Urinary Metabolites of Leukotriene B4 in the Human Subject

Journal of Biological Chemistry

Volumn 278, Issue 27, 2003, Pages 24449-24460

  Berry, Karin A Zemski ^a   Borgeat, Pierre ^b,c   Gosselin, Jean ^b,c   Flamand, Louis ^b,c   Murphy, Robert C ^a  

^a NATIONAL JEWISH MEDICAL AND RESEARCH CENTER   (United States)

^b Virocell Inc   (Canada)

^c LAVAL UNIVERSITY   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

BIOSYNTHESIS; ISOTOPES; LIQUID CHROMATOGRAPHY; METABOLISM; METABOLITES; ULTRAVIOLET SPECTROSCOPY;

INFLAMMATORY RESPONSE;

BIOCHEMISTRY;

BETA GLUCURONIDASE; CHEMOATTRACTANT; G PROTEIN COUPLED RECEPTOR; LEUKOTRIENE B4; LIPOXYGENASE; PLACEBO;

ARACHIDONIC ACID METABOLISM; ARTICLE; BIOTRANSFORMATION; ENZYME ACTIVATION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN CELL; INFLAMMATION; ISOTOPE DILUTION ASSAY; MACROPHAGE ACTIVATION; METABOLITE; NEUTROPHIL; PRIORITY JOURNAL; TANDEM MASS SPECTROMETRY; ULTRAVIOLET SPECTROSCOPY; URINARY EXCRETION; CLINICAL TRIAL; INTRAVENOUS DRUG ADMINISTRATION; PHASE 1 CLINICAL TRIAL; URINE;

CHROMATOGRAPHY, HIGH PRESSURE LIQUID; HUMANS; INJECTIONS, INTRAVENOUS; LEUKOTRIENE B4;

EID: 0042591284     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M300856200     Document Type: Article

References (37)

1. Ford-Hutchinson, A. W. (1990) Crit. Rev. Immunol. 10, 1-12
2. Leslie, C. C. (1997) J. Biol. Chem. 272, 16709-16712
3. Funk, C. F. (2001) Science 294, 1871-1875
4. Samuelsson, B., and Funk, C. D. (1989) J. Biol. Chem. 264, 19469-19472
5. Yokomizo, T., Kato, K., Terawaki, K. Izumi, T., and Shimizu, T. (2000) J. Exp. Med. 192, 421-432
6. Yokomizo, T., Izumi, T., Chang, K., Takuwa, Y., and Shimizu, T. (1997) Nature 367, 620-624
7. Dasari, V. R., Jin, J., and Kunapuli, S. P. (2000) Immunopharmacology 48, 157-163
8. Kikuta, Y., Kato, M., Yamashita, Y., Miyauchi, Y., Tanaka, K., Kamada, N., and Kusunose, M. (1998) DNA Cell Biol. 17, 221-230
9. Hill, E., and Murphy, R. C. (1992) Biol. Mass Spectrom. 21, 249-253
10. Soberman, R. J., Sutyak, J. P., Okita, R. T., Wendelborn, D. F., Roberts, L. J., and Austen, K. F. (1988) J. Biol. Chem. 263, 7996-8002
11. Sutyak, J., Austen, K. F., and Soberman, R. J. (1989) J. Biol. Chem. 264, 14818-14823
12. Baumer, T., Huber, M., Mayer, D., and Keppler, D. (1989) Eur. J. Biochem. 182, 223-229
13. Wheelan, P., Hankin, J. A., Bilir, B., Guenette, D., and Murphy, R. C. (1999) J. Pharm. Exp. Ther. 288, 326-334
14. Shirley, M. A., and Murphy, R. C. (1990) J. Biol. Chem. 265, 16288-16295
15. Yokomizo, T., Izumi, T., Takahashi, T., Kasama, T., Kobayashi, Y., Sato, F., Taketani, Y., and Shimizu, T. (1993) J. Biol. Chem. 268, 18128-18135
16. Wheelan, P., Zirrolli, J. A., Morelli, J. G., and Murphy, R. C. (1993) J. Biol. Chem. 268, 25439-25448
17. Kumlin, M., Falck, J. R., Raud, J., Harada, Y., Dahlen, S. E., and Granstrom, E. (1990) Biochem. Biophys. Res. Commun. 170, 23-29
18. Fitzgerald, G. A., Pedersen, A. K., and Patrono, C. (1983) Circulation 67, 1174-1177
19. Roberts, L. J., Sweetman, B. J., and Oates, J. A. (1981) J. Biol. Chem. 256, 8384-8394
20. Maclouf, J., Antoine, C., De Caterina, R., Sicari, R., Murphy, R. C., Patrignani, P., Loizzo, S., and Patrono, C. (1992) Am. J. Physiol. 263, H244-H249
21. Willemsen, M. A. A. P., Rotteveel, J. J., de Jong, J. G. N., Wanders, R. J. A., Ijlist, L., Hoffmann, G. F., and Mayatepek, E. (2001) J. Neurosci. 183, 61-67
22. Mayatepek, E., Lehmann, W. D., Fauler, J., Tsikas, D., Frolich, J. C., Schutgens, R. B. H., Wanders, R. J. A., and Keppler, D. (1993) J. Clin. Invest. 91, 881-888
23. Murphy, R. C. (1993) in The Handbook of Lipid Research (Snyder, F., ed) Vol. 7, pp. 155-160, Plenum Publishing Corp., New York
24. Wheelan, P., Zirrolli, J. A., and Murphy, R. C. (1995) J. Am. Soc. Mass Spectrom. 6, 40-51
25. Brodowsky, I. D., and Oliw, E. H. (1992) Biochim. Biophys. Acta 1124, 59-65
26. Zenser, T. V., Lakshmi, V. M., and Davis, B. B. (1999) Drug Metab. Dispos. 27, 1064-1067
27. Hall, L. M., and Murphy, R. C. (1998) J. Am. Soc. Mass Spectrom. 9, 527-532
28. Powell, W. S. (1982) Methods Enzymol. 86, 467-477
29. Wheelan, P., Zirrolli, J. A., and Murphy, R. C. (1996) J. Am. Soc. Mass Spectrom. 7, 129-139
30. Powell, W. S., and Gravelle, F. (1990) J. Biol. Chem. 265, 9131-9139
31. Romano, M. C., Eckardt, R. D., Bender, P. E., Leonard, T. B., Straub, K. M., and Newton, J. F. (1987) J. Biol. Chem. 262, 1590-1595
32. King, A. R., and Dickinson, R. G. (1991) Biochem. Pharmacol. 42, 2289-2299
33. Hagmann, W., and Korte, M. (1990) Biochem. J. 267, 467-470
34. Serafín, W. E., Oates, J. A., and Hubbard, W. C. (1983) Prostaglandins 27, 899-911
35. Mulder, G. J. (1992) Annu. Rev. Pharmacol. Toxicol. 32, 25-49
36. Miners, J. O., and Mackenzie, P. I. (1991) Pharmacol. Ther. 51, 347-369
37. Bylund, J., Harder, A. G., Maier, K. G., Roman, R. J., and Harder, D. R. (2003) Arch. Biochem. Biophys. 412, 34-41