Soy isoflavone intake lowers serum LDL cholesterol: A meta-analysis of 8 randomized controlled trials in humans

Journal of Nutrition

Volumn 134, Issue 9, 2004, Pages 2395-2400

  Zhuo, Xing Gang ^a   Melby, Melissa K ^a   Watanabe, Shaw ^a  

^a TOKYO UNIVERSITY OF AGRICULTURE   (Japan)

Author keywords

Cholesterol; Isoflavones; LDL; Meta analysis; Soy protein

Indexed keywords

CHOLESTEROL; ISOFLAVONE; LOW DENSITY LIPOPROTEIN CHOLESTEROL; SOYBEAN PROTEIN;

ARTICLE; BODY WEIGHT; CHOLESTEROL BLOOD LEVEL; CHOLESTEROL DIET; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; DIET; DRUG ACTIVITY; DRUG EFFECT; FIBER; HUMAN; HYPERCHOLESTEROLEMIA; LANGUAGE; LIPID BLOOD LEVEL; MEDLINE; META ANALYSIS; PROTEIN BLOOD LEVEL; PROTEIN INTAKE; PUBLICATION; RANDOMIZED CONTROLLED TRIAL; SYSTEMATIC REVIEW;

GLYCINE MAX;

EID: 4444292230     PISSN: 00223166     EISSN: None     Source Type: Journal    
DOI: 10.1093/jn/134.9.2395     Document Type: Article

References (53)

1. Anderson, J. W., Johnstone, B. M. & Cook-Newell, M. E. (1995) Metaanalysis of the effects of soy protein intake on serum lipids. N. Engl. J. Med. 333: 276-282.
2. Baum, J. A., Teng, H., Erdman, J. W., Jr., Weigel, R. M., Klein, B. P., Persky, V. W., Freels, S., Surya, P., Bakhit, R. M., Ramos, E., Shay, N. F. & Potter, S.M. (1998) Long-term intake of soy protein improves blood lipid profiles and increases mononuclear cell low-density-lipoprotein receptor messenger RNA in hypercholesterolemic, postmenopausal women. Am. J. Clin. Nutr. 68: 545-551.
3. Crouse, J. R., 3rd, Morgan, T., Terry, J. G., Ellis, J., Vitolins, M. & Burke, G. L. (1999) A randomized trial comparing the effect of casein with that of soy protein containing varying amounts of isoflavones on plasma concentrations of lipids and lipoproteins. Arch. Intern. Med. 159: 2070-2076.
4. Gardner, C. D., Newell, K. A., Cherin, R. & Haskell, W. L. (2001) The effect of soy protein with or without isoflavones relative to milk protein on plasma lipids in hypercholesterolemic postmenopausal women. Am. J. Clin. Nutr. 73: 728-735.
5. Teede, H. J., Dalais, F. S., Kotsopoulos, D., Liang, Y. L., Davis, S. & McGrath, B. P. (2001) Dietary soy has both beneficial and potentially adverse cardiovascular effects: a placebo-controlled study in men and postmenopausal women. J. Clin. Endocrinol. Metab. 86: 3053-3060.
6. Nilausen, K. & Meinertz, H. (1998) Variable lipemic response to dietary soy protein in healthy, normolipemic men. Am. J. Clin. Nutr. 68: 1380S-1384S.
7. Duane, W. C. (1999) Effects of soybean protein and very low dietary cholesterol on serum lipids, biliary lipids, and fecal sterols in humans. Metabolism 48: 489-494.
8. Nestel, P. J., Yamashita, T., Sasahara, T., Pomeroy, S., Dart, A., Komesaroff, P., Owen, A. & Abbey, M. (1997) Soy isoflavones improve systemic arterial compliance but not plasma lipids in menopausal and perimenopausal women. Arterioscler Thromb. Vasc. Biol. 17: 3392-3398.
9. Hodgson, J. M., Puddey, I. B., Beilin, L. J., Mori, T. A. & Croft, K. D. (1998) Supplementation with isoflavonoid phytoestrogens does not alter serum lipid concentrations: a randomized controlled trial in humans. J. Nutr. 128: 728-732.
10. Simons, L. A., von Konigsmark, M., Simons, J. & Celermajer, D. S. (2000) Phytoestrogens. do not influence lipoprotein levels or endothelial function in healthy, postmenopausal women. Am. J. Cardiol. 85: 1297-1301.
11. Nestel, P. J., Pomeroy, S., Kay, S., Komesaroff, P., Behrsing, J., Cameron, J. D. & West, L. (1999) Isoflavones from red clover improve systemic arterial compliance but not plasma lipids in menopausal women. J. Clin. Endocrinol. Metab. 84: 895-898.
12. Samman, S., Lyons Wall, P. M., Chan, G. S., Smith, S. J. & Petocz, P. (1999) The effect of supplementation with isoflavones on plasma lipids and oxidisability of low density lipoprotein in premenopausal women. Atherosclerosis 147: 277-283.
13. Weggemans, R. M. & Trautwein, E. A. (2003) Relation between soy-associated isoflavones and LDL and HDL cholesterol concentrations in humans: a meta-analysis. Eur. J. Clin. Nutr. 57: 940-946.
14. Irwig, L., Tosteson, A. N., Gatsonis, C., Lau, J., Colditz, G., Chalmers, T. C. & Mosteller, F. (1994) Guidelines for meta-analyses evaluating diagnostic tests. Ann. Intern. Med. 120: 667-676.
15. Gibaldi, M. (1993) Meta-analysis. A review of its place in therapeutic decision making. Drugs 46: 805-818.
16. Sacks, H. S., Berrier, J., Reitman, D., Ancona-Berk, V. A. & Chalmers, T. C. (1987) Meta-analyses of randomized controlled trials. N. Engl. J. Med. 316: 450-455.
17. Teixeira, S. R., Potter, S. M., Weigel, R., Hannum, S., Erdman, J. W., Jr. & Hasler, C. M. (2000) Effects of feeding 4 levels of soy protein for 3 and 6 wk on blood lipids and apolipoproteins in moderately hypercholesterolemic men. Am. J. Clin. Nutr. 71: 1077-1084.
18. Cruz, M. L., Wong, W. W., Mimouni, F., Hachey, D. L., Setchell, K. D., Klein, P. D. & Tsang, R. C. (1994) Effects of infant nutrition on cholesterol synthesis rates. Pediatr. Res. 35: 135-140.
19. Takatsuka, N., Nagata, C., Kurisu, Y., Inaba, S., Kawakami, N. & Shimizu, H. (2000) Hypocholesterolemic effect of soymilk supplementation with usual diet in premenopausal normolipidemic Japanese women. Prev. Med. 31: 308-314.
20. Dewell, A., Hollenbeck, C. B. & Bruce, B. (2002) The effects of soy-derived phytoestrogens on serum lipids and lipoproteins in moderately hypercholesterolemic postmenopausal women. J. Clin. Endocrinol. Metab. 87: 118-121.
21. Gooderham, M. H., Adlercreutz, H., Ojala, S. T., Wahala, K. & Holub, B. J. (1996) A soy protein isolate rich in genistein and daidzein and its effects on plasma isoflavone concentrations, platelet aggregation, blood lipids and fatty acid composition of plasma phospholipid in normal men. J. Nutr. 126: 2000-2006.
22. Hermansen, K., Sondergaard, M., Hole, L., Carstensen, M. & Brock, B. (2001) Beneficial effects of a soy-based dietary supplement on lipid levels and cardiovascular risk markers in type 2 diabetic subjects. Diabetes Care 24: 228-233.
23. Jayagopal, V., Albertazzi, P., Kilpatrick, E. S., Howarth, E. M., Jennings, P. E., Hepburn, D. A. & Atkin, S. L. (2002) Beneficial effects of soy phytoestrogen intake in postmenopausal women with type 2 diabetes. Diabetes Care 25: 1709-1714.
24. Jenkins, D. J., Kendall, C. W., Connelly, P. W., Jackson, C. J., Parker, T., Faulkner, D. & Vidgen, E. (2002) Effects of high- and low-isoflavone (phytoestrogen) soy foods on inflammatory biomarkers and proinflammatory cytokines in middle-aged men and women. Metabolism 51: 919-924.
25. Jenkins, D. J., Kendall, C. W., Vidgen, E., Vuksan, V., Jackson, C. J., Augustin, L. S., Lee, B., Garsetti, M., Agarwal, S., Rao, A. V., Cagampang, G. B. & Fulgoni, V., 3rd (2000) Effect of soy-based breakfast cereal on blood lipids and oxidized low-density lipoprotein. Metabolism 49: 1496-1500.
26. Jenkins, D. J., Kendall, C. W., Garsetti, M., Rosenberg-Zand, R. S., Jackson, C. J., Agarwal, S., Rao, A. V., Diamandis, E. P., Parker, T., Faulkner, D., Vuksan, V. & Vidgen, E. (2000) Effect of soy protein foods on low-density lipoprotein oxidation and ex vivo sex hormone receptor activity-a controlled crossover trial. Metabolism 49: 537-543.
27. Puska, P., Korpelainen, V., Hole, L. H., Skovlund, E., Lahti, T. & Smerud, K. T. (2002) Soy in hypercholesterolaemia: a double-blind, placebo-controlled trial. Eur. J. Clin. Nutr. 56: 352-357.
28. Jenkins, D. J., Kendall, C. W., Jackson, C. J., Connelly, P. W., Parker, T., Faulkner, D., Vidgen, E., Cunnane, S. C., Leiter, L. A. & Josse, R. G. (2002) Effects of high- and low-isoflavone soyfoods on blood lipids, oxidized LDL, homocysteine, and blood pressure in hypedipidemic men and women. Am. J. Clin. Nutr. 76: 365-372.
29. Wangen, K. E., Duncan, A. M., Xu, X. & Kurzer, M. S. (2001) Soy isoflavones improve plasma lipids in normocholesterolemic and mildly hypercholesterolemic postmenopausal women. Am. J. Clin. Nutr. 73: 225-231.
30. Urban, D., Irwin, W., Kirk, M., Markiewicz, M. A., Myers, R., Smith, M., Weiss, H., Grizzle, W. E. & Barnes, S. (2001) The effect of isolated soy protein on plasma biomarkers in elderly men with elevated serum prostate specific antigen. J. Urol. 165: 294-300.
31. Mackey, R., Ekangaki, A. & Eden, J. A. (2000) The effects of soy protein in women and men with elevated plasma lipids. Biofactors 12: 251-257.
32. Lichtenstein, A. H., Jalbert, S. M., Adlercreutz, H., Goldin, B. R., Rasmussen, H., Schaefer, E. J. & Ausman, L. M. (2002) Lipoprotein response to diets high in soy or animal protein with and without isoflavones in moderately hypercholesterolemic subjects. Arterioscler. Thromb. Vasc. Biol. 22: 1852-1858.
33. Merz-Demlow, B. E., Duncan, A. M., Wangen, K. E., Xu, X., Carr, T. P., Phipps, W. R. & Kurzer, M. S. (2000) Soy isoflavones improve plasma lipids in normocholesterolemic, premenopausal women. Am. J. Clin. Nutr. 71: 1462-1469.
34. Potter, S. M., Baum, J. A., Teng, H., Stillman, R. J., Shay, N. F. & Erdman, J. W., Jr. (1998) Soy protein and isoflavones: their effects on blood lipids and bone density in postmenopausal women. Am. J. Clin. Nutr. 68: 1375S-1379S.
35. Sanders, T. A., Dean, T. S., Grainger, D., Miller, G. J. & Wiseman, H. (2002) Moderate intakes of intact soy protein rich in isoflavones compared with ethanol-extracted soy protein increase HDL but do not influence transforming growth factor beta(1) concentrations and hemostatic risk factors for coronary heart disease in healthy subjects. Am. J. Clin. Nutr. 76: 373-377.
36. Dalais, F. S., Ebeling, P. R., Kotsopoulos, D., McGrath, B. P. & Teede, H. J. (2003) The effects of soy protein containing isoflavones on lipids and indices of bone resorption in postmenopausal women. Clin. Endocrinol. 58: 704-709.
37. Washburn, S., Burke, G. L., Morgan, T. & Anthony, M. (1999) Effect of soy protein supplementation on serum lipoproteins, blood pressure, and menopausal symptoms in perimenopausal women. Menopause 6: 7-13.
38. Steinberg, F. M., Guthrie, N. L., Villablanca, A. C., Kumar, K. & Murray, M. J. (2003) Soy protein with isoflavones has favorable effects on endothelial function that are Independent of lipid and antioxidant effects in healthy postmenopausal women. Am. J. Clin. Nutr. 78: 123-130.
39. Vigna, G. B., Pansini, F., Bonaccorsi, G., Albertazzi, P., Donega, P., Zanotti, L., De Aloysio, D., Mollica, G. & Fellin, R. (2000) Plasma lipoproteins in soy-treated postmenopausal women: a double-blind, placebo-controlled trial. Nutr. Metab. Cardiovasc. Dis. 10: 315-322.
40. Dent, S. B., Peterson, C. T., Brace, L. D., Swain, J. H., Reddy, M. B., Hanson, K. B., Robinson, J. G. & Alekel, D. L. (2001) Soy protein intake by perimenopausal women does not affect circulating lipids and lipoproteins or coagulation and fibrinolytic factors. J. Nutr. 131: 2280-2287.
41. Meinertz, H., Nilausen, K. & Hilden, J. (2002) Alcohol-extracted, but not intact, dietary soy protein lowers lipoprotein(a) markedly. Arterioscler. Thromb. Vasc. Biol. 22: 312-316.
42. The Cochrane Collaboration (2003) RevMan 4.2.2 for Windows. http://www.cochrane.org/software/revman.htm. [Last accessed 15 Jan 2004].
43. Laboratory Methods Committee of the Lipids Research Clinics Program (1977) Cholesterol and triglyceride concentrations in serum/plasma pairs. Clin. Chem. 23: 60-63.
44. Arai, Y., Watanabe, S., Kimira, M., Shimoi, K., Mochizuki, R. & Kinae, N. (2000) Dietary intakes of flavonols, flavones and isoflavones by Japanese women and the inverse correlation between quercetin intake and plasma LDL cholesterol concentration. J. Nutr. 130: 2243-2250.
45. Rossouw, J. E. (1999) Hormone replacement therapy and cardiovascular disease. Curr. Opin. Lipidol. 10: 429-434.
46. Dwyer, J. T., Goldin, B. R., Saul, N., Gualtieri, L., Barakat, S. & Adlercreutz, H. (1994) Tofu and soy drinks contain phytoestrogens. J. Am. Diet. Assoc. 94: 739-743.
47. Axelson, M., Sjovall, J., Gustafsson, B. E. & Setchell, K. D. (1984) Soya - a dietary source of the non-steroidal oestrogen equol in man and animals. J. Endocrinol. 102: 49-56.
48. Setchell, K. D., Borriello, S. P., Hulme, P., Kirk, D. N. & Axelson, M. (1984) Nonsteroidal estrogens of dietary origin: possible roles in hormone-dependent disease. Am. J. Clin. Nutr. 40: 569-578.
49. Arai, Y., Uehara, M., Sato, Y., Kimira, M., Eboshida, A., Adlercreutz, H. & Watanabe, S. (2000) Comparison of isoflavones among dietary intake, plasma concentration and urinary excretion for accurate estimation of phytoestrogen intake. J. Epidemiol. 10: 127-135.
50. Watanabe, S., Yamaguchi, M., Sobue, T., Takahashi, T., Miura, T., Arai, Y., Mazur, W., Wahala, K. & Adlercreutz, H. (1998) Pharmacokinetics of soybean isoflavones in plasma, urine and feces of men after ingestion of 60 g baked soybean powder (kinako). J. Nutr. 128: 1710-1715.
51. Morito, K., Hirose, T., Kinjo, J., Hirakawa, T., Okawa, M., Nohara, T., Ogawa, S., Inoue, S., Muramatsu, M. & Masamune, Y. (2001) Interaction of phytoestrogens with estrogen receptors alpha and beta. Biol. Pharm. Bull. 24: 351-356.
52. Meyer, B. J., Larkin, T. A., Owen, A. J., Astheimer, L. B., Tapsell, L. C. & Howe, P. R. (2004) Limited lipid-lowering effects of regular consumption of whole soybean foods. Ann. Nutr. Metab. 48: 67-78.
53. Anthony, M. S., Blair, R. M. & Clarkson, T. B. (2000) Neither isoflavones nor the alcohol-extracted fraction added to alcohol-washed soy protein isolate restores the lipoprotein effects of soy protein isolate. J. Nutr. 132: 583S (abs.).