Usefulness of phytooestrogens in reduction of blood pressure. Systematic review and meta-analysis;Utilidad de los fitoestrógenos en la reducción de la presión arterial. Revisión sistemática y metaanálisis

Atencion Primaria

Volumn 40, Issue 4, 2008, Pages 177-186

  Rosero Arenas, M Ángeles ^a,d   Rosero Arenas, Esteban ^a   Portaceli Armiñana, M Amparo ^b   García García, Miguel Ángel ^c  

^a Centro de Salud Nazaret   (Spain)

^b Medicina del Trabajo Tejidos Royo   (Spain)

^c HOSPITAL DE SAGUNTO   (Spain)

^d Hospital de Sagunto ^*  (Spain)

Author keywords

Blood pressure; Hypertension; Phytoestrogens; Soy foods

Indexed keywords

ISOFLAVONE; PHYTOESTROGEN; PLACEBO; PLANT EXTRACT; RHEUM RHAPONTICUM EXTRACT; SOYBEAN PROTEIN; UNCLASSIFIED DRUG;

ARTICLE; BLOOD PRESSURE REGULATION; BLOOD PRESSURE VARIABILITY; CLINICAL TRIAL; COCHRANE LIBRARY; COMPUTER PROGRAM; CONFIDENCE INTERVAL; DIASTOLIC BLOOD PRESSURE; DIET THERAPY; EMBASE; EXPERIMENTAL STUDY; HUMAN; HYPERTENSION; INFORMATION RETRIEVAL; MEDLINE; META ANALYSIS; OBSERVATIONAL STUDY; RANDOMIZATION; SAMPLE SIZE; SOYBEAN MILK; STATISTICAL MODEL; SYSTEMATIC REVIEW; SYSTOLIC BLOOD PRESSURE;

EID: 42149188220     PISSN: 02126567     EISSN: 15781275     Source Type: Journal    
DOI: 10.1157/13118060     Document Type: Article

References (73)

1. Kearney PM, Whelton M, Reynolds K, Muntner P, Whelton PK, He J. Global burden of hypertension: analysis of worldwide data. Lancet. 2005;365:217-23.
2. Banegas JR, Rodríguez-Artalejo F, de la Cruz-Troca JJ, Guallar-Castillón P, del Rey Calero J. Blood presure in Spain: distribution awareness, control, and benefits of a reduction in average presure. Hypertension. 1998;32:998-1002.
3. Banegas JR, Rodríguez-Artalejo F, Ruilope LM, Graciani A, Luque M, de la Cruz-Troca JJ, et al.Hypertension magnitude and management in the elderly population of Spain. J Hypertens. 2002;20:2157-64.
4. Llisterri JL, Rodríguez-Roca GC,Alonso JF,Santos JA,Carrasco E, Aguirre JC, et al. Control de la hipertensión arterial y de otros factores cardiovasculares en población de alto riesgo asistida en Atención Primaria. Estudio Evento. SEMERGEN. 2005;31:53-60.
5. Llisterri JL, Rodríguez-Roca GC, Alonso JF, Lou S, Divisón JA, Santos JA, et al. Control de la presión arterial en la población hipertensa española atendida en atención primaria. Estudio PRESCAP. Med Clin (Barc). 2004;122:165-71.
6. Miura K, Daviglus ML, Dyer AR. Relatioship of blood pressure to 25-year mortality due to coronary heart disease, cardiovascular diseases and all causes in young adult men: The Chicago Heart Association detection Project in industry. Arch Intern Med. 2001;161:1501.
7. Lewington S, Clarke R, Qizilbash N. Age-specific relevance of usual blood pressure to vascular mortality: a meta-analysis of individual data for one million adults in 61 prospective studies. Lancet. 2002;360:1903.
8. Yusuf S, Hawken S, Ounpuu S. Effect of potentially modifiable risk factors associated with myocardial infarction in 52 countries (the INTERHEART study): case-control study. Lancet. 2004;364:937.
9. Wasserteil-Smoller S, Hendrix SL, Limacher M, Heiss G, Kooperberg C, Rossouw JE, et al. Effect of estrogen plus progestin on stroke in postmenopausical women: the Women's Health Initiative: a randomized trial. JAMA. 2003;289:2673-84.
10. Manson JE, Hsia J, Johnson KC, Rosouw JE, Assaf AR, Lasser SR, et al. Estrogens plus progestin and the risk of coronary hearty disease. N Engl J Med. 2003;349:523-34.
11. Haya J, Camil Castelo-Branco C, Pérez- Medina T. Fitoestrógenos: conocimientos básicos y utilidad clínica.Toko-Gin Pract. 2002;61:337-63.
12. Messina MJ. Soy foods and soybean isoflavones and menopausal health.Nutr Clin Care. 2002;5:272-82.
13. Krebs EE, Ensrud KE,MacDonald R,Wilt TJ. Phytoestrogens for treatment of menopausal symptoms: a systematic review. Obstet Gynecol. 2004;104:824-36.
14. Sacks FM, Lichtenstein A, Van Horn L, Harris W, Kris-Etherton P, Winston M. Soy protein, isoflavones and cardiovascular health. An American Heart Association science advisory for professionals from the Nutrition Committee. Circulation. 2006;113:1034-44.
15. Zhan S, Ho SC. Meta-analysis of the effects of soy protein containing isoflavones on the lipid profile. Am J Clin Nutr. 2005;81:397-408.
16. Zhuo XG, Melby MK,Watanabe S. Soy isoflavone intake lowers serum LDL cholesterol: a meta-analysis of 8 randomized controlled trials in humans. J Nutr. 2004;134:2395-400.
17. Anderson JW, Johnstone BM, Cook-Newell E. Meta-analysis of the effects of soy protein intake on serum lipids. NEJM. 1995;333:276-82.
18. Nestel P. Isoflavones: their effects on cardiovascular risk and functions. Curr Opin Lipidol. 2003;14:3-8.
19. Vanharanta M, Voutilainen S, Lakka TA, van der Lee M, Adlercreutz H. Risk of acute coronary events according to serum concentrations of enterolactone: a prospective population-based case-control study. Lancet. 1999;354:2112-5.
20. Hedges LV, Olkin I. Statistical methods for meta-analysis. Orlando: Academic Press; 1985.
21. Jadad AR, Moore RA, Carroll D, Jenkinson C, Reynolds DJ, Gavaghan DJ, et al. Assesing the quality reports of randomized controlled trials: is blinding necessary? Control Clin Trials. 1996;17:1-12.
22. Van der Schouw YT, Kreijkamp-Kaspers S, Peeters PHM, Keinan-Boker L, Rimm EB, Grobbee DE. Prospective study on usual dietary phytoestrogens intake and cardiovascular disease risk in western women. Circulation. 2005;111:465-71.
23. Yang G, Shu X, Jin F, Zhang X, Li H, Li Q, et al. Longitudinal study of soy food intake and blood pressure among middle-aged and elderly chinese women. Am J Clin Nutr. 2005;81:1012-7.
24. Kreijkamp-Kaspers S, Kok L, Bots ML, Grobbee DE, van der Schouw YT. Dietary phytoestrogens and vascular function in postmenopausal women: a cross-sectional study. J Hypertens. 2004;22:1381-8.
25. Nagata C, Shimizu H, Yakani R, Hayashi M, Takeda N, Yasuda K. Association of blood pressure with intake of soy products and other food grows in japanese men and women. Prev Med. 2003;36:692-7.
26. De Kleijn MJJ, van der Schouw YT,Wilson PWF,Grobbee DE, Jacques PF. Dietary intake of phytoestrogens is associated with a favorable metabolic cardiovascular risk profile in postmenopausal US women: the Framingham Study. J Nutr. 2002;132:276-82.
27. Goodman-Gruen D, Kritz-Silverstein D. Usual dietary isoflavone intake is associated with cardiovascular disease risk factors in postmenopausal women. J Nutr. 2001;131:1202-6.
28. Arai Y,Watanabe S, Kimira M, Shimoi K, Mochizuki R, Kinae N. Dietary intakes of flavonols, flavones and isoflavones by japanese women and the inverse correlation between quercetin intake and plasma LDL cholesterol concentration. J Nutr. 2000;130:2243-50.
29. Fujii M, Fukui T, Miyoshi T. Effect of freeze-dried soybean curd (tofu) on various bodily functions. J Med Invest. 1999;46:67-74.
30. Takashima Y, Iwase Y,Yoshida M, Kokaze A,Takagi Y,Tsubono Y, et al. Relationship of food intake and dietary patterns with blood pressure levels among middle-aged japanese men. J Epidemiol. 1998;8:106-15.
31. Anderson JW, Blake JE,Turner J, Smith BM. Effects of soy protein on renal function and proteinura in patients with type 2 diabetes. Am J Clin Nutr. 1998;68 Suppl:S1347-53.
32. Bloedon L, Jeffcoat AR, Lopaczinski W, Schell MJ, Black TM, Dix KJ, et al. Safetu and pharmacokinetics of purified soy isoflavones: single-dose administration to postmenopausal women. Am J Clin Nutr. 2002;76:1126-37.
33. Crouse JR,Morgan T,Terry JG, Ellis J,Vitolins M, Burke GL.A randomized trial comparing the effect of casein with that of soy protein containing varying amounts of isoflavones on plasma concentrations of lipids and lipoproteins. Arch Int Med. 1999;159:2070-6.
34. Drapier Faure E, Chantre P, Mares P. Effects of a standardized soy extrac on hot flushes: a multicenter, double-blind, randomized, placebo-controlled study.Menopause. 2002;9:329-34.
35. Harrison RA, Sagara M, Rajpura A, Armitage L, Birt N, Birt CA, et al. Can foods with added soya-protein or fish-oil reduce risk factor for coronary disease? A factorial randomized controlled trial.Nutr Metab Cardiovasc Dis. 2004;14:344-50.
36. Hodgson JM, Puddey IB, Beilin LJ, Mori TA, Burke V, Croft KD, et al. Effects of isoflavonoids on blood pressure in subjects with high-normal ambulatory blood pressure levels. Am J Hypertens. 1999;12:47-53.
37. Hutchins AM, McIver IE, Johnston CS. Soy isoflavone and ascorbic acid supplementation alone or in combination minimally affect plasma lipid peroxides in healthy postmenopausal women. J Am Diet Assoc. 2005;105:1134-7.
38. Lo GS, Cole TG. Soy cotyledon fiber products reduce plasma lipids. Atherosclerosis. 1990;82:59-67.
39. Research Committee to the Medical Research Council. Controlled trial of soya-bean oil in myocardial infarction. Lancet. 1968;2:693-700.
40. Nestel PJ, Yamashita T, Sasahara T, Pomeroy S, Dart A, Komesaroff P, et al. Soy isoflavones improve systemic arterial compliance but not plasma lipids in menopausal and perimenopausal women. Arterioscler Throm Vasc Biol. 1997;17:3392-8.
41. Nestel PJ, Pomeroy S,Kay S, Komesaroff P, Behrsing J, Cameron JD, et al. Isoflavones from red clover improve systemic arterial compliance but not plasma llpids in menopausal women. J Clin Endocrinol Metab. 1999;84:895-8.
42. Perasadina VR, Dmitrievskaia MN, Mal'tsev GI, Pogozheva AV, Vasil'ev AV. The use of nutritional antioxidants for the correction of metabolic disorders of cardiovascular patients. Vopr Pitan. 2004;73:3-6.
43. Pogozheva AV, Kondakova MN, Pokrovskaia GR, Mal'tsvev GI. Effects of antiatherosclerosis diet including soy protein on the dynamics of clinical, bioquemical and inmunologic indicators in patients with ischemic heart disease and hypertension. Vopr Pitan. 1999;68:27-31.
44. Pogozheva AV, Derbeneva SA, Pavliuchkova MS, Kondakova MN,Vasil'ev AV,Parkhomenko ON. Soybean proteins in correction of coronary risk factors in patients with cardiovascular diseases. Vopr Pitan. 2002;71:16-9.
45. Pogozheva AV, Pavliuchkova MS, Miagkova MA. Effect of an anti - atherogenic diet, including soy protein products with various levels of phytoestrogens, on indicators of humoral immunity in patients with hypertension and ischemic heart disease. Vopr Pitan. 2002;71:8-11.
46. Raus K, Brucker C, Gorkow C,Wuttke W. First-time proof of endometrial safety of the special black cohosh extract (Actaea or Cimicifuga racemosa extract) CR BNO 1055. Menopause. 2006;13:678-91.
47. Wuttke W, Gorkov C, Seidlová-Wuttke D. Effects of black cohosh (Cimicifuga racemosa) on bone turnover, vaginal mucosa, and various blood parameters in postmenopausal women: a double-blind, placebo-controlled, and conjugated estrogens-controlled study.Menopause. 2006;13:185-96.
48. Washburn S, Burke G, Morgan T, Anthony M. Effect of soy protein supplementation on serum lipoproteins, blood pressure and menopausal symptoms in perimenopausal women. Menopause. 1999;6:7-13.
49. Simons LA, von Konigsmark M, Simons J, Celermajer DS. Phytoestrogens do not influence lipoprotein levels or endothelial function in healthy postmenopausal women. Am J Cardiol. 2000;85:1297-301.
50. Teede HJ,Dalais FS, Kotsopoulos D, Liang L, Davis S,McGrath P. Dietary soy has both benefitial and potentially adverse cardiovascular effects: a placebo-controlled study in men and postmenopausal women. J Clin Endocrin Metab. 2001;86:3053-60.
51. Han KK, Soares JM, Mauro MD, Hadair MA, Rodrigues GR, Baracat E. Benefits of soy isoflavone therapeutic regimen on menopausal symptoms.Obstet Gynecol. 2002;99:389-94.
52. Jayagopal V, Albertazzi P, KilPatrick ES,Howarth EM, Jennings PE, Hepburn DA, et al. Benefitial effects of soy phytoestrogen intake in postmenopausal women with type 2 diabetes. Diab Care. 2002;25:1709-14.
53. Jorissen BL, Brouns F, van Boxtel MPG, Riedel WJ. Safety of soy-derived phosphatidylserine in elderly people. Nutritional Neuroscience. 2002;5:337-43.
54. Allison DB, Gadbury G, Schwartz LG, Murugesan R, Kraker JL, Heshka S, et al. A novel soy-based meal replacement formula for weight loss among obese individuals: a randomized controlled clinical trial. Eur J Clin Nutr. 2003;57:514-22.
55. Teede HJ, McGrath BP, deSilva L, Cehun M, Fassoulakis A, Nestel PJ. Isoflavones reduce arterial stiffness. A placebo-controlled study in men and postmenopausal women. Arterioscler Thromb Vasc Biol. 2003;23:1066-71.
56. Puska P, Korpelainen V, Hoie LH, Skovlund E, Smerud KT. Isolated soya protein with standardised levels of isoflavones, cotyledon soya fibres and soya phospholipids improves plasma lipids in hypercholesterolaemia: a double-blind, placebo-controlled, trial fo a yoghurt formulation. Br J Nutr. 2004;91:393-401.
57. Appel LJ, Sacks FM, Carey WJ, Obarzanek E, Swain JF, Miller ER, et al. Effects of protein, monounsaturated fat, and carbohydrate intake on blood pressure and serum lipids. JAMA. 2005;294:2455-64. 58. He J,Gu D,Wu X, Chen J,Duan X, Chen J, et al. Effects of soybean protein on blood pressure: a randomized, controlled trial. Ann Intern Med. 2005;143:1-9.
58. Kreijkamp-Kasper S, Kok L, Bots ML,Grobbee DE,Lampe JW, van der Schouw YT.Randomized controlled trial of the effects of soy protein containing isoflavones on vascular function in postmenopausal women. Am J Clin Nutr. 2005;81:189-95.
59. Heger M,Ventskovskiy BM, Borzenko I, Kneis KC, Rettenberger R, Kaszkin-Bettag M, et al. Efficacy and safety of a special extract of Rheum Rhaponticum (ERr 731) in perimenopausal women with climacteric complaints: a 12-week randomized, double-blind, placebo-controlled trial. Menopause. 2006;13:744-59.
60. Teede HJ, Giannopoulos D, Dalais FS, Hodgson J, McGrath BP. Randomised, controlled, cross-over trial of soy protein with isoflavones on blood pressure and arterial function in hypertensive subjects. J Am Coll Nutr. 2006;25:533-40.
61. Brussard JH, Joop MS, van Raaija MA, Stasse-Wolthuis M, Katan MB, Hautvast JG. Blood pressure and diet in normotensive volunteers: absence of effect of dietary fiber, protein or fat. Am J Clin Nutr. 1981;34:2023-9.
62. Casiglia E, Semplicini A, Businaro R, Petucco S, Colangeli G, Dal Palú C. Effects of medium-term soybean treatment on lipid pattern and hemodinamics. Advances in Therapy. 1991;8:78-85.
63. Kurowska EM, Jordan J, Spence JD, Wetmore S, Piché LA, Radzikowski M, et al. Effects of substituting dietary soybean protein and oil for milk protein and fat in subjects with hypercholesterolemia. Clin Invest Med. 1997;20:162-70.
64. Jenkins DJA, Kendall CWC, Mehling CC, Parker T,Venket Rao A, Agarwal S, et al. Combined effect of vegetable protein (soy) and soluble fiber added to a standard cholesterol-lowering diet. Metabolism. 1999;48:809-16.
65. Burke V, Hodgson JM, Beilin LJ,Giangiulioi N, Rogers P, Puddey B. Dietary protein and soluble fiber reduce ambulatory blood pressure in treated hypertensives. Hypertension. 2001;38:821-6.
66. Hermansen K, Sondegaard M, Hoie L, Carstensen M, Brock B. Beneficial effects of a soy-based dietary supplement on lipids levels and cardiovascular risk markers in type 2 diabetes subjects. Diab Care. 2001;24:228-33.
67. Chiechi LM, Secreto G, Vimercati A, Greco P, Venturelli E, Pansini F, et al. The effects of a soy rich diet on serum lipids: the MENFIS randomized trial. Maturitas. 2002;41:97-104.
68. Jenkins DJA, Kendall CWC, Jackson C, Connelly PW, Parker T, Faulkner D, et al. Effects of high- and low-isoflavone soy foods on blood lipids, oxidized LDL, homocysteine, and blood pressure in hyperlipidemic men and women. Am J Clin Nutr. 2002;76:365-72.
69. Rivas M, Garay RP, Escanero JF, Cia P, Cia P Jr,Alda J. Soy milk lowers blood pressure in men and women with mild to moderate essential hypertension. J Nutr. 2002;132:1900-2.
70. Cuevas AM, Irribarra VL, Castillo OA, Yáñez MD, Germain AM. Isolated soy protein improves endothelial function in postmenopausal hypercholesterolemic women. Eur J Clin Nutr. 2003;57:889-94.
71. Sagara M, Kanda T, Njelekera M,Teramoto T, Armitage L, Birt N, et al. Effects of dietary intake of soy protein and isoflavones on cardiovascular disease risk factors in high risk, middle - aged men in Scotlan. J Am Coll Nutr. 2003;23:85-91.
72. Meyer BJ, Larkin TA, Owen AJ, Astheimer LB, Tapsell LC, Howe PRC. Limited lipid-lowering effects of regular consumption of whole soybean foods. Ann Nutr Metab. 2004;48:67-78.
73. Anderson JW, Hoie LH.Weight lost and lipid changes with low-energy diets: comparator study of milk-based versus soy-based liquid meal replacement interventions. J Am Coll Nutr. 2005;24:210-6.