Efficient transduction of green fluorescent protein in spinal cord neurons using adeno-associated virus vectors containing cell type-specific promoters

Gene Therapy

Volumn 4, Issue 1, 1997, Pages 16-24

  Peel, A L ^a,c   Zolotukhin, S ^b   Schrimsher, G W ^a   Muzyczka, N ^b   Reier, P J ^a  

^a UNIVERSITY OF FLORIDA COLLEGE OF MEDICINE   (United States)

^b UNIVERSITY OF FLORIDA   (United States)

^c College of Medicine ^*  (United States)

Author keywords

GFP; In vivo gene delivery; NSE promoter; PDGF promoter; Recombinant AAV

Indexed keywords

GREEN FLUORESCENT PROTEIN; NEURON SPECIFIC ENOLASE; PLATELET DERIVED GROWTH FACTOR; VIRUS VECTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CELL STRUCTURE; CELL TYPE; CONTROLLED STUDY; FEMALE; GENE EXPRESSION; GENE TARGETING; GENE THERAPY; GENETIC TRANSDUCTION; GLIA CELL; IMMUNOCYTOCHEMISTRY; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; RAT; SPINAL CORD; SPINAL CORD LESION; SPINAL CORD NERVE CELL; TRANSGENE; VIRUS RECOMBINANT;

ADENO-ASSOCIATED VIRUS; ADENOVIRIDAE; ANIMALIA;

EID: 0031014887     PISSN: 09697128     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.gt.3300358     Document Type: Article

References (39)

1. Miller DG, Adam MA, Miller AD Gene transfer by retrovirus vectors occurs only in cells that are actively replicating at the time of infection [published erratum appears in Mol Cell Biol 1992 Jan; 12(1): 433]. Mol Cell Biol 1990; 10: 4239-4242.
2. Karpati G, Lochmuller H, Nalbantoglu J, Durham H. The principles of gene therapy for the nervous system TINS 1996; 19: 49-54.
3. Naldini L et al. In vivo gene delivery and stable transduction of nondividing cells by a Jentiviral vector. Science 1996; 272: 263-267.
4. Davar G et al. Comparative efficacy of expression of genes delivered to mouse sensory neurons with herpes virus vectors. J Comp Neurol 1994; 339: 3-11.
5. During MJ, Naegele JR, O'Malley KL, Geller AI. Long-term behavioral recovery in Parkinsonian rats by an HSV vector expressing tyrosine hydroxylase. Science 1994; 266: 1399-1403.
6. Federoff HJ, Geschwind MD, Geller AI, Kassler JA. Expression of NGF in vivo, from a defective HSV-1 vector, prevents effects of axotomy on sympathetic neurons. Proc Natl Acad Sci USA 1992; 89: 1636-1640.
7. Freese A, Geller AI, Neve R. HSV-1 vector mediated neuronal gene transfer: strategies for molecular neuroscience and neurology. Biochem Pharma 1990; 40: 2189-2199.
8. Ho DY et al. Use of herpes simplex virus vectors for protection from neocrotic neuron death. In: Kaplitt MG (ed.). Viral Vectors. Academic Press: New York, 1993, pp 133-153.
9. Roemer K, Johnson PA, Friedmann T. Transduction of foreign regulatory sequences by a replication-defective herpes simplex virus type 1: the rat neuron-specific enolase promoter. Virus Res 1995; 35: 81-89.
10. Akli S et al. Transfer of a foreign gene into the brain using adenovirus vectors. Nat Genet 1993; 3: 224-228.
11. Davidson BL et al. A model system for in vivo gene transfer into the central nervous system using an adenoviral vector (see comments). Nat Genet 1993; 3: 219-223.
12. Ghadge GD et al. CNS gene delivery by retrograde transport of recombinant replication-defective adenoviruses. Gene Therapy 1995; 2: 132-137.
13. Ridoux V et al. Adenoviral vectors as functional retrograde neuronal tracers. Brain Res 1994; 648: 171-175.
14. Finiels F, Ribotta MGA, Barkats M, Samolyk ML. Specific and efficient gene transfer strategy offers new potentialities for the treatment of motor neuron diseases. NeuroReport 1996; 7: 373-378.
15. Byrnes AP, Wood MJA, Charlton HM. Role of T cells in inflammation caused by adenovirus vectors in the brain. Gene Therapy 1996; 3: 644-651.
16. Wood MJA et al. Inflammatory effects of gene transfer into the CNS with defective HSV-1 vectors. Gene Therapy 1994; 1: 283-291.
17. Ali M, Lemoine NR, Ring CJ. The use of DNA viruses as vectors for gene therapy. Gene Therapy 1994; 1: 367-384.
18. Peel AL et al. AAV vectors capable of cell type-specific transgene expression in the CNS and PNS. Soc Neurosci 1996; 22: (Abstr.).
19. Peel AL et al. Adeno-associated virus vectors facilitate neuron-specific expression of green fluorescent protein in the adult mammalian spinal cord. Neural Regen Conf 1995 (Abstr.).
20. Kaplitt MG et al. Long-term gene expression and phenotypic correction using adeno-associated virus vectors in the mammalian brain. Nat Genet 1994; 8: 148-154.
21. Afione SA et al. In vivo model of adeno-associated virus persistence and rescue. J Virol 1996; 70: 3235-3241.
22. Zolotukhin S, Hauswirth WW, Guy J, Muzyczka N. A 'humanized' green fluorescent protein cDNA adapted for high level expression in mammalian cells. J Virol 1996; 70: 4646-4654.
23. McCown TJ et al. Differential and persistent expression patterns of CNS gene transfer by an adeno-associated virus (AAV) vector. Brain Res 1996; 713: 99-107.
24. Muzyczka N. Use of adeno-associated virus as a general transduction vector for mammalian cells. Curr Top Microbiol Immunol 1992; 158: 97-129.
25. Freeman TB et al. Bilateral fetal nigral transplantation into the postcommissural putamen in Parkinson's disease. Ann Neurol 1995; 38: 379-388.
26. Baskar JF et al. The enhancer domain of the human cytomegalovirus major immediate-early promoter determines cell type-specific expression in transgenic mice. J Virol 1996; 70: 3207-3214.
27. Sakimura K, Kushiya E, Takahashi Y, Suzuki Y. The structure and expression of neuron-specific enolase gene. Proc Natl Acad Sci USA 1987; 60: 103-113.
28. Forss Petter S et al. Transgenic mice expressing β-galactosidase in mature neurons under neuron-specific enolase promoter control. Neuron 1990; 5: 187-197.
29. Andersen JK, Frim DM, Isacson O, Breakefield XO. Herpesvirus-mediated gene delivery into the rat brain: specificity and efficiency of the neuron-specific enolase promoter. Cell Mol Neurobiol 1993; 13: 503-515.
30. Games D et al. Alzheimer-type neuropathology in transgenic mice overexpressing V717F B-amyloid precursor protein. Nature 1995; 373: 523-527.
31. Sasahara M et al. PDGF B-chain in neurons of the central nervous System, posterior pituitary, and in a transgenic model. Cell 1991; 64: 217-227.
32. Russell DW, Alexander IE, Miller AD. DNA synthesis and topo-isomerase inhibitors increase transduction by adeno-associated virus vectors. Proc Natl Acad Sci USA 1995; 92: 5719-5723.
33. Alexander IE, Russell DW, Spence AM, Miller AD. Effects of gamma irradiation on the transduction of dividing and nondividing cells in brain and muscle of rats by adeno-associated virus vectors. Hum Gene Ther 1996; 7: 841-850.
34. Ferrari FK, Samulski T, Shenk T, Samulski RJ. Second-strand synthesis is a rate-limiting step for efficient transduction by recombinant adeno-associated virus vectors. J Virol 1996; 70: 3227-3234.
35. Lindvall O. Neural transplantation. Cell Transplant 1995; 4: 393-400.
36. Chalfie M et al. Green fluorescent protein as a marker for gene expression. Science 1994; 263: 802-805.
37. Breeze RE, Wells TH Jr, Freed CR. Implantation of fetal tissue for the management of Parkinson's disease: a technical note. Neurosurgery 1995; 36: 1044-1047.
38. Cormack BP, Valdivia RH, Falkow S. FACS-optimized mutants of the green fluorescent protein (GFP). Proc Natl Acad Sci USA 1996; 173: 33-38.
39. Levy JP, Muldoon RR, Zolotukhin S, Link CJ Jr. Retroviral transfer and expression of a humanized, red-shifted green fluorescent protein gene into human tumor cells. Nature Biotechnol 1996; 14: 610-614.