메뉴 건너뛰기




Volumn 11, Issue 2, 2008, Pages 301-308

DNA vaccine therapy for Alzheimer's disease: Present status and future direction

Author keywords

[No Author keywords available]

Indexed keywords

AMYLOID BETA PROTEIN; AMYLOID BETA PROTEIN ANTIBODY; DNA VACCINE;

EID: 42649133143     PISSN: 15491684     EISSN: None     Source Type: Journal    
DOI: 10.1089/rej.2007.0638     Document Type: Review
Times cited : (16)

References (37)
  • 1
    • 0036828769 scopus 로고    scopus 로고
    • Alzheimer's disease: Treatments in discovery and development
    • Citron M. Alzheimer's disease: treatments in discovery and development. Nat Neurosci 2002;5(Suppl):1055-1057.
    • (2002) Nat Neurosci , vol.5 , Issue.SUPPL. , pp. 1055-1057
    • Citron, M.1
  • 2
    • 0025899041 scopus 로고
    • Amyloid deposition as the central event in the aetiology of Alzheimer's disease
    • Hardy J, Allsop D. Amyloid deposition as the central event in the aetiology of Alzheimer's disease. Trends Pharmacol Sci.1991;12:383-388.
    • (1991) Trends Pharmacol Sci , vol.12 , pp. 383-388
    • Hardy, J.1    Allsop, D.2
  • 3
    • 0033536163 scopus 로고    scopus 로고
    • Immunization with amyloid-beta attenuates Alzheimer-disease-like pathology in the PDAPP mouse
    • Schenk D, Barbour R, Dunn W, et al. Immunization with amyloid-beta attenuates Alzheimer-disease-like pathology in the PDAPP mouse. Nature 1999;400:173-177.
    • (1999) Nature , vol.400 , pp. 173-177
    • Schenk, D.1    Barbour, R.2    Dunn, W.3
  • 4
    • 84984755327 scopus 로고    scopus 로고
    • A beta peptide vaccination prevents memory loss in an animal model of Alzheimer's disease
    • Morgan D, Diamond DM, Gottschall PE, et al. A beta peptide vaccination prevents memory loss in an animal model of Alzheimer's disease. Nature 2000;408:982-985.
    • (2000) Nature , vol.408 , pp. 982-985
    • Morgan, D.1    Diamond, D.M.2    Gottschall, P.E.3
  • 5
    • 0034700471 scopus 로고    scopus 로고
    • A beta peptide immunization reduces behavioural impairment and plaques in a model of Alzheimer's disease
    • Janus C, Pearson J, McLaurin J, et al. A beta peptide immunization reduces behavioural impairment and plaques in a model of Alzheimer's disease. Nature 2000;408:979-982.
    • (2000) Nature , vol.408 , pp. 979-982
    • Janus, C.1    Pearson, J.2    McLaurin, J.3
  • 6
    • 10744230547 scopus 로고    scopus 로고
    • Subacute meningoencephalitis in a subset of patients with AD after Abeta42 immunization
    • Orgogozo JM, Gilman S, Dartigues JF, et al. Subacute meningoencephalitis in a subset of patients with AD after Abeta42 immunization. Neurology 2003;61:46-54.
    • (2003) Neurology , vol.61 , pp. 46-54
    • Orgogozo, J.M.1    Gilman, S.2    Dartigues, J.F.3
  • 7
    • 0037393454 scopus 로고    scopus 로고
    • Neuropathology of human Alzheimer disease after immunization with amyloid-beta peptide: A case report
    • Nicoll JA, Wilkinson D, Holmes C, et al. Neuropathology of human Alzheimer disease after immunization with amyloid-beta peptide: a case report. Nat Med 2003;9:448-452.
    • (2003) Nat Med , vol.9 , pp. 448-452
    • Nicoll, J.A.1    Wilkinson, D.2    Holmes, C.3
  • 8
    • 24644435506 scopus 로고    scopus 로고
    • Nasal vaccination with a proteosome-based adjuvant and glatiramer acetate clears beta-amyloid in a mouse model of Alzheimer disease
    • Frenkel D, Maron R, Burt DS, Weiner HL. Nasal vaccination with a proteosome-based adjuvant and glatiramer acetate clears beta-amyloid in a mouse model of Alzheimer disease. J Clin Invest 2005;115:2423-2433.
    • (2005) J Clin Invest , vol.115 , pp. 2423-2433
    • Frenkel, D.1    Maron, R.2    Burt, D.S.3    Weiner, H.L.4
  • 9
    • 33646062007 scopus 로고    scopus 로고
    • Developing novel immunogens for an effective, safe Alzheimer's disease vaccine
    • Maier M, Seabrook TJ, Lemere CA. Developing novel immunogens for an effective, safe Alzheimer's disease vaccine. Neurodegen Dis 2005;2:267-272.
    • (2005) Neurodegen Dis , vol.2 , pp. 267-272
    • Maier, M.1    Seabrook, T.J.2    Lemere, C.A.3
  • 10
    • 33646938005 scopus 로고    scopus 로고
    • Short amyloid-beta (Abeta) immunogens reduce cerebral Abeta load and learning deficits in an Alzheimer's disease mouse model in the absence of an Abeta-specific cellular immune response
    • Maier M, Seabrook TJ, Lazo ND, et al. Short amyloid-beta (Abeta) immunogens reduce cerebral Abeta load and learning deficits in an Alzheimer's disease mouse model in the absence of an Abeta-specific cellular immune response. J Neurosci 2006;26:4717-4728.
    • (2006) J Neurosci , vol.26 , pp. 4717-4728
    • Maier, M.1    Seabrook, T.J.2    Lazo, N.D.3
  • 11
    • 33750603844 scopus 로고    scopus 로고
    • Alzheimer's centennial legacy: Prospects for rational therapeutic intervention targeting the Abeta amyloid pathway
    • Masters CL, Beyreuther K. Alzheimer's centennial legacy: prospects for rational therapeutic intervention targeting the Abeta amyloid pathway. Brain 2006;129:2823-2839.
    • (2006) Brain , vol.129 , pp. 2823-2839
    • Masters, C.L.1    Beyreuther, K.2
  • 12
    • 0033835996 scopus 로고    scopus 로고
    • Peripherally administered antibodies against amyloid beta-peptide enter the central nervous system and reduce pathology in a mouse model of Alzheimer disease
    • Bard F, Cannon C, Barbour R, et al. Peripherally administered antibodies against amyloid beta-peptide enter the central nervous system and reduce pathology in a mouse model of Alzheimer disease. Nat Med 2000;6:916-919.
    • (2000) Nat Med , vol.6 , pp. 916-919
    • Bard, F.1    Cannon, C.2    Barbour, R.3
  • 13
    • 0037112201 scopus 로고    scopus 로고
    • Cerebral hemorrhage after passive anti-Abeta immunotherapy
    • Pfeifer M, Boncristiano S, Bondolfi L, et al. Cerebral hemorrhage after passive anti-Abeta immunotherapy. Science 2002;298:1379.
    • (2002) Science , vol.298 , pp. 1379
    • Pfeifer, M.1    Boncristiano, S.2    Bondolfi, L.3
  • 14
    • 0026579897 scopus 로고
    • Genetic immunization is a simple method for eliciting an immune response
    • Tang DC, DeVit M, Johnston SA. Genetic immunization is a simple method for eliciting an immune response. Nature 1992;356:152-154.
    • (1992) Nature , vol.356 , pp. 152-154
    • Tang, D.C.1    DeVit, M.2    Johnston, S.A.3
  • 15
    • 0028863527 scopus 로고
    • Protection against mycoplasma infection using expression-library immunization
    • Barry MA, Lai WC, Johnston SA. Protection against mycoplasma infection using expression-library immunization. Nature 1995;377:632-635.
    • (1995) Nature , vol.377 , pp. 632-635
    • Barry, M.A.1    Lai, W.C.2    Johnston, S.A.3
  • 16
    • 0027411456 scopus 로고
    • Heterologous protection against influenza by injection of DNA encoding a viral protein
    • Ulmer JB, Donnelly JJ, Parker SE, et al. Heterologous protection against influenza by injection of DNA encoding a viral protein. Science 1993;259:1745-1749.
    • (1993) Science , vol.259 , pp. 1745-1749
    • Ulmer, J.B.1    Donnelly, J.J.2    Parker, S.E.3
  • 17
    • 0029551958 scopus 로고
    • Nucleic acid malaria vaccines. Current status and potential
    • Hoffman SL, Doolan DL, Sedegah M, et al. Nucleic acid malaria vaccines. Current status and potential. Ann NY Acad Sci 1995;772:88-94.
    • (1995) Ann NY Acad Sci , vol.772 , pp. 88-94
    • Hoffman, S.L.1    Doolan, D.L.2    Sedegah, M.3
  • 18
    • 10744225891 scopus 로고    scopus 로고
    • A novel recombinant adeno-associated virus vaccine reduces behavioral impairment and beta-amyloid plaques in a mouse model of Alzheimer's disease
    • Zhang J, Wu X, Qin C, et al. A novel recombinant adeno-associated virus vaccine reduces behavioral impairment and beta-amyloid plaques in a mouse model of Alzheimer's disease. Neurobiol Dis 2003;14:365-379.
    • (2003) Neurobiol Dis , vol.14 , pp. 365-379
    • Zhang, J.1    Wu, X.2    Qin, C.3
  • 19
    • 14244252864 scopus 로고    scopus 로고
    • Development of a safe oral Abeta vaccine using recombinant adeno-associated virus vector for Alzheimer's disease
    • Hara H, Monsonego A, Yuasa K, et al. Development of a safe oral Abeta vaccine using recombinant adeno-associated virus vector for Alzheimer's disease. J Alzheimers Dis 2004;6:483-488.
    • (2004) J Alzheimers Dis , vol.6 , pp. 483-488
    • Hara, H.1    Monsonego, A.2    Yuasa, K.3
  • 20
    • 24344497384 scopus 로고    scopus 로고
    • Induction of anti-inflammatory immune response by an adenovirus vector encoding 11 tandem repeats of Abeta1-6: Toward safer and effective vaccines against Alzheimer's disease
    • Kim HD, Maxwell JA, Kong FK, et al. Induction of anti-inflammatory immune response by an adenovirus vector encoding 11 tandem repeats of Abeta1-6: toward safer and effective vaccines against Alzheimer's disease. Biochem Biophys Res Commun 2005;336:84-92.
    • (2005) Biochem Biophys Res Commun , vol.336 , pp. 84-92
    • Kim, H.D.1    Maxwell, J.A.2    Kong, F.K.3
  • 21
    • 0036431701 scopus 로고    scopus 로고
    • Insect cells as a factory to produce adeno-associated virus type 2 vectors
    • Urabe M, Ding C, Kotin RM. Insect cells as a factory to produce adeno-associated virus type 2 vectors. Hum Gene Ther 2002;13:1935-1943.
    • (2002) Hum Gene Ther , vol.13 , pp. 1935-1943
    • Urabe, M.1    Ding, C.2    Kotin, R.M.3
  • 22
    • 0034913116 scopus 로고    scopus 로고
    • Nonviral vectors in the new millennium: Delivery barriers in gene transfer
    • Nishikawa M, Huang L. Nonviral vectors in the new millennium: delivery barriers in gene transfer. Hum Gene Ther 2001;12:861-870.
    • (2001) Hum Gene Ther , vol.12 , pp. 861-870
    • Nishikawa, M.1    Huang, L.2
  • 23
    • 0036512761 scopus 로고    scopus 로고
    • Nonviral approaches satisfying various requirements for effective in vivo gene therapy
    • Nishikawa M, Hashida M. Nonviral approaches satisfying various requirements for effective in vivo gene therapy. Biol Pharm Bull 2002;25:275-283.
    • (2002) Biol Pharm Bull , vol.25 , pp. 275-283
    • Nishikawa, M.1    Hashida, M.2
  • 24
    • 10744223260 scopus 로고    scopus 로고
    • Generation and characterization of the humoral immune response to DNA immunization with a chimeric beta-amyloid-interleukin-4 minigene
    • Ghochikyan A, Vasilevko V, Petrushina I, et al. Generation and characterization of the humoral immune response to DNA immunization with a chimeric beta-amyloid-interleukin-4 minigene. Eur J Immunol 2003;33:3232-3241.
    • (2003) Eur J Immunol , vol.33 , pp. 3232-3241
    • Ghochikyan, A.1    Vasilevko, V.2    Petrushina, I.3
  • 25
    • 7944236860 scopus 로고    scopus 로고
    • Antibodies from a DNA peptide vaccination decrease the brain amyloid burden in a mouse model of Alzheimer's disease
    • Schulz JG, Salzer U, Mohajeri MH, et al. Antibodies from a DNA peptide vaccination decrease the brain amyloid burden in a mouse model of Alzheimer's disease. J Mol Med 2004;82:706-714.
    • (2004) J Mol Med , vol.82 , pp. 706-714
    • Schulz, J.G.1    Salzer, U.2    Mohajeri, M.H.3
  • 26
    • 33745476486 scopus 로고    scopus 로고
    • Nonviral Abeta DNA vaccine therapy against Alzheimer's disease: Long-term effects and safety
    • Okura Y, Miyakoshi A, Kohyama K, et al. Nonviral Abeta DNA vaccine therapy against Alzheimer's disease: long-term effects and safety. Proc Natl Acad Sci USA 2006;103:9619-9624.
    • (2006) Proc Natl Acad Sci USA , vol.103 , pp. 9619-9624
    • Okura, Y.1    Miyakoshi, A.2    Kohyama, K.3
  • 27
    • 0037452779 scopus 로고    scopus 로고
    • Epitope and isotype specificities of antibodies to beta -amyloid peptide for protection against Alzheimer's disease-like neuropathology
    • Bard F, Barbour R, Cannon C, et al. Epitope and isotype specificities of antibodies to beta -amyloid peptide for protection against Alzheimer's disease-like neuropathology. Proc Natl Acad Sci USA 2003;100:2023-2028.
    • (2003) Proc Natl Acad Sci USA , vol.100 , pp. 2023-2028
    • Bard, F.1    Barbour, R.2    Cannon, C.3
  • 28
    • 1642497601 scopus 로고    scopus 로고
    • Microglial activation facilitates Abeta plaque removal following intracranial anti-Abeta antibody administration
    • Wilcock DM, Munireddy SK, Rosenthal A, et al. Microglial activation facilitates Abeta plaque removal following intracranial anti-Abeta antibody administration. Neurobiol Dis 2004;15:11-20.
    • (2004) Neurobiol Dis , vol.15 , pp. 11-20
    • Wilcock, D.M.1    Munireddy, S.K.2    Rosenthal, A.3
  • 29
    • 0037107177 scopus 로고    scopus 로고
    • Non-Fc-mediated mechanisms are involved in clearance of amyloid-beta in vivo by immunotherapy
    • Bacskai BJ, Kajdasz ST, McLellan ME, et al. Non-Fc-mediated mechanisms are involved in clearance of amyloid-beta in vivo by immunotherapy. J Neurosci 2002;22:7873-7878.
    • (2002) J Neurosci , vol.22 , pp. 7873-7878
    • Bacskai, B.J.1    Kajdasz, S.T.2    McLellan, M.E.3
  • 31
    • 0035902619 scopus 로고    scopus 로고
    • Peripheral anti-A beta antibody alters CNS and plasma A beta clearance and decreases brain A beta burden in a mouse model of Alzheimer's disease
    • DeMattos RB, Bales KR, Cummins DJ, et al. Peripheral anti-A beta antibody alters CNS and plasma A beta clearance and decreases brain A beta burden in a mouse model of Alzheimer's disease. Proc Natl Acad Sci USA 2001;98:8850-8855.
    • (2001) Proc Natl Acad Sci USA , vol.98 , pp. 8850-8855
    • DeMattos, R.B.1    Bales, K.R.2    Cummins, D.J.3
  • 32
    • 0036240395 scopus 로고    scopus 로고
    • Immunization reverses memory deficits without reducing brain Abeta burden in Alzheimer's disease model
    • Dodart JC, Bales KR, Gannon KS, et al. Immunization reverses memory deficits without reducing brain Abeta burden in Alzheimer's disease model. Nat Neurosci 2002;5:452-457.
    • (2002) Nat Neurosci , vol.5 , pp. 452-457
    • Dodart, J.C.1    Bales, K.R.2    Gannon, K.S.3
  • 33
    • 3843148352 scopus 로고    scopus 로고
    • Prefibrillar amyloid protein aggregates share common features of cytotoxicity
    • Bucciantini M, Calloni G, Chiti F, et al. Prefibrillar amyloid protein aggregates share common features of cytotoxicity. J Biol Chem 2004;279:31374-31382.
    • (2004) J Biol Chem , vol.279 , pp. 31374-31382
    • Bucciantini, M.1    Calloni, G.2    Chiti, F.3
  • 34
    • 0037041420 scopus 로고    scopus 로고
    • Inherent toxicity of aggregates implies a common mechanism for protein misfolding diseases
    • Bucciantini M, Giannoni E, Chiti F, et al. Inherent toxicity of aggregates implies a common mechanism for protein misfolding diseases. Nature 2002;416:507-511.
    • (2002) Nature , vol.416 , pp. 507-511
    • Bucciantini, M.1    Giannoni, E.2    Chiti, F.3
  • 35
    • 33846861744 scopus 로고    scopus 로고
    • Intracerebroventricular passive immunization with anti-oligoAbeta antibody in TgCRND8
    • Chauhan NB. Intracerebroventricular passive immunization with anti-oligoAbeta antibody in TgCRND8. J Neurosci Res 2007;85:451-463.
    • (2007) J Neurosci Res , vol.85 , pp. 451-463
    • Chauhan, N.B.1
  • 36
    • 0036703483 scopus 로고    scopus 로고
    • Reversible memory loss in a mouse transgenic model of Alzheimer's disease
    • Kotilinek LA, Bacskai B, Westerman M, et al. Reversible memory loss in a mouse transgenic model of Alzheimer's disease. J Neurosci 2002;22:6331-6335.
    • (2002) J Neurosci , vol.22 , pp. 6331-6335
    • Kotilinek, L.A.1    Bacskai, B.2    Westerman, M.3
  • 37
    • 26444471910 scopus 로고    scopus 로고
    • Risk factors associated with beta-amyloid(1-42) immunotherapy in preimmunization gene expression patterns of blood cells
    • O'Toole M, Janszen DB, Slonim DK, et al. Risk factors associated with beta-amyloid(1-42) immunotherapy in preimmunization gene expression patterns of blood cells. Arch Neurol 2005;62:1531-1536.
    • (2005) Arch Neurol , vol.62 , pp. 1531-1536
    • O'Toole, M.1    Janszen, D.B.2    Slonim, D.K.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.