Interacting genetic loci on chromosomes 20 and 10 influence extreme human obesity

American Journal of Human Genetics

Volumn 72, Issue 1, 2003, Pages 115-124

  Dong, Chuanhui ^a   Wang, Shuang ^b   Li, Wei Dong ^a   Li, Ding ^a   Zhao, Hongyu ^b   Price, R Arlen ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALLELE; ARTICLE; BODY MASS; CHROMOSOME 10; CHROMOSOME 20; CHROMOSOME 7; CONTROLLED STUDY; CORRELATION ANALYSIS; EXPERIMENTAL MODEL; FAMILY; GENE FREQUENCY; GENE IDENTIFICATION; GENE INTERACTION; GENETIC EPISTASIS; GENETIC LINKAGE; HUMAN; MAJOR CLINICAL STUDY; MULTIVARIATE ANALYSIS; OBESITY; PHENOTYPE; PRIORITY JOURNAL; RACE; SIBLING; SYNTENY; VARIANCE;

ANIMALIA;

EID: 0037219566     PISSN: 00029297     EISSN: None     Source Type: Journal    
DOI: 10.1086/345648     Document Type: Article

References (41)

1. Almasy L, Blangero J (1998) Multipoint quantitative-trait linkage analysis in general pedigrees. Am J Hum Genet 62:1198-1211
2. Carroll KK (1998) Obesity as a risk factor for certain types of cancer. Lipids 33:1055-1059
3. Chen AS, Marsh DJ, Trumbauer ME, Frazier EG, Guan XM, Yu H, Rosenblum CI, Vongs A, Feng Y, Cao L, Metzger JM, Strack AM, Camacho RE, Mellin TN, Nunes CN, Min W, Fisher J, Gopal-Truter S, MacIntyre DE, Chen HY, Van der Ploeg LH (2000) Inactivation of the mouse melanocortin-3 receptor results in increased fat mass and reduced lean body mass. Nat Genet 26:97-102
4. Coleman DL, Hummel KP (1975) Symposium IV: Diabetic syndrome in animals. Influence of genetic background on the expression of mutations at the diabetes locus in the mouse. II. Studies on background modifiers. Isr J Med Sci 11:708-713
5. Cox NJ, Frigge M, Nicolae DL, Concannon P, Hanis CL, Bell GI, Kong A (1999) Loci on chromosomes 2 (NIDDM1) and 15 interact to increase susceptibility to diabetes in Mexican Americans. Nat Genet 21:213-215
6. Deng HW, Deng H, Liu YJ, Liu YZ, Xu FH, Shen H, Conway T, Li JL, Huang QY, Davies KM, Recker RR (2002) A genomewide linkage scan for quantitative-trait loci for obesity phenotypes. Am J Hum Genet 70:1138-1151
7. Fong TM, Mao C, MacNeil T, Kalyani R, Smith T, Weinberg D, Tota MR, Van der Ploeg LH (1997) ART (protein product of agouti-related transcript) as an antagonist of MC-3 and MC-4 receptors. Biochem Biophys Res Commun 237:629-631
8. Grilo CM, Pogue-Geile MF (1991) The nature of environmental influences on weight and obesity: A behavior genetic analysis. Psychol Bull 110:520-537
9. Gunay-Aygun M, Cassidy SB, Nicholls RD (1997) Prader-Willi and other syndromes associated with obesity and mental retardation. Behav Genet 27:307-324
10. Hager J, Dina C, Francke S, Dubois S, Houari M, Vatin V, Vaillant E, Lorentz N, Basdevant A, Clement K, Guy-Grand B, Froguel P (1998) A genome-wide scan for human obesity genes reveals a major susceptibility locus on chromosome 10. Nat Genet 20:304-308
11. Hinney A, Ziegler A, Oeffner F, Wedewardt C, Vogel M, Wulftange H, Geller F, Stubing K, Siegfried W, Goldschmidt HP, Remschmidt H, Hebebrand J (2000) Independent confirmation of a major locus for obesity on chromosome 10. J Clin Endocrinol Metab 85:2962-2965
12. Horikawa Y, Oda N, Cox NJ, Li X, Orho-Melander M, Hara M, Hinokio Y, et al (2000) Genetic variation in the gene encoding calpain-10 is associated with type 2 diabetes mellitus. Nat Genet 26:163-175 (erratum 26:502)
13. Hunt SC, Abkevich V, Hensel CH, Gutin A, Neff CD, Russell DL, Tran T, Hong X, Jammulapati S, Riley R, Weaver-Feldhaus J, Macalma T, Richards MM, Gress R, Francis M, Thomas A, Frech GC, Adams TD, Shattuck D, Stone S (2001) Linkage of body mass index to chromosome 20 in Utah pedigrees. Hum Genet 109:279-285
14. Kong A, Cox NJ (1997) Allele-sharing models: LOD scores and accurate linkage tests. Am J Hum Genet 61:1179-1188
15. Kopelman PG (2000) Obesity as a medical problem. Nature 404:635-643
16. Kruglyak L, Daly MJ, Reeve-Daly MP, Lander ES (1996) Parametric and nonparametric linkage analysis: A unified multipoint approach. Am J Hum Genet 58:1347-1363
17. Kruglyak L, Lander ES (1995) Complete multipoint sib-pair analysis of qualitative and quantitative traits. Am J Hum Genet 57:439-454
18. Lee JH, Reed DR, Li WD, Xu W, Joo EJ, Kilker RL, Nanthakumar E, North M, Sakul H, Bell C, Price RA (1999) Genome scan for human obesity and linkage to markers in 20q13. Am J Hum Genet 64:196-209
19. Li WD, Reed DR, Lee JH, Xu W, Kilker RL, Sodam BR, Price RA (1999) Sequence variants in the 5′ flanking region of the leptin gene are associated with obesity in women. Ann Hum Genet 63:227-234
20. Maes HH, Neale MC, Eaves LJ (1997) Genetic and environmental factors in relative body weight and human adiposity. Behav Genet 27:325-351
21. Miller MW, Duhl DM, Vrieling H, Cordes SP, Ollmann MM, Winkes BM, Barsh GS (1993) Cloning of the mouse agouti gene predicts a secreted protein ubiquitously expressed in mice carrying the lethal yellow mutation. Genes Dev 7:454-467
22. Niswender KD, Morton GJ, Stearns WH, Rhodes CJ, Myers MG Jr, Schwartz MW (2001) Intracellular signalling: Key enzyme in leptin-induced anorexia. Nature 413:794-795
23. Norman RA, Tataranni PA, Pratley R, Thompson DB, Hanson RL, Prochazka M, Baier L, Ehm MG, Sakul H, Foroud T, Garvey WT, Burns D, Knowler WC, Bennett PH, Bogardus C, Ravussin E (1998) Autosomal genomic scan for loci linked to obesity and energy metabolism in Pima Indians. Am J Hum Genet 62:659-668
24. Ollmann MM, Wilson BD, Yang YK, Kerns JA, Chen Y, Gantz I, Barsh GS (1997) Antagonism of central melanocortin receptors in vitro and in vivo by agouti-related protein. Science 278:135-138
25. Perusse L, Chagnon YC, Weisnagel SJ, Rankinen T, Snyder E, Sands J, Bouchard C (2001) The human obesity gene map: The 2000 update. Obes Res 9:135-169
26. Price RA (1987) Genetics of human obesity. Ann Behav Med 9:9-14
27. _ (2002) Genetics and common obesities: Background, current status, strategies and future prospects. In: Wadden T (ed) Obesity, Theory and Therapy. Guilford Publications, New York
28. Price RA, Gottesman II (1991) Body fat in identical twins reared apart: Roles for genes and environment. Behav Genet 21:1-7
29. Price RA, Li WD, Bernstein A, Crystal A, Golding EM, Weisberg SJ, Zuckerman WA (2001) A locus affecting obesity in human chromosome region 10p12. Diabetologia 44:363-366
30. Price RA, Reed DR, Guido NJ (2000) Resemblance for body mass index in families of obese African American and European American women. Obes Res 8:360-366
31. Price RA, Reed DR, Lee JH (1998) Obesity related phenotypes in families selected for extreme obesity and leanness. Int J Obes Relat Metab Disord 22:406-413
32. Rankinen T, Perusse L, Weisnagel SJ, Snyder EE, Chagnon YC, Bouchard C (2002) The human obesity gene map: The 2001 update. Obes Res 10:196-243
33. Reed DR, Ding Y, Xu W, Cather C, Green ED, Price RA (1996) Extreme obesity may be linked to markers flanking the human OB gene. Diabetes 45:691-694
34. Shintani M, Ikegami H, Yamato E, Kawaguchi Y, Fujisawa T, Nakagawa Y, Hamada Y, Ueda H, Miki T, Ogihara T (1996) A novel microsatellite polymorphism in the human OB gene: A highly polymorphic marker for linkage analysis. Diabetologia 39:1398-1401
35. Shmulewitz D, Auerbach SB, Lehner T, Blundell ML, Winick JD, Youngman LD, Skilling V, Heath SC, Ott J, Stoffel M, Breslow JL, Friedman JM (2001) Epidemiology and factor analysis of obesity, type II diabetes, hypertension, and dyslipidemia (syndrome X) on the island of Kosrae, Federated States of Micronesia. Hum Hered 51:8-19
36. Sorensen TI, Price RA, Stunkard AJ, Schulsinger F (1989) Genetics of obesity in adult adoptees and their biological siblings. BMJ 298:87-90
37. Spiegelman BM, Flier JS (2001) Obesity and the regulation of energy balance. Cell 104:531-543
38. Stunkard AJ, Harris JR, Pedersen NL, McClearn GE (1990) The body-mass index of twins who have been reared apart. N Engl J Med 322:1483-1487
39. Stunkard AJ, Sorensen TI, Hanis C, Teasdale TW, Chakraborty R, Schull WJ, Schulsinger F (1986) An adoption study of human obesity. N Engl J Med 314:193-198
40. Wolk A, Gridley G, Svensson M, Nyren O, McLaughlin JK, Fraumeni JF, Adam HO (2001) A prospective study of obesity and cancer risk (Sweden). Cancer Causes Control 12:13-21
41. Yeh WC, Cao Z, Classon M, McKnight SL (1995) Cascade regulation of terminal adipocyte differentiation by three members of the C/EBP family of leucine zipper proteins. Genes Dev 9:168-181