Effects of a standardized soy extract on hot flushes: A multicenter, double-blind, randomized, placebo-controlled study

Menopause

Volumn 9, Issue 5, 2002, Pages 329-334

  Faure, Evelyne Drapier ^a   Chantre, Philippe ^b   Mares, Pierre ^c  

^a EDOUARD HERRIOT HOSPITAL   (France)

^b Laboratoires Arkopharma   (France)

^c DEPARTMENT OF NEUROLOGY   (France)

Author keywords

Hormone replacement therapy; Hot flush; Isoflavone; Menopause; Soy

Indexed keywords

BIOCHANIN A; DAIDZEIN; FORMONONETIN; GENISTEIN; ISOFLAVONE; NATURAL PRODUCT; PLACEBO; DAIDZIN; ESTROGEN; GENISTIN; ISOFLAVONE DERIVATIVE; PHYTOSOYA; PLANT EXTRACT;

ADULT; ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DIET SUPPLEMENTATION; DISEASE SEVERITY; DOUBLE BLIND PROCEDURE; DRUG EFFICACY; DRUG SAFETY; FEMALE; FOLLOW UP; HOT FLUSH; HUMAN; MAJOR CLINICAL STUDY; MENOPAUSAL SYNDROME; MULTICENTER STUDY; RANDOMIZED CONTROLLED TRIAL; SIDE EFFECT; SOYBEAN; TIME SERIES ANALYSIS; TREATMENT OUTCOME; VERTIGO; WEIGHT GAIN; ESTROGEN THERAPY; MIDDLE AGED; POSTMENOPAUSE;

DOUBLE-BLIND METHOD; ESTROGEN REPLACEMENT THERAPY; ESTROGENS, NON-STEROIDAL; FEMALE; HOT FLASHES; HUMANS; ISOFLAVONES; MIDDLE AGED; PLANT EXTRACTS; POSTMENOPAUSE; SOYBEANS;

EID: 0036728454     PISSN: 10723714     EISSN: None     Source Type: Journal    
DOI: 10.1097/00042192-200209000-00005     Document Type: Article

References (31)

1. Polo-Kantola P, Erkkola R, Helenius H, Irjala K, Polo O. When does estrogen replacement therapy improve sleep quality? Am J Obstet Gynecol 1998;178:1002-1009.
2. Scharf M, McDannold M, Stover R, Zaretsky N, Berkowitz D. Effects of estrogen replacement therapy on rates of cyclic alternating patterns and hot-flush events during sleep in postmenopausal women: a pilot study. Clin Ther 1997;19:304-311.
3. Doven M, Schneider H. The impact of different HRT regimens on compliance. Int J Fertil 1996;168:129-139.
4. Daly E, Roche M, Barlow D, Gray A, McPherson K, Vessey M. HRT: an analysis of benefits, risks and costs. Br Med Bull 1992;48: 368-400.
5. Baber R, Templeman C, Morton T, Kelly G, West L. Randomized placebo-controlled trial of an isoflavone supplement and menopausal symptoms in women. Climacteric 1999;2:85-92.
6. Boulet M, Oddens B, Lehert P, Vemer H, Visser A. Climacteric and menopause in seven south-east Asian countries. Maturitas 1994;19: 157-176.
7. Lock M. Encounters with aging: mythologies of menopause in Japan and North America. Berkeley, CA: University of California Press, 1993.
8. Notelovitz M. Estrogen replacement therapy indications, contraindications and agent selection. Am J Obstet Gynecol 1989;167:8-17.
9. Rekers H. Mastering the menopause. In: Burger H, Boulet M, eds. A Portrait of the Menopause. Park Bridge, New Jersey: The Parthenon Publishing Group, 1991:23-43.
10. Adlercreutz H. Phytoestrogens: epidemiology and a possible role in cancer protection. Environ Health Perspect 1995;103:103-112.
11. Grady D, Rubin S, Petitti D. Hormone therapy to prevent disease and prolong life in posmenopausal women. Ann Intern Med 1992; 117:1016-1037.
12. Salonieni H, Wahala K, Nykanen-Kurki P, Kallela K, Saastamoinen I. Phytoestrogen content and estrogenic effect of legume fodder. Proc Soc Exp Biol Med 1995;208:13-17.
13. Murphy P. Phytoestrogen content of processed soybean products. Food Technol 1982;34:60-64.
14. Coward L, Barnes N, Setchell K. Genistein and daidzein and their glycoside conjugates: anti-tumor isoflavones in soybean foods from American and Asian diets. J Agric Food Chem 1993;41:1961-1967.
15. Mathieson R, Kitts W. Binding of phytoestrogen and 17 β-estradiol by cytoplasmic receptors in the pituitary gland and hypothalamus of the ewe. J Endocrinol 1980;85:317-325.
16. Martin P, Horwitz K, Ryan D, McGuire W. Phytoestrogen interaction with estrogen receptors in human breast cells. Endocrinology 1978;103:1860-1867.
17. Kuiper G, Lemmen J, Carlsson B. Interaction of estrogenic chemicals and phytoestrogens with estrogen receptor. Endocrinology 1998;139:4252-4263.
18. Peterson G, Barnes S. Genistein inhibits both estrogen and growth factor-stimulated proliferation of human breast cancer cells. Cell Growth Differ 1996;7:1345-1351.
19. Kuiper G, Carlsson B, Grandien K. Comparison of the ligand binding specificity and transcript tissue distribution of estrogen receptors α and β. Endocrinology 1997;138:863-870.
20. Makela S, Davis V, Tally W. Dietary estrogens act through estrogen receptor-mediated processes and show no antiestrogenicity in cultured breast cancer cells. Environ Health Perspect 1994;102:572-578.
21. Santell R, Chang Y, Nair M, Helferich W. Dietary genistein exerts estrogenic effects upon the uterus, mammary gland and the hypothalamic/pituitary axis in rats. J Nutr 1997;127:263-269.
22. Mikisicek R. Interaction of naturally occurring nonsteroidal estrogens with expressed recombinant human estrogen receptor. J Steroid Biochem Molec Biol 1994;49:153-160.
23. Schonherr E, Kinsella M, Wight T. Genistein selectively inhibits platelet-derived growth factor-stimulated versican biosynthesis in monkey arterial smooth muscle cells. Arch Biochem Biophys 1997; 339:353-361.
24. Gillings D, Koch G. The application of the principle of intention -to-treat to the analysis of clinical trials. Drug Inf J 1991;25:411-424.
25. Wasburn S, Burke GL, Morgan T, Anthony M. Effect of soy protein supplementation on serum lipoproteins, blood pressure, and menopausal symptoms in perimenopausal women. Menopause 1999;6: 7-13.
26. Brzezinski A, Adlercreut Z, Shaoul R, et al. Short-term effects of phytoestrogen-rich diet on postmenopausal women. Menopause 1997;4:89-94.
27. Albertazzi P, Pansini F, Bonaccorsi G, Zanotti L, Forini E, De Aloysio D. The effect of dietary soy supplementation on hot flushes. Obstet Gynecol 1998;91:6-11.
28. Scambia G, Mango D, Signorile P, et al. Clinical effects of a standardized soy extract in postmenopausal women: a pilot study. Menopause 2000;7:105-111.
29. Upmalis D, Lobo R, Bradley L, Warren M, Cone F, Lamia C. Vasomotor symptom relief by soy isoflavone extract tablets in post-menopausal women: a multicenter, double-blind, randomized, placebo-controlled study. Menopause 2000;7:236-242.
30. Quella SK, Loprinzi CL, Barton DL, et al. Evaluation of soy phytoestrogens for the treatment of hot flashes in breast cancer survivors: a north central cancer treatment group trial. J Clin Oncol 2000; 18:1068-1074.
31. St Germain A, Peterson CT, Robinson JG, Alekel DL. Isoflavonesrich or isoflavone-poor soy protein does not reduce menopausal symptoms during 24 weeks of treatment. Menopause 2001;8: 17-26.