메뉴 건너뛰기




Volumn 233, Issue 5, 2008, Pages 540-548

Zinc supplementation inhibits hepatic apoptosis in mice subjected to a long-term ethanol exposure

Author keywords

Alcoholic liver disease; Apoptosis; Death receptors; Oxidative stress; Zinc

Indexed keywords

ALCOHOL; CASPASE 3; CASPASE 8; CHEMOATTRACTANT; FAS ANTIGEN; FAS ASSOCIATED DEATH DOMAIN PROTEIN; FAS LIGAND; GLUTATHIONE; MESSENGER RNA; METALLOTHIONEIN; MONOCYTE CHEMOTACTIC PROTEIN 1; REACTIVE OXYGEN METABOLITE; TUMOR NECROSIS FACTOR ALPHA; TUMOR NECROSIS FACTOR RECEPTOR 1; ZINC;

EID: 43249086787     PISSN: 15353702     EISSN: 15353699     Source Type: Journal    
DOI: 10.3181/0710-RM-265     Document Type: Article
Times cited : (55)

References (52)
  • 5
    • 0035408265 scopus 로고    scopus 로고
    • Ethanol-induced apoptosis in mouse liver: Fas- and cytochrome c-mediated caspase-3 activation pathway
    • Zhou Z, Sun X, Kang YJ. Ethanol-induced apoptosis in mouse liver: Fas- and cytochrome c-mediated caspase-3 activation pathway. Am J Pathol 159:329-338, 2001.
    • (2001) Am J Pathol , vol.159 , pp. 329-338
    • Zhou, Z.1    Sun, X.2    Kang, Y.J.3
  • 6
    • 0038323922 scopus 로고    scopus 로고
    • Suppression of Fas-mediated signaling pathway is involved in zinc inhibition of ethanol-induced liver apoptosis
    • Lambert JC, Zhou Z, Kang YJ. Suppression of Fas-mediated signaling pathway is involved in zinc inhibition of ethanol-induced liver apoptosis. Exp Biol Med 228:406-412, 2003.
    • (2003) Exp Biol Med , vol.228 , pp. 406-412
    • Lambert, J.C.1    Zhou, Z.2    Kang, Y.J.3
  • 7
    • 21344458172 scopus 로고    scopus 로고
    • Apoptosis in alcoholic and nonalcoholic steatohepatitis
    • Feldstein AE, Gores GJ. Apoptosis in alcoholic and nonalcoholic steatohepatitis. Front Biosci 10:3093-3099, 2005.
    • (2005) Front Biosci , vol.10 , pp. 3093-3099
    • Feldstein, A.E.1    Gores, G.J.2
  • 8
    • 33644527617 scopus 로고    scopus 로고
    • Alcohol and oxidative liver injury
    • Dey A, Cederbaum AI. Alcohol and oxidative liver injury. Hepatology 43:S63-S74, 2006.
    • (2006) Hepatology , vol.43
    • Dey, A.1    Cederbaum, A.I.2
  • 9
    • 0031958219 scopus 로고    scopus 로고
    • Cytotoxicity and apoptosis produced by cytochrome P450 2E1 in HepG2 cells
    • Chen Q, Cederbaum AI. Cytotoxicity and apoptosis produced by cytochrome P450 2E1 in HepG2 cells. Mol Pharmacol 53:638-648, 1998.
    • (1998) Mol Pharmacol , vol.53 , pp. 638-648
    • Chen, Q.1    Cederbaum, A.I.2
  • 10
    • 0032904051 scopus 로고    scopus 로고
    • Ethanol-induced apoptosis to stable HepG2 cell lines expressing human cytochrome P-4502E1
    • Wu D, Cederbaum AI. Ethanol-induced apoptosis to stable HepG2 cell lines expressing human cytochrome P-4502E1. Alcohol Clin Exp Res 23:67-76, 1999.
    • (1999) Alcohol Clin Exp Res , vol.23 , pp. 67-76
    • Wu, D.1    Cederbaum, A.I.2
  • 13
    • 0037960128 scopus 로고    scopus 로고
    • Betaine decreases hyperhomocysteinemia, endoplasmic reticulum stress, and liver injury in alcohol-fed mice
    • Ji C, Kaplowitz N. Betaine decreases hyperhomocysteinemia, endoplasmic reticulum stress, and liver injury in alcohol-fed mice. Gastroenterology 124:1488-1499, 2003.
    • (2003) Gastroenterology , vol.124 , pp. 1488-1499
    • Ji, C.1    Kaplowitz, N.2
  • 14
    • 33847637127 scopus 로고    scopus 로고
    • Acute ethanol pretreatment increases FAS-mediated liver injury in mice: Role of oxidative stress and CYP2E1-dependent and -independent pathways
    • Wang X, Cederbaum AI. Acute ethanol pretreatment increases FAS-mediated liver injury in mice: role of oxidative stress and CYP2E1-dependent and -independent pathways. Free Radic Biol Med 42:971-984, 2007.
    • (2007) Free Radic Biol Med , vol.42 , pp. 971-984
    • Wang, X.1    Cederbaum, A.I.2
  • 16
    • 24044547078 scopus 로고    scopus 로고
    • Zinc prevention and treatment of alcoholic liver disease
    • Kang YJ, Zhou Z. Zinc prevention and treatment of alcoholic liver disease. Mol Aspects Med 26:391-404, 2005.
    • (2005) Mol Aspects Med , vol.26 , pp. 391-404
    • Kang, Y.J.1    Zhou, Z.2
  • 17
    • 19544364689 scopus 로고    scopus 로고
    • Zinc supplementation prevents alcoholic liver injury in mice through attenuation of oxidative stress
    • Zhou Z, Wang L, Song Z, Saari JT, McClain CJ, Kang YJ. Zinc supplementation prevents alcoholic liver injury in mice through attenuation of oxidative stress. Am J Pathol 166:1681-1690, 2005.
    • (2005) Am J Pathol , vol.166 , pp. 1681-1690
    • Zhou, Z.1    Wang, L.2    Song, Z.3    Saari, J.T.4    McClain, C.J.5    Kang, Y.J.6
  • 18
    • 0034653559 scopus 로고    scopus 로고
    • Apoptosis induced by chelation of intracellular zinc is associated with depletion of cellular reduced glutathione level in rat hepatocytes
    • Nakatani T, Tawaramoto M, Opare Kennedy D, Kojima A, Matsui-Yuasa I. Apoptosis induced by chelation of intracellular zinc is associated with depletion of cellular reduced glutathione level in rat hepatocytes. Chem Biol Interact 125:151-163, 2000.
    • (2000) Chem Biol Interact , vol.125 , pp. 151-163
    • Nakatani, T.1    Tawaramoto, M.2    Opare Kennedy, D.3    Kojima, A.4    Matsui-Yuasa, I.5
  • 19
    • 0034792801 scopus 로고    scopus 로고
    • Effects of intracellular zinc depletion on metallothionein and ZIP2 transporter expression and apoptosis
    • Cao J, Bobo JA, Liuzzi JP, Cousins RJ. Effects of intracellular zinc depletion on metallothionein and ZIP2 transporter expression and apoptosis. J Leukoc Biol 70:559-566, 2001.
    • (2001) J Leukoc Biol , vol.70 , pp. 559-566
    • Cao, J.1    Bobo, J.A.2    Liuzzi, J.P.3    Cousins, R.J.4
  • 20
    • 33644950641 scopus 로고    scopus 로고
    • Zinc modulates airway epithelium susceptibility to death receptor-mediated apoptosis
    • Bao S, Knoell DL. Zinc modulates airway epithelium susceptibility to death receptor-mediated apoptosis. Am J Physiol Lung Cell Mol Physiol 290:L433-L441, 2006.
    • (2006) Am J Physiol Lung Cell Mol Physiol , vol.290
    • Bao, S.1    Knoell, D.L.2
  • 21
    • 0033967061 scopus 로고    scopus 로고
    • Zinc protects against apoptosis of endothelial cells induced by linoleic acid and tumor necrosis factor alpha
    • Meerarani P, Ramadass P, Toborek M, Bauer HC, Bauer H, Hennig B. Zinc protects against apoptosis of endothelial cells induced by linoleic acid and tumor necrosis factor alpha. Am J Clin Nutr 71:81-87, 2000.
    • (2000) Am J Clin Nutr , vol.71 , pp. 81-87
    • Meerarani, P.1    Ramadass, P.2    Toborek, M.3    Bauer, H.C.4    Bauer, H.5    Hennig, B.6
  • 22
    • 34247611973 scopus 로고    scopus 로고
    • Preservation of hepatocyte nuclear factor-4alpha is associated with zinc protection against TNF-alpha hepatotoxicity in mice
    • Zhou Z, Kang X, Jiang Y, Song Z, Feng W, McClain CJ, Kang YJ. Preservation of hepatocyte nuclear factor-4alpha is associated with zinc protection against TNF-alpha hepatotoxicity in mice. Exp Biol Med 232:622-628, 2007.
    • (2007) Exp Biol Med , vol.232 , pp. 622-628
    • Zhou, Z.1    Kang, X.2    Jiang, Y.3    Song, Z.4    Feng, W.5    McClain, C.J.6    Kang, Y.J.7
  • 23
    • 0001062124 scopus 로고
    • Glutamate-oxaloacetate transaminase: Colorimetric assay of Reitman and Frankel
    • Bergmeyer HU Ed, 2nd ed, New York: Academic Press
    • Bergmeyer HU, Bernt E. Glutamate-oxaloacetate transaminase: Colorimetric assay of Reitman and Frankel. In: Bergmeyer HU Ed. Methods of Enzymatic Analysis (2nd ed). New York: Academic Press, Vol 2: pp760-764, 1974.
    • (1974) Methods of Enzymatic Analysis , vol.2 , pp. 760-764
    • Bergmeyer, H.U.1    Bernt, E.2
  • 24
    • 0026336011 scopus 로고
    • Determination of metallothionein in tissues by cadmium-hemoglobin affinity assay
    • Eaton DL, Cherian MG. Determination of metallothionein in tissues by cadmium-hemoglobin affinity assay. Methods Enzymol 205:83-88, 1991.
    • (1991) Methods Enzymol , vol.205 , pp. 83-88
    • Eaton, D.L.1    Cherian, M.G.2
  • 25
    • 0028868238 scopus 로고
    • S-adenosyl-L-methionine prevents both ethanol-induced depletion of mitochondrial glutathione and mitochondrial dysfunction in periportal and perivenous rat hepatocytes
    • Fermandez-Checa JC, Morales A, Colell A, Bellesta A, Rodes J, Kaplowitz N. S-adenosyl-L-methionine prevents both ethanol-induced depletion of mitochondrial glutathione and mitochondrial dysfunction in periportal and perivenous rat hepatocytes. Hepatology 21:207-214, 1995.
    • (1995) Hepatology , vol.21 , pp. 207-214
    • Fermandez-Checa, J.C.1    Morales, A.2    Colell, A.3    Bellesta, A.4    Rodes, J.5    Kaplowitz, N.6
  • 27
    • 0027533507 scopus 로고
    • Oxygen free radicals and metallothionein
    • Sato M, Bremner I. Oxygen free radicals and metallothionein. Free Radical Biol Med 14:325-337, 1993.
    • (1993) Free Radical Biol Med , vol.14 , pp. 325-337
    • Sato, M.1    Bremner, I.2
  • 28
    • 0032756355 scopus 로고    scopus 로고
    • The antioxidant function of metallothionein in the heart
    • Kang YJ. The antioxidant function of metallothionein in the heart. Proc Soc Exp Biol Med 222:263-273, 1999.
    • (1999) Proc Soc Exp Biol Med , vol.222 , pp. 263-273
    • Kang, Y.J.1
  • 29
    • 0021944046 scopus 로고
    • Possible role for metallothionein in protection against radiation-induced oxidative stress. Kinetics and mechanism of its reaction with superoxide and hydroxyl radicals
    • Thornalley PJ, Vasak M. Possible role for metallothionein in protection against radiation-induced oxidative stress. Kinetics and mechanism of its reaction with superoxide and hydroxyl radicals. Biochim Biophys Acta 827:36-44, 1985.
    • (1985) Biochim Biophys Acta , vol.827 , pp. 36-44
    • Thornalley, P.J.1    Vasak, M.2
  • 30
    • 0024523351 scopus 로고
    • Inhibition of hydroxyl-radical-generated DNA degradation by metallothionein
    • Abel J, de Ruiter N. Inhibition of hydroxyl-radical-generated DNA degradation by metallothionein. Toxicol Lett 47:191-196, 1989.
    • (1989) Toxicol Lett , vol.47 , pp. 191-196
    • Abel, J.1    de Ruiter, N.2
  • 31
    • 0036521544 scopus 로고    scopus 로고
    • Metallothionein protection against alcoholic liver injury through inhibition of oxidative stress
    • Zhou Z, Sun X, Kang YJ. Metallothionein protection against alcoholic liver injury through inhibition of oxidative stress. Exp Biol Med 227:214-222, 2002.
    • (2002) Exp Biol Med , vol.227 , pp. 214-222
    • Zhou, Z.1    Sun, X.2    Kang, Y.J.3
  • 32
    • 0036083963 scopus 로고    scopus 로고
    • Metallothionein-independent zinc protection from alcoholic liver injury
    • Zhou Z, Sun X, Lambert JC, Saari JT, Kang YJ. Metallothionein-independent zinc protection from alcoholic liver injury. Am J Pathol 160:2267-2274, 2002.
    • (2002) Am J Pathol , vol.160 , pp. 2267-2274
    • Zhou, Z.1    Sun, X.2    Lambert, J.C.3    Saari, J.T.4    Kang, Y.J.5
  • 35
    • 4444230118 scopus 로고    scopus 로고
    • Ethanol increases tumor necrosis factor-alpha receptor-1 (TNF-R1) levels in hepatic, intestinal, and cardiac cells
    • Rodriguez DA, Moncada C, Nunez MT, Lavandero S, Ponnappa BC, Israel Y. Ethanol increases tumor necrosis factor-alpha receptor-1 (TNF-R1) levels in hepatic, intestinal, and cardiac cells. Alcohol 33:9-15, 2004.
    • (2004) Alcohol , vol.33 , pp. 9-15
    • Rodriguez, D.A.1    Moncada, C.2    Nunez, M.T.3    Lavandero, S.4    Ponnappa, B.C.5    Israel, Y.6
  • 36
    • 0035028779 scopus 로고    scopus 로고
    • Possible involvement of reactive oxygen species in D-galactosamine-induced sensitization against tumor necrosis factor-alpha-induced hepatocyte apoptosis
    • Osawa Y, Nagaki M, Banno Y, Yamada Y, Imose M, Nozawa Y, Moriwaki H, Nakashima S. Possible involvement of reactive oxygen species in D-galactosamine-induced sensitization against tumor necrosis factor-alpha-induced hepatocyte apoptosis. J Cell Physiol 187:374-385, 2001.
    • (2001) J Cell Physiol , vol.187 , pp. 374-385
    • Osawa, Y.1    Nagaki, M.2    Banno, Y.3    Yamada, Y.4    Imose, M.5    Nozawa, Y.6    Moriwaki, H.7    Nakashima, S.8
  • 37
    • 4644248469 scopus 로고    scopus 로고
    • S-adenosylhomocysteine sensitizes to TNF-alpha hepatotoxicity in mice and liver cells: A possible etiological factor in alcoholic liver disease
    • Song Z, Zhou Z, Uriarte S, Wang L, Kang YJ, Chen T, Barve S, McClain CJ. S-adenosylhomocysteine sensitizes to TNF-alpha hepatotoxicity in mice and liver cells: a possible etiological factor in alcoholic liver disease. Hepatology 40:989-997, 2004.
    • (2004) Hepatology , vol.40 , pp. 989-997
    • Song, Z.1    Zhou, Z.2    Uriarte, S.3    Wang, L.4    Kang, Y.J.5    Chen, T.6    Barve, S.7    McClain, C.J.8
  • 38
    • 34250782784 scopus 로고    scopus 로고
    • Alcohol-induced S-adenosylhomocysteine accumulation in the liver sensitizes to TNF hepatotoxicity: Possible involvement of mitochondrial S-adenosylmethionine transport
    • Song Z, Zhou Z, Song M, Uriarte S, Chen T, Deaciuc I, McClain CJ. Alcohol-induced S-adenosylhomocysteine accumulation in the liver sensitizes to TNF hepatotoxicity: possible involvement of mitochondrial S-adenosylmethionine transport. Biochem Pharmacol 74:521-531, 2007.
    • (2007) Biochem Pharmacol , vol.74 , pp. 521-531
    • Song, Z.1    Zhou, Z.2    Song, M.3    Uriarte, S.4    Chen, T.5    Deaciuc, I.6    McClain, C.J.7
  • 39
    • 34247611973 scopus 로고    scopus 로고
    • Preservation of hepatocyte nuclear factor-4alpha is associated with zinc protection against TNF-alpha hepatotoxicity in mice
    • Zhou Z, Kang X, Jiang Y, Song Z, Feng W, McClain CJ, Kang YJ. Preservation of hepatocyte nuclear factor-4alpha is associated with zinc protection against TNF-alpha hepatotoxicity in mice. Exp Biol Med 232:622-628, 2007.
    • (2007) Exp Biol Med , vol.232 , pp. 622-628
    • Zhou, Z.1    Kang, X.2    Jiang, Y.3    Song, Z.4    Feng, W.5    McClain, C.J.6    Kang, Y.J.7
  • 42
    • 33750283354 scopus 로고    scopus 로고
    • Ethanol-induced apoptosis in polarized hepatic cells possibly through regulation of the Fas pathway
    • McVicker BL, Tuma DJ, Kubik JL, Tuma PL, Casey CA. Ethanol-induced apoptosis in polarized hepatic cells possibly through regulation of the Fas pathway. Alcohol Clin Exp Res 30:1906-1915, 2006.
    • (2006) Alcohol Clin Exp Res , vol.30 , pp. 1906-1915
    • McVicker, B.L.1    Tuma, D.J.2    Kubik, J.L.3    Tuma, P.L.4    Casey, C.A.5
  • 43
    • 33847637127 scopus 로고    scopus 로고
    • Acute ethanol pretreatment increases FAS-mediated liver injury in mice: Role of oxidative stress and CYP2E1-dependent and -independent pathways
    • Wang X, Cederbaum AI. Acute ethanol pretreatment increases FAS-mediated liver injury in mice: role of oxidative stress and CYP2E1-dependent and -independent pathways. Free Radic Biol Med 42:971-984, 2007.
    • (2007) Free Radic Biol Med , vol.42 , pp. 971-984
    • Wang, X.1    Cederbaum, A.I.2
  • 44
    • 0038647789 scopus 로고    scopus 로고
    • Dilinoleoylphosphatidylcholine reproduces the antiapoptotic actions of polyenylphosphatidylcholine against ethanol-induced hepatocyte apoptosis
    • Mak KM, Wen K, Ren C, Lieber CS. Dilinoleoylphosphatidylcholine reproduces the antiapoptotic actions of polyenylphosphatidylcholine against ethanol-induced hepatocyte apoptosis. Alcohol Clin Exp Res 27:997-1005, 2003.
    • (2003) Alcohol Clin Exp Res , vol.27 , pp. 997-1005
    • Mak, K.M.1    Wen, K.2    Ren, C.3    Lieber, C.S.4
  • 45
    • 0034092622 scopus 로고    scopus 로고
    • Attenuation of alcohol-induced apoptosis of hepatocytes in rat livers by polyenylphosphatidylcholine (PPC)
    • Katz GG, Shear NH, Malkiewicz IM, Valentino K, Neuman MG. Attenuation of alcohol-induced apoptosis of hepatocytes in rat livers by polyenylphosphatidylcholine (PPC). Alcohol Clin Exp Res 24:207-212, 2000.
    • (2000) Alcohol Clin Exp Res , vol.24 , pp. 207-212
    • Katz, G.G.1    Shear, N.H.2    Malkiewicz, I.M.3    Valentino, K.4    Neuman, M.G.5
  • 46
    • 0043166952 scopus 로고    scopus 로고
    • Lycopene attenuates alcoholic apoptosis in HepG2 cells expressing CYP2E1
    • Xu Y, Leo MA, Lieber CS. Lycopene attenuates alcoholic apoptosis in HepG2 cells expressing CYP2E1. Biochem Biophys Res Commun 308:614-618, 2003.
    • (2003) Biochem Biophys Res Commun , vol.308 , pp. 614-618
    • Xu, Y.1    Leo, M.A.2    Lieber, C.S.3
  • 47
    • 18144417465 scopus 로고    scopus 로고
    • DLPC attenuates alcohol-induced cytotoxicity in HepG2 cells expressing CYP2E1
    • Xu Y, Leo MA, Lieber CS. DLPC attenuates alcohol-induced cytotoxicity in HepG2 cells expressing CYP2E1. Alcohol Alcohol 40:172-175, 2005.
    • (2005) Alcohol Alcohol , vol.40 , pp. 172-175
    • Xu, Y.1    Leo, M.A.2    Lieber, C.S.3
  • 49
    • 0042920699 scopus 로고    scopus 로고
    • Betaine lowers elevated s-adenosylhomocysteine levels in hepatocytes from ethanol-fed rats
    • Barak AJ, Beckenhauer HC, Mailliard ME, Kharbanda KK, Tuma DJ. Betaine lowers elevated s-adenosylhomocysteine levels in hepatocytes from ethanol-fed rats. J Nutr 133:2845-2848, 2003.
    • (2003) J Nutr , vol.133 , pp. 2845-2848
    • Barak, A.J.1    Beckenhauer, H.C.2    Mailliard, M.E.3    Kharbanda, K.K.4    Tuma, D.J.5
  • 50
    • 34447259792 scopus 로고    scopus 로고
    • Purohit V, Abdelmalek MF, Barve S, Benevenga NJ, Halsted CH, Kaplowitz N, Kharbanda KK, Liu QY, Lu SC, McClain CJ, Swanson C, Zakhari S. Role of S-adenosylmethionine, folate, and betaine in the treatment of alcoholic liver disease: summary of a symposium. Am J Clin Nutr 86:14-24, 2007.
    • Purohit V, Abdelmalek MF, Barve S, Benevenga NJ, Halsted CH, Kaplowitz N, Kharbanda KK, Liu QY, Lu SC, McClain CJ, Swanson C, Zakhari S. Role of S-adenosylmethionine, folate, and betaine in the treatment of alcoholic liver disease: summary of a symposium. Am J Clin Nutr 86:14-24, 2007.
  • 52
    • 0033166152 scopus 로고    scopus 로고
    • Nutritional and metabolic effects of alcoholism: Their relationship with alcoholic liver disease
    • Bunout D. Nutritional and metabolic effects of alcoholism: their relationship with alcoholic liver disease. Nutrition 15:583-589, 1999.
    • (1999) Nutrition , vol.15 , pp. 583-589
    • Bunout, D.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.