Suppression of Fas-mediated signaling pathway is involved in zinc inhibition of ethanol-induced liver apoptosis

Experimental Biology and Medicine

Volumn 228, Issue 4, 2003, Pages 406-412

  Lambert, Jason C ^a   Zhou, Zhanxiang ^a   Kang, Y James ^a,b  

^a University of Louisville School of Medicine   (United States)

^b UNIVERSITY OF LOUISVILLE   (United States)

Author keywords

Acute ethanol; Caspase 3; Fas Apo 1; Programmed cell death; Zinc

Indexed keywords

ALCOHOL; CASPASE 3; FAS ANTIGEN; FAS LIGAND; ZINC; ZINC SULFATE; CASP3 PROTEIN, MOUSE; CASPASE;

ALCOHOL CONSUMPTION; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL DEATH; CELL PROTECTION; CONTROLLED STUDY; ELECTRON MICROSCOPY; ENZYME REPRESSION; IMMUNOHISTOCHEMISTRY; LIVER PROTECTION; MALE; MOUSE; NICK END LABELING; NONHUMAN; ANIMAL; DRUG ANTAGONISM; DRUG EFFECT; ENZYME ACTIVATION; ENZYME IMMUNOASSAY; ENZYMOLOGY; LIVER; METABOLISM; PATHOLOGY; PHYSIOLOGY; SIGNAL TRANSDUCTION; ULTRASTRUCTURE;

ANIMALIA;

ANIMALS; ANTIGENS, CD95; APOPTOSIS; CASPASE 3; CASPASES; ENZYME ACTIVATION; ETHANOL; IMMUNOENZYME TECHNIQUES; IN SITU NICK-END LABELING; LIVER; MALE; MICE; MICROSCOPY, ELECTRON; SIGNAL TRANSDUCTION; ZINC;

EID: 0038323922     PISSN: 15353702     EISSN: None     Source Type: Journal    
DOI: 10.1177/153537020322800411     Document Type: Article

References (50)

1. Ishak KG, Walker DH, Coetzer JAW, Gardner JJ, Gorelkin L. Viral hemorrhagic fevers with hepatic involvement: pathologic aspects with clinical correlations. In: Popper H, Schaffner F, Eds. Progress in Liver Diseases. New York: Grune and Stratton, pp495-515, 1982.
2. Baroni GS, Marucci L, Benedetti A, Mancini R, Jezequel AM, Orlandi F. Chronic ethanol feeding increases apoptosis and cell proliferation in rat liver. J Hepatol 20:508-513, 1994.
3. Benedetti A, Jezequel AM, Orlandi F. A quantitative evaluation of apoptotic bodies in rat liver. Liver 8:172-177, 1988.
4. Dienes HP, Popper H, Arnold W, Lobeck H. Histologic observations in human hepatitis non-A, non-B. Hepatology 2:562-571, 1982.
5. Goldin RD, Hunt NC, Clark J, Wickramasinghe SN. Apoptotic bodies in a murine model of alcoholic liver disease: reversibility of ethanol-induced changes. J Pathol 171:73-76, 1993.
6. Snover DC, Sibley RK, Freese DK, Sharp HL, Bloomer JR, Najarian JS, Ascher NL. Orthotopic liver transplantation: a pathological study of 63 serial liver biopsies from 17 patients with special reference to the diagnostic features and natural history of rejection. Hepatology 4:1212-1222, 1984.
7. Zhou Z, Sun X, Kang YJ. Ethanol-induced apoptosis in mouse liver: Fas and cytochrome c-mediated caspase-3 activation pathway. Am J Pathol 159:329-338, 2001.
8. Kawahara H, Matsuda Y, Takase S. Is apoptosis involved in alcoholic hepatitis? Alcohol 29(Suppl 1):113-118, 1994.
9. French SW, Nash J, Shitabata P, Kachi K, Hara C, Chedid A, Mendenhall CL. Pathology of alcoholic liver disease. VA cooperative study group 119. Sem Liver Dis 13:154-169, 1993.
10. Yacoub LK, Fogt F, Nanji AA. Apoptosis and Bcl-2 expression in experimental alcoholic liver disease in the rat. Alcohol Clin Exp Res 19:854-859, 1995.
11. Neuman MG, Brenner DA, Rehermann B, Taieb J, Chollet-Martin S, Cohard M, Garaud JJ, Poynard T, Katz GG, Cameron RG, Shear NH, Gao B, Takamatsu M, Yamauchi M, Ohata M, Saito S, Maeyama S, Uchikoshi T, Toda G, Kumagi T, Akbar SM, Abe M, Michitaka K, Horiike N, Onji M. Mechanisms of alcoholic liver disease: cytokines. Alcohol Clin Exp Res 25(Suppl):251S-253S, 2001.
12. Galle PR, Hofmann WJ, Walczak H, Schaller H, Otto G, Stremmel W, Krammer PH, Runkel L. Involvement of the CD95 (APO-1/Fas) receptor and ligand in liver damage. J Exp Med 182:1223-1230, 1995.
13. Kurose I, Higuchi H, Miura S, Saito H, Watanabe N, Hokari R, Hirokawa M, Takaishi M, Zeki S, Nakamura T, Ebinuma H, Kato S, Ishii H. Oxidative stress-mediated apoptosis of hepatocytes exposed to acute ethanol intoxication. Hepatology 25:368-378, 1997.
14. Deaciuc IV, D'Souza NB, Spitzer JJ. Tumor necrosis factor-α cell-surface receptors of liver parenchymal and nonparenchymal cells during acute and chronic alcohol administration to rats. Alcohol Clin Exp Res 19:332-338, 1995.
15. Ogasawara J, Watanabe-Fukunaga R, Adachi M, Matsuzawa A, Kasugai T, Kitamura Y, Itoh N, Suda T, Nagata S. Lethal effect of the anti-Fas antibody in mice. Nature 364:806-809, 1993.
16. Deaciuc IV, Fortunato F, D'Souza NB, Hill DB, Schmidt J, Lee EY, McClain CJ. Modulation of caspase-3 activity and Fas ligand mRNA expression in rat liver cells in vivo by alcohol and lipopolysaccharide. Alcohol Clin Exp Res 23:349-356, 1999.
17. Thornberry NA, Lazebnik Y. Caspases: enemies within. Science 281:1312-1316, 1998.
18. Chandler JM, Cohen GM, MacFarlane M. Different subcellular distribution of caspase-3 and caspase-7 following Fas-induced apoptosis in mouse liver. J Biol Chem 273:10815-10818, 1998.
19. Cursio R, Gugenheim J, Ricci JE, Crenesse D, Rostagno P, Maulon L, Saint-Paul MC, Ferrua B, Auberger AP. A caspase inhibitor fully protects rats against lethal normothermic liver ischemia by inhibition of liver apoptosis. FASEB J 13:253-261, 1999.
20. Sun X-M, MacFarlane M, Zhuang J, Wolf BB, Green DR, Cohen GM. Distinct caspase cascades are initiated in receptor-mediated and chemical-induced apoptosis. J Biol Chem 274:5053-5060, 1999.
21. Deaciuc IV, D'Souza NB, de Villiers WJS, Burikhanov R, Sarphie TG, Hill DB, McClain CJ. Inhibition of caspases in vivo protects the rat liver against alcohol-induced sensitization to bacterial lipopolysaccharide. Alcohol Clin Exp Res 25:935-943, 2001.
22. Scaffidi C, Schmitz I, Zha J, Korsmeyer SJ, Krammer PH, Peter ME. Differential modulation of apoptosis sensitivity in CD95 type I and type II cells. J Biol Chem 274:22532-22538, 1999.
23. Powell SR. The antioxidant properties of zinc. J Nutr 130(5S Suppl):1447S-1454S, 2000.
24. Truong-Tran AQ, Ho LH, Chai F, Zalewski PD. Cellular zinc fluxes and the regulation of apoptosis/gene-directed cell death. J Nutr 130(5S Suppl):1459S-1466S, 2000.
25. Cohen JJ, Duke RC. Glucocorticoid activation of a calcium-dependent endonuclease in thymocyte nuclei leads to cell death. J Immunol 132:38-42, 1984.
26. Aiuchi T, Mihara S, Nakaya M, Masuda Y, Nakajo S, Nakaya K. Zinc ions prevent processing of caspase-3 during apoptosis induced by geranylgeraniol in HL-60 cells. J Biochem 124:300-303, 1998.
27. Lambert JC, Zhou Z, Kang YJ. Zinc inhibition of caspase-3 activation does not protect HeLa cells from apoptotic cell death. Toxicol Appl Pharmacol 175:89-93, 2001.
28. Carson EJ, Pruett SB. Development and characterization of a binge drinking model in mice for evaluation of the immunological effects of ethanol. Alcohol Clin Exp Res 20:132-138, 1996.
29. Earnshaw WC. Nuclear changes in apoptosis. Curr Opin Cell Biol 7:337-343, 1995.
30. Liu X, Zou H, Slaughter C, Wang X. DFF, a heterodimeric protein that functions downstream of caspase-3 to trigger DNA fragmentation during apoptosis. Cell 89:175-184, 1997.
31. Rust C, Gores GJ. Apoptosis and liver disease. Am J Med 108:567-573, 2000.
32. Biava C, Mukhlova-Montiel M. Electron microscopic observations on Councilman-like acidophilic bodies and other forms of acidophilic changes in human liver cells. Am J Pathol 46:775-802, 1965.
33. Cohen GM. Caspases: the executioners of apoptosis. Biochem J 326:1-16, 1997.
34. Perry DK, Smyth MJ, Stennicke HR, Salvesen GS, Duriez P, Poirier GG, Hannun YA. Zinc is a potent inhibitor of the apoptotic protease, caspase-3. J Biol Chem 272:18530-18533, 1997.
35. Nicholson DW, Thomberry NA. Caspases: killer proteases. Trends Biochem Sci 22:299-306, 1997.
36. Natori S, Rust C, Staheim LM, Srinivasan A, Burgart LJ, Gores GJ. Hepatocyte apoptosis is a pathologic feature of human alcoholic hepatitis. J Hepatol 34:248-253, 2001.
37. Nagata S. Fas ligand-induced apoptosis. Annu Rev Genet 33:29-55, 1999.
38. Peter ME, Krammer PH. Mechanisms of CD95 (Apo-1/Fas)-mediated apoptosis. Curr Opin Immunol 10:545-551, 1998.
39. Scaffidi C, Fulda S, Srinivasan A, Friesen C, Li F, Tomaselli KJ, Debatin K-M, Krammer PH, Peter ME. Two CD95 (Apo-1/Fas) signaling pathways. EMBO J 17:1675-1687, 1998.
40. 2+-independent T cell-mediated cytotoxicity. J Exp Med 177:195-200, 1993.
41. Suda T, Okazaki T, Naito Y, Yokota T, Arai N. Expression of the fas ligand in T-cell-lineage. J Immunol 154:3806-3813, 1995.
42. Oshimi Y, Oda S, Honda Y, Nagata S, Miyazaki S. Involvement of fas ligand and fas-mediated pathway in the cytotoxicity of human natural killer cells. J Immunol 157:2909-2915, 1996.
43. Hug H, Strand S, Grambihler A, Galle J, Hack V, Stremmel W, Krammer PH, Galle PR. Reactive oxygen intermediates are involved in the induction of CD95 ligand mRNA expression by cytostatic drugs in hepatoma cells. J Biol Chem 272:28191-28193, 1997.
44. Mueller M, Scaffidi C, Peters M, Stremmel W, Galle P, Krammer P. Involvement of the CD95 system in alcohol-induced liver damage. Hepatology 26:270A, 1997.
45. Faubion WA, Gores GJ. Death receptors in liver biology and pathobiology. Hepatology 29:1-4, 1999.
46. Bradham CA, Qian T, Streetz K, Trautwein C, Brenner DA, Lemasters JJ. The mitochondrial permeability transition is required for tumor necrosis factor α-mediated apoptosis and cytochrome c release. Mol Cell Biol 18:6353-6364, 1998.
47. Haidara K, Moffatt P, Denizeau F. Metallothionein induction attenuates the effects of glutathione depletors in rat hepatocytes. Toxicol Sci 49:297-305, 1999.
48. Kimura T, Fujita I, Itoh N, Muto N, Nakanishi T, Takahashi K, Azuma J, Tanaka K. Metallothionein acts as a cytoprotectant against doxorubicin toxicity. J Pharmacol Exp Ther 292:299-302, 2000.
49. Pathak A, Mahmood A, Pathak R, Dhawan D. Effect of zinc on hepatic lipid peroxidation and antioxidative enzymes in ethanol-fed rats. J Appl Toxicol 22:207-210, 2002.
50. Seyoum G, Persaud TV. Protective influence of zinc against the deleterious effects of ethanol in postimplantation rat embryos in vivo. Exp Toxicol Pathol 47:75-79, 1995.