CSF cytokine and chemokine profiles in acute disseminated encephalomyelitis

Journal of Neuroimmunology

Volumn 175, Issue 1-2, 2006, Pages 52-58

  Ishizu, Takaaki ^a   Minohara, Motozumi ^a   Ichiyama, Takashi ^b   Kira, Ryutaro ^c   Tanaka, Masahito ^a   Osoegawa, Manabu ^a   Hara, Toshiro ^c   Furukawa, Susumu ^b   Kira, Jun ichi ^a  

^a KYUSHU UNIVERSITY   (Japan)

^b YAMAGUCHI UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^c KYUSHU UNIVERSITY   (Japan)

Author keywords

Acute disseminated encephalomyelitis; Cerebrospinal fluid; Chemokine; Cytokine

Indexed keywords

CHEMOKINE; CYTOKINE; GAMMA INTERFERON; GRANULOCYTE COLONY STIMULATING FACTOR RECEPTOR; INTERLEUKIN 10; INTERLEUKIN 1BETA; INTERLEUKIN 2; INTERLEUKIN 4; INTERLEUKIN 5; INTERLEUKIN 6; MACROPHAGE INFLAMMATORY PROTEIN 1BETA;

ARTICLE; CD4 LYMPHOCYTE COUNT; CELL COUNT; CEREBROSPINAL FLUID; CHILD; CLINICAL ARTICLE; CONTROLLED STUDY; ENCEPHALOMYELITIS; FEMALE; FLUORESCENCE; HUMAN; IMMUNOASSAY; INFLAMMATION; MACROPHAGE; MALE; MEMORY T LYMPHOCYTE; MICROGLIA; PRIORITY JOURNAL; TH1 CELL; TH2 CELL; UPREGULATION;

CHEMOKINES; CHILD; CHILD, PRESCHOOL; CYTOKINES; DEMYELINATING AUTOIMMUNE DISEASES, CNS; ENCEPHALOMYELITIS, ACUTE DISSEMINATED; FEMALE; HUMANS; INFANT; MALE;

EID: 33646760288     PISSN: 01655728     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jneuroim.2006.03.020     Document Type: Article

References (16)

1. Cua D.J., Sherlock J., Chen Y., Murphy C.A., Joyce B., Seymour B., Lucian L., To W., Kwan S., Churakova T., Zurawski S., Wiekowski M., Lira S.A., Gorman D., Kastelein R.A., and Sedgwick J.D. Interleukin-23 rather than interleukin-12 is the critical cytokine for autoimmune inflammation of the brain. Nature 421 (2003) 744-748
2. Dale R.C. Acute disseminated encephalomyelitis. Semin. Pediatr. Infect. Dis. 14 (2003) 90-95
3. Dale R.C., and Morovat A. Interleukin-6 and oligoclonal IgG synthesis in children with acute disseminated encephalomyelitis. Neuropediatrics 34 (2003) 141-145
4. Dale R.C., de Sousa C., Chong W.K., Cox T.C., Harding B., and Neville B.G. Acute disseminated encephalomyelitis, multiphasic disseminated encephalomyelitis and multiple sclerosis in children. Brain 123 Pt. 12 (2000) 2407-2422
5. Dale R.C., Church A.J., Cardoso F., Goddard E., Cox T.C., Chong W.K., Williams A., Klein N.J., Neville B.G., Thompson E.J., and Giovannoni G. Poststreptococcal acute disseminated encephalomyelitis with basal ganglia involvement and auto-reactive antibasal ganglia antibodies. Ann. Neurol. 50 (2001) 588-595
6. Garg R.K. Acute disseminated encephalomyelitis. Postgrad. Med. J. 79 (2003) 11-17
7. Ichiyama T., Shoji H., Kato M., Sawaishi Y., Ozawa H., Matsubara T., and Furukawa S. Cerebrospinal fluid levels of cytokines and soluble tumour necrosis factor receptor in acute disseminated encephalomyelitis. Eur. J. Pediatr. 161 (2002) 133-137
8. Ishizu T., Osoegawa M., Mei F.J., Kikuchi H., Tanaka M., Takakura Y., Minohara M., Murai H., Mihara F., Taniwaki T., and Kira J. Intrathecal activation of the IL-17/IL-8 axis in opticospinal multiple sclerosis. Brain 128 (2005) 988-1002
9. Jorens P.G., VanderBorght A., Ceulemans B., Van Bever H.P., Bossaert L.L., Ieven M., Goossens H., Parizel P.M., Van Dijk H., Raus J., and Stinissen P. Encephalomyelitis-associated antimyelin autoreactivity induced by streptococcal exotoxins. Neurology 54 (2000) 1433-1441
10. Kolls J.K., and Linden A. Interleukin-17 family members and inflammation. Immunity 21 (2004) 467-476
11. 2) cells cause experimental autoimmune encephalomyelitis in immunodeficient hosts rather than protect them from the disease. J. Exp. Med. 186 (1997) 307-312
12. Langrish C.L., Chen Y., Blumenschein W.M., Mattson J., Basham B., Sedgwick J.D., McClanahan T., Kastelein R.A., and Cua D.J. IL-23 drives a pathogenic T cell population that induces autoimmune inflammation. J. Exp. Med. 201 (2005) 233-240
13. Langrish C.L., McKenzie B.S., Wilson N.J., de Waal Malefyt R., Kastelein R.A., and Cua D.J. IL-12 and IL-23: master regulators of innate and adaptive immunity. Immunol. Rev. 202 (2004) 96-105
14. 2 shift in vasculitic neuropathy in CSF. J. Neurol. Sci. 228 (2005) 75-85
15. Shtrichman R., and Samuel C.E. The role of gamma interferon in antimicrobial immunity. Curr. Opin. Microbiol. 4 (2001) 251-259
16. Zavala F., Abad S., Ezine S., Taupin V., Masson A., and Bach J.F. G-CSF therapy of ongoing experimental allergic encephalomyelitis via chemokine- and cytokine-based immune deviation. J. Immunol. 168 (2002) 2011-2019