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Volumn 65, Issue 7-8, 2008, Pages 1086-1098

Genetic factors for human obesity

Author keywords

Candidate gene; Genome wide association study; Obesity; Polymorphism; Susceptibility gene

Indexed keywords

ADENOSINE DIPHOSPHATE RIBOSYLATION FACTOR; BETA 2 ADRENERGIC RECEPTOR; BETA 3 ADRENERGIC RECEPTOR; BETA ADRENERGIC RECEPTOR; BRAIN DERIVED NEUROTROPHIC FACTOR; BRAIN DERIVED NEUROTROPHIC FACTOR RECEPTOR; COMPLEMENTARY DNA; CORTICOTROPIN; DIPEPTIDYL CARBOXYPEPTIDASE; FURIN; GUANINE NUCLEOTIDE BINDING PROTEIN; INTERMEDIN; LEPTIN; LEPTIN RECEPTOR; MELANOCORTIN 4 RECEPTOR; MESSENGER RNA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PROOPIOMELANOCORTIN; TUMOR NECROSIS FACTOR ALPHA; UNCOUPLING PROTEIN 1; UNCOUPLING PROTEIN 2; UNCOUPLING PROTEIN 3;

EID: 42449102208     PISSN: 1420682X     EISSN: 15691632     Source Type: Journal    
DOI: 10.1007/s00018-007-7453-8     Document Type: Review
Times cited : (54)

References (141)
  • 1
    • 0020533259 scopus 로고
    • Obesity as an independent risk factor for cardiovascular disease: A 26-year follow-up of participants in the Framingham Heart Study
    • Hubert, H. B., Feinleib, M., McNamara, P. M. and Castelli, W. P. (1983) Obesity as an independent risk factor for cardiovascular disease: A 26-year follow-up of participants in the Framingham Heart Study. Circulation 67, 968-977.
    • (1983) Circulation , vol.67 , pp. 968-977
    • Hubert, H.B.1    Feinleib, M.2    McNamara, P.M.3    Castelli, W.P.4
  • 4
    • 0032577404 scopus 로고    scopus 로고
    • Environmental contributions to the obesity epidemic
    • Hill, J. O. and Peters, J. C. (1998) Environmental contributions to the obesity epidemic. Science 280, 1371-1374.
    • (1998) Science , vol.280 , pp. 1371-1374
    • Hill, J.O.1    Peters, J.C.2
  • 5
    • 33749017409 scopus 로고    scopus 로고
    • Rankinen, T., Zuberi, A., Chagnon, Y. C., Weisnagel, S. J., Argyropoulos, G., Walts, B., Pérusse, L. and Bouchard, C. (2006) The human obesity gene map: The 2005 update. Obesity (Silver Spring) 14, 529-644.
    • Rankinen, T., Zuberi, A., Chagnon, Y. C., Weisnagel, S. J., Argyropoulos, G., Walts, B., Pérusse, L. and Bouchard, C. (2006) The human obesity gene map: The 2005 update. Obesity (Silver Spring) 14, 529-644.
  • 8
    • 0028139089 scopus 로고
    • Positional cloning of the mouse obese gene and its human homologue
    • Zhang, Y., Proenca, R., Maffei, M., Barone, M., Leopold, L. and Friedman, J. M. (1994) Positional cloning of the mouse obese gene and its human homologue. Nature 372, 425-432.
    • (1994) Nature , vol.372 , pp. 425-432
    • Zhang, Y.1    Proenca, R.2    Maffei, M.3    Barone, M.4    Leopold, L.5    Friedman, J.M.6
  • 11
    • 0030006511 scopus 로고    scopus 로고
    • Mapping of the OB receptor to 1p in a region of nonconserved gene order from mouse and rat to human
    • Chung, W. K., Power-Kehoe, L., Chua, M. and Leibel, R. L. (1996) Mapping of the OB receptor to 1p in a region of nonconserved gene order from mouse and rat to human. Genome Res. 6, 431-438.
    • (1996) Genome Res , vol.6 , pp. 431-438
    • Chung, W.K.1    Power-Kehoe, L.2    Chua, M.3    Leibel, R.L.4
  • 14
  • 16
    • 0011819393 scopus 로고    scopus 로고
    • Zabel, B. U., Naylor, S. L., Sakaguchi, A. Y., Bell, G. I. and Shows, T. B. (1983) High-resolution chromosomal localization of human genes for amylase, proopiomelanocortin, somatostatin, and a DNA fragment (D3S1) by in situ hybridization. Proc. Nat. Acad. Sci. USA 80, 6932-6936.
    • Zabel, B. U., Naylor, S. L., Sakaguchi, A. Y., Bell, G. I. and Shows, T. B. (1983) High-resolution chromosomal localization of human genes for amylase, proopiomelanocortin, somatostatin, and a DNA fragment (D3S1) by in situ hybridization. Proc. Nat. Acad. Sci. USA 80, 6932-6936.
  • 17
    • 0031838353 scopus 로고    scopus 로고
    • Severe early-onset obesity, adrenal insufficiency and red hair pigmentation caused by POMC mutations in humans
    • Krude, H., Biebermann, H., Luck, W., Horn, R., Brabant, G. and Grüters, A. (1998) Severe early-onset obesity, adrenal insufficiency and red hair pigmentation caused by POMC mutations in humans. Nat. Genet. 19, 155-157.
    • (1998) Nat. Genet , vol.19 , pp. 155-157
    • Krude, H.1    Biebermann, H.2    Luck, W.3    Horn, R.4    Brabant, G.5    Grüters, A.6
  • 21
    • 0031668219 scopus 로고    scopus 로고
    • A frameshift mutation in MC4R associated with dominantly inherited human obesity
    • Yeo, G. S., Farooqi, I. S., Aminian, S., Halsall, D. J., Stanhope, R. G. and O'Rahilly, S. (1998) A frameshift mutation in MC4R associated with dominantly inherited human obesity. Nat. Genet. 20, 111-112.
    • (1998) Nat. Genet , vol.20 , pp. 111-112
    • Yeo, G.S.1    Farooqi, I.S.2    Aminian, S.3    Halsall, D.J.4    Stanhope, R.G.5    O'Rahilly, S.6
  • 22
    • 0031662163 scopus 로고    scopus 로고
    • A frameshift mutation in human MC4R is associated with a dominant form of obesity
    • Vaisse, C., Clement, K., Guy-Grand, B. and Froguel, P. (1998) A frameshift mutation in human MC4R is associated with a dominant form of obesity. Nat. Genet. 20, 113-114.
    • (1998) Nat. Genet , vol.20 , pp. 113-114
    • Vaisse, C.1    Clement, K.2    Guy-Grand, B.3    Froguel, P.4
  • 23
    • 0034913118 scopus 로고    scopus 로고
    • A novel melanocortin 4 receptor (MC4R) gene mutation associated with morbid obesity
    • Mergen, M., Mergen, H., Ozata, M., Oner, R. and Oner, C. (2001) A novel melanocortin 4 receptor (MC4R) gene mutation associated with morbid obesity. J. Clin. Endocrinol. Metab. 86, 3448.
    • (2001) J. Clin. Endocrinol. Metab , vol.86 , pp. 3448
    • Mergen, M.1    Mergen, H.2    Ozata, M.3    Oner, R.4    Oner, C.5
  • 27
    • 0034016043 scopus 로고    scopus 로고
    • Profound obesity associated with a balanced translocation that disrupts the SIM1 gene
    • Holder, J. L. Jr., Butte, N. F. and Zinn, A. R. (2000) Profound obesity associated with a balanced translocation that disrupts the SIM1 gene. Hum. Mol. Genet. 9, 101-108.
    • (2000) Hum. Mol. Genet , vol.9 , pp. 101-108
    • Holder Jr., J.L.1    Butte, N.F.2    Zinn, A.R.3
  • 31
    • 23044467704 scopus 로고    scopus 로고
    • Molecular physiology of syndromic obesities in humans
    • Chung, W. K. and Leibel, R. L. (2005) Molecular physiology of syndromic obesities in humans. Trends Endocrinol. Metab. 16, 267-272.
    • (2005) Trends Endocrinol. Metab , vol.16 , pp. 267-272
    • Chung, W.K.1    Leibel, R.L.2
  • 32
    • 0035515362 scopus 로고    scopus 로고
    • The changing purpose of Prader-Willi syndrome clinical diagnostic criteria and proposed revised criteria
    • Gunay-Aygun, M., Schwartz, S., Heeger, S., O'Riordan, M. A. and Cassidy, S. B. (2001) The changing purpose of Prader-Willi syndrome clinical diagnostic criteria and proposed revised criteria. Pediatrics 108, E92.
    • (2001) Pediatrics , vol.108
    • Gunay-Aygun, M.1    Schwartz, S.2    Heeger, S.3    O'Riordan, M.A.4    Cassidy, S.B.5
  • 33
    • 33645455075 scopus 로고    scopus 로고
    • Imprinting defects on human chromosome 15
    • Horsthemke, B. and Buiting, K. (2006) Imprinting defects on human chromosome 15. Cytogenet. Genome Res. 113, 292-299.
    • (2006) Cytogenet. Genome Res , vol.113 , pp. 292-299
    • Horsthemke, B.1    Buiting, K.2
  • 34
    • 0035777024 scopus 로고    scopus 로고
    • Genome organization, function, and imprinting in Prader-Willi and Angelman syndromes
    • Nicholls, R. D. and Knepper, J. L. (2001) Genome organization, function, and imprinting in Prader-Willi and Angelman syndromes. Annu. Rev. Genomics Hum. Genet. 2, 153-175.
    • (2001) Annu. Rev. Genomics Hum. Genet , vol.2 , pp. 153-175
    • Nicholls, R.D.1    Knepper, J.L.2
  • 36
    • 0035509699 scopus 로고    scopus 로고
    • The IC-SNURF-SNRPN transcript serves as a host for multiple small nucleolar RNA species and as an antisense RNA for UBE3A
    • Runte, M., Hüttenhofer, A., Gross, S., Kiefmann, M., Horsthemke, B. and Buiting, K. (2001) The IC-SNURF-SNRPN transcript serves as a host for multiple small nucleolar RNA species and as an antisense RNA for UBE3A. Hum. Mol. Genet. 10, 2687-2700.
    • (2001) Hum. Mol. Genet , vol.10 , pp. 2687-2700
    • Runte, M.1    Hüttenhofer, A.2    Gross, S.3    Kiefmann, M.4    Horsthemke, B.5    Buiting, K.6
  • 37
    • 0033951792 scopus 로고    scopus 로고
    • Interstitial 6q deletion with a Prader-Willi-like phenotype:Anew case and review of the literature
    • Gilhuis, H. J., van Ravenswaaij, C. M., Hamel, B. J. and Gabreëls, F. J. (2000) Interstitial 6q deletion with a Prader-Willi-like phenotype:Anew case and review of the literature. Eur. J. Paediatr. Neurol. 4, 39-43.
    • (2000) Eur. J. Paediatr. Neurol , vol.4 , pp. 39-43
    • Gilhuis, H.J.1    van Ravenswaaij, C.M.2    Hamel, B.J.3    Gabreëls, F.J.4
  • 38
    • 0033062278 scopus 로고    scopus 로고
    • New criteria for improved diagnosis of Bardet-Biedl syndrome: Results of a population survey
    • Beales, P. L., Elcioglu, N., Woolf, A. S., Parker, D. and Flinter, F. A. (1999) New criteria for improved diagnosis of Bardet-Biedl syndrome: Results of a population survey. J. Med. Genet. 36, 437-446.
    • (1999) J. Med. Genet , vol.36 , pp. 437-446
    • Beales, P.L.1    Elcioglu, N.2    Woolf, A.S.3    Parker, D.4    Flinter, F.A.5
  • 39
  • 50
    • 0030732665 scopus 로고    scopus 로고
    • Genealogy, natural history, and phenotype of Alstrom syndrome in a large Acadian kindred and three additional families
    • Marshall, J. D., Ludman, M. D., Shea, S. E., Salisbury, S. R., Willi, S. M., LaRoche, R. G. and Nishina, P. M. (1997) Genealogy, natural history, and phenotype of Alstrom syndrome in a large Acadian kindred and three additional families. Am. J. Med. Genet. 73, 150-161.
    • (1997) Am. J. Med. Genet , vol.73 , pp. 150-161
    • Marshall, J.D.1    Ludman, M.D.2    Shea, S.E.3    Salisbury, S.R.4    Willi, S.M.5    LaRoche, R.G.6    Nishina, P.M.7
  • 55
    • 0024854232 scopus 로고
    • Börjeson-Forssman-Lehmann syndrome: Clinical manifestations and gene localization to Xq26-27
    • Turner, G., Gedeon, A., Mulley, J., Sutherland, G., Rae, J., Power, K. and Arthur, I. (1989) Börjeson-Forssman-Lehmann syndrome: Clinical manifestations and gene localization to Xq26-27. Am. J. Med. Genet. 34, 463-469.
    • (1989) Am. J. Med. Genet , vol.34 , pp. 463-469
    • Turner, G.1    Gedeon, A.2    Mulley, J.3    Sutherland, G.4    Rae, J.5    Power, K.6    Arthur, I.7
  • 59
    • 0035653510 scopus 로고    scopus 로고
    • Genome-wide linkage analysis assessing parent-of-origin effects in the inheritance of type 2 diabetes and BMI in Pima Indians
    • Lindsay, R. S., Kobes, S., Knowler, W. C., Bennett, P. H. and Hanson, R. L. (2001) Genome-wide linkage analysis assessing parent-of-origin effects in the inheritance of type 2 diabetes and BMI in Pima Indians. Diabetes 50, 2850-2857.
    • (2001) Diabetes , vol.50 , pp. 2850-2857
    • Lindsay, R.S.1    Kobes, S.2    Knowler, W.C.3    Bennett, P.H.4    Hanson, R.L.5
  • 63
    • 0032830999 scopus 로고    scopus 로고
    • A quantitative trait locus influencing BMI maps to the region of the beta-3 adrenergic receptor
    • Mitchell, B. D., Cole, S. A., Comuzzie, A. G., Almasy, L., Blangero, J., MacCluer, J. W. and Hixson, J. E. (1999) A quantitative trait locus influencing BMI maps to the region of the beta-3 adrenergic receptor. Diabetes 48, 1863-1867.
    • (1999) Diabetes , vol.48 , pp. 1863-1867
    • Mitchell, B.D.1    Cole, S.A.2    Comuzzie, A.G.3    Almasy, L.4    Blangero, J.5    MacCluer, J.W.6    Hixson, J.E.7
  • 64
    • 10744228132 scopus 로고    scopus 로고
    • Platte, P., Papanicolaou, G. J., Johnston, J., Klein, C. M., Doheny, K. F., Pugh, E. W., Roy-Gagnon, M. H., Stunkard, A. J., Francomano, C. A. and Wilson, A. F. (2003) A study of linkage and association of body mass index in the Old Order Amish. Am. J. Med. Genet. C. Semin. Med. Genet. 121, 71-80.
    • Platte, P., Papanicolaou, G. J., Johnston, J., Klein, C. M., Doheny, K. F., Pugh, E. W., Roy-Gagnon, M. H., Stunkard, A. J., Francomano, C. A. and Wilson, A. F. (2003) A study of linkage and association of body mass index in the Old Order Amish. Am. J. Med. Genet. C. Semin. Med. Genet. 121, 71-80.
  • 66
    • 19944426878 scopus 로고    scopus 로고
    • Norris, J. M., Langefeld, C. D., Scherzinger, A. L., Rich, S. S., Bookman, E., Beck, S. R., Saad, M. F., Haffner, S. M., Bergman, R. N., Bowden, D. W. and Wagenknecht, L. E. (2005) Quantitative trait loci for abdominal fat and BMI in Hispanic-Americans and African-Americans: The IRAS Family study. Int. J. Obes. (Lond.) 29, 67-77.
    • Norris, J. M., Langefeld, C. D., Scherzinger, A. L., Rich, S. S., Bookman, E., Beck, S. R., Saad, M. F., Haffner, S. M., Bergman, R. N., Bowden, D. W. and Wagenknecht, L. E. (2005) Quantitative trait loci for abdominal fat and BMI in Hispanic-Americans and African-Americans: The IRAS Family study. Int. J. Obes. (Lond.) 29, 67-77.
  • 67
    • 0037407315 scopus 로고    scopus 로고
    • Linkage for BMI at 3q27 region confirmed in an African-American population
    • Luke, A., Wu, X., Zhu, X., Kan, D., Su, Y. and Cooper, R. (2003) Linkage for BMI at 3q27 region confirmed in an African-American population. Diabetes 52, 1284-1287.
    • (2003) Diabetes , vol.52 , pp. 1284-1287
    • Luke, A.1    Wu, X.2    Zhu, X.3    Kan, D.4    Su, Y.5    Cooper, R.6
  • 70
    • 20144380431 scopus 로고    scopus 로고
    • Lewis, C. E., North, K. E., Arnett, D., Borecki, I. B., Coon, H., Ellison, R. C., Hunt, S. C., Oberman, A., Rich, S. S., Province, M. A. and Miller, M. B. (2005) Sex-specific findings from a genome-wide linkage analysis of human fatness in non-Hispanic whites and African Americans: The HyperGEN study. Int. J. Obes. (Lond.) 29, 639-649.
    • Lewis, C. E., North, K. E., Arnett, D., Borecki, I. B., Coon, H., Ellison, R. C., Hunt, S. C., Oberman, A., Rich, S. S., Province, M. A. and Miller, M. B. (2005) Sex-specific findings from a genome-wide linkage analysis of human fatness in non-Hispanic whites and African Americans: The HyperGEN study. Int. J. Obes. (Lond.) 29, 639-649.
  • 71
    • 0036260045 scopus 로고    scopus 로고
    • An X-chromosome scan reveals a locus for fat distribution in chromosome region Xp21-22
    • Price, R. A., Li, W. D. and Kilker, R. (2002) An X-chromosome scan reveals a locus for fat distribution in chromosome region Xp21-22. Diabetes 51, 1989-1991.
    • (2002) Diabetes , vol.51 , pp. 1989-1991
    • Price, R.A.1    Li, W.D.2    Kilker, R.3
  • 72
    • 0037219566 scopus 로고    scopus 로고
    • Interacting genetic loci on chromosomes 20 and 10 influence extreme human obesity
    • Dong, C., Wang, S., Li, W. D., Li, D., Zhao, H. and Price, R. A. (2003) Interacting genetic loci on chromosomes 20 and 10 influence extreme human obesity. Am. J. Hum. Genet. 72, 115-124.
    • (2003) Am. J. Hum. Genet , vol.72 , pp. 115-124
    • Dong, C.1    Wang, S.2    Li, W.D.3    Li, D.4    Zhao, H.5    Price, R.A.6
  • 73
    • 0036234398 scopus 로고    scopus 로고
    • A combined analysis of genomewide linkage scans for body mass index from the National Heart, Lung, and Blood Institute Family Blood Pressure Program
    • Wu, X., Cooper, R. S., Borecki, I., Hanis, C., Bray, M., Lewis, C. E., Zhu, X., Kan, D., Luke, A. and Curb, D. (2002) A combined analysis of genomewide linkage scans for body mass index from the National Heart, Lung, and Blood Institute Family Blood Pressure Program. Am. J. Hum. Genet. 70, 1247-1256.
    • (2002) Am. J. Hum. Genet , vol.70 , pp. 1247-1256
    • Wu, X.1    Cooper, R.S.2    Borecki, I.3    Hanis, C.4    Bray, M.5    Lewis, C.E.6    Zhu, X.7    Kan, D.8    Luke, A.9    Curb, D.10
  • 76
    • 84872239364 scopus 로고    scopus 로고
    • A genome-wide linkage scan for body mass index on Framingham Heart Study families
    • Moslehi, R., Goldstein, A. M., Beerman, M., Goldin, L. and Bergen, A. W. (2003) A genome-wide linkage scan for body mass index on Framingham Heart Study families. BMC Genet. 4 (Suppl. 1), S97.
    • (2003) BMC Genet , vol.4 , Issue.SUPPL. 1
    • Moslehi, R.1    Goldstein, A.M.2    Beerman, M.3    Goldin, L.4    Bergen, A.W.5
  • 78
    • 10744229883 scopus 로고    scopus 로고
    • Linkage analysis of a composite factor for the multiple metabolic syndrome: The National Heart, Lung, and Blood Institute Family Heart Study
    • Tang, W., Miller, M. B., Rich, S. S., North, K. E., Pankow, J. S., Borecki, I. B., Myers, R. H., Hopkins, P. N., Leppert, M. and Arnett, D. K. (2003) Linkage analysis of a composite factor for the multiple metabolic syndrome: The National Heart, Lung, and Blood Institute Family Heart Study. Diabetes 52, 2840-2847.
    • (2003) Diabetes , vol.52 , pp. 2840-2847
    • Tang, W.1    Miller, M.B.2    Rich, S.S.3    North, K.E.4    Pankow, J.S.5    Borecki, I.B.6    Myers, R.H.7    Hopkins, P.N.8    Leppert, M.9    Arnett, D.K.10
  • 82
    • 33645489353 scopus 로고    scopus 로고
    • Genome scan for body mass index and height in the Framingham Heart Study
    • Geller, F., Dempfle, A. and Görg, T. (2003) Genome scan for body mass index and height in the Framingham Heart Study. BMC Genet. 4 (Suppl. 1), S91.
    • (2003) BMC Genet , vol.4 , Issue.SUPPL. 1
    • Geller, F.1    Dempfle, A.2    Görg, T.3
  • 83
    • 2342644820 scopus 로고    scopus 로고
    • Genomewide linkage to chromosome 6 for waist circumference in the Framingham Heart Study
    • Fox, C. S., Heard-Costa, N. L., Wilson, P. W., Levy, D., D'Agostino, R. B. Sr. and Atwood, L. D. (2004) Genomewide linkage to chromosome 6 for waist circumference in the Framingham Heart Study. Diabetes 53, 1399-1402.
    • (2004) Diabetes , vol.53 , pp. 1399-1402
    • Fox, C.S.1    Heard-Costa, N.L.2    Wilson, P.W.3    Levy, D.4    D'Agostino Sr., R.B.5    Atwood, L.D.6
  • 84
    • 0037645695 scopus 로고    scopus 로고
    • Linkage and linkage disequilibrium mapping of genes influencing human obesity in chromosome region 7q22.1-7q35
    • Li, W. D., Li, D., Wang, S., Zhang, S., Zhao, H. and Price, R. A. (2003) Linkage and linkage disequilibrium mapping of genes influencing human obesity in chromosome region 7q22.1-7q35. Diabetes 52, 1557-1561.
    • (2003) Diabetes , vol.52 , pp. 1557-1561
    • Li, W.D.1    Li, D.2    Wang, S.3    Zhang, S.4    Zhao, H.5    Price, R.A.6
  • 85
    • 0036139010 scopus 로고    scopus 로고
    • Quantitative-trait loci influencing body-mass index reside on chromosomes 7 and 13: The National Heart, Lung, and Blood Institute Family Heart Study
    • Feitosa, M. F., Borecki, I. B., Rich, S. S., Arnett, D. K., Sholinsky, P., Myers, R. H., Leppert, M. and Province, M. A. (2002) Quantitative-trait loci influencing body-mass index reside on chromosomes 7 and 13: The National Heart, Lung, and Blood Institute Family Heart Study. Am. J. Hum. Genet. 70, 72-82.
    • (2002) Am. J. Hum. Genet , vol.70 , pp. 72-82
    • Feitosa, M.F.1    Borecki, I.B.2    Rich, S.S.3    Arnett, D.K.4    Sholinsky, P.5    Myers, R.H.6    Leppert, M.7    Province, M.A.8
  • 86
    • 1442349994 scopus 로고    scopus 로고
    • An obesity-related locus in chromosome region 12q23-24
    • Li, W. D., Dong, C., Li, D., Zhao, H. and Price, R. A. (2004) An obesity-related locus in chromosome region 12q23-24. Diabetes 53, 812-820.
    • (2004) Diabetes , vol.53 , pp. 812-820
    • Li, W.D.1    Dong, C.2    Li, D.3    Zhao, H.4    Price, R.A.5
  • 87
    • 0038040484 scopus 로고    scopus 로고
    • Genetic linkage and imprinting effects on body mass index in children and young adults
    • Gorlova, O. Y., Amos, C. I., Wang, N. W., Shete, S., Turner, S. T. and Boerwinkle, E. (2003) Genetic linkage and imprinting effects on body mass index in children and young adults. Eur. J. Hum. Genet. 11, 425-432.
    • (2003) Eur. J. Hum. Genet , vol.11 , pp. 425-432
    • Gorlova, O.Y.1    Amos, C.I.2    Wang, N.W.3    Shete, S.4    Turner, S.T.5    Boerwinkle, E.6
  • 90
    • 0000082145 scopus 로고
    • An exploratory investigation of genetic linkage with body composition and fatness phenotypes: The Quebec Family Study
    • Borecki, I. B., Rice, T., Perusse, L., Bouchard, C. and Rao, D. C. (1994) An exploratory investigation of genetic linkage with body composition and fatness phenotypes: The Quebec Family Study. Obes. Res. 2, 213-219.
    • (1994) Obes. Res , vol.2 , pp. 213-219
    • Borecki, I.B.1    Rice, T.2    Perusse, L.3    Bouchard, C.4    Rao, D.C.5
  • 91
    • 1442349990 scopus 로고    scopus 로고
    • A genome-wide scan for childhood obesity-associated traits in French families shows significant linkage on chromosome 6q22.31-q23.2
    • Meyre, D., Lecoeur, C., Delplanque, J., Francke, S., Vatin, V., Durand, E., Weill, J., Dina, C. and Froguel, P. (2004) A genome-wide scan for childhood obesity-associated traits in French families shows significant linkage on chromosome 6q22.31-q23.2. Diabetes 53, 803-811.
    • (2004) Diabetes , vol.53 , pp. 803-811
    • Meyre, D.1    Lecoeur, C.2    Delplanque, J.3    Francke, S.4    Vatin, V.5    Durand, E.6    Weill, J.7    Dina, C.8    Froguel, P.9
  • 99
    • 1942499472 scopus 로고    scopus 로고
    • Further evidence for a QTL influencing body mass index on chromosome 7p from a genome-wide scan in Dutch families
    • Heijmans, B. T., Beem, A. L., Willemsen, G., Posthuma, D., Slagboom, P. E. and Boomsma, D. (2004) Further evidence for a QTL influencing body mass index on chromosome 7p from a genome-wide scan in Dutch families. Twin Res. 7, 192-196.
    • (2004) Twin Res , vol.7 , pp. 192-196
    • Heijmans, B.T.1    Beem, A.L.2    Willemsen, G.3    Posthuma, D.4    Slagboom, P.E.5    Boomsma, D.6
  • 102
    • 4644227228 scopus 로고    scopus 로고
    • Genome-wide scan for metabolic syndrome and related quantitative traits in Hong Kong Chinese and confirmation of a susceptibility locus on chromosome 1q21-q25
    • Ng, M. C., So, W. Y., Lam, V. K., Cockram, C. S., Bell, G. I., Cox, N. J. and Chan, J. C. (2004) Genome-wide scan for metabolic syndrome and related quantitative traits in Hong Kong Chinese and confirmation of a susceptibility locus on chromosome 1q21-q25. Diabetes 53, 2676-2683.
    • (2004) Diabetes , vol.53 , pp. 2676-2683
    • Ng, M.C.1    So, W.Y.2    Lam, V.K.3    Cockram, C.S.4    Bell, G.I.5    Cox, N.J.6    Chan, J.C.7
  • 103
    • 0029741063 scopus 로고    scopus 로고
    • The future of genetic studies of complex human diseases
    • Risch, N. and Merikangas, K. (1996) The future of genetic studies of complex human diseases. Science 273, 1516-1517.
    • (1996) Science , vol.273 , pp. 1516-1517
    • Risch, N.1    Merikangas, K.2
  • 104
    • 0032189782 scopus 로고    scopus 로고
    • Obesity associated with a mutation in a genetic regulator of adipocyte differentiation
    • Ristow, M., Müller-Wieland, D., Pfeiffer, A., Krone, W. and Kahn, C. R. (1998) Obesity associated with a mutation in a genetic regulator of adipocyte differentiation. N. Engl. J. Med. 339, 953-959.
    • (1998) N. Engl. J. Med , vol.339 , pp. 953-959
    • Ristow, M.1    Müller-Wieland, D.2    Pfeiffer, A.3    Krone, W.4    Kahn, C.R.5
  • 105
    • 0031595923 scopus 로고    scopus 로고
    • A Pro12Ala substitution in PPARgamma2 associated with decreased receptor activity, lower body mass index and improved insulin sensitivity
    • Deeb, S. S., Fajas, L., Nemoto, M., Pihlajamäki, J., Mykkänen, L., Kuusisto, J., Laakso, M., Fujimoto, W. and Auwerx, J. (1998) A Pro12Ala substitution in PPARgamma2 associated with decreased receptor activity, lower body mass index and improved insulin sensitivity. Nat. Genet. 20, 284-287.
    • (1998) Nat. Genet , vol.20 , pp. 284-287
    • Deeb, S.S.1    Fajas, L.2    Nemoto, M.3    Pihlajamäki, J.4    Mykkänen, L.5    Kuusisto, J.6    Laakso, M.7    Fujimoto, W.8    Auwerx, J.9
  • 106
    • 0035215987 scopus 로고    scopus 로고
    • The effect of the Gly16Arg polymorphism of the beta(2)-adrenergic receptor gene on plasma free fatty acid levels is modulated by physical activity
    • Meirhaeghe, A., Luan, J., Selberg-Franks, P., Hennings, S., Mitchell, J., Halsall, D., O'Rahilly, S. and Wareham, N. J. (2001) The effect of the Gly16Arg polymorphism of the beta(2)-adrenergic receptor gene on plasma free fatty acid levels is modulated by physical activity. J. Clin. Endocrinol. Metab. 86, 5881-5887.
    • (2001) J. Clin. Endocrinol. Metab , vol.86 , pp. 5881-5887
    • Meirhaeghe, A.1    Luan, J.2    Selberg-Franks, P.3    Hennings, S.4    Mitchell, J.5    Halsall, D.6    O'Rahilly, S.7    Wareham, N.J.8
  • 107
    • 21544454653 scopus 로고    scopus 로고
    • Beta2- and beta3-adrenergic receptor polymorphisms are related to the onset of weight gain and blood pressure elevation over 5 years
    • Masuo, K., Katsuya, T., Fu, Y., Rakugi, H., Ogihara, T. and Tuck, M. L. (2005) Beta2- and beta3-adrenergic receptor polymorphisms are related to the onset of weight gain and blood pressure elevation over 5 years. Circulation 111, 3429-3434.
    • (2005) Circulation , vol.111 , pp. 3429-3434
    • Masuo, K.1    Katsuya, T.2    Fu, Y.3    Rakugi, H.4    Ogihara, T.5    Tuck, M.L.6
  • 108
    • 0036525939 scopus 로고    scopus 로고
    • The 27Glu polymorphism of the beta2-adrenergic receptor gene interacts with physical activity influencing obesity risk among female subjects
    • Corbalán, M. S., Marti, A., Forga, L., Martínez- González, M. A. and Martínez, J. A. (2002) The 27Glu polymorphism of the beta2-adrenergic receptor gene interacts with physical activity influencing obesity risk among female subjects. Clin. Genet. 61, 305-307.
    • (2002) Clin. Genet , vol.61 , pp. 305-307
    • Corbalán, M.S.1    Marti, A.2    Forga, L.3    Martínez- González, M.A.4    Martínez, J.A.5
  • 111
    • 0029658675 scopus 로고    scopus 로고
    • The Trp64Arg mutation of the beta3 adrenergic receptor gene has no effect on obesity phenotypes in the Québec Family Study and Swedish Obese Subjects cohorts
    • Gagnon, J., Maurige, P., Roy, S., Sjöström, D., Chagnon, Y. C., Dionne, F. T., Oppert, J. M., Pérusse, L., Sjöström, L. and Bouchard, C. (1996) The Trp64Arg mutation of the beta3 adrenergic receptor gene has no effect on obesity phenotypes in the Québec Family Study and Swedish Obese Subjects cohorts. J. Clin. Invest. 98, 2086-2093.
    • (1996) J. Clin. Invest , vol.98 , pp. 2086-2093
    • Gagnon, J.1    Maurige, P.2    Roy, S.3    Sjöström, D.4    Chagnon, Y.C.5    Dionne, F.T.6    Oppert, J.M.7    Pérusse, L.8    Sjöström, L.9    Bouchard, C.10
  • 112
    • 0346101834 scopus 로고    scopus 로고
    • The Trp(64)Arg polymorphism of the beta(3)-adrenergic receptor gene is not associated with body weight or body mass index in Japanese: A longitudinal analysis
    • Matsushita, Y., Yokoyama, T., Yoshiike, N., Matsumura, Y., Date, C., Kawahara, K. and Tanaka, H. (2003) The Trp(64)Arg polymorphism of the beta(3)-adrenergic receptor gene is not associated with body weight or body mass index in Japanese: A longitudinal analysis. J. Clin. Endocrinol. Metab. 88, 5914-5920.
    • (2003) J. Clin. Endocrinol. Metab , vol.88 , pp. 5914-5920
    • Matsushita, Y.1    Yokoyama, T.2    Yoshiike, N.3    Matsumura, Y.4    Date, C.5    Kawahara, K.6    Tanaka, H.7
  • 113
    • 0029843407 scopus 로고    scopus 로고
    • Additive effect of A→G (-3826) variant of the uncoupling protein gene and the Trp64Arg mutation of the beta 3-adrenergic receptor gene on weight gain in morbid obesity
    • Clément, K., Ruiz, J., Cassard-Doulcier, A. M., Bouillaud, F., Ricquier, D., Basdevant, A., Guy-Grand, B. and Froguel, P. (1996) Additive effect of A→G (-3826) variant of the uncoupling protein gene and the Trp64Arg mutation of the beta 3-adrenergic receptor gene on weight gain in morbid obesity. Int. J. Obes. Relat. Metab. Disord. 20, 1062-1066.
    • (1996) Int. J. Obes. Relat. Metab. Disord , vol.20 , pp. 1062-1066
    • Clément, K.1    Ruiz, J.2    Cassard-Doulcier, A.M.3    Bouillaud, F.4    Ricquier, D.5    Basdevant, A.6    Guy-Grand, B.7    Froguel, P.8
  • 114
    • 0346101854 scopus 로고    scopus 로고
    • The-3826 A→G variant of the uncoupling protein-1 gene diminishes postprandial thermogenesis after a high fat meal in healthy boys
    • Nagai, N., Sakane, N., Ueno, L. M., Hamada, T. and Moritani, T. (2003) The-3826 A→G variant of the uncoupling protein-1 gene diminishes postprandial thermogenesis after a high fat meal in healthy boys. J. Clin. Endocrinol. Metab. 88, 5661-5667.
    • (2003) J. Clin. Endocrinol. Metab , vol.88 , pp. 5661-5667
    • Nagai, N.1    Sakane, N.2    Ueno, L.M.3    Hamada, T.4    Moritani, T.5
  • 116
    • 0034003721 scopus 로고    scopus 로고
    • Agenetic variation in the 5′ flanking region of the UCP3 gene is associated with body mass index in humans in interaction with physical activity
    • Otabe, S., Clement, K., Dina, C., Pelloux, V., Guy-Grand, B., Froguel, P. and Vasseur, F. (2000)Agenetic variation in the 5′ flanking region of the UCP3 gene is associated with body mass index in humans in interaction with physical activity. Diabetologia 43, 245-249.
    • (2000) Diabetologia , vol.43 , pp. 245-249
    • Otabe, S.1    Clement, K.2    Dina, C.3    Pelloux, V.4    Guy-Grand, B.5    Froguel, P.6    Vasseur, F.7
  • 117
    • 0035016780 scopus 로고    scopus 로고
    • G-308A polymorphism of the tumor necrosis factor alpha gene promoter and salivary cortisol secretion
    • Rosmond, R., Chagnon, M., Bouchard, C. and Björntorp, P. (2001) G-308A polymorphism of the tumor necrosis factor alpha gene promoter and salivary cortisol secretion. J. Clin. Endocrinol. Metab. 86, 2178-2180.
    • (2001) J. Clin. Endocrinol. Metab , vol.86 , pp. 2178-2180
    • Rosmond, R.1    Chagnon, M.2    Bouchard, C.3    Björntorp, P.4
  • 121
    • 0034620791 scopus 로고    scopus 로고
    • G protein beta3 subunit 825 TT genotype and post-pregnancy weight retention
    • Gutersohn, A., Naber, C., Müller, N., Erbel, R. and Siffert, W. (2000) G protein beta3 subunit 825 TT genotype and post-pregnancy weight retention. Lancet 355, 1240-1241.
    • (2000) Lancet , vol.355 , pp. 1240-1241
    • Gutersohn, A.1    Naber, C.2    Müller, N.3    Erbel, R.4    Siffert, W.5
  • 122
    • 0034621062 scopus 로고    scopus 로고
    • Association of maternal G protein beta3 subunit 825T allele with low birth weight
    • Hocher, B., Slowinski, T., Stolze, T., Pleschka, A., Neumayer, H. H. and Halle, H. (2000) Association of maternal G protein beta3 subunit 825T allele with low birth weight. Lancet 355, 1241-1242.
    • (2000) Lancet , vol.355 , pp. 1241-1242
    • Hocher, B.1    Slowinski, T.2    Stolze, T.3    Pleschka, A.4    Neumayer, H.H.5    Halle, H.6
  • 123
    • 0034527931 scopus 로고    scopus 로고
    • Association of the G-2548A polymorphism in the 5′ region of the LEP gene with overweight
    • Mammès, O., Betoulle, D., Aubert, R., Herbeth, B., Siest, G. and Fumeron, F. (2000) Association of the G-2548A polymorphism in the 5′ region of the LEP gene with overweight. Ann. Hum. Genet. 64, 391-394.
    • (2000) Ann. Hum. Genet , vol.64 , pp. 391-394
    • Mammès, O.1    Betoulle, D.2    Aubert, R.3    Herbeth, B.4    Siest, G.5    Fumeron, F.6
  • 125
    • 0032871802 scopus 로고    scopus 로고
    • Sequence variants in the 5′ flanking region of the leptin gene are associated with obesity in women
    • Li, W. D., Reed, D. R., Lee, J. H., Xu, W., Kilker, R. L., Sodam, B. R. and Price, R. A. (1999) Sequence variants in the 5′ flanking region of the leptin gene are associated with obesity in women. Ann. Hum. Genet. 63, 227-234.
    • (1999) Ann. Hum. Genet , vol.63 , pp. 227-234
    • Li, W.D.1    Reed, D.R.2    Lee, J.H.3    Xu, W.4    Kilker, R.L.5    Sodam, B.R.6    Price, R.A.7
  • 126
    • 0035073893 scopus 로고    scopus 로고
    • A single nucleotide polymorphism (SNP) in the leptin receptor is associated with BMI, fat mass and leptin levels in postmenopausal Caucasian women
    • Quinton, N. D., Lee, A. J., Ross, R. J., Eastell, R. and Blakemore, A. I. (2001) A single nucleotide polymorphism (SNP) in the leptin receptor is associated with BMI, fat mass and leptin levels in postmenopausal Caucasian women. Hum. Genet. 108, 233-236.
    • (2001) Hum. Genet , vol.108 , pp. 233-236
    • Quinton, N.D.1    Lee, A.J.2    Ross, R.J.3    Eastell, R.4    Blakemore, A.I.5
  • 127
    • 0034917636 scopus 로고    scopus 로고
    • Leptin receptor gene polymorphisms are associated with insulin in obese women with impaired glucose tolerance
    • Wauters, M., Mertens, I., Rankinen, T., Chagnon, M., Bouchard, C. and Van Gaal, L. (2001) Leptin receptor gene polymorphisms are associated with insulin in obese women with impaired glucose tolerance. J. Clin. Endocrinol. Metab. 86, 3227-3232.
    • (2001) J. Clin. Endocrinol. Metab , vol.86 , pp. 3227-3232
    • Wauters, M.1    Mertens, I.2    Rankinen, T.3    Chagnon, M.4    Bouchard, C.5    Van Gaal, L.6
  • 128
    • 33748465942 scopus 로고    scopus 로고
    • Leptin receptor Lys656Asn polymorphism is associated with decreased leptin response and weight loss secondary to a lifestyle modification in obese patients
    • de Luis Roman, D., de la Fuente, R. A., Sagrado, M. G., Izaola, O. and Vicente, R. C. (2006) Leptin receptor Lys656Asn polymorphism is associated with decreased leptin response and weight loss secondary to a lifestyle modification in obese patients. Arch. Med. Res. 37, 854-859.
    • (2006) Arch. Med. Res , vol.37 , pp. 854-859
    • de Luis Roman, D.1    de la Fuente, R.A.2    Sagrado, M.G.3    Izaola, O.4    Vicente, R.C.5
  • 132
    • 34848889315 scopus 로고    scopus 로고
    • Evaluation of genome-wide power of genetic association studies based on empirical data from the HapMap Project
    • Nannya, Y., Taura, K., Kurokawa, M. and Ogawa, S. (2007) Evaluation of genome-wide power of genetic association studies based on empirical data from the HapMap Project. Hum. Mol. Genet. 16, 3494-3505.
    • (2007) Hum. Mol. Genet , vol.16 , pp. 3494-3505
    • Nannya, Y.1    Taura, K.2    Kurokawa, M.3    Ogawa, S.4
  • 133
    • 84969213492 scopus 로고    scopus 로고
    • Genome-wide association study of 14 000 cases of seven common diseases and 3000 shared controls
    • Wellcome Trust Case Control Consortium
    • Wellcome Trust Case Control Consortium (2007) Genome-wide association study of 14 000 cases of seven common diseases and 3000 shared controls. Nature 447, 661-678.
    • (2007) Nature , vol.447 , pp. 661-678
  • 141
    • 42449145150 scopus 로고    scopus 로고
    • World Health Organization. http://www.who.int./en/.


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