Quantitative-trait loci influencing body-mass index reside on chromosomes 7 and 13: The National Heart, Lung, and Blood Institute Family Heart Study

American Journal of Human Genetics

Volumn 70, Issue 1, 2002, Pages 72-82

  Feitosa, Mary F ^a   Borecki, Ingrid B ^a   Rich, Stephen S ^b   Arnett, Donna K ^c   Sholinsky, Phyliss ^d   Myers, Richard H ^e   Leppert, Mark ^f   Province, Michael A ^a  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b WAKE FOREST SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF MINNESOTA   (United States)

^d NATIONAL INSTITUTES OF HEALTH   (United States)

^e BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^f UNIVERSITY OF UTAH SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

LEPTIN;

ADULT; AGED; ARTICLE; BODY MASS; CHROMOSOME 1; CHROMOSOME 13; CHROMOSOME 13Q; CHROMOSOME 14; CHROMOSOME 15; CHROMOSOME 2; CHROMOSOME 3; CHROMOSOME 5; CHROMOSOME 6; CHROMOSOME 7; CHROMOSOME 7Q; FEMALE; GENE LOCUS; GENE MAPPING; GENETIC LINKAGE; GENETIC MARKER; HUMAN; MALE; NORMAL HUMAN; OBESITY; PRIORITY JOURNAL; QUANTITATIVE TRAIT;

MAMMALIA;

EID: 0036139010     PISSN: 00029297     EISSN: None     Source Type: Journal    
DOI: 10.1086/338144     Document Type: Article

References (65)

1. Meta-analysis of linkage data under worst-case conditions: A demonstration using the human OB region
2. Paradoxical decrease of an adipose-specific protein, adiponectin, in obesity
3. Genome-wide linkage analysis of blood pressure in Mexican Americans
4. 5-HT2A receptor gene polymorphism is associated with food and alcohol intake in obese people
5. Evidence for at least two major loci influencing human fatness
6. Influence of genotype-dependent effects of covariates on the outcome of segregation analysis of the body mass index
7. Evidence for multiple determinants of the body mass index: The National Heart, Lung, and Blood Institute Family Heart Study
8. The impact of marker allele frequency misspecification in variance components quantitative trait locus analysis using sibship data
9. False positives and false negatives in variance components linkage analysis of quantitative traits using SEGPATH
10. Commingling analysis of generalized body mass and composition measures: The Quebec Family Study
11. An exploratory investigation of genetic linkage with body composition and fatness phenotypes: The Quebec family study
12. The genetics of human obesity
13. Linkage analysis of candidate obesity genes among the Mexican-American population of Starr County, Texas
14. Comprehensive human genetic maps: Individual and sex-specific variation in recombination
15. Blood pressure and insulin resistance cosegregate at two distinct regions on chromosome 7
16. A sib-pair analysis study of 15 candidate genes in French families with morbid obesity: Indication for linkage with islet 1 locus on chromosome 5q
17. Indication for linkage of the human OB gene region with extreme obesity
18. A major quantitative trait locus determining serum leptin levels and fat mass is located on human chromosome 2
19. Correcting for ascertainment bias in the COGA data set
20. Ascertainment issues in variance components models
21. DNA variation in the genes of the Na, K-adenosine triphosphatase and its relation with resting metabolic rate, respiratory quotient, and body fat
22. Quantitative variation in obesity-related traits and insulin precursors linked to the OB gene region on human chromosome 7
23. Overweight and obesity in the United States: Prevalence and trends, 1960-1994
24. Leptin and the regulation of body weight in mammals
25. A genome-wide scan for human obesity genes reveals a major susceptibility locus on chromosome 10
26. An autosomal genomic scan for loci linked to type II diabetes mellitus and body-mass index in Pima Indians
27. Recessive inheritance of obesity in familial non-insulin-dependent diabetes mellitus, and lack of linkage to nine candidate genes
28. Affectedsib-pair interval mapping and exclusion for complex genetic traits: Sampling considerations
29. NHLBI Family Heart Study: Objectives and design
30. Genomewide linkage analysis of stature in multiple populations reveals several regions with evidence of linkage to adult height
31. Association of polymorphisms in the β2-adrenergic receptor gene with obesity, hypertriglyceridaemia, and diabetes mellitus
32. Linkage and association of the sodium potassium-adenosine triphosphatase α2 and β1 genes with respiratory quotient and resting metabolic rate in the Quebec Family Study
33. Quantitative trait loci on chromosomes 3 and 17 influence phenotypes of the metabolic syndrome
34. A cholesterollowering gene maps to chromosome 13q
35. Complete multipoint sib-pair analysis of qualitative and quantitative traits
36. Minisymposium on obesity: Overview and some strategic considerations
37. Relationship of a novel polymorphic marker near the human obese (OB) gene to fat mass in healthy women
38. Human beta-2 adrenoceptor gene polymorphisms are highly frequent in obesity and associate with altered adipocyte beta-2 adrenoceptor function
39. Genome scan for human obesity and linkage to markers in 20q13
40. The role of serotonin in eating disorders
41. Estrogen receptor gene polymorphism, but not estradiol levels, is related to bone density in healthy adolescent boys: A cross-sectional and longitudinal study
42. Effects of misspecification of allele frequencies on the type I error rate of model-free linkage analysis
43. β2-adrenoceptor gene polymorphism, body weight, and physical activity
44. A quantitative trait locus influencing BMI maps to the region of the β-3 adrenergic receptor
45. The genetic and environmental sources of body mass index variability: The Muscatine Ponderosity Family Study
46. Autosomal genomic scan for loci linked to obesity and energy metabolism in Pima Indians
47. Genome-wide scan of obesity in Finnish sibpairs reveals linkage to chromosome Xq24
48. Novel modulator for endothelial adhesion molecules: Adipocyte-derived plasma protein adiponectin
49. Quantitative-trait-locus analysis of body-mass index and of stature, by combined analysis of genome scans of five Finnish study groups
50. Common major gene inheritance of extreme overweight
51. Strong evidence for a major gene for obesity in the large, unselected, total Community Health study of Tecumseh
52. A multivariate and multilocus variance components approach using structural relationships to assess quantitative trait linkage via SEGPATH
53. A genome search identifies major quantitative trait loci on human chromosomes 3 and 4 that influence cholesterol concentrations in small LDL particles
54. Extreme obesity may be linked to markers flanking the human OB gene
55. Familial aggregation of body mass index and subcutaneous fat measures in the longitudinal Quebec family study
56. Genome-wide linkage analysis of systolic and diastolic blood pressure: The Quebec Family Study
57. A glucocorticoid receptor gene marker is associated with abdominal obesity, leptin, and dysregulation of the hypothalamic-pituitary-adrenal axis
58. Further support for linkage of extreme obesity to the obese gene in a study group of obese children and adolescents
59. A collection of ordered tetranucleotide-repeat markers from the human genome
60. Some hazards of obesity and its treatment
61. Apolipoprotein-D polymorphism: A genetic marker for obesity and hyperinsulinemia
62. Genomewide search for type 2 diabetes-susceptibility genes in French whites: Evidence for a novel susceptibility locus for early-onset diabetes on chromosome 3q27-qter and independent replication of a type 2-diabetes locus on chromosome 1q21-q24
63. The public health impact of obesity
64. 2-adrenergic receptor gene associated with obesity and type 2 diabetes