Long-term expression of human alpha1-antitrypsin gene in mouse liver achieved by intravenous administration of plasmid DNA using a hydrodynamics-based procedure

Gene Therapy

Volumn 7, Issue 15, 2000, Pages 1344-1349

  Zhang, G ^a   Song, Y K ^a   Liu, D ^a  

^a UNIVERSITY OF PITTSBURGH   (United States)

Author keywords

Gene delivery; Gene therapy; Hydrodynamics based transfection; Naked DNA; 1 antitrypsin

Indexed keywords

ALPHA 1 ANTITRYPSIN; PLASMA PROTEIN; PLASMID DNA; RNA; SECRETORY PROTEIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; EPISOME; EXTRACTION; GENE EXPRESSION; GENE TRANSFER; GENETIC CODE; GENETIC SCREENING; GENETIC TRANSFECTION; HYDRODYNAMICS; LIVER CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN SYNTHESIS; REPORTER GENE; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SOUTHERN BLOTTING; TARGET ORGAN; TRANSGENE;

ANIMALIA;

EID: 0033893570     PISSN: 09697128     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.gt.3301229     Document Type: Article

References (35)

1. Retroviral-mediated gene transfer into hepatocytes in vivo
2. Persistent gene expression after retroviral gene transfer into liver cells in vivo
3. Liver-directed gene therapy: Quantitative evaluation of promoter elements by using in vitro retroviral transduction
4. A simple and efficient method for the concentration and purification of recombinant retrovirus for increased hepatocyte transduction in vivo
5. Highly efficient retrovirus-mediated gene transfer into rat hepatocytes in vivo
6. Adenovirus-mediated in vivo gene transfer and expression in normal rat liver
7. Assessment of recombinant adenoviral vectors for hepatic gene therapy
8. Ablation of E2A in recombinant adenoviruses improves transgene persistence and decreases inflammatory response in mouse liver
9. Adenovirus-mediated transfer of human factor IX gene in immunodeficient and normal mice: Evidence for prolonged stabilitya nd activity of the transgene in liver
10. Genomic DNA transfer with a high-capacity adenovirus vector results in improved in vivo gene expression and decreased toxicity
11. Persistent and therapeutic concentrations of human factor IX in mice after hepatic gene transfer of recombinant AAV vectors
12. Adneo-associated virus 2-mediated gene transfer in vivo: Organ-tropism and expression of transduced sequences in mice
13. Adeno-associated viral vector-mediated gene transfer of human blood coagulation factor IX into mouse liver
14. Receptor-mediated gene delivery in vivo. Partial correction of genetic analbuminemia in Nagase rats
15. High-efficiency receptor-mediated delivery of small and large (48 kilobase) gene constructs using the endosome-disruption activity of defective or chemically inactivated adenovirus particles
16. Coupling of adenovirus to transferrin-polylysine/DNA complexes greatly enhances receptor-mediated gene delivery and expression of transfected genes
17. Expression of the hepatitis C virus genome in rat liver after cationic liposome-mediated in vivo gene transfer
18. In vivo gene transfer of insulin gene into neonatal rats by the HVJ-liposome method resulted in sustained transgene expression
19. In vivo gene delivery to the liver using reconstituted chylomicron remnants as a novel nonviral vector
20. In vivo regional delivery of retrovirally mediated foreign genes to rat liver cells: Need for partial hepatectomy for successful foreign gene expression
21. MHC class I-restricted cytotoxic T lymphocytes to viral antigens destroy hepatocytes in mice infected with E1-deleted recombinant adenoviruses
22. Cellular immunity to viral antigens limits E1-deleted adenoviruses for gene therapy
23. Strain related variations in adenovirally mediated transgene expression from mouse hepatocytes in vivo: Comparisons between immunocompetent and immunodeficient inbred strains
24. Quantitative analysis of the packaging capacity of recombinant adeno-associated virus
25. Hydrodynamics-based transfection in animals by systemic administration of plasmid DNA
26. High levels of foreign gene expression in hepatocytes after tail vein injections of naked plasmid DNA
27. Structure and variation of human α1-antitrypsin
28. Naked DNA delivered intraportally expresses efficiently in hepatocytes
29. Long-term persistence of plasmid DNA and foreign gene expression in mouse muscle
30. Gene expression following direct injection of DNA into liver
31. Dexamethasone enhancement of gene expression after direct hepatic DNA injection
32. Expression of naked plasmid DNA injected into the afferent and efferent vessels of rodent and dog livers
33. Production of glycosylated physiologically 'normal' human alpha 1-antitrypsin by mouse fibroblasts modified by insertion of a human alpha 1-antitrypsin cDNA using a retroviral vector
34. Factors controlling efficiency of cationic lipid-mediated transfection in vivo via intravenous administration