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Proceedings of the National Academy of Sciences of the United States of America

Volumn 105, Issue 12, 2008, Pages 4745-4750

PHDs overactivation during chronic hypoxia "desensitizes" HIFα and protects cells from necrosis

(5) Ginouvès, Amandine a Ilc, Karine a Macías, Nuria b Pouysségur, Jacques a Berra, Edurne a,b

a CNRS (France)

b CIC BIOGUNE (Spain)

Author keywords

Cell survival; Oxygen sensing

Indexed keywords

HYPOXIA INDUCIBLE FACTOR 1ALPHA; HYPOXIA INDUCIBLE FACTOR 2ALPHA; ISOPROTEIN; PROCOLLAGEN PROLINE 2 OXOGLUTARATE 4 DIOXYGENASE; PROTEASOME; OXYGEN; VON HIPPEL LINDAU PROTEIN;

ARTICLE; CELL DEATH; CELL PROTECTION; CELL SURVIVAL; CONTROLLED STUDY; DESENSITIZATION; ENZYME ACTIVATION; FEEDBACK SYSTEM; FEMALE; HUMAN; HUMAN CELL; HYDROXYLATION; HYPOXIA; MITOCHONDRIAL RESPIRATION; MOUSE; NONHUMAN; OXYGEN SENSING; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN FUNCTION; PROTEIN STABILITY; ANIMAL; APOPTOSIS; C57BL MOUSE; CELL HYPOXIA; CELL LINE; DRUG EFFECT; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; NECROSIS; PROTEIN PROCESSING; PROTEIN TERTIARY STRUCTURE;

MUS;

ANIMALS; APOPTOSIS; CELL HYPOXIA; CELL LINE; ENZYME ACTIVATION; FEMALE; GENE EXPRESSION REGULATION; HUMANS; HYDROXYLATION; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; MICE; MICE, INBRED C57BL; NECROSIS; OXYGEN; PROCOLLAGEN-PROLINE DIOXYGENASE; PROTEASOME ENDOPEPTIDASE COMPLEX; PROTEIN PROCESSING, POST-TRANSLATIONAL; PROTEIN STRUCTURE, TERTIARY; VON HIPPEL-LINDAU TUMOR SUPPRESSOR PROTEIN;

EID: 42449111722 PISSN: 00278424 EISSN: 10916490 Source Type: Journal
DOI: 10.1073/pnas.0705680105 Document Type: Article

Times cited : (217)

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