Attenuation of seizures and neuronal death by adeno-associated virus vector galanin expression and secretion

Nature Medicine

Volumn 9, Issue 8, 2003, Pages 1076-1080

  Haberman, Rebecca P ^a   Samulski, R Jude ^a   McCown, Thomas J ^a  

^a UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOVIRUS VECTOR; ANTISENSE OLIGONUCLEOTIDE; DOXYCYCLINE; EXCITATORY AMINO ACID RECEPTOR; FIBRONECTIN; GALANIN; GENE PRODUCT; KAINIC ACID; LENTIVIRUS VECTOR; MESSENGER RNA; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; NEUROPEPTIDE; PLASMID VECTOR; SIGNAL PEPTIDE; TETRACYCLINE;

ADENO ASSOCIATED VIRUS; AMINO ACID SEQUENCE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN CELL; BRAIN DEPTH STIMULATION; CELL DEATH; CONTROLLED STUDY; DRUG INFUSION; DRUG TARGETING; ELECTROENCEPHALOGRAM; ELECTROSTIMULATION; ENZYME LINKED IMMUNOSORBENT ASSAY; GENE CONSTRUCT; GENETIC CODE; GENETIC TRANSDUCTION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; INFERIOR COLLICULUS; MALE; MOLECULAR CLONING; MOLECULAR STABILITY; NERVE CELL NECROSIS; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN SECRETION; RAT; REGULATORY MECHANISM; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SEIZURE; SEIZURE SUSCEPTIBILITY; SEIZURE THRESHOLD; SIGNAL TRANSDUCTION; VIRAL GENE DELIVERY SYSTEM; VIRAL GENE THERAPY; VIRUS PARTICLE; WESTERN BLOTTING;

ANIMALS; CELL DEATH; DEPENDOVIRUS; ELECTROENCEPHALOGRAPHY; EXCITATORY AMINO ACID AGONISTS; GALANIN; GENE THERAPY; GENETIC VECTORS; GREEN FLUORESCENT PROTEINS; HELA CELLS; HIPPOCAMPUS; HUMANS; KAINIC ACID; LUMINESCENT PROTEINS; MALE; MICROINJECTIONS; NEURONS; RATS; RATS, SPRAGUE-DAWLEY; RECOMBINANT FUSION PROTEINS; SEIZURES;

ADENO-ASSOCIATED VIRUS; ADENOVIRIDAE; ANIMALIA; LENTIVIRUS;

EID: 0041464695     PISSN: 10788956     EISSN: None     Source Type: Journal    
DOI: 10.1038/nm901     Document Type: Article

References (26)

1. Kaplitt, M.G. et al. Long term gene expression and phenotypic correction using adeno-associated virus vectors in the mammalian brain. Nat. Genet. 8, 148-154 (1994).
2. McCown, T.J. et al. Differential and persistent expression patterns of CNS gene transfer by an adeno-associated virus (AAV) vector. Brain Res. 713, 99-107 (1996).
3. Naldini, L. et al. Efficient transfer, integration and sustained long-term expression of the transgene in adult rat brains injected with a lentiviral vector. Proc. Nat. Acad. Sci. USA 93, 11382-11388 (1996).
4. Haberman, R.P. et al. Therapeutic liabilities of in vivo viral vector tropism: adeno-associated virus (AAV) vectors, NMDAR 1 antisense and focal seizure sensitivity. Mol. Ther. 6, 495-500 (2002).
5. Mazarati, A.M. et al. Galanin modulation of seizures and seizure modulation of hippocampal galanin in animal models of status epilepticus. J. Neurosci. 18, 10070-10077 (1998).
6. Bartfai, T., Hokfelt, T. & Langel, U. Galanin - a neuroendocrine peptide. Crit. Rev. Neurobiol. 7, 229-274 (1993).
7. Hynes, R.O. Fibronectins. (Springer-Verlag, New York, 1990).
8. Kelly, R.B. Pathways of protein secretion in eukaryotes. Science 230, 25-32 (1985).
9. Schwarzbauer, J.E., Patel, R.S., Fonda, D. & Hynes, R.O. Multiple sites of alternative splicing of the rat fibronectin gene transcript. EMBO J. 6, 2573-2580 (1987).
10. Crawley, J.N. Galanin-acetylcholine interactions: relevance to memory and Alzheimer's disease. Life Sci. 58, 2185-2199 (1996).
11. Haberman, R.P., McCown, T.J. & Samulski, R.J. Inducible long-term gene expression in brain with adeno-associated virus gene transfer. Gene Ther. 5, 1604-1611 (1998).
12. McCown, T.J., Greenwood, R.S., Frye, G.D. & Breese, G.R. Electrically elicited seizures from the inferior colliculus: a potential site for the genesis of epilepsy? Exp. Neurol. 86, 527-542 (1984).
13. McCown, T.J., Duncan, G.E. & Breese, G.R. Neuroanatomical characterization of inferior collicular seizure genesis: 2-deoxyglucose and stimulation mapping. Brain Res. 567, 25-32 (1991).
14. Burazin, T.C.D., Larm, J.A., Ryan, M.C. & Gundlach, A.L. Galanin-R1 and -R2 receptor mRNA expression during the development of rat brain suggests differential subtype involvement in synaptic transmission and plasticity. Eur. J. Neurosci. 12, 2901-2917 (2000).
15. Baron, U. & Bujard, H. Tet repressor-based system for regulated gene expression in eukaryotic cells: principles and advances. Meth. Enzymol. 327, 401-421 (2000).
16. Nadler, J.V. Kainic acid as a tool for the study of temporal lobe epilepsy. Life Sci. 29, 2031-2042 (1981).
17. Buckmaster, P.S. & Dudek, F.E. Neuron loss, granule cell axon reorganization, and functional changes in the dentate gyrus of epileptic kainite-treated rats. J. Comp. Neurol. 385, 385-404 (1997).
18. Sarang, S.S. et al. Discovery of molecular mechanisms of neuroprotection using cell-based bioassays and oligonucleotide arrays. Physiol. Genomics 11, 45-52 (2002).
19. Ben-Ari, Y. Galanin and gilbenclamide modulate the anoxic release of glutamate in rat CA3 hippocampal neurons. Eur. J. Neurosci. 1, 62-68 (1990).
20. Huber, H. et al. Grafts of adenosine-releasing cells suppress seizures in kindling epilepsy. Proc. Nat. Acad. Sci. USA 98, 7611-7616 (2001).
21. Haberman, R.P., McCown, T.J. & Samulski, R.J. Novel transcriptional regulatory signals in the adeno-associated virus terminal repeat A/D junction element. J. Virol. 74, 8732-8739 (2000).
22. Xiao, X., Li, J. & Samulski, R.J. Production of high-titer recombinant adeno-associated virus vectors in the absence of helper adenovirus. J. Virol. 72, 2224-2232 (1998).
23. Zeng, G. Sticky-end PCR: a new method for subcloning. Biotechniques 25, 206-208 (1998).
24. Paxinos, G. & Watson, C. The Rat Brain in Stereotaxic Coordinates (Academic Press, San Diego, 1988).
25. Racine, R.J. Modification of seizure activity by electrical stimulation II. Motor seizure. Electroencephalogr. Clin. Neurophysiol. 32, 281-294 (1972).
26. A isoreceptors on individual neurons. Neuropharmacology 36, 1641-1652 (1998).