The effect of CpG sequences on the B cell response to a viral glycoprotein encoded by a plasmid vector

Gene Therapy

Volumn 6, Issue 8, 1999, Pages 1448-1455

  Pasquini, S ^a,b   Deng, H ^a   Reddy, S T ^a   Giles Davis, W ^a   Ertl, H C J ^a  

^a WISTAR INSTITUTE   (United States)

^b HAMMERSMITH HOSPITAL   (United Kingdom)

Author keywords

CpG sequences; Expression vector; Gene therapy; Immune responses; Methylation

Indexed keywords

PALINDROMIC DNA; PLASMID VECTOR; VIRUS GLYCOPROTEIN;

ANIMAL CELL; ANTIBODY RESPONSE; ANTIBODY TITER; ARTICLE; B LYMPHOCYTE; CPG ISLAND; DNA METHYLATION; EXPRESSION VECTOR; FEMALE; GENE THERAPY; MOUSE; NONHUMAN; PRIORITY JOURNAL;

ANIMALS; ANTIBODY FORMATION; B-LYMPHOCYTES; CPG ISLANDS; CYTOMEGALOVIRUS; GENE TRANSFER TECHNIQUES; GENETIC VECTORS; MICE; MICE, INBRED C3H; MICE, INBRED C57BL; PLASMIDS; PROMOTER REGIONS (GENETICS); RABIES VIRUS; SITE-SPECIFIC DNA METHYLTRANSFERASE (CYTOSINE-SPECIFIC); VIRAL ENVELOPE PROTEINS;

EID: 0032870522     PISSN: 09697128     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.gt.3300964     Document Type: Article

References (31)

1. Yakaukas MA et al. Long term anti-nucleoprotein cellular and humoral immunity is induced by intramuscular injection of plasmid DNA containing NP gene. DNA Cell Biol 1993; 12: 771-777.
2. Krieg AM et al. CpG motifs in bacterial DNA trigger direct B-cell activation. Nature 1995; 374: 546-551.
3. Yamamoto S et al. Unique palindromic sequences in synthetic oligonucleotides are required to induce IFN and augment IFN-mediated natural killer cell activity. J Immunol 1992; 148: 4072-4076.
4. Matzinger P. Tolerance, danger and the extended family. Annu Rev Immunol 1994; 12: 991-1045.
5. Yang Y, Li Q, Ertl HCJ, Wilson JM. Lung-directed gene therapy with recombinant adenoviruses is limited by destructive class 1 restricted cytotoxic T cell responses to virus-infected cells. J Virol 1995; 69: 2004-2015.
6. Yang Y, Xiang ZQ, Ertl HCJ, Wilson JM. Upregulation of class 1 MHC antigens by interferon-γ is necessary for the T cell-mediated elimination of recombinant adenovirus infected hepatocytes in vivo. Proc Natl Acad Sci USA 1995; 92: 7257-7261.
7. Yang Y et al. Immune responses to viral antigens versus transgene product in the elimination of recombinant adenovirus infected hepatocyte in viva. Gene Ther 1995; 3: 137-144.
8. Biggs R. Jaundice and antibodies against factor VIII and IX in patients treated for hemophilia or Christmas disease in the United Kingdom. Br J Haematol 1974; 26: 313-329.
9. Ehrenfort S et al. Incidence of development of factor VIII and factor IX inhibitors in hemophiliacs. Lancet 1992; 339: 594-598.
10. Kay MA et al. In vivo hepatic gene therapy: complete albeit transient correction of factor IC+X deficiency in hemophilia B dogs. Proc Natl Acad Sci USA 1994; 91: 2353-2357.
11. Monahan P et al. Direct intramuscular injection with recombinant AAV results in sustained expression in a dog model of hemophilia. Gene Therapy 1998; 5: 40-49.
12. Klinman DM, Yamshchikov G, Ishigatsubo Y. Contribution of CpG motifs to the immunogenicity of DNA vaccines. J Immunol 1997; 158: 3635-3639.
13. Hug M et al. Transcriptional repression by methylation: cooperativity between a CpG cluster in the promoter and remote CpG-rich regions. FEBS Lett 1996; 379: 251-254.
14. Klinman DM et al. CpG motifs present in bacterial DNA rapidly induce lymphocytes to secrete interleukin 6, interleukin 12 and interferon y. Proc Natl Acad Sci USA 1996; 93: 2879-2883.
15. Fradin A, Manley JL, Prives CL. Methylation of simian virus 40 HpaII site affects late, but not early, viral gene expression. Proc Natl Acad Sci USA 1982; 79: 5142-5146.
16. Sato Y et al. Immunostimulatory DNA sequences necessary for effective intradermal gene immunization. Science 1996; 273: 352-354.
17. Jooss K, Ertl HCJ, Wilson JM. CTL target proteins and their MHC class 1 restriction in response to adenoviral vectors delivered to mouse liver. J Virol 1998; 72: 2945-2954.
18. Tang D, DeVit M, Johnston SA. Genetic immunization is a simple method for eliciting an immune response. Nature (London) 1992; 356: 152-154.
19. Ulmer B et al. Heterologous protection against influenza by injection of DNA encoding a viral protein. Science 1993; 259: 1745-1749.
20. Condon C. DNA-based immunization by in vivo transfection of dendritic cells. Nature Med 1996; 2: 1122-1128.
21. Porgador A. Predominant role for directly transfected dendritic cells in antigen presentation to CD8+ T cells after gene gun immunization. J Exp Med 1998; 188: 1075-1082.
22. Fu TM et al. Priming of cytotoxic T lymphocytes by DNA vaccines: requirement for professional antigen presenting cells and evidence for antigen transfer from myocytes. Mol Med 1997; 3: 362-371
23. McMahon JM et al. Inflammatory responses following direct injection of plasmid DNA into skeletal muscle. Gene Therapy 1998; 5: 1283-1290.
24. Ballas ZK, Rasmussen WL, Kreig AM. Induction of NK activity in murine and human cells by CpG motifs in oligonucleotides and bacterial DNA. J Immunol 1996; 157: 1840-1845.
25. Wiktor TJ, Dietzschold B, Leamson N, Koprowski H. Induction and biological properties of defective interfering particles of rabies virus. J Virol 1977; 21: 626-633.
26. Dietzschold BD et al. Mechanism of rabies virus neutralization by glycoprotein specific monoclonal antibodies. Virology 1987; 161: 29-36.
27. Xiang ZQ et al. Vaccination with a plasmid vector carrying the rabies virus glycoprotein gene induces protective immunity against rabies virus. Virology 1994; 199: 132-140.
28. Burger SR et al. Stable expression of rabies virus glycoprotein in Chinese hamster ovary cells. J Gen Virol 1991; 72: 359-367.
29. Xiang ZQ, Ertl HCJ. Transfer of maternal antibodies results in inhibition of specific immune reponses in the offspring. Virus Res 1992; 24: 297-314.
30. Wang Y, Xiang ZQ, Pasquini S, Ertl HCJ. Immune response to neonatal genetic immunization. Virology 1997; 228: 278-284.
31. Wiktor TJ. Tissue culture methods. In: Kaplan M, Koprowski H (eds). Laboratory Techniques in Rabies. 2nd edn, Vol 23. World Health Organization Monograph: Geneva, 1973, pp 101-120.