메뉴 건너뛰기




Volumn 15, Issue 4, 2003, Pages 380-386

Tumor necrosis factor biology in experimental and clinical arthritis

Author keywords

[No Author keywords available]

Indexed keywords

INFLIXIMAB; RECEPTOR BLOCKING AGENT; TUMOR NECROSIS FACTOR; TUMOR NECROSIS FACTOR ANTAGONIST; UNCLASSIFIED DRUG;

EID: 0038772008     PISSN: 10408711     EISSN: None     Source Type: Journal    
DOI: 10.1097/00002281-200307000-00003     Document Type: Review
Times cited : (63)

References (88)
  • 1
    • 0034735827 scopus 로고    scopus 로고
    • A comparison of etanercept and methotrexate in patients with early rheumatoid arthritis
    • Bathon JM, Martin RW, Fleischmann RM, et al.: A comparison of etanercept and methotrexate in patients with early rheumatoid arthritis. N Engl J Med 2000, 343:1586-1593.
    • (2000) N Engl J Med , vol.343 , pp. 1586-1593
    • Bathon, J.M.1    Martin, R.W.2    Fleischmann, R.M.3
  • 2
    • 0034735842 scopus 로고    scopus 로고
    • Infliximab and methotrexate in the treatment of rheumatoid arthritis
    • Anti-Tumor Necrosis Factor Trial in Rheumatoid Arthritis with Concomitant Therapy Study Group
    • Lipsky PE, vander Heijde DM, St Clair EW, et al.: Infliximab and methotrexate in the treatment of rheumatoid arthritis. Anti-Tumor Necrosis Factor Trial in Rheumatoid Arthritis with Concomitant Therapy Study Group. N Engl J Med 2000, 343:1594-1602.
    • (2000) N Engl J Med , vol.343 , pp. 1594-1602
    • Lipsky, P.E.1    Vander Heijde, D.M.2    St Clair, E.W.3
  • 3
    • 0037231533 scopus 로고    scopus 로고
    • Adalimumab, a fully human antitumor necrosis factor alpha monoclonal antibody, for the treatment of rheumatoid arthritis in patients taking concomitant methotrexate: The ARMADA trial
    • Weinblatt ME, Keystone EC, Furst DE, et al.: Adalimumab, a fully human antitumor necrosis factor alpha monoclonal antibody, for the treatment of rheumatoid arthritis in patients taking concomitant methotrexate: the ARMADA trial. Arthritis Rheum 2003, 48:35-45.
    • (2003) Arthritis Rheum , vol.48 , pp. 35-45
    • Weinblatt, M.E.1    Keystone, E.C.2    Furst, D.E.3
  • 4
    • 0036188187 scopus 로고    scopus 로고
    • Randomized double-blind comparison of chimeric monoclonal antibody to tumor necrosis factor a (infliximab) versus placebo in active spondyloarthropathy
    • Van den Bosch F, Kruithof E, Baeten D, et al.: Randomized double-blind comparison of chimeric monoclonal antibody to tumor necrosis factor a (infliximab) versus placebo in active spondyloarthropathy. Arthritis Rheum 2002, 46:755-765.
    • (2002) Arthritis Rheum , vol.46 , pp. 755-765
    • Van Den Bosch, F.1    Kruithof, E.2    Baeten, D.3
  • 5
    • 0037007683 scopus 로고    scopus 로고
    • Treatment of ankylosing spondylitis by inhibition of tumor necrosis factor alpha
    • Gorman JD, Sack KE, Davis JC Jr: Treatment of ankylosing spondylitis by inhibition of tumor necrosis factor alpha. N Engl J Med 2002, 346:1349-1356.
    • (2002) N Engl J Med , vol.346 , pp. 1349-1356
    • Gorman, J.D.1    Sack, K.E.2    Davis J.C., Jr.3
  • 6
    • 0037029430 scopus 로고    scopus 로고
    • Treatment of active ankylosing spondylitis with infliximab: A randomized controlled multicenter trial
    • Braun J, Brandt J, Listing J, et al.: Treatment of active ankylosing spondylitis with infliximab: a randomized controlled multicenter trial. Lancet 2002, 359:1187-1193.
    • (2002) Lancet , vol.359 , pp. 1187-1193
    • Braun, J.1    Brandt, J.2    Listing, J.3
  • 7
    • 0034729950 scopus 로고    scopus 로고
    • Etanercept in the treatment of psoriatic arthritis and psoriasis: A randomized trial
    • Mease PJ, Goffe BS, Metz J, et al.: Etanercept in the treatment of psoriatic arthritis and psoriasis: a randomized trial. Lancet 2000, 356:385-390.
    • (2000) Lancet , vol.356 , pp. 385-390
    • Mease, P.J.1    Goffe, B.S.2    Metz, J.3
  • 8
    • 0037109268 scopus 로고    scopus 로고
    • Open-label study of infliximab treatment for psoriatic arthritis: Clinical and magnetic resonance imaging measurements of reduction of inflammation
    • Antoni C, Dechant C, Hanns-Martin Lorenz PD, et al.: Open-label study of infliximab treatment for psoriatic arthritis: clinical and magnetic resonance imaging measurements of reduction of inflammation. Arthritis Rheum 2002, 47:506-512.
    • (2002) Arthritis Rheum , vol.47 , pp. 506-512
    • Antoni, C.1    Dechant, C.2    Hanns-Martin Lorenz, P.D.3
  • 9
    • 0036796830 scopus 로고    scopus 로고
    • Efficacy of the anti-TNF-a antibody infliximab against refractory systemic vasculitides: An open pilot study on 10 patients
    • Bartolucci P, Ramanoelina J, Cohen P, et al.: Efficacy of the anti-TNF-a antibody infliximab against refractory systemic vasculitides: an open pilot study on 10 patients. Rheumatology 2002, 41:1126-1132.
    • (2002) Rheumatology , vol.41 , pp. 1126-1132
    • Bartolucci, P.1    Ramanoelina, J.2    Cohen, P.3
  • 10
    • 0035963872 scopus 로고    scopus 로고
    • Effect of infliximab in sight-threatening panuveitis in Behcet's disease
    • Sfikakis PP, Theodossiades PG, Katsiari CG, et al.: Effect of infliximab in sight-threatening panuveitis in Behcet's disease. Lancet 2001, 358:295-296.
    • (2001) Lancet , vol.358 , pp. 295-296
    • Sfikakis, P.P.1    Theodossiades, P.G.2    Katsiari, C.G.3
  • 11
    • 0036838908 scopus 로고    scopus 로고
    • Behcet's disease: A new target for anti-tumor necrosis factor treatment
    • Sfikakis PP: Behcet's disease: a new target for anti-tumor necrosis factor treatment. Ann Rheum Dis 2002, 61 (suppl 2):ii51-ii53.
    • (2002) Ann Rheum Dis , vol.61 , Issue.SUPPL. 2
    • Sfikakis, P.P.1
  • 12
    • 0036838681 scopus 로고    scopus 로고
    • Updated consensus statement on biological agents for the treatment of rheumatoid arthritis and other rheumatic diseases
    • Furst DE, Breedveld FC, Kalden JR et al.: Updated consensus statement on biological agents for the treatment of rheumatoid arthritis and other rheumatic diseases. Ann Rheum Dis 2002, 61 (suppl II):ii2-ii7.
    • (2002) Ann Rheum Dis , vol.61 , Issue.SUPPL. II
    • Furst, D.E.1    Breedveld, F.C.2    Kalden, J.R.3
  • 14
    • 0026039673 scopus 로고
    • Transgenic mice expressing human tumour necrosis factor: A predictive genetic model of arthritis
    • Keffer J, Probert L, Cazlaris H, et al.: Transgenic mice expressing human tumour necrosis factor: a predictive genetic model of arthritis. EMBO J 1991; 10:4025-4031.
    • (1991) EMBO J , vol.10 , pp. 4025-4031
    • Keffer, J.1    Probert, L.2    Cazlaris, H.3
  • 15
    • 0032969285 scopus 로고    scopus 로고
    • Tumor necrosis factor receptor and fas signaling mechanisms
    • Wallach D, Varfolomeev EE, Malinin NL, et al.: Tumor necrosis factor receptor and fas signaling mechanisms. Annu Rev Immunol 1999, 17:331-367.
    • (1999) Annu Rev Immunol , vol.17 , pp. 331-367
    • Wallach, D.1    Varfolomeev, E.E.2    Malinin, N.L.3
  • 16
    • 0032813516 scopus 로고    scopus 로고
    • On the role of tumor necrosis factor and receptors in models of multiorgan failure, rheumatoid arthritis, multiple sclerosis and inflammatory bowel disease
    • Kollias G, Douni E, Kassiotis G, et al.: On the role of tumor necrosis factor and receptors in models of multiorgan failure, rheumatoid arthritis, multiple sclerosis and inflammatory bowel disease. Immunol Rev 1999, 169:175-194.
    • (1999) Immunol Rev , vol.169 , pp. 175-194
    • Kollias, G.1    Douni, E.2    Kassiotis, G.3
  • 17
    • 0004185166 scopus 로고    scopus 로고
    • TNF and TNFR biology in health and disease
    • McDermott MF; TNF and TNFR biology in health and disease. Cell Mol Biol (Noisy-le-Grand) 2001, 47:619-635. A comprehensive review of the molecular mechanics of TNF and its receptors at the physiological state and their deregulation in disease, including chronic inflammatory arthritis.
    • (2001) Cell Mol Biol (Noisy-le-Grand) , vol.47 , pp. 619-635
    • McDermott, M.F.1
  • 18
    • 0036356811 scopus 로고    scopus 로고
    • The role of TNF/TNFR in organ-specific and systemic autoimmunity: Implications for the design of optimized "anti-TNF" therapies
    • Kollias G, Kontoyiannis D, Douni E, et al.: The role of TNF/TNFR in organ-specific and systemic autoimmunity: implications for the design of optimized "anti-TNF" therapies. Curr Dir Autoimmun 2002, 5:30-50. A thorough discussion of experimental data on the dual role of TNF in the pathogenesis and progression of organ-specific and systemic autoimmunity. The heterogeneity of receptor usage by TNF in autoimmune suppression versus inflammatory tissue damage may provide clues for alternative anti-TNF therapeutic strategies.
    • (2002) Curr Dir Autoimmun , vol.5 , pp. 30-50
    • Kollias, G.1    Kontoyiannis, D.2    Douni, E.3
  • 19
    • 0037008847 scopus 로고    scopus 로고
    • Regulation on TNF-alpha-mediated hyperplasia through TNF receptors, TRAFs, and NF-kappa B in synoviocytes obtained from patients with rheumatoid arthritis
    • Youn J, Kim HY: Park JH, et al.: Regulation on TNF-alpha-mediated hyperplasia through TNF receptors, TRAFs, and NF-kappa B in synoviocytes obtained from patients with rheumatoid arthritis. Immunol Lett 2002, 83:85-93.
    • (2002) Immunol Lett , vol.83 , pp. 85-93
    • Youn, J.1    Kim, H.Y.2    Park, J.H.3
  • 20
    • 0036164274 scopus 로고    scopus 로고
    • Evidence that rheumatoid arthritis synovial T cells are similar to cytokine-activated T cells: Involvement of phosphatidylinositol 3-kinase and nuclear factor kappaB pathways in tumor necrosis factor alpha production in rheumatoid arthritis
    • Brennan FM, Hayes AL, Ciesielski CJ, et al.: Evidence that rheumatoid arthritis synovial T cells are similar to cytokine-activated T cells: involvement of phosphatidylinositol 3-kinase and nuclear factor kappaB pathways in tumor necrosis factor alpha production in rheumatoid arthritis. Arthritis Rheum 2002, 46:31-41. This elegant study suggests that TNF production in chronic inflammatory rheumatoid tissues is a T cell-dependent process regulated differently from physiologic antigen-dependent TNF production.
    • (2002) Arthritis Rheum , vol.46 , pp. 31-41
    • Brennan, F.M.1    Hayes, A.L.2    Ciesielski, C.J.3
  • 21
    • 0037087298 scopus 로고    scopus 로고
    • Activation of nuclear orphan receptor NURR1 transcription by NF-kappa B and cyclic adenosine 5′-monophosphate response element-binding protein in rheumatoid arthritis synovial tissue
    • McEvoy AN, Murphy EA, Ponnio T, et al.: Activation of nuclear orphan receptor NURR1 transcription by NF-kappa B and cyclic adenosine 5′-monophosphate response element-binding protein in rheumatoid arthritis synovial tissue. J Immunol 2002, 168:2979-2987.
    • (2002) J Immunol , vol.168 , pp. 2979-2987
    • McEvoy, A.N.1    Murphy, E.A.2    Ponnio, T.3
  • 22
    • 18344387341 scopus 로고    scopus 로고
    • cDNA macroarray analysis of gene expression in synoviocytes stimulated with TNF alpha
    • Sugiyama T, Ishii S, Yamamoto J, et al.: cDNA macroarray analysis of gene expression in synoviocytes stimulated with TNF alpha. FEBS Lett 2002, 517:121-128.
    • (2002) FEBS Lett , vol.517 , pp. 121-128
    • Sugiyama, T.1    Ishii, S.2    Yamamoto, J.3
  • 23
    • 0035056003 scopus 로고    scopus 로고
    • Anti-TNF a therapy of rheumatoid arthritis: What have we learned?
    • Feldmann M, Maini RN: Anti-TNF a therapy of rheumatoid arthritis: what have we learned? Annu Rev Immunol 2001, 19:163-196. A comprehensive review of experimental and clinical studies which have implied that TNF is the key cytokine in the pathogenesis of RA.
    • (2001) Annu Rev Immunol , vol.19 , pp. 163-196
    • Feldmann, M.1    Maini, R.N.2
  • 24
    • 0036160784 scopus 로고    scopus 로고
    • Constitutive expression of angiopoietin-1 and -2 and modulation of their expression by inflammatory cytokines in rheumatoid arthritis synovial fibroblasts
    • Scott BB, Zaratin PF, Colombo A, et al.: Constitutive expression of angiopoietin-1 and -2 and modulation of their expression by inflammatory cytokines in rheumatoid arthritis synovial fibroblasts. J Rheumatol 2002, 29:230-239.
    • (2002) J Rheumatol , vol.29 , pp. 230-239
    • Scott, B.B.1    Zaratin, P.F.2    Colombo, A.3
  • 25
    • 0035317378 scopus 로고    scopus 로고
    • Tumor necrosis factor 5′ promoter single nucleotide polymorphisms influence susceptibility to rheumatoid arthritis (RA) in immunogenetically defined multiplex RA families
    • Waldron-Lynch F, Adams C, Amos C, et al.: Tumor necrosis factor 5′ promoter single nucleotide polymorphisms influence susceptibility to rheumatoid arthritis (RA) in immunogenetically defined multiplex RA families. Genes Immun 2001, 2:82-87.
    • (2001) Genes Immun , vol.2 , pp. 82-87
    • Waldron-Lynch, F.1    Adams, C.2    Amos, C.3
  • 26
    • 0036676852 scopus 로고    scopus 로고
    • Single-nucleotide polymorphism in tumor necrosis factor receptor genes: Definition of novel haplotypes and racial/ethnic differences
    • Bridges SL Jr, Jenq G, Moran M, et al.: Single-nucleotide polymorphism in tumor necrosis factor receptor genes: definition of novel haplotypes and racial/ethnic differences. Arthritis Rheum 2002, 46:2045-2050.
    • (2002) Arthritis Rheum , vol.46 , pp. 2045-2050
    • Bridges S.L., Jr.1    Jenq, G.2    Moran, M.3
  • 27
    • 0036158534 scopus 로고    scopus 로고
    • Susceptibility for and clinical manifestations of rheumatoid arthritis are associated with polymorphisms of the TNF-aipha, II-1beta and IL-1Ra genes
    • Cvetkovic JT, Wallberg-Jonsson S, Stegmayr B, et al.: Susceptibility for and clinical manifestations of rheumatoid arthritis are associated with polymorphisms of the TNF-aipha, II-1beta and IL-1Ra genes. J Rheumatol 2002, 29:212-219.
    • (2002) J Rheumatol , vol.29 , pp. 212-219
    • Cvetkovic, J.T.1    Wallberg-Jonsson, S.2    Stegmayr, B.3
  • 28
    • 0036733749 scopus 로고    scopus 로고
    • Tumor necrosis factor-alpha receptor II polymorphism in patients from southern Europe with mild-moderate and severe rheumatoid arthritis
    • Fabris M, Tolusso B, Di Poi E, et al.: Tumor necrosis factor-alpha receptor II polymorphism in patients from southern Europe with mild-moderate and severe rheumatoid arthritis. J Rheumatol 2002, 29:1847-1850.
    • (2002) J Rheumatol , vol.29 , pp. 1847-1850
    • Fabris, M.1    Tolusso, B.2    Di Poi, E.3
  • 29
    • 0036138727 scopus 로고    scopus 로고
    • Tumor necrosis factor-alpha gene polymorphism in severe and mild-moderate rheumatoid arthritis
    • Fabris M, Di PE, D'Elia A, et al.: Tumor necrosis factor-alpha gene polymorphism in severe and mild-moderate rheumatoid arthritis. J Rheumatol 2002, 29:29-33.
    • (2002) J Rheumatol , vol.29 , pp. 29-33
    • Fabris, M.1    Di, P.E.2    D'Elia, A.3
  • 30
    • 0036844290 scopus 로고    scopus 로고
    • Nodular disease in rheumatoid arthritis: Association with cigarette smoking and HLA-DRB1/TNF gene interaction
    • Mattey DL, Dawes PT, Fisher J, et al.: Nodular disease in rheumatoid arthritis: association with cigarette smoking and HLA-DRB1/TNF gene interaction. J Rheumatol 2002, 29:2313-2318.
    • (2002) J Rheumatol , vol.29 , pp. 2313-2318
    • Mattey, D.L.1    Dawes, P.T.2    Fisher, J.3
  • 31
    • 0036100840 scopus 로고    scopus 로고
    • Tumour necrosis factor receptor II polymorphism and juvenile idiopathic arthritis
    • The British Paediatric Rheumatology Study Group
    • Zeggini E, Thomson W, Alansari A, et al.: The British Paediatric Rheumatology Study Group. Tumour necrosis factor receptor II polymorphism and juvenile idiopathic arthritis. Rheumatology 2002, 41:462-465.
    • (2002) Rheumatology , vol.41 , pp. 462-465
    • Zeggini, E.1    Thomson, W.2    Alansari, A.3
  • 32
    • 0036101612 scopus 로고    scopus 로고
    • Tumour necrosis factor alpha G→a -238 and G→A -308 polymorphisms in juvenile idiopathic arthritis
    • Ozen S, Alikasifoglu M, Bakkaloglu A, et al.: Tumour necrosis factor alpha G→a -238 and G→A -308 polymorphisms in juvenile idiopathic arthritis. Rheumatology 2002, 41:223-227.
    • (2002) Rheumatology , vol.41 , pp. 223-227
    • Ozen, S.1    Alikasifoglu, M.2    Bakkaloglu, A.3
  • 33
    • 0036759013 scopus 로고    scopus 로고
    • Lack of association of TNF-238A and -308A in Japanese patients with psoriasis vulgaris, psoriatic arthritis and generalized pustular psoriasis
    • Nishibu A, Oyama N, Nakamura K, et al.: Lack of association of TNF-238A and -308A in Japanese patients with psoriasis vulgaris, psoriatic arthritis and generalized pustular psoriasis. J Dermatol Sci 2002, 29:181-184.
    • (2002) J Dermatol Sci , vol.29 , pp. 181-184
    • Nishibu, A.1    Oyama, N.2    Nakamura, K.3
  • 34
    • 0036181398 scopus 로고    scopus 로고
    • Differential association of polymorphisms in the TNFalpha region with psoriatic arthritis but not psoriasis
    • Hohler T, Grossmann S, Stradmann-Bellinghausen B, et al.: Differential association of polymorphisms in the TNFalpha region with psoriatic arthritis but not psoriasis. Ann Rheum Dis 2002, 61:213-218.
    • (2002) Ann Rheum Dis , vol.61 , pp. 213-218
    • Hohler, T.1    Grossmann, S.2    Stradmann-Bellinghausen, B.3
  • 35
    • 0036260511 scopus 로고    scopus 로고
    • Tumour necrosis factor-alpha polymorphism and the HLA-Cw*0602 allele in psoriatic arthritis
    • Al-Heresh AM, Proctor J, Jones SM, et al.: Tumour necrosis factor-alpha polymorphism and the HLA-Cw*0602 allele in psoriatic arthritis. Rheumatology (Oxf) 2002, 41:525-530.
    • (2002) Rheumatology (Oxf) , vol.41 , pp. 525-530
    • Al-Heresh, A.M.1    Proctor, J.2    Jones, S.M.3
  • 36
    • 0034853490 scopus 로고    scopus 로고
    • Cytokine gene polymorphisms relevant for the spondyloarthropathies
    • Rudwaleit M, Hohler T: Cytokine gene polymorphisms relevant for the spondyloarthropathies. Curr Opin Rheumatol 2001, 13:250-254.
    • (2001) Curr Opin Rheumatol , vol.13 , pp. 250-254
    • Rudwaleit, M.1    Hohler, T.2
  • 37
    • 0037007696 scopus 로고    scopus 로고
    • Anti-TNF-a therapy for ankylosing spondylitis: A specific or non-specific treatment?
    • Dayer JM, Krane SM: Anti-TNF-a therapy for ankylosing spondylitis: a specific or non-specific treatment? N Engl J Med 2002, 346:1399-1400.
    • (2002) N Engl J Med , vol.346 , pp. 1399-1400
    • Dayer, J.M.1    Krane, S.M.2
  • 38
    • 0035150659 scopus 로고    scopus 로고
    • Immunomodulatory effects of anti-TNF alpha therapy on synovium in spondyloarthropathy: Histologic findings in eight patients from an open-label pilot study
    • Baeten D, Kruithof E, Van den Bosch F, et al.: Immunomodulatory effects of anti-TNF alpha therapy on synovium in spondyloarthropathy: histologic findings in eight patients from an open-label pilot study. Arthritis Rheum 2001, 44:186-195.
    • (2001) Arthritis Rheum , vol.44 , pp. 186-195
    • Baeten, D.1    Kruithof, E.2    Van Den Bosch, F.3
  • 39
    • 0028990467 scopus 로고
    • Monoclonal anti-TNF alpha antibody as a probe of pathogenesis and therapy of rheumatoid disease
    • Maini RN, Elliot MJ, Brennan FM, et al.: Monoclonal anti-TNF alpha antibody as a probe of pathogenesis and therapy of rheumatoid disease. Immunol Rev 1995, 144:195-223.
    • (1995) Immunol Rev , vol.144 , pp. 195-223
    • Maini, R.N.1    Elliot, M.J.2    Brennan, F.M.3
  • 40
    • 0037100511 scopus 로고    scopus 로고
    • Anemia of chronic disease in rheumatoid arthritis is associated with increased apoptosis of bone marrow erythroid cells: Improvement following anti-tumor necrosis factor-alpha antibody therapy
    • Papadaki HA, Kritikos HD, Vatatas V, et al.: Anemia of chronic disease in rheumatoid arthritis is associated with increased apoptosis of bone marrow erythroid cells: improvement following anti-tumor necrosis factor-alpha antibody therapy. Blood 2002, 100:474-482. A prospective study suggesting that anemia of chronic disease in patients with RA is associated with TNF-mediated apoptosis of bone marrow erythroid precursor cells.
    • (2002) Blood , vol.100 , pp. 474-482
    • Papadaki, H.A.1    Kritikos, H.D.2    Vatatas, V.3
  • 41
    • 0036493402 scopus 로고    scopus 로고
    • Bone marrow progenitor cell reserve and function and stromal cell function are defective in rheumatoid arthritis: Evidence for a tumor necrosis factor alpha-mediated effect
    • Papadaki HA, Kritikos HD, Gemetzi C, et al.: Bone marrow progenitor cell reserve and function and stromal cell function are defective in rheumatoid arthritis: evidence for a tumor necrosis factor alpha-mediated effect. Blood 2002, 99:1610-1619.
    • (2002) Blood , vol.99 , pp. 1610-1619
    • Papadaki, H.A.1    Kritikos, H.D.2    Gemetzi, C.3
  • 42
    • 0037159293 scopus 로고    scopus 로고
    • Anti-tumor necrosis factor-alpha treatment improves endothelial function in patients with rheumatoid arthritis
    • Hurlimann D, Forster A, Noll G, et al.: Anti-tumor necrosis factor-alpha treatment improves endothelial function in patients with rheumatoid arthritis. Circulation 2002, 106:2184-2187.
    • (2002) Circulation , vol.106 , pp. 2184-2187
    • Hurlimann, D.1    Forster, A.2    Noll, G.3
  • 43
    • 0036269445 scopus 로고    scopus 로고
    • The relationship of serum Infliximab concentrations to clinical improvement in rheumatoid arthritis: Results from ATTRACT, a multicenter, randomized, double-blind, placebo-controlled trial
    • St Clair EW, Wagner CL, Fasanmade AA, et al.: The relationship of serum Infliximab concentrations to clinical improvement in rheumatoid arthritis: results from ATTRACT, a multicenter, randomized, double-blind, placebo-controlled trial. Arthritis Rheum 2002, 46:1451-1459.
    • (2002) Arthritis Rheum , vol.46 , pp. 1451-1459
    • St Clair, E.W.1    Wagner, C.L.2    Fasanmade, A.A.3
  • 44
    • 0036274944 scopus 로고    scopus 로고
    • Etanercept versus methotrexate in patients with early rheumatoid arthritis: Two-year radiographic and clinical outcomes
    • Genovese MC, Bathon JM, Martin RW, et al.: Etanercept versus methotrexate in patients with early rheumatoid arthritis: two-year radiographic and clinical outcomes. Arthritis Rheum 2002, 46:1443-1450.
    • (2002) Arthritis Rheum , vol.46 , pp. 1443-1450
    • Genovese, M.C.1    Bathon, J.M.2    Martin, R.W.3
  • 45
    • 0036839607 scopus 로고    scopus 로고
    • Tumor necrosis factor superfamily cytokines and the pathogenesis of inflammatory osteolysis
    • Lam J, Abu-Amer Y, Nelson CA, et al.: Tumor necrosis factor superfamily cytokines and the pathogenesis of inflammatory osteolysis. Ann Rheum Dis 2002, 61 (suppl II):ii82-ii83. A concise review of the authors own outstanding work on the pathogenesis of inflammatory ostolysis and the role of TNF.
    • (2002) Ann Rheum Dis , vol.61 , Issue.SUPPL. II
    • Lam, J.1    Abu-Amer, Y.2    Nelson, C.A.3
  • 46
    • 0035089788 scopus 로고    scopus 로고
    • The role of osteoprotegerin and receptor activator of nuclear factor kB ligand in the pathogenesis and treatment of rheumatoid arthritis
    • Hofbauer LC, Heufelder AE: The role of osteoprotegerin and receptor activator of nuclear factor kB ligand in the pathogenesis and treatment of rheumatoid arthritis. Arthritis Rheum 2001, 44:253-259.
    • (2001) Arthritis Rheum , vol.44 , pp. 253-259
    • Hofbauer, L.C.1    Heufelder, A.E.2
  • 47
    • 0036218666 scopus 로고    scopus 로고
    • RANK-L and RANK: T cells, bone loss, and mammalian evolution
    • Theill LE, Boyle WJ, Penninger JM: RANK-L and RANK: T cells, bone loss, and mammalian evolution. Annu Rev Immunol 2002, 20:795-823.
    • (2002) Annu Rev Immunol , vol.20 , pp. 795-823
    • Theill, L.E.1    Boyle, W.J.2    Penninger, J.M.3
  • 48
    • 0034282878 scopus 로고    scopus 로고
    • Tumor necrosis factor receptors types 1 and 2 differentially regulate osteoctastogenesis
    • Abu-Amer Y, Erdmann J, Kollias G, et al.: Tumor necrosis factor receptors types 1 and 2 differentially regulate osteoctastogenesis. J Biol Chem 2000, 275:27307-27310.
    • (2000) J Biol Chem , vol.275 , pp. 27307-27310
    • Abu-Amer, Y.1    Erdmann, J.2    Kollias, G.3
  • 49
    • 0036172368 scopus 로고    scopus 로고
    • Involvement of receptor activator of NFkB ligand and tumor necrosis factor-a in bone destruction in rheumatoid arthritis
    • Romas E, Gillespie MT, Martin TJ: Involvement of receptor activator of NFkB ligand and tumor necrosis factor-a in bone destruction in rheumatoid arthritis. Bone 2002, 30:340-346.
    • (2002) Bone , vol.30 , pp. 340-346
    • Romas, E.1    Gillespie, M.T.2    Martin, T.J.3
  • 50
    • 0036069790 scopus 로고    scopus 로고
    • High levels of osteoprotegerin and soluble receptor activator of nuclear factor kappa B ligand in serum of rheumatoid arthritis patients and their normalization after anti-tumor necrosis factor alpha treatment
    • Ziolkowska M, Kurowska M, Radzikowska A, et al.: High levels of osteoprotegerin and soluble receptor activator of nuclear factor kappa B ligand in serum of rheumatoid arthritis patients and their normalization after anti-tumor necrosis factor alpha treatment. Arthritis Rheum 2002, 46:1744-1753. This the first evidence that in vivo neutralization of TNF in patients with RA is associated with normalization of serum levels of two key factors affecting bone metabolism, osteoprotogerin and RANKL. The results suggest a mechanism to explain the prevention of bone damage seen with this treatment.
    • (2002) Arthritis Rheum , vol.46 , pp. 1744-1753
    • Ziolkowska, M.1    Kurowska, M.2    Radzikowska, A.3
  • 51
    • 0029004771 scopus 로고
    • Chimeric anti-TNF-alpha monoclonal antibody cA2 binds recombinant transmembrane TNF-alpha and activates immune effector functions
    • Scallon BJ, Moore MA, Trih H, et al.: Chimeric anti-TNF-alpha monoclonal antibody cA2 binds recombinant transmembrane TNF-alpha and activates immune effector functions. Cytokine 1995, 7:251-259.
    • (1995) Cytokine , vol.7 , pp. 251-259
    • Scallon, B.J.1    Moore, M.A.2    Trih, H.3
  • 52
    • 0036229932 scopus 로고    scopus 로고
    • Binding and functional comparisons of two types of tumor necrosis factor antagonists
    • Scallon B, Cai A, Solowski N, et al.: Binding and functional comparisons of two types of tumor necrosis factor antagonists. J Pharmacol Exp Ther 2002, 301:418-426. This in vitro study shows the structure-related differences between etanercept and Infliximab in recognition and stability of their complexes with soluble and transmembrane TNF. If confirmed in vivo, these results may have important consequences for the use of anti-TNF agents in clinical practice.
    • (2002) J Pharmacol Exp Ther , vol.301 , pp. 418-426
    • Scallon, B.1    Cai, A.2    Solowski, N.3
  • 53
    • 0034761594 scopus 로고    scopus 로고
    • Transmembrane TNF-a, induction of apoptosis, and the efficacy of TNF-targeting therapies in Crohn's disease
    • van Deventer SJH: Transmembrane TNF-a, induction of apoptosis, and the efficacy of TNF-targeting therapies in Crohn's disease. Gastroenterology 2001, 121:1242-1245.
    • (2001) Gastroenterology , vol.121 , pp. 1242-1245
    • Van Deventer, S.J.H.1
  • 54
    • 0037434552 scopus 로고    scopus 로고
    • Influence of immunogenicity on the long-term efficacy of infliximab in Crohn's disease
    • Baert F, Noman M, Vermeire S, et al.: Influence of immunogenicity on the long-term efficacy of infliximab in Crohn's disease. N Engl J Med 2003, 348:601-607.
    • (2003) N Engl J Med , vol.348 , pp. 601-607
    • Baert, F.1    Noman, M.2    Vermeire, S.3
  • 55
    • 0035846326 scopus 로고    scopus 로고
    • Tuberculosis associated with infliximab, a tumor necrosis factor alpha-neutralizing agent
    • Keane J, Gershon S, Wise RP, et al.: Tuberculosis associated with infliximab, a tumor necrosis factor alpha-neutralizing agent. N Engl J Med 2001, 345:1098-1104.
    • (2001) N Engl J Med , vol.345 , pp. 1098-1104
    • Keane, J.1    Gershon, S.2    Wise, R.P.3
  • 56
    • 0036822552 scopus 로고    scopus 로고
    • Life-threatening histoplasmosis complicating immunotherapy with TNFa antagonists infliximab and etanercept
    • Lee JH, Slifman NR, Gershon SK, et al.: Life-threatening histoplasmosis complicating immunotherapy with TNFa antagonists infliximab and etanercept. Arthritis Rheum 2002, 46:2565-2570.
    • (2002) Arthritis Rheum , vol.46 , pp. 2565-2570
    • Lee, J.H.1    Slifman, N.R.2    Gershon, S.K.3
  • 57
    • 0037331223 scopus 로고    scopus 로고
    • Listeria monocytogenes infection as a complication of treatment with tumor necrosis factor alpha-neutralizing agents
    • Slifman NR, Gershon SK, Lee JH, et al.: Listeria monocytogenes infection as a complication of treatment with tumor necrosis factor alpha-neutralizing agents. Arthritis Rheum 2003, 48:319-324.
    • (2003) Arthritis Rheum , vol.48 , pp. 319-324
    • Slifman, N.R.1    Gershon, S.K.2    Lee, J.H.3
  • 58
    • 0036673687 scopus 로고    scopus 로고
    • Pneumocystis carinii pneumonia following a second infusion of infliximab
    • Tai TL, O'Rourke KP, McWeeney M, et al.: Pneumocystis carinii pneumonia following a second infusion of infliximab. Rheumatology 2002, 41:951-952.
    • (2002) Rheumatology , vol.41 , pp. 951-952
    • Tai, T.L.1    O'Rourke, K.P.2    McWeeney, M.3
  • 59
    • 0030769165 scopus 로고    scopus 로고
    • The role of TNFa and related cytokines in the development and function of the autoreactive T cell repertoire
    • Cope A, Ettinger R, McDevitt H: The role of TNFa and related cytokines in the development and function of the autoreactive T cell repertoire. Res Immunol 1997, 148:307-312.
    • (1997) Res Immunol , vol.148 , pp. 307-312
    • Cope, A.1    Ettinger, R.2    McDevitt, H.3
  • 60
    • 0032725836 scopus 로고    scopus 로고
    • Tumor necrosis factor and other cytokines in murine lupus
    • Theofilopoulos AN, Lawson BR: Tumor necrosis factor and other cytokines in murine lupus. Ann Rheum Dis 1999, 58(suppl 1 ):149-155.
    • (1999) Ann Rheum Dis , vol.58 , Issue.SUPPL. 1 , pp. 149-155
    • Theofilopoulos, A.N.1    Lawson, B.R.2
  • 61
    • 0035892750 scopus 로고    scopus 로고
    • In vivo neutralization on TNF-alpha promotes humoral autoimmunity by preventing the induction of CTL
    • Via CS, Shustov A, Rus V, et al.: In vivo neutralization on TNF-alpha promotes humoral autoimmunity by preventing the induction of CTL. J Immunol 2001, 167:6821-6826. An elegant study showing that induction of cytotoxic T cells in mice undergoing acute graft versus host disease is prevented by anti-TNF treatment. Because such T cells would normally suppress autoreactive B cells, these findings imply an additional protective activity of TNF.
    • (2001) J Immunol , vol.167 , pp. 6821-6826
    • Via, C.S.1    Shustov, A.2    Rus, V.3
  • 62
    • 0033763979 scopus 로고    scopus 로고
    • Assessment of antibodies to double-stranded DNA induced in rheumatoid arthritis patients following treatment with infliximab, a monoclonal antibody to TNF alpha: Findings in open-label and randomized placebo-controlled trials
    • Chades PJ, Smeenk RG, De Jong J, et al.: Assessment of antibodies to double-stranded DNA induced in rheumatoid arthritis patients following treatment with infliximab, a monoclonal antibody to TNF alpha: findings in open-label and randomized placebo-controlled trials. Arthritis Rheum 2000, 43:2383-2389.
    • (2000) Arthritis Rheum , vol.43 , pp. 2383-2389
    • Chades, P.J.1    Smeenk, R.G.2    De Jong, J.3
  • 63
    • 0036900501 scopus 로고    scopus 로고
    • Tumor necrosis factor antagonist therapy and lymphoma development: Twenty-six cases reported to the Food and Drug Administration
    • Brown SL, Greene MH, Gershon SK, et al.: Tumor necrosis factor antagonist therapy and lymphoma development: twenty-six cases reported to the Food and Drug Administration. Arthritis Rheum 2002, 46:3151-3158.
    • (2002) Arthritis Rheum , vol.46 , pp. 3151-3158
    • Brown, S.L.1    Greene, M.H.2    Gershon, S.K.3
  • 64
    • 0037116836 scopus 로고    scopus 로고
    • Drug-induced systemic lupus erythematosus associated with etanercept therapy
    • Shakoor N, Michalska M, Harris CA, et al.: Drug-induced systemic lupus erythematosus associated with etanercept therapy. Lancet 2002, 359:579-580.
    • (2002) Lancet , vol.359 , pp. 579-580
    • Shakoor, N.1    Michalska, M.2    Harris, C.A.3
  • 65
    • 0033546665 scopus 로고    scopus 로고
    • TNF neutralization in MS: Results of a randomized, placebo-controlled multicenter study
    • The Lenercept Multiple Sclerosis Study Group and the University of British Columbia MS/MRI Analysis Group
    • TNF neutralization in MS: results of a randomized, placebo-controlled multicenter study. The Lenercept Multiple Sclerosis Study Group and the University of British Columbia MS/MRI Analysis Group. Neurology 1999, 53:457-465.
    • (1999) Neurology , vol.53 , pp. 457-465
  • 66
    • 0035674613 scopus 로고    scopus 로고
    • Demyelination occurring during anti-tumor necrosis factor alpha therapy for inflammatory arthritides
    • Mohan N, Edwards ET, Cupps TR, et al.: Demyelination occurring during anti-tumor necrosis factor alpha therapy for inflammatory arthritides. Arthritis Rheum 2001, 44:2862-2869.
    • (2001) Arthritis Rheum , vol.44 , pp. 2862-2869
    • Mohan, N.1    Edwards, E.T.2    Cupps, T.R.3
  • 67
    • 0035464263 scopus 로고    scopus 로고
    • Demyelinating and neurologic events reported in association with TNF-a antagonism: By what mechanisms could TNF-a antagonists improve rheumatoid arthritis but exacerbate multiple sclerosis?
    • Robinson WH, Genovese MC, Moreland LW: Demyelinating and neurologic events reported in association with TNF-a antagonism: by what mechanisms could TNF-a antagonists improve rheumatoid arthritis but exacerbate multiple sclerosis? Arthritis Rheum 2001, 44:1977-1983.
    • (2001) Arthritis Rheum , vol.44 , pp. 1977-1983
    • Robinson, W.H.1    Genovese, M.C.2    Moreland, L.W.3
  • 68
    • 0035179804 scopus 로고    scopus 로고
    • Rapid onset of cutaneous squamous cell carcinoma in patients with rheumatoid arthritis after starting tumor necrosis factor alpha receptor IgG1-Fc fusion complex therapy
    • Smith KJ, Skelton HG: Rapid onset of cutaneous squamous cell carcinoma in patients with rheumatoid arthritis after starting tumor necrosis factor alpha receptor IgG1-Fc fusion complex therapy. J Am Acad Dermatol 2001, 45:953-956.
    • (2001) J Am Acad Dermatol , vol.45 , pp. 953-956
    • Smith, K.J.1    Skelton, H.G.2
  • 69
    • 0029045458 scopus 로고
    • The type I interleukin-1 receptor acts in series with tumor necrosis factor (TNF) to induce arthritis in TNF-transgenic mice
    • Probert L, Plows D, Kontogeorgos G, et al.: The type I interleukin-1 receptor acts in series with tumor necrosis factor (TNF) to induce arthritis in TNF-transgenic mice. Eur J Immunol 1995, 6:1794-1797.
    • (1995) Eur J Immunol , vol.6 , pp. 1794-1797
    • Probert, L.1    Plows, D.2    Kontogeorgos, G.3
  • 70
    • 0029554533 scopus 로고    scopus 로고
    • Transgenic and knockout analyses of the role of TNF in immune regulation and disease pathogenesis
    • Douni E, Akasoglou K, Alexopoulou L, et al.: Transgenic and knockout analyses of the role of TNF in immune regulation and disease pathogenesis. J Inflamm 1996, 47:27-38.
    • (1996) J Inflamm , vol.47 , pp. 27-38
    • Douni, E.1    Akasoglou, K.2    Alexopoulou, L.3
  • 71
    • 0029891052 scopus 로고    scopus 로고
    • Transmembrane TNF is sufficient to induce localized tissue toxicity and chronic inflammatory arthritis in transgenic mice
    • Georgopoulos S, Plows D, Kollias G: Transmembrane TNF is sufficient to induce localized tissue toxicity and chronic inflammatory arthritis in transgenic mice. J Inflamm 1996, 46:86-97.
    • (1996) J Inflamm , vol.46 , pp. 86-97
    • Georgopoulos, S.1    Plows, D.2    Kollias, G.3
  • 72
    • 0033103805 scopus 로고    scopus 로고
    • Impaired on/off regulation of TNF biosynthesis in mice lacking TNF AU-rich elements: Implications for joint and gut-associated immunopathologies
    • Kontoyiannis D, Pasparakis M, Pizarro TT, et al.: Impaired on/off regulation of TNF biosynthesis in mice lacking TNF AU-rich elements: implications for joint and gut-associated immunopathologies. Immunity 1999, 10:387-398.
    • (1999) Immunity , vol.10 , pp. 387-398
    • Kontoyiannis, D.1    Pasparakis, M.2    Pizarro, T.T.3
  • 73
    • 0033555398 scopus 로고    scopus 로고
    • Mice lacking mature T and B lymphocytes develop arthritic lesions after immunization with type II collagen
    • Plows D, Kontogeorgos G, Kollias G: Mice lacking mature T and B lymphocytes develop arthritic lesions after immunization with type II collagen. J Immunol 1999, 162:1018-1023.
    • (1999) J Immunol , vol.162 , pp. 1018-1023
    • Plows, D.1    Kontogeorgos, G.2    Kollias, G.3
  • 74
    • 4244179537 scopus 로고    scopus 로고
    • Effects of giucocorticoid and methotrexate administration on the tg 197 TNF-transgenic mouse model of chronic inflammatory polyarthritis
    • Sfikakis PP, Haralambous S, Kollias G: Effects of giucocorticoid and methotrexate administration on the tg 197 TNF-transgenic mouse model of chronic inflammatory polyarthritis. Arthritis Rheum 1998, 41 (suppl):S100.
    • (1998) Arthritis Rheum , vol.41 , Issue.SUPPL.
    • Sfikakis, P.P.1    Haralambous, S.2    Kollias, G.3
  • 75
    • 4243591860 scopus 로고    scopus 로고
    • Comparison of adalimumab, infliximab, and etanercept in the prevention of polyarthritis in a transgenic murine model of rheumatoid arthritis
    • Kaymakcalan Z, Beam C, Kamen R, et al.: Comparison of adalimumab, infliximab, and etanercept in the prevention of polyarthritis in a transgenic murine model of rheumatoid arthritis. Arthritis Rheum 2002, 46(suppl):S304.
    • (2002) Arthritis Rheum , vol.46 , Issue.SUPPL.
    • Kaymakcalan, Z.1    Beam, C.2    Kamen, R.3
  • 76
    • 75749092436 scopus 로고    scopus 로고
    • Anti-TNF-alpha antibody allows healing of joint damage in polyarthritic transgenic mice
    • Shealy DJ, Wooley PH, Emmell E, et al.: Anti-TNF-alpha antibody allows healing of joint damage in polyarthritic transgenic mice. Arthritis Res 2002, 4:R7.
    • (2002) Arthritis Res , vol.4
    • Shealy, D.J.1    Wooley, P.H.2    Emmell, E.3
  • 77
    • 0036185343 scopus 로고    scopus 로고
    • Tumor necrosis factor alpha-mediated joint destruction is inhibited by targeting osteoclasts with osteoprotegerin
    • Redlich K, Hayer S, Maier A, et al.: Tumor necrosis factor alpha-mediated joint destruction is inhibited by targeting osteoclasts with osteoprotegerin. Arthritis Rheum 2002, 46:785-792. Confirming that TNF-driven joint inflammation and joint destruction may occur uncoupled, this paper shows that osteoclast-targeted therapies reduce the number of bone-resorbing cells in the inflammatory tissues of TNF transgenic mice.
    • (2002) Arthritis Rheum , vol.46 , pp. 785-792
    • Redlich, K.1    Hayer, S.2    Maier, A.3
  • 78
    • 0030267786 scopus 로고    scopus 로고
    • Attenuation of collagen-induced arthritis in 55-kDa TNF receptor type 1 (TNFR1)-IgG1-treated and TNFR1-deficient mice
    • Mori L, Iselin S, De Libero G, et al.: Attenuation of collagen-induced arthritis in 55-kDa TNF receptor type 1 (TNFR1)-IgG1-treated and TNFR1-deficient mice. J Immunol 1996, 157:3178-3182.
    • (1996) J Immunol , vol.157 , pp. 3178-3182
    • Mori, L.1    Iselin, S.2    De Libero, G.3
  • 79
    • 0032169765 scopus 로고    scopus 로고
    • Different roles of TNFa and IL-1 in murine streptococcal cell wall arthritis
    • Kuiper S, Joosten LA, Bendele AM, et al.: Different roles of TNFa and IL-1 in murine streptococcal cell wall arthritis. Cytokine 1998, 10:690-702.
    • (1998) Cytokine , vol.10 , pp. 690-702
    • Kuiper, S.1    Joosten, L.A.2    Bendele, A.M.3
  • 80
    • 0036681846 scopus 로고    scopus 로고
    • The importance of IL-1 beta and TNF-alpha, and the non-involvement of IL-6, in the development of monoclonal antibody-induced arthritis
    • Kagari T, Doi H, Shimozato T: The importance of IL-1 beta and TNF-alpha, and the non-involvement of IL-6, in the development of monoclonal antibody-induced arthritis. J Immunol 2002, 169:1456-1466.
    • (2002) J Immunol , vol.169 , pp. 1456-1466
    • Kagari, T.1    Doi, H.2    Shimozato, T.3
  • 81
    • 0036172594 scopus 로고    scopus 로고
    • Inflammation is preceded by TNF-dependent infiltration of mesenchymal cells in experimental arthritis
    • Marinova-Mutafchieva L, Williams RO, Funa K, et al.: Inflammation is preceded by TNF-dependent infiltration of mesenchymal cells in experimental arthritis. Arthritis Rheum 2002, 46:507-513.
    • (2002) Arthritis Rheum , vol.46 , pp. 507-513
    • Marinova-Mutafchieva, L.1    Williams, R.O.2    Funa, K.3
  • 82
    • 0036853027 scopus 로고    scopus 로고
    • Ex vivo gene delivery of IL-1 Ra and soluble TNF receptor confers a distal synergistic therapeutic effect in antigen-induced arthritis
    • Kim SH, Lechman ER, Kim S, et al.: Ex vivo gene delivery of IL-1 Ra and soluble TNF receptor confers a distal synergistic therapeutic effect in antigen-induced arthritis. Mol Ther 2002, 6:591-600.
    • (2002) Mol Ther , vol.6 , pp. 591-600
    • Kim, S.H.1    Lechman, E.R.2    Kim, S.3
  • 83
    • 0037114178 scopus 로고    scopus 로고
    • A novel dendritic cell-induced model of erosive inflammatory arthritis: Distinct roles for dendritic cells in T cell activation and induction of local inflammation
    • Leung BP, Conacher M, Hunter D, et al.: A novel dendritic cell-induced model of erosive inflammatory arthritis: distinct roles for dendritic cells in T cell activation and induction of local inflammation. J Immunol 2002, 169:7071-7077.
    • (2002) J Immunol , vol.169 , pp. 7071-7077
    • Leung, B.P.1    Conacher, M.2    Hunter, D.3
  • 84
    • 0036105564 scopus 로고    scopus 로고
    • The role of TNF-alpha in the pathogenesis of inflammation and joint destruction in rheumatoid arthritis (RA): A study using a human RA/SCID mouse chimera
    • Matsumo H, Yudoh K, Katayama R, et al.: The role of TNF-alpha in the pathogenesis of inflammation and joint destruction in rheumatoid arthritis (RA): a study using a human RA/SCID mouse chimera. Rheumatology 2002, 41:329-337.
    • (2002) Rheumatology , vol.41 , pp. 329-337
    • Matsumo, H.1    Yudoh, K.2    Katayama, R.3
  • 85
    • 0036645277 scopus 로고    scopus 로고
    • Critical roles for interleukin 1 and tumor necrosis factor alpha in antibody-induced arthritis
    • Ji H, Pettit A, Ohmura K, et al.: Critical roles for interleukin 1 and tumor necrosis factor alpha in antibody-induced arthritis. J Exp Med 2002, 196:77-85. Elegant studies exploring the analogy between the K/BxN spontaneous mouse model of arthritis and human patients. TNF has a variable role in this model, reminiscent of that observed in patients with RA, which is not genetically programmed but rather relates to subtle environmental changes.
    • (2002) J Exp Med , vol.196 , pp. 77-85
    • Ji, H.1    Pettit, A.2    Ohmura, K.3
  • 86
    • 0036853902 scopus 로고    scopus 로고
    • Osteoclasts are essential for TNF-alpha-mediated joint destruction
    • Redlich K, Hayer S, Ricci R, et al.: Osteoclasts are essential for TNF-alpha-mediated joint destruction. J Clin Invest 2002, 110:1419-1427. An important paper showing that TNF transgenic mice lacking osteoclasts develop TNF-dependent arthritis but are fully protected against bone destruction.
    • (2002) J Clin Invest , vol.110 , pp. 1419-1427
    • Redlich, K.1    Hayer, S.2    Ricci, R.3
  • 87
    • 0036792512 scopus 로고    scopus 로고
    • Osteoprotegerin reduces osteoclast numbers and prevents bone erosion in collagen-induced arthritis
    • Romas E, Sims NA, Hards DK, et al.: Osteoprotegerin reduces osteoclast numbers and prevents bone erosion in collagen-induced arthritis. Am J Pathol 2002, 161:1419-1427. This study shows that short-term Fc-osteoprotegerin treatment depletes osteoclast numbers and effectively prevents joint destruction in the presence of inflammation in collagen-induced adhritis.
    • (2002) Am J Pathol , vol.161 , pp. 1419-1427
    • Romas, E.1    Sims, N.A.2    Hards, D.K.3
  • 88
    • 0036694562 scopus 로고    scopus 로고
    • Role of TNF/TNFR in autoimmunity: Specific TNF receptor blockade may be advantageous to anti-TNF treatment
    • Kollias G, Kontoyiannis D: Role of TNF/TNFR in autoimmunity: specific TNF receptor blockade may be advantageous to anti-TNF treatment. Cytokine Growth Factor Rev 2002, 13:315-321.
    • (2002) Cytokine Growth Factor Rev , vol.13 , pp. 315-321
    • Kollias, G.1    Kontoyiannis, D.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.