-
-
0024322270
-
Expression of Trypanosoma congolense trypanothione reductase in Escherichia coli: overproduction, purification and characterisation
-
18 Sullivan, F. X., Shames, S. L. & Walsh, C. T. (1989) Expression of Trypanosoma congolense trypanothione reductase in Escherichia coli: overproduction, purification and characterisation, Biochemistry 28, 4986–4992.
-
(1989)
Biochemistry
, vol.28
, pp. 4986-4992
-
-
Sullivan, F.X.1
Shames, S.L.2
Walsh, C.T.3
-
19
-
-
0027457137
-
Substrate interactions between trypanothione reductase and N1‐glutathionylspermidine at 0.28‐nm resolution
-
19 Bailey, S., Smith, K., Fairlamb, A. H. & Hunter, W. N., (1993) Substrate interactions between trypanothione reductase and N 1 ‐glutathionylspermidine at 0.28‐nm resolution, Eur. J. Biochem. 213, 67–75.
-
(1993)
Eur. J. Biochem.
, vol.213
, pp. 67-75
-
-
Bailey, S.1
Smith, K.2
Fairlamb, A.H.3
Hunter, W.N.4
-
20
-
-
0025608171
-
Initiating a crystallographic study of trypanothione reductase
-
20 Hunter, W. N., Smith, K., Derewenda, Z., Harrop, S. J., Habash, J., Islam, M. S., Helliwell, J. R. & Fairlamb, A. H. (1990) Initiating a crystallographic study of trypanothione reductase, J. Mol. Biol. 216, 235–237.
-
(1990)
J. Mol. Biol.
, vol.216
, pp. 235-237
-
-
Hunter, W.N.1
Smith, K.2
Derewenda, Z.3
Harrop, S.J.4
Habash, J.5
Islam, M.S.6
Helliwell, J.R.7
Fairlamb, A.H.8
-
21
-
-
0026760326
-
Active site of trypanothione reductase–a target for rational drug design
-
21 Hunter, W. N., Bailey, S., Habash, J., Harrop, S. J., Helliwell, J. R., Aboagye‐Kwarteng, T., Smith, K. & Fairlamb, A. H. (1992) Active site of trypanothione reductase–a target for rational drug design, J. Mol. Biol. 227, 322–333.
-
(1992)
J. Mol. Biol.
, vol.227
, pp. 322-333
-
-
Hunter, W.N.1
Bailey, S.2
Habash, J.3
Harrop, S.J.4
Helliwell, J.R.5
Aboagye‐Kwarteng, T.6
Smith, K.7
Fairlamb, A.H.8
-
22
-
-
0025997701
-
X‐Ray structure of trypanothione reductase from Crithidia fasciculata at 2.4 A resolution
-
22 Kuriyan, J., Kong, X. P., Krishna, T. S. R., Sweet, R. M., Murgolo, N. J., Field, H., Cerami, A. & Henderson, G. B. (1991) X‐Ray structure of trypanothione reductase from Crithidia fasciculata at 2.4 A resolution, Proc. Natl Acad. Sci. USA 88, 8764–8768.
-
(1991)
Proc. Natl Acad. Sci. USA
, vol.88
, pp. 8764-8768
-
-
Kuriyan, J.1
Kong, X.P.2
Krishna, T.S.R.3
Sweet, R.M.4
Murgolo, N.J.5
Field, H.6
Cerami, A.7
Henderson, G.B.8
-
23
-
-
0025752362
-
Mutational analysis of parasite trypanothione reductase–aquisition of glutathione reductase activity in a triple mutant
-
23 Sullivan, F. X., Sobolov, S. B., Bradley, M. & Walsh C. T. (1991) Mutational analysis of parasite trypanothione reductase–aquisition of glutathione reductase activity in a triple mutant, Biochemistry 30, 2761–2767.
-
(1991)
Biochemistry
, vol.30
, pp. 2761-2767
-
-
Sullivan, F.X.1
Sobolov, S.B.2
Bradley, M.3
Walsh, C.T.4
-
24
-
-
0026642472
-
Kinetic isotope effect analysis of the reaction catalysed by Trypanosoma congolense trypanothione reductase
-
24 Leichus, B. N., Bradley, M., Nadeau, K., Walsh, C. T. & Blanchard, J. S. (1992) Kinetic isotope effect analysis of the reaction catalysed by Trypanosoma congolense trypanothione reductase, Biochemistry 31, 6414–6420.
-
(1992)
Biochemistry
, vol.31
, pp. 6414-6420
-
-
Leichus, B.N.1
Bradley, M.2
Nadeau, K.3
Walsh, C.T.4
Blanchard, J.S.5
-
25
-
-
0021099182
-
The catalytic mechanism of glutathione reductase as derived from X‐ray diffraction analyses of reaction intermediates
-
25 Pai, E. F. & Schultz, G. E. (1983) The catalytic mechanism of glutathione reductase as derived from X‐ray diffraction analyses of reaction intermediates, J. Biol. Chem. 258, 1752–1757.
-
(1983)
J. Biol. Chem.
, vol.258
, pp. 1752-1757
-
-
Pai, E.F.1
Schultz, G.E.2
-
26
-
-
0024959343
-
A crystallographic study of the glutathione binding site of glutathione reductase at 0.3‐nm resolution
-
26 Karplus, P. A., Pai, E. F. & Schulz, G. E. (1989) A crystallographic study of the glutathione binding site of glutathione reductase at 0.3‐nm resolution, Eur. J. Biochem. 178, 693–703.
-
(1989)
Eur. J. Biochem.
, vol.178
, pp. 693-703
-
-
Karplus, P.A.1
Pai, E.F.2
Schulz, G.E.3
-
27
-
-
0026724643
-
Generating compatible translation initiation regions for heterologous gene expression in Escherichia coli by exhaustive Perishine‐Dalgarno mutagenesis–human glutathione reductase CDNA as a model
-
27 Bücheler, U. S., Werner, D. & Schirmer, R. H. (1992) Generating compatible translation initiation regions for heterologous gene expression in Escherichia coli by exhaustive Perishine‐Dalgarno mutagenesis–human glutathione reductase CDNA as a model, Nucleic Acids Res. 20, 3127–3133.
-
(1992)
Nucleic Acids Res.
, vol.20
, pp. 3127-3133
-
-
Bücheler, U.S.1
Werner, D.2
Schirmer, R.H.3
-
28
-
-
0028270181
-
Use of transferred nuclear‐overhauser‐effect spectroscopy to measure the bound conformation of a disulfide‐replaced analogue of glutathione disulfide as an inhibitor of yeast glutathione reductase
-
28 Embrey, K. J., Mehta, A. Carrington, S. J., Jaouhari, R., McKie, J. H. & Douglas, K. T. (1994) Use of transferred nuclear‐overhauser‐effect spectroscopy to measure the bound conformation of a disulfide‐replaced analogue of glutathione disulfide as an inhibitor of yeast glutathione reductase, Eur. J. Biochem. 221, 793–799.
-
(1994)
Eur. J. Biochem.
, vol.221
, pp. 793-799
-
-
Embrey, K.J.1
Mehta, A.2
Carrington, S.J.3
Jaouhari, R.4
McKie, J.H.5
Douglas, K.T.6
-
29
-
-
0023278434
-
Substrate specificity of the flavoprotein trypanothione disulfide reductase from Crithidia fasciculata
-
29 Henderson, G. B., Fairlamb, A. H., Ulrich, P. & Cerami, A. (1987) Substrate specificity of the flavoprotein trypanothione disulfide reductase from Crithidia fasciculata, Biochemistry 26, 3023–3027.
-
(1987)
Biochemistry
, vol.26
, pp. 3023-3027
-
-
Henderson, G.B.1
Fairlamb, A.H.2
Ulrich, P.3
Cerami, A.4
-
30
-
-
0026000158
-
Synthesis of N‐benzyloxycarbonyl‐l‐cysteinylglycine 3‐dimethylaminopropylamide disulfide: a cheap and convenient new assay for trypanothione reductase
-
30 El‐Waer, A., Douglas, K. T., Smith, K. & Fairlamb, A. H. (1991) Synthesis of N‐benzyloxycarbonyl‐l‐cysteinylglycine 3‐dimethylaminopropylamide disulfide: a cheap and convenient new assay for trypanothione reductase, Anal. Biochem. 198, 212–216.
-
(1991)
Anal. Biochem.
, vol.198
, pp. 212-216
-
-
El‐Waer, A.1
Douglas, K.T.2
Smith, K.3
Fairlamb, A.H.4
-
31
-
-
0027472014
-
Synthesis of substrate analogues for trypanothione reductase
-
31 El‐Waer, A., Benson, T. & Douglas, K. T. (1993) Synthesis of substrate analogues for trypanothione reductase, Int. J. Peptide Protein Res. 41, 141–346.
-
(1993)
Int. J. Peptide Protein Res.
, vol.41
, pp. 141-346
-
-
El‐Waer, A.1
Benson, T.2
Douglas, K.T.3
-
32
-
-
0027432023
-
The glutamyl binding site of trypanothione reductase from Crithidia fasciculata: enzyme kinetic properties of γ‐glutamyl‐modified substrate analogues
-
32 El‐Waer, K. T., Smith, K., McKie, J. H., Benson, T., Fairlamb, A. H. & Douglas, K. T. (1993) The glutamyl binding site of trypanothione reductase from Crithidia fasciculata: enzyme kinetic properties of γ‐glutamyl‐modified substrate analogues, Biochim. Biophys. Acta 1203, 93–98.
-
(1993)
Biochim. Biophys. Acta
, vol.1203
, pp. 93-98
-
-
El‐Waer, K.T.1
Smith, K.2
McKie, J.H.3
Benson, T.4
Fairlamb, A.H.5
Douglas, K.T.6
-
33
-
-
0029920453
-
Solid phase polyamine linkers‐their utility in synthesis and the preparation of directed libraries against trypanothione reductase
-
33 Marsh, I., Smith, H. K. & Bradley, M. (1996) Solid phase polyamine linkers‐their utility in synthesis and the preparation of directed libraries against trypanothione reductase, J. Chem. Soc. Chem. Commun., 941–942.
-
(1996)
J. Chem. Soc. Chem. Commun.
, pp. 941-942
-
-
Marsh, I.1
Smith, H.K.2
Bradley, M.3
-
34
-
-
0003423124
-
Solid phase peptide synthesis–a practical approach
-
34 Atherton, E. & Sheppard, R. C. (1989) Solid phase peptide synthesis–a practical approach, IRL Press, Oxford.
-
(1989)
-
-
Atherton, E.1
Sheppard, R.C.2
-
35
-
-
37049117277
-
Trifluoromethanesulfonic acid as a deprotecting reagent in peptide chemistry
-
35 Yajima, H., Fujii, N., Ogawa, H. & Kawatani, H. (1974) Trifluoromethanesulfonic acid as a deprotecting reagent in peptide chemistry, J. Chem. Soc. Chem. Commun., 107–108.
-
(1974)
J. Chem. Soc. Chem. Commun.
, pp. 107-108
-
-
Yajima, H.1
Fujii, N.2
Ogawa, H.3
Kawatani, H.4
-
36
-
-
0027953858
-
Facile detosylation of cyclic peptides. An effective synthesis of platelet glycoprotein IIb/IIIa inhibitors
-
36 Zhang, L.‐H. & Ma, P. (1994) Facile detosylation of cyclic peptides. An effective synthesis of platelet glycoprotein IIb/IIIa inhibitors, Tetrahedron Lett. 35, 5765–5768.
-
(1994)
Tetrahedron Lett.
, vol.35
, pp. 5765-5768
-
-
Zhang, L.‐H.1
Ma, P.2
-
37
-
-
37049075358
-
Synthesis and NMR characterisation of the trypanosomatid metabolite, N1, N8‐bis(glutathionyl)spermidine disulphide (trypanothione disulphide)
-
37 Henderson, G. B., Glushka, J., Cowburn, D. & Cerami, A. (1990) Synthesis and NMR characterisation of the trypanosomatid metabolite, N 1, N 8 ‐ bis (glutathionyl)spermidine disulphide (trypanothione disulphide), J. Chem. Soc. Perkin Trans. 1, 911–914.
-
(1990)
J. Chem. Soc. Perkin Trans.
, vol.1
, pp. 911-914
-
-
Henderson, G.B.1
Glushka, J.2
Cowburn, D.3
Cerami, A.4
-
38
-
-
0028670451
-
Identification and biosynthesis of N1,N9‐bis (glutathionyl)aminopropyl‐cadaverine (homotrypanothione) in Trypanosoma cruzi
-
38 Hunter, K. J., Le Quesne, S. A. & Fairlamb, A. H. (1994) Identification and biosynthesis of N 1, N 9 ‐ bis (glutathionyl)aminopropyl‐cadaverine (homotrypanothione) in Trypanosoma cruzi, Eur. J. Biochem. 226, 1019–1027.
-
(1994)
Eur. J. Biochem.
, vol.226
, pp. 1019-1027
-
-
Hunter, K.J.1
Le Quesne, S.A.2
Fairlamb, A.H.3
|