Neonatal intramuscular injection with recombinant adeno-associated virus results in prolonged β-glucuronidase expression in situ and correction of liver pathology in mucopolysaccharidosis type VII mice

Human Gene Therapy

Volumn 10, Issue 1, 1999, Pages 85-94

  Daly, Thomas M ^a   Okuyama, Torayuki ^a,b   Vogler, Carole ^c   Haskins, Mark E ^d   Muzyczka, Nicholas ^e   Sands, Mark S ^a  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b NATIONAL RESEARCH INSTITUTE FOR CHILD HEALTH AND DEVELOPMENT   (Japan)

^c SAINT LOUIS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d UNIVERSITY OF PENNSYLVANIA   (United States)

^e UNIVERSITY OF FLORIDA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BETA GLUCURONIDASE; COMPLEMENTARY DNA;

ADENO ASSOCIATED VIRUS; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; EXPRESSION VECTOR; GENE TRANSFER; LIVER; MOUSE; MUCOPOLYSACCHARIDOSIS TYPE 7; NEWBORN; NEWBORN PERIOD; NONHUMAN; PROTEIN EXPRESSION; QUADRICEPS FEMORIS MUSCLE; SPLEEN; VIRUS RECOMBINANT;

AGE FACTORS; ANIMALS; ANIMALS, NEWBORN; BETA-N-ACETYLHEXOSAMINIDASE; BLOTTING, SOUTHERN; DEPENDOVIRUS; GENE EXPRESSION REGULATION, ENZYMOLOGIC; GENE THERAPY; GENETIC VECTORS; GLUCURONIDASE; GLYCOSAMINOGLYCANS; HUMANS; INJECTIONS, INTRAMUSCULAR; LIVER; LYSOSOMES; MICE; MICE, MUTANT STRAINS; MUCOPOLYSACCHARIDOSIS VII; SPLEEN;

EID: 0032906299     PISSN: 10430342     EISSN: None     Source Type: Journal    
DOI: 10.1089/10430349950019219     Document Type: Article

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