Zinc protects against apoptosis of endothelial cells induced by linoleic acid and tumor necrosis factor α

American Journal of Clinical Nutrition

Volumn 71, Issue 1, 2000, Pages 81-87

  Meerarani, P ^b   Ramadass, P ^b   Toborek, Michal ^b   Bauer, Hans Christian ^b   Bauer, Hannelore ^b   Hennig, Bernhard ^a  

^a UNIVERSITY OF KENTUCKY   (United States)

^b NONE

Author keywords

Annexin V; Apoptosis; Apoptotic cell death; Atherosclerosis; Caspase 3; Cell destabilizing agents; Cytokines; Endothelial cells; Inflammatory conditions; Linoleic acid; Polyunsaturated lipids; Tumor necrosis factor ; Vascular endothelium; Zinc; Zinc deficiency; Zinc supplementation

Indexed keywords

CASPASE 3; LINOLEIC ACID; LIPOCORTIN 5; TUMOR NECROSIS FACTOR ALPHA; ZINC;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL PROTECTION; CONTROLLED STUDY; CYTOKINE PRODUCTION; DIET SUPPLEMENTATION; ENDOTHELIUM CELL; ENDOTHELIUM LESION; INFLAMMATION; NONHUMAN; SWINE; ZINC DEFICIENCY;

EID: 0033967061     PISSN: 00029165     EISSN: None     Source Type: Journal    
DOI: 10.1093/ajcn/71.1.81     Document Type: Article

References (48)

1. Ashkenazi A, Dixit VM. Death receptors: signaling and modulation. Science 1998;281:1305-8.
2. Bochaton-Piallat ML, Gabbiani F, Redard M, Desmouliere A, Gabbiani G. Apoptosis participates in cellularity regulation during rat aortic intimai thickening. Am J Pathol 1995;146:1059-64.
3. Cai W, Devaux B, Schaper W, Schaper J. The role of Fas/APO 1 and apoptosis in the development of human atherosclerotic lesions. Atherosclerosis 1997;131:177-86.
4. Kockx MM. Apoptosis in the atherosclerotic plaque. Arterioscler Thromb Vasc Biol 1998;18:1519-22.
5. Best PJM, Hasdai D, Sangiorgi G, et al. Apoptosis. Basic concepts and implications in coronary artery disease. Arterioscler Thromb Vasc Biol 1999;19:12-22.
6. Alvarez RJ Jr, Gips SJ, Moldovan N, et al. 17β-estradiol inhibits apoptosis of endothelial cells. Biochem Biophys Res Commun 1997; 237:372-81.
7. Hawkins RA, Sangster K, Arends MJ. Apoptotic death of pancreatic cancer cells induced by polyunsaturated fatty acids varies with double bond number and involves an oxidative mechanism. J Pathol 1998;185:61-70.
8. Buttke TM, Sandstrom PA. Oxidative stress as a mediator of apoptosis. Immunol Today 1994;15:7-10.
9. Tatton WG, Chalmers-Redman RM. Mitochondria in neurodegenerative apoptosis: an opportunity for therapy? Ann Neurol 1998; 44:S134-41.
10. Watabe M, Ito K, Masuda Y, Nakajo S, Nakaya K. Activation of AP-1 is required for bufalin-induced apoptosis in human leukemia U937 cells. Oncogene 1998;16:779-87.
11. Jacobs-Helber SM, Wickrema A, Birrer MJ, Sawyer ST. AP-1 regulation of proliferation and initiation of apoptosis in erythropoietin-dependent erythroid cells. Mol Cell Biol 1998; 18: 3699-707.
12. Ishikawa Y, Yokoo T, Kitamura M. c-Jun/AP-1, but not NF-kappa B, is a mediator for oxidant-initiated apoptosis in glomerular mesangial cells. Biochem Biophys Res Commun 1997;240:496-501.
13. Thornberry NA, Lazebnik Y. Caspases: enemies within. Science 1998;281:1312-6.
14. Woo M, Hakem R, Soengas MS, et al. Essential contribution of caspase 3/CPP32 to apoptosis and its associated nuclear changes. Genes Dev 1998;12:806-19.
15. Dimmeler S, Haendeler J, Galle J, Zeiher AM. Oxidized low-density lipoprotein induces apoptosis of human endothelial cells by activation of CPP32-like proteases. A mechanistic clue to the 'response to injury' hypothesis. Circulation 1997;95:1760-3.
16. Hennig B, Wang Y, Ramasamy S, McClain CJ. Zinc deficiency alters barrier function of cultured porcine endothelial cells. J Nutr 1992;122:1242-7.
17. Clair J, Talwalkar R, McClain CJ, Hennig B. Selective removal of zinc from cell culture media. J Trace Elem Exp Med 1995;7: 143-51.
18. Bray TM, Bettger WJ. The physiological role of zinc as an antioxidant. Free Radic Biol Med 1990;8:281-91.
19. Bettger WJ, O'Dell BL. Physiological roles of zinc in the plasma membrane of mammalian cells. J Nutr Biochem 1993;4: 194-207.
20. Hennig B, Wang Y, Ramasamy S, McClain CJ. Zinc protects against tumor necrosis factor-induced disruption of porcine endothelial cell monolayer integrity. J Nutr 1993;123:1003-9.
21. Hennig B, Meerarani P, Toborek M, McClain CJ. Antioxidant-like properties of zinc in activated endothelial cells. J Am Coll Nutr 1999;18:152-8.
22. Lizard G, Moisant M, Cordelet C, Monier S, Gambert P, Lagrost L. Induction of similar features of apoptosis in human and bovine vascular endothelial cells treated by 7-ketocholesterol. J Pathol 1997; 183:330-8.
23. Hennig B, Toborek M, McClain CJ. Antiatherogenic properties of zinc: implications in endothelial cell metabolism. Nutrition 1996; 12:711-7.
24. Shankar AH, Prasad AS. Zinc and immune function: the biological basis of altered resistance to infection. Am J Clin Nutr 1998; 68:447S-63S.
25. Perry DK, Smyth MJ, Stennicke HR, et al. Zinc is a potent inhibitor of the apoptotic protease, caspase-3. A novel target for zinc in the inhibition of apoptosis. J Biol Chem 1997;272:18530-3.
26. Trapp C, Duffy JY, Daston GP, Keen CL. Induction of caspase 3 activity in 3T3 cells cultured in zinc deficient medium. FASEB J 1998;12:A522 (abstr).
27. Aiuchi T, Mihara S, Nakaya M, Masuda Y, Nakajo S, Nakaya K. Zinc ions prevent processing of caspase-3 during apoptosis induced by geranylgeraniol in HL-60 cells. J Biochem 1998;124:300-3.
28. Hennig B, Shasby DM, Fulton AB, Spector AA. Exposure to free fatty acid increases the transfer of albumin across cultured endothelial monolayers. Arteriosclerosis 1984;4:489-97.
29. MacDonald RS, Wollard-Biddle LC, Browning JD. Thornton WH, O'Dell BL. Zinc deprivation of murine 3T3 cells by use of diethylenetrinitrilopentaacetate impairs DNA synthesis upon stimulation with insulin-like growth factor-I (IGF-I). J Nutr 1998;128: 1600-5.
30. Treves S, Trentini PL, Ascanelli M, Bucci G, Di Virgilio F. Apoptosis is dependent on intracellular zinc and independent of intracellular calcium in lymphocytes. Exp Cell Res 1994;211:339-43.
31. Toborek M, Barger SW, Mattson MP, Barve S, McClain CJ, Hennig B. Linoleic acid and TNF-α cross-amplify oxidative injury and dysfunction of endothelial cells. J Lipid Res 1996;37:123-35.
32. Connell P, Young VM, Toborek M, et al. Zinc attenuates tumor necrosis factor-mediated activation of transcription factors in endothelial cells. J Am Coll Nutr 1997;16:411-7.
33. Wang H, Keiser JA. Molecular characterization of rabbit CPP32 and its function in vascular smooth muscle cell apoptosis. Am J Physiol 1998;274:H1132-40.
34. Chomczynski P, Mackey K, Drews R, Wilfinger W. DNAzol. A reagent for the rapid isolation of genomic DNA. Biotechniques 1997;22:550-3.
35. Snedecor GW, Cochran WG. Statistical methods. 7th ed. Ames, IA: Iowa State University Press, 1974.
36. Di Corleto PE, Chisolm GM. Participation of the endothelium in the development of the atherosclerotic plaque. Prog Lipid Res 1986; 25:365-74.
37. Scharf RE, Harker LA. Thrombosis and atherosclerosis: regulatory role of interactions among blood components and endothelium. Blut 1987;53:131-44.
38. Mantovani A. Bussolino F. Dejana E. Cytokine regulation of endothelial cell function. FASEB J 1992;6:2591-9.
39. Hennig B. Toborek M, Cader AA. Nutrition, endothelial cell metabolism and atherosclerosis. Crit Rev Food Sci Nutr 1994;34:253-82.
40. Ross R, Harker L. Hyperlipidemia and atherosclerosis. Chronic hyperlipidemia initiates and maintains lesions by endothelial cell desquamation and lipid accumulation. Science 1976;193:1094-100.
41. Bürrig KF, The endothelium of advanced arteriosclerotic plaques in humans. Arteriosclerosis 1991;11:1678-89.
42. Flavahan NA. Atherosclerosis or lipoprotein-induced endothelial dysfunction. Circulation 1992;85:1927-38.
43. Dimmeler S, Hermann C. Zeiher AM. Apoptosis of endothelial cells. Contribution to the pathophysiology of atherosclerosis? Eur Cytokine Netw 1998;9:697-8.
44. Toborek M, Blanc EM, Kaiser S, Mattson MP, Hennig B. Linoleic acid potentiates TNF-mediated oxidative stress, disruption of calcium homeostasis and apoptosis of cultured vascular endothelial cells. J Lipid Res 1997;38:2155-67.
45. Sunderman FW Jr. The influence of zinc on apoptosis. Ann Clin Lab Sci 1995;25:134-42.
46. Masuda Y. Kawazoe N, Nakajo S, Yoshida T, Kuroiwa Y, Nakaya K. Bufalin induces apoptosis and influences the expression of apoptosis-related genes in human leukemia cells. Leuk Res 1995;19: 549-61.
47. Fernandes-Alnemri T, Litwack G, Alnemri ES. CPP32, a novel human apoptotic protein with homology to Caenorhabditis elegans cell death protein Ced-3 and mammalian interleukin-1 beta-converting enzyme. J Biol Chem 1994;269:30761-4.
48. Ham J, Babij C, Whitefield J. et al. A c-Jun dominant negative mutant protects sympathetic neurons against programmed cell death. Neuron 1995;14:927-39.