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1
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84890611839
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Sequence-dependent DNA dynamics: the regulator of DNA-mediated charge transport
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Wagenknecht H.A. (Ed), Wiley-VCH
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O'Neill M.A., and Barton J.K. Sequence-dependent DNA dynamics: the regulator of DNA-mediated charge transport. In: Wagenknecht H.A. (Ed). Charge Transfer in DNA: From Mechanism to Application (2005), Wiley-VCH 27-75
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Charge Transfer in DNA: From Mechanism to Application
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O'Neill, M.A.1
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0029833916
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Oxidative DNA damage through long-range electron transfer
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Hall D.B., Holmlin R.E., and Barton J.K. Oxidative DNA damage through long-range electron transfer. Nature 382 (1996) 731-735
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Nature
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Hall, D.B.1
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0031027125
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How easily oxidizable is DNA? One electron reduction potentials of adenosine and guanosine in aqueous solution
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Steenken S., and Jovanovich S. How easily oxidizable is DNA? One electron reduction potentials of adenosine and guanosine in aqueous solution. J Am Chem Soc 119 (1997) 617-618
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Photoinduced DNA cleavage via electron transfer: demonstration that guanine residues located 5′ to guanine are the most electron donating sites
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Saito I., Takayama M., Sugiyama H., Nakatani K., Tsuchida A., and Yamamoto M. Photoinduced DNA cleavage via electron transfer: demonstration that guanine residues located 5′ to guanine are the most electron donating sites. J Am Chem Soc 117 (1995) 6406-6407
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Yamamoto, M.6
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5
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0033079847
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Long range oxidative damage to DNA: effects of distance and sequence
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Nunez M.E., Hall D.B., and Barton J.K. Long range oxidative damage to DNA: effects of distance and sequence. Chem Biol 6 (1999) 85-97
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Chem Biol
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Nunez, M.E.1
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6
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0033552244
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Mechanism of charge transport in DNA: internally linked anthraquinone conjugates support phonon-assisted polaron hopping
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Ly D., Sanil L., and Schuster G.B. Mechanism of charge transport in DNA: internally linked anthraquinone conjugates support phonon-assisted polaron hopping. J Am Chem Soc 121 (1999) 9400-9410
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J Am Chem Soc
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Ly, D.1
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7
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34547421768
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Distance-independent DNA charge transport across an adenine tract
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A flat distance dependence in DNA CT is demonstrated across a 5 nm adenine tract with a time scale of ∼10 ps.
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Augustyn K.E., Genereux J.C., and Barton J.K. Distance-independent DNA charge transport across an adenine tract. ACIE 46 (2007) 5731-5733. A flat distance dependence in DNA CT is demonstrated across a 5 nm adenine tract with a time scale of ∼10 ps.
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ACIE
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Augustyn, K.E.1
Genereux, J.C.2
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8
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0038304533
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Reductive electron transfer and transport of excess electrons in DNA
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Wagenknecht H.A. Reductive electron transfer and transport of excess electrons in DNA. ACIE 42 (2003) 2454-2460
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ACIE
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Wagenknecht, H.A.1
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9
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0033772184
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Mutation detection by electrocatalysis at DNA-modified electrodes
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Boon E.M., Ceres D.M., Drummond T.G., Hill M.G., and Barton J.K. Mutation detection by electrocatalysis at DNA-modified electrodes. Nat Biotechnol 18 (2000) 1096-1100
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Nat Biotechnol
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Boon, E.M.1
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Hill, M.G.4
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10
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15244353024
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Electrochemical detection of lesions in DNA
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Boal A.K., and Barton J.K. Electrochemical detection of lesions in DNA. Bioconjug Chem 16 (2005) 312-321
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Bioconjug Chem
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Boal, A.K.1
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11
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38649104819
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Charge migration along the DNA duplex: hole versus electron transport
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Elias B., Shao F., and Barton J.K. Charge migration along the DNA duplex: hole versus electron transport. J Am Chem Soc 130 (2008) 1152-1153
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J Am Chem Soc
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Elias, B.1
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Oxidative nucleobase modifications leading to strand scission
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Burrows C.J., and Muller J.G. Oxidative nucleobase modifications leading to strand scission. Chem Rev 98 (1998) 1109-1151
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Long-distance charge transport in DNA: the hopping mechanism
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Giese B. Long-distance charge transport in DNA: the hopping mechanism. Acc Chem Res 33 (2000) 631-636
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Acc Chem Res
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Giese, B.1
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Role of oxygen radicals in DNA damage and cancer incidence
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Valko M., Izakovic M., Mazur M., Rhodes C.J., and Telser J. Role of oxygen radicals in DNA damage and cancer incidence. Mol Cell Biochem 266 (2004) 37-56
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Valko, M.1
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0035969706
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On the non-uniform distribution of guanine in introns of human genes: possible protection of exons against oxidation by proximal intron poly-g sequences
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Friedman K.A., and Heller A. On the non-uniform distribution of guanine in introns of human genes: possible protection of exons against oxidation by proximal intron poly-g sequences. J Phys Chem B 105 (2001) 11859-11865
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Friedman, K.A.1
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1542366714
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Guanosine distribution and oxidation resistance in eight eukaryotic genomes
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Analysis of genome sequences shows that exons contain a paucity of oxidation-prone guanines, suggesting that protein-encoding regions of the genome may be preferentially protected from oxidative damage.
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Friedman K.A., and Heller A. Guanosine distribution and oxidation resistance in eight eukaryotic genomes. J Am Chem Soc 126 (2004) 2368-2371. Analysis of genome sequences shows that exons contain a paucity of oxidation-prone guanines, suggesting that protein-encoding regions of the genome may be preferentially protected from oxidative damage.
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J Am Chem Soc
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Friedman, K.A.1
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17
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0344198178
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Charge transport in DNA duplex/quadruplex conjugates
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Delaney S., and Barton J.K. Charge transport in DNA duplex/quadruplex conjugates. Biochemistry 42 (2003) 14159-14165
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Biochemistry
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Delaney, S.1
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18
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0037181064
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Site-specific probing of oxidative reactivity and telomerase function using 7,8-dihydro-8-oxoguanine in telomeric DNA
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Szalai V.A., Singer M.J., and Thorp H.H. Site-specific probing of oxidative reactivity and telomerase function using 7,8-dihydro-8-oxoguanine in telomeric DNA. J Am Chem Soc 124 (2002) 1625-1631
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Szalai, V.A.1
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19
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Investigating human cancer etiology by DNA lesion footprinting and mutagenicity analysis
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Besaratinia A., and Pfeifer G.P. Investigating human cancer etiology by DNA lesion footprinting and mutagenicity analysis. Carcinogenesis 27 (2006) 1526-1537
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Besaratinia, A.1
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20
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0035940432
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Evidence for DNA charge transport in the nucleus
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Nunez M.E., Holmquist G.P., and Barton J.K. Evidence for DNA charge transport in the nucleus. Biochemistry 40 (2001) 12465-12471
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Biochemistry
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Nunez, M.E.1
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21
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A mitochondrial paradigm of metabolic and degenerative diseases, aging, and cancer: a dawn for evolutionary medicine
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Wallace D.C. A mitochondrial paradigm of metabolic and degenerative diseases, aging, and cancer: a dawn for evolutionary medicine. Annu Rev Biochem 39 (2005) 359-407
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Wallace, D.C.1
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22
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33947212757
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Oxidation by DNA charge transport damages conserved sequence block II, a regulatory element in mitochondrial DNA
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In the mitochondrion DNA regulatory region, conserved sequence block II is preferentially damaged through long-range DNA CT, and this funneling of damage may provide a damage checkpoint for the replication of the mitochondrial DNA.
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Merino E.J., and Barton J.K. Oxidation by DNA charge transport damages conserved sequence block II, a regulatory element in mitochondrial DNA. Biochemistry 46 (2007) 2805-2811. In the mitochondrion DNA regulatory region, conserved sequence block II is preferentially damaged through long-range DNA CT, and this funneling of damage may provide a damage checkpoint for the replication of the mitochondrial DNA.
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Biochemistry
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Merino, E.J.1
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Merino EJ, Barton JK: DNA oxidation by charge transport in mitochondria. Biochemistry 2008, 47:1511-1517.
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Merino EJ, Barton JK: DNA oxidation by charge transport in mitochondria. Biochemistry 2008, 47:1511-1517. DNA damage is also preferentially funneled by DNA CT to conserve sequence block II in functioning mitochondria. Here also protein-DNA crosslinking promoted by DNA oxidation is detected.
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24
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0036170578
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Comprehensive scanning of somatic mitochondrial DNA mutations in breast cancer
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Tan D.J., Bai R.K., and Wong L.J.C. Comprehensive scanning of somatic mitochondrial DNA mutations in breast cancer. Cancer Res 62 (2002) 972-976
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Tan, D.J.1
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25
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0035826678
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How different DNA binding proteins affect long range oxidative damage to DNA
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Rajski S.R., and Barton J.K. How different DNA binding proteins affect long range oxidative damage to DNA. Biochemistry 40 (2001) 5556-5564
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(2001)
Biochemistry
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Rajski, S.R.1
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26
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0036197920
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An electrical probe of protein-DNA interactions on DNA-modified surfaces
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Boon E.M., Salas J.E., and Barton J.K. An electrical probe of protein-DNA interactions on DNA-modified surfaces. Nat Biotech 20 (2002) 282-286
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Nat Biotech
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Boon, E.M.1
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27
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41449104768
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Gorodetsky AA, Ebrahim A, Barton JK: Electrical detection of TATA-binding protein at DNA-modified microelectrodes. J Am Chem Soc 2008, in press.
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Gorodetsky AA, Ebrahim A, Barton JK: Electrical detection of TATA-binding protein at DNA-modified microelectrodes. J Am Chem Soc 2008, in press.
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28
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0036009330
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Suppression of DNA mediated charge transport by BamHI binding
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Nakatani K., Dohno C., Ogawa A., and Saito I. Suppression of DNA mediated charge transport by BamHI binding. Chem Biol 9 (2002) 361-366
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Chem Biol
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Nakatani, K.1
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29
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0036238830
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Oxidative charge transport through DNA in nucleosome core particles
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Nunez M.E., Noyes K.T., and Barton J.K. Oxidative charge transport through DNA in nucleosome core particles. Chem Biol 9 (2002) 403-415
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(2002)
Chem Biol
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Nunez, M.E.1
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30
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1842411320
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Crystal structure of the nucleosome core particle at 2.8 Å resolution
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Luger K., Mader A., Richmond R., Sargent D., and Richmond T.J. Crystal structure of the nucleosome core particle at 2.8 Å resolution. Nature 389 (1997) 251-260
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31
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33646044409
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Attenuation of DNA charge transport by compaction into a nucleosome core particle
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Bjorklund C.C., and David W.B. Attenuation of DNA charge transport by compaction into a nucleosome core particle. Nucleic Acids Res 34 (2006) 1836-1846
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Nucleic Acids Res
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Bjorklund, C.C.1
David, W.B.2
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32
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34648813440
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Stable DNA protein crosslinks are products of DNA charge transport in a nucleosome core particle
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Protein-DNA crosslinking, another important source of oxidative damage, is associated with DNA CT in the nucleosome.
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Bjorklund C.C., and Davis W.B. Stable DNA protein crosslinks are products of DNA charge transport in a nucleosome core particle. Biochemistry 46 (2007) 10745-10755. Protein-DNA crosslinking, another important source of oxidative damage, is associated with DNA CT in the nucleosome.
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Bjorklund, C.C.1
Davis, W.B.2
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Radical initiation in the class I ribonucleotide reductase: long range proton coupled electron transfer?
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Stubbe J., Nocera D.G., Yee C.S., and Chang M.C. Radical initiation in the class I ribonucleotide reductase: long range proton coupled electron transfer?. Chem Rev 103 (2003) 2167-2201
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Stubbe, J.1
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34
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0034625045
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DNA-bound peptide radicals generated through DNA-mediated electron transport
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Wagenknecht H.A., Stemp E.D.A., and Barton J.K. DNA-bound peptide radicals generated through DNA-mediated electron transport. Biochemistry 39 (2000) 5482-5491
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(2000)
Biochemistry
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Wagenknecht, H.A.1
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35
-
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23344454240
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Electrically monitoring DNA repair by photolyase
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The photoreaction of photolyase with thymine dimers in DNA is monitored electrochemically on DNA-modified electrodes, and the protein-containing flavin can be probed in a DNA-mediated reaction.
-
DeRosa M.C., Sancar A., and Barton J.K. Electrically monitoring DNA repair by photolyase. Proc Natl Acad Sci U S A 102 (2005) 10788-10792. The photoreaction of photolyase with thymine dimers in DNA is monitored electrochemically on DNA-modified electrodes, and the protein-containing flavin can be probed in a DNA-mediated reaction.
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Proc Natl Acad Sci U S A
, vol.102
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DeRosa, M.C.1
Sancar, A.2
Barton, J.K.3
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36
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24644464640
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DNA charge transport leading to disulfide bond formation
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Takada T., and Barton J.K. DNA charge transport leading to disulfide bond formation. J Am Chem Soc 127 (2005) 12204-12205
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(2005)
J Am Chem Soc
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Takada, T.1
Barton, J.K.2
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37
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37649023948
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A role for DNA-mediated charge transport in regulating p53: oxidation of the DNA-bound protein from a distance
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Thiols in DNA-bound p53 may be oxidized from a distance through DNA CT, leading to the oxidative dissociation of p53 from some promoters.
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Augustyn K.E., Merino E.J., and Barton J.K. A role for DNA-mediated charge transport in regulating p53: oxidation of the DNA-bound protein from a distance. Proc Natl Acad Sci U S A 104 (2007) 18907-18912. Thiols in DNA-bound p53 may be oxidized from a distance through DNA CT, leading to the oxidative dissociation of p53 from some promoters.
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Proc Natl Acad Sci U S A
, vol.104
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Augustyn, K.E.1
Merino, E.J.2
Barton, J.K.3
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38
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0027983669
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Crystal structure of a p53 tumor suppressor-DNA complex: understanding tumorigenic mutations
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Cho Y., Gorina S., Jeffrey P.D., and Pavletich N.P. Crystal structure of a p53 tumor suppressor-DNA complex: understanding tumorigenic mutations. Science 265 (1994) 346-354
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Cho, Y.1
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The p53 pathway
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Prives C., and Hall P.A. The p53 pathway. J Pathol 187 (1999) 112-126
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J Pathol
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DNA-mediated charge transport for DNA repair
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Boon E.M., Livingston A.L., Chmiel N.H., David S.S., and Barton J.K. DNA-mediated charge transport for DNA repair. Proc Natl Acad Sci U S A 100 (2003) 12543-12547
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Proc Natl Acad Sci U S A
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Boon, E.M.1
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David, S.S.4
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41
-
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20444411178
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DNA-bound redox activity of DNA repair glycosylases containing [4Fe-4S] clusters
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DNA-binding shifts the redox potential of DNA base excision repair proteins that contain a [4Fe4S] cluster, activating the proteins toward oxidation. DNA CT through this redox activation provides a strategy for the efficient initial detection of DNA lesions by the repair proteins.
-
Boal A.K., Yavin E., Lukianova O.A., O'Shea V.L., David S.S., and Barton J.K. DNA-bound redox activity of DNA repair glycosylases containing [4Fe-4S] clusters. Biochemistry 44 (2005) 8397-8407. DNA-binding shifts the redox potential of DNA base excision repair proteins that contain a [4Fe4S] cluster, activating the proteins toward oxidation. DNA CT through this redox activation provides a strategy for the efficient initial detection of DNA lesions by the repair proteins.
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Biochemistry
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Boal, A.K.1
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Chemistry of glycosylases and endonucleases involved in base-excision repair
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David S.S., and Williams S.D. Chemistry of glycosylases and endonucleases involved in base-excision repair. Chem Rev 98 (1998) 1221-1262
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Endonuclease III is an iron-sulfur protein
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Cunningham R.P., Asahara H., Bank J.F., Scholes C.P., Salerno J.C., Surereus K., Munck E., McCracken J., Peisach J., and Emptage M.H. Endonuclease III is an iron-sulfur protein. Biochemistry 28 (1989) 4450-4455
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Cunningham, R.P.1
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Munck, E.7
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44
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33644857131
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Electron trap for DNA-bound repair enzymes: a strategy for DNA-mediated signalling
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The trapping of an electron on a modified base in DNA as a function of binding DNA repair proteins is demonstrated. DNA binding serves to activate redox signaling by the proteins through DNA CT.
-
Yavin E., Stemp E.D.A., O'Shea V.L., David S.S., and Barton J.K. Electron trap for DNA-bound repair enzymes: a strategy for DNA-mediated signalling. Proc Natl Acad Sci U S A 103 (2006) 3610-3614. The trapping of an electron on a modified base in DNA as a function of binding DNA repair proteins is demonstrated. DNA binding serves to activate redox signaling by the proteins through DNA CT.
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Proc Natl Acad Sci U S A
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Yavin, E.1
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David, S.S.4
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45
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14844353576
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Protein-DNA charge transport: redox activation of a DNA repair protein by guanine radical
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Guanine radicals, generated in the DNA through DNA CT, can oxidize MutY, a DNA repair protein that contains a [4Fe4S] cluster. Guanine radicals, in providing an early signal of oxidative stress, may serve to activate the DNA repair proteins to detect base lesions.
-
Yavin E., Boal A.K., Stemp E.D.A., Boon E.M., Livingston A.L., O'Shea V.L., David S.S., and Barton J.K. Protein-DNA charge transport: redox activation of a DNA repair protein by guanine radical. Proc Natl Acad Sci U S A 102 (2005) 3546-3551. Guanine radicals, generated in the DNA through DNA CT, can oxidize MutY, a DNA repair protein that contains a [4Fe4S] cluster. Guanine radicals, in providing an early signal of oxidative stress, may serve to activate the DNA repair proteins to detect base lesions.
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Proc Natl Acad Sci U S A
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Yavin, E.1
Boal, A.K.2
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O'Shea, V.L.6
David, S.S.7
Barton, J.K.8
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46
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33748790129
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Direct electrochemistry of Endonuclease III in the presence and absence of DNA
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DNA binding promotes a shift in the 3+/2+ redox potential of the [4Fe4S] cluster of Endonuclease III by more than -200 mV, which corresponds to more than a thousand-fold difference in DNA-binding affinity for the oxidized versus reduced form of the protein.
-
Gorodetsky A.A., Boal A.K., and Barton J.K. Direct electrochemistry of Endonuclease III in the presence and absence of DNA. J Am Chem Soc 128 (2006) 12082-12083. DNA binding promotes a shift in the 3+/2+ redox potential of the [4Fe4S] cluster of Endonuclease III by more than -200 mV, which corresponds to more than a thousand-fold difference in DNA-binding affinity for the oxidized versus reduced form of the protein.
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J Am Chem Soc
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Gorodetsky, A.A.1
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47
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MUTYH-associated polyposis-from defect in base excision repair to clinical genetic testing
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A predisposition to colon cancer is associated with mutations in the human gene for MutY, the repair enzyme containing a [4Fe4S] cluster that is redox-activated on DNA binding.
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