Human fibroblast growth factor receptor 1 is a co-receptor for infection by adeno-associated virus 2

Nature Medicine

Volumn 5, Issue 1, 1999, Pages 71-77

  Qing, Keyun ^a,b,c   Mah, Cathryn ^a,b,c   Hansen, Jonathan ^a,b,c   Zhou, Shangzhen ^d   Dwarki, Varavani ^d   Srivastava, Arun ^a,b,c  

^a INDIANA UNIVERSITY   (United States)

^b INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c WALTHER CANCER INSTITUTE   (United States)

^d NOVARTIS PHARMA AG   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

FIBROBLAST GROWTH FACTOR RECEPTOR; PROTEOHEPARAN SULFATE; VIRUS VECTOR;

ADENOVIRUS; ARTICLE; GENE TARGETING; GENE THERAPY; HUMAN; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; VIRUS DNA CELL DNA INTERACTION;

3T3 CELLS; ANIMALS; DEPENDOVIRUS; DNA-BINDING PROTEINS; FIBROBLAST GROWTH FACTORS; HELA CELLS; HEPARAN SULFATE PROTEOGLYCANS; HUMANS; MICE; PHOSPHORYLATION; RECEPTOR PROTEIN-TYROSINE KINASES; RECEPTOR, FIBROBLAST GROWTH FACTOR, TYPE 1; RECEPTORS, FIBROBLAST GROWTH FACTOR; RECEPTORS, VIRUS; RIBONUCLEOPROTEINS; TRANSGENES; TUMOR CELLS, CULTURED;

ADENO-ASSOCIATED VIRUS; ADENO-ASSOCIATED VIRUS 2; ADENOVIRIDAE; MURINAE;

EID: 0033010884     PISSN: 10788956     EISSN: None     Source Type: Journal    
DOI: 10.1038/4758     Document Type: Article

References (12)

1. Berns, K.I. & Giraud, C. Biology of adeno-associated virus. Curr. Top. Microbiol. Immunol. 218, 1-23 (1996).
2. Srivastava, A., Lusby, E.W. & Berns, K.I. Nucleotide sequence and organization of the adeno-associated virus 2 genome. J. Virol. 45, 555-564 (1983).
3. Kotin, R.M., Menninger, J.C., Ward, D.C. & Berns, K.I. Mapping and direct visualization of a region-specific viral DNA integration site on chromosome 19q13-qter. Genomics 10, 831-834 (1991).
4. Samulski, R.J. et al. Targeted integration of adeno-associated virus (AAV) into human chromosome 19. EMBO J. 10, 3941-3950 (1991).
5. Kearns, W.C. et al. Recombinant adeno-associated virus (AAV-CFTR) vectors do not integrate in a site-specific fashion in an immortalized epithelial cell line. Gene Ther. 3, 748-755 (1996).
6. Ponnazhagan, S. et al. Lack of site-specific integration of the recombinant adeno-associated virus 2 genomes in human cells. Hum. Gene Ther. 8, 275-284 (1997).
7. Qing, K.Y. et al. Role of tyrosine phosphorylation of a cellular protein in adeno-associated virus 2-mediated transgene expression. Proc. Natl. Acad. Sci. USA 94, 10879-10884 (1997).
8. Qing, K.Y. et al. Adeno-associated virus type 2-mediated gene transfer: Correlation of tyrosine phosphorylation of the cellular single-stranded D sequence-binding protein with transgene expression in human cells in vitro and murine tissues in vivo. J. Virol. 72, 1593-1599 (1998).
9. Fisher K.J. et al. Transduction with recombinant adeno-associated virus for gene therapy is limited by leading strand synthesis. J. Virol. 70, 520-532 (1996).
10. Ferrari, F.K., Samulski, T., Shenk, T. & Samulski, R.J. Second-strand synthesis is a rate limiting step for efficient transduction by recombinant adeno-associated virus vectors. J. Virol. 70, 3227-3234 (1996).
11. Muzyczka N. Use of adeno-associated virus as a general transduction vector for mammalian cells. Curr. Top. Microbiol. Immunol. 158, 97-129 (1992).
12. Summerford, C. & Samulski, R.J. Membrane-associated heparan sulfate proteoglycan is a receptor for adeno-associated virus type 2 virions. J. Virol. 72, 1438-1445 (1998).