Attenuation of alcohol-induced apoptosis of hepatocytes in rat livers by polyenylphosphatidylcholine (PPC)

Alcoholism: Clinical and Experimental Research

Volumn 24, Issue 2, 2000, Pages 207-212

  Mi, Li Jun ^b   Mak, Ki M ^b   Lieber, Charles S ^a  

^a VETERANS AFFAIRS MEDICAL CENTER   (United States)

^b NONE

Author keywords

Alcohol; Apoptosis; Cytochrome P 4502E1(CYP2E1); Hepatocytes; Polyenylphosphatidylcholine (PPC)

Indexed keywords

ALCOHOL; FREE RADICAL; LINOLEIC ACID; PHOSPHATIDYLCHOLINE;

ALCOHOL CONSUMPTION; ALCOHOL METABOLISM; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIOXIDANT ACTIVITY; APOPTOSIS; ARTICLE; CHROMATIN; INCIDENCE; LIPID PEROXIDATION; LIVER CELL; LIVER INJURY; MALE; MICROSCOPY; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; RAT; SOYBEAN;

EID: 0034092622     PISSN: 01456008     EISSN: None     Source Type: Journal    
DOI: 10.1097/00000374-200002000-00011     Document Type: Article

References (45)

1. Aleynik MK Leo MA, Aleynik SI, Lieber CS (1999) Polyenylphosphatidylcholine opposes the increase of cytochrome P-4502E1 by ethanol and corrects its iron-induced decrease. Alcohol Clin Exp Res 23:96-100.
2. Aleynik SI, Leo MA, Ma X, Aleynik MK, Lieber CS (1997) Polyenylphosphatidylcholine prevents carbon tetrachloride-induced lipid peroxidation while it attenuates liver fibrosis. J Hepatol 27:554-561.
3. Arai M, Gordon ER, Lieber CS (1984a) Decreased cytochrome oxidase activity in hepatic mitochondria after chronic ethanol consumption and the possible role of decreased cytochrome aa3 content and changes in phospholipids. Biochim Biophys Acta 797:320-327.
4. Arai M, Leo MA, Nakano M, Gorden ER, Lieber CS (1984b) Biochemical and morphological alteration of baboon hepatic mitochondria after chronic ethanol consumption. Hepatology 4:165-174.
5. Ashkenazi A, Dixit VM (1998) Death receptors: Signaling and modulation. Science (Wash. DC) 281:1305-1308.
6. Benedetti A, Brunelli E, Risicato R, Cilluffo T, Jezequel AM, Orlandi F (1988) Subcellular changes and apoptosis induced by ethanol in rat liver. J Hepatol 6:137-143.
7. Chen Q, Cederbaum AI (1998) Cytotoxicity and apoptosis produced by cytochrome P450 2E1 in Hep G2 cells. Mol Pharmacol 53:638-648.
8. Cohen PA, Mak KM, Rosman AS, Kessova I, Mishin VM, Koivisto T, Lieber CS (1997) Immunohistochemical determination of hepatic cytochrome P-4502E1 in formalin-fixed, paraffin-embedded sections. Alcohol Clin Exp Res 21:1057-1062.
9. Deaciuc IV, D'Souza NB, Spitzer JJ (1995) Tumor necrosis factor-α cell surface receptors of liver parenchymal and nonparenchymal cells during acute and chronic alcohol administration to rats. Alcohol Clin Exp Res 19:332-338.
10. Deaciuc IV, Fortunato F, D'Souza NB, Hill DB, Schmidt J, Lee EY, McClain CJ (1999) Modulation of caspase-3 activity and Fas ligand mRNA expression in rat liver cells in vivo by alcohol and lipopolysaccharide. Alcohol Clin Exp Res 23:349-356.
11. Diehl AM (1999) Cytokines and the molecular mechanisms of alcoholic liver disease. Alcohol Clin Exp Res 9:1419-1424.
12. Gavrieli Y, Sherman Y, Ben-Sasson SA (1992) Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation. J Cell Biol 119:493-501.
13. Goldin RD, Hunt NC, Clark J, Wickramasinghe SN (1993) Apoptotic bodies in a murine model of alcoholic liver disease: Reversibility of ethanol-induced changes. J Pathol 171:73-76.
14. Gorczyca W, Gong JP, Darzynkiewicz Z (1993) Detection of DNA strand breaks in individual apoptotic cells by the in situ terminal deoxynucleotidyl transferase and nick translation assays. Cancer Res 53:1945-1951.
15. Grasl-Kraupp B, Ruttkay-Nedecky B, Koudelka H, Bukowska K, Bursch W, Schulte-Hermann R (1995) In situ detection of fragmented DNA (TUNEL assay) fails to discriminate among apoptosis, necrosis, and autolytic cell death: A cautionary note. Hepatology 21:1465-1468.
16. Green R, Reed JC (1998) Mitochondria and apoptosis. Science (Wash. DC) 281:1309-1312.
17. Halsted CH, Villanueva J, Chandler CJ, Stabler SP, Allen RH, Muskhelishvili L, James SJ, Poirer L (1996) Ethanol feeding of micropigs alters methionine metabolism and increases hepatocellular apoptosis and proliferation. Hepatology 23:497-505.
18. Hamada E, Nishida T, Uchiyama Y, Nakamura J, Isahara K, Kauzu H, Huang T, Momoi T, Ito T, Matsuda H (1999) Activation of Kupffer cells and caspase-3 involved in rat hepatocyte apoptosis induced by endotoxin. J Hepatol 30:807-818.
19. Iseri OA, Lieber CS, Gottlieb LS (1966) The ultrastructure of fatty liver induced by prolonged ethanol ingestion. Am J Pathol 48:535-555.
20. Junge J, Horn T, Christoffersen P (1987) Megamitochondria as a diagnostic marker of alcohol-induced centrilobular and periportal fibrosis of the liver. Virchows Arch A 410:553-558.
21. Kerr JFR, Wyllie AH, Currie AR (1972) Apoptosis: A basic biological phenomenon with wide-ranging implications in tissue kinetics. Br J Cancer 26:239-257.
22. Kessova IG, DeCarli LM, Lieber CS (1998) Inducibility of cytochromes P-4502E1 and P4501A1 in the rat pancreas. Alcohol Clin Exp Res 22:501-504.
23. Kurose I, Higuchi H, Miura S, Saito H, Watanabe N, Hokari R, Hirokawa M, Takaishi M, Zeki S, Nakamura T, Ebinuma H, Kato S, Ishii H (1997) Oxidative stress-mediated apoptosis of hepatocytes exposed to acute ethanol intoxication. Hepatology 25:368-378.
24. Labat-Moleur F, Guillemet C, Lorimier P, Robert C, Lantuejoul S, Brambilla E, Negoescu A (1998) TUNEL apoptotic cell detection in tissue sections: Critical evaluation and improvement. J Histochem Cytochem 46:327-334.
25. Leist M, Gantner F, Bohlinger I, Tiegs G, Germann PG, Wendel A (1995) Tumor necrosis factor-induced hepatocyte apoptosis precedes liver failure in experimental murine shock models. Am J Pathol 146:1220-1234.
26. Lieber CS (1997) Role of oxidative stress and antioxidant therapy in alcoholic and nonalcoholic liver disease. Adv Pharm 38:601-628.
27. Lieber CS, DeCarli LM (1994) Animal models of chronic ethanol toxicity. Methods Enzymol 233:585-593.
28. Lieber CS, Leo MA, Aleynik SI, Aleynik MK, DeCarli LM (1997) Polyenylphosphatidylcholine decreases alcohol-induced oxidative stress in the baboon. Alcohol Clin Exp Res 21:375-379.
29. Muskhelishvili L, Hart RW, Turturro A, James SJ (1995) Age-related changes in the intrinsic rate of apoptosis in livers of diet-restricted and ad libitum-fed B6C3F1 mice. Am J Pathol 147:20-24.
30. Nanji AA (1998) Apoptosis and alcoholic liver disease. Semin Liver Dis 18:187-190.
31. Navder KP, Baraona E, Lieber CS (1997) Polyenylphosphatidylcholine attenuates alcohol-induced fatty liver and hyperlipemia in rats. Nutr Metab 127:1800-1806.
32. Oneta CM, Mak KM, Lieber CS (1999) Dilinoleoylphosphatidylcholine selectively modulates lipopolysaccharide-induced Kupffer cell activation. J Lab Clin Med 134:466-470.
33. Rodrigues CMP, Fan GS, Ma XM, Kren BT, Steer CJ (1998) A novel role for ursodeoxycholic acid in inhibiting apoptosis by modulating mitochondrial membrane perturbation. J Clin Invest 101:2790-2799.
34. Slater AFG, Stefan C, Nobel I, van den Dobbelsteen DJ, Orrenius S (1995) Signalling mechanisms and oxidative stress in apoptosis. Toxicol Lett 82/83:149-153.
35. Slomiany A, Piotrowski E, Grabska M, Piotrowski J, Slomiany BL (1999) Chronic ethanol-initiated apoptosis in hepatocytes is induced by changes in membrane biogenesis and intracellular transport. Alcohol Clin Exp Res 23:334-343.
36. Steller H (1995) Mechanisms and genes of cellular suicide. Science (Wash. DC) 267:1445-1449.
37. Svegliati-Baroni G, Marucci L, Benedetti A, Mancini R, Jezequel A-M, Orlandi F (1994) Chronic ethanol feeding increases apoptosis and cell proliferation in rat liver. J Hepatol 20:508-513.
38. Thompson CB (1995) Apoptosis in the pathogenesis and treatment of diseases. Science (Wash. DC) 267:1456-1462.
39. Thornberry NA, Lazebnik Y (1998) Caspases: Enemies within. Science (Wash. DC) 281:1312-1316.
40. Tsutsumi M, Lasker JM, Shimizu M, Rosman AS, Lieber CS (1989) The intralobular distribution of ethanol-inducible P450IIE1 in rat and human liver. Hepatology 10:437-446.
41. Wallace DC (1999) Mitochondrial diseases in man and mouse. Science (Wash. DC) 283:1482-1488.
42. Wu D, Cederbaum AI (1999) Ethanol-induced apoptosis to stable HepG2 cell lines expressing human cytochrome P-4502E1. Alcohol Clin Exp Res 23:67-76.
43. Wyllie AH, Kerr JFR, Currie AR (1980) Cell death: The significance of apoptosis. Int Rev Cytol 68:251-306.
44. Yacoub LK, Fogt F, Griniuviene B, Nanji AA (1995) Apoptosis and Bcl-2 protein expression in experimental alcoholic liver disease in the rat. Alcohol Clin Exp Res 19:854-859.
45. Zhao M, Laissue JA, Zimmermann A (1997) TUNEL-positive hepatocytes in alcoholic liver disease - A retrospective biopsy study using DNA nick end-labelling. Virchows Arch A 431:337-344.