Identification of a subtype selective human PPARα agonist through parallel-array synthesis

Bioorganic and Medicinal Chemistry Letters

Volumn 11, Issue 9, 2001, Pages 1225-1227

  Brown, Peter J ^a   Stuart, L William ^a   Hurley, Kevin P ^a   Lewis, Michael C ^a   Winegar, Deborah A ^a   Wilson, Joan G ^a   Wilkison, William O ^a   Ittoop, Olivia R ^a   Willson, Timothy M ^a  

^a GLAXOSMITHKLINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 [4 [2 [3 (2,4 DIFLUOROPHENYL) 1 HEPTYLUREIDO]ETHYL]PHENYLTHIO] 2 METHYLPROPIONIC ACID; ANTILIPEMIC AGENT; BUTYRIC ACID DERIVATIVE; GW 2433; GW 7647; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR AGONIST; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA AGONIST; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR DELTA AGONIST; RECEPTOR SUBTYPE; THIOISOBUTYRIC ACID DERIVATIVE; TRIACYLGLYCEROL; UNCLASSIFIED DRUG; UREA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DRUG ACTIVITY; DRUG POTENCY; DRUG SELECTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; DYSLIPIDEMIA; HAMSTER; HUMAN; HUMAN CELL; LIPID METABOLISM; NONHUMAN; REACTION ANALYSIS; STEREOCHEMISTRY;

ANIMALS; ANTILIPEMIC AGENTS; BUTYRIC ACIDS; CRICETINAE; DIETARY FATS; DRUG DESIGN; HYPERLIPIDEMIAS; PHENYLUREA COMPOUNDS; RECEPTORS, CYTOPLASMIC AND NUCLEAR; TRANSCRIPTION FACTORS;

ANIMALIA;

EID: 0035821394     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(01)00188-3     Document Type: Article

References (8)