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Volumn 8, Issue 4, 2008, Pages 475-489

T lymphocyte engineering ex vivo for cancer and infectious disease

Author keywords

Adoptive immunotherapy; Clinical trials; Gene therapy; T lymphocytes; Vaccines

Indexed keywords

ADOPTIVE IMMUNOTHERAPY; ADOPTIVE TRANSFER; ALLOGENIC BONE MARROW TRANSPLANTATION; ANTIGEN PRESENTING CELL; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CELL DEATH; CELL SURVIVAL; CELL THERAPY; CHRONIC MYELOID LEUKEMIA; CLINICAL TRIAL; CYTOTOXIC T LYMPHOCYTE; DRUG EFFICACY; EX VIVO STUDY; GENE THERAPY; GENE TRANSFER; GENETIC ENGINEERING; GRAFT VERSUS HOST REACTION; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; IMMUNE RESPONSE; INFECTION; LYMPHOCYTE ACTIVATION; LYMPHOCYTE DIFFERENTIATION; LYMPHOCYTE FUNCTION; MELANOMA; MEMORY T LYMPHOCYTE; MYELOMA; NEUROBLASTOMA; REVIEW; T LYMPHOCYTE; TUMOR IMMUNITY; VACCINATION; ANIMAL; ANTIBODY PRODUCTION; CELLULAR IMMUNITY; COMMUNICABLE DISEASE; CULTURE TECHNIQUE; GENETICS; IMMUNOLOGY; LYMPHOCYTE TRANSFUSION; METHODOLOGY; NEOPLASM; T LYMPHOCYTE SUBPOPULATION; TRANSPLANTATION; TREATMENT OUTCOME;

EID: 42149096101     PISSN: 14712598     EISSN: None     Source Type: Journal    
DOI: 10.1517/14712598.8.4.475     Document Type: Review
Times cited : (32)

References (114)
  • 1
    • 0035348175 scopus 로고    scopus 로고
    • + T cell differentiation: Initial antigen encounter triggers a developmental program in naive cells
    • + T cell differentiation: initial antigen encounter triggers a developmental program in naive cells. Nat Immunol 2001;2(5):415-22
    • (2001) Nat Immunol , vol.2 , Issue.5 , pp. 415-422
    • Kaech, S.M.1    Ahmed, R.2
  • 2
    • 2142730100 scopus 로고    scopus 로고
    • Central memory and effector memory T cell subsets: Function, generation, and maintenance
    • Sallusto F, Geginat J, Lanzavecchia A. Central memory and effector memory T cell subsets: function, generation, and maintenance. Ann Rev Immunol 2004;22:745-63
    • (2004) Ann Rev Immunol , vol.22 , pp. 745-763
    • Sallusto, F.1    Geginat, J.2    Lanzavecchia, A.3
  • 3
    • 0035854521 scopus 로고    scopus 로고
    • Arrested differentiation, the self-renewing memory lymphocyte, and vaccination
    • Fearon DT, Manders P, Wagner SD. Arrested differentiation, the self-renewing memory lymphocyte, and vaccination. Science 2001;293(5528):248-50
    • (2001) Science , vol.293 , Issue.5528 , pp. 248-250
    • Fearon, D.T.1    Manders, P.2    Wagner, S.D.3
  • 4
    • 0033548496 scopus 로고    scopus 로고
    • Linear differentiation of cytotoxic effectors into memory T lymphocytes
    • Opferman JT, Ober BT, Shton-Rickardt PG. Linear differentiation of cytotoxic effectors into memory T lymphocytes. Science 1999;283(5408):1745-8
    • (1999) Science , vol.283 , Issue.5408 , pp. 1745-1748
    • Opferman, J.T.1    Ober, B.T.2    Shton-Rickardt, P.G.3
  • 5
    • 14244259568 scopus 로고    scopus 로고
    • Lineage relationships, homeostasis, and recall capacities of central- and effector-memory CD8 T cells in vivo
    • Bouneaud C, Garcia Z, Kourilsky P, Pannetier C. Lineage relationships, homeostasis, and recall capacities of central- and effector-memory CD8 T cells in vivo. J Exp Med 2005;201(4):579-90
    • (2005) J Exp Med , vol.201 , Issue.4 , pp. 579-590
    • Bouneaud, C.1    Garcia, Z.2    Kourilsky, P.3    Pannetier, C.4
  • 6
    • 33947730608 scopus 로고    scopus 로고
    • Asymmetric T lymphocyte division in the initiation of adaptive immune responses
    • Chang JT, Palanivel VR, Kinjyo I, et al. Asymmetric T lymphocyte division in the initiation of adaptive immune responses. Science 2007;315(5819):1687-91
    • (2007) Science , vol.315 , Issue.5819 , pp. 1687-1691
    • Chang, J.T.1    Palanivel, V.R.2    Kinjyo, I.3
  • 7
    • 2442714006 scopus 로고    scopus 로고
    • Extensive replicative capacity of human central memory T cells
    • Maus MV, Kovacs B, Kwok WW, et al. Extensive replicative capacity of human central memory T cells. J Immunol 2004;172(11):6675-83
    • (2004) J Immunol , vol.172 , Issue.11 , pp. 6675-6683
    • Maus, M.V.1    Kovacs, B.2    Kwok, W.W.3
  • 8
    • 0031463644 scopus 로고    scopus 로고
    • Tales of tails: Regulation of telomere length and telomerase activity during lymphocyte development, differentiation, activation, and aging
    • Weng NP, Palmer LD, Levine BL, et al. Tales of tails: regulation of telomere length and telomerase activity during lymphocyte development, differentiation, activation, and aging. Immunol Rev 1997;160:43-54
    • (1997) Immunol Rev , vol.160 , pp. 43-54
    • Weng, N.P.1    Palmer, L.D.2    Levine, B.L.3
  • 9
    • 0033554726 scopus 로고    scopus 로고
    • Two subsets of memory T lymphocytes with distinct homing potentials and effector functions
    • Sallusto F, Lenig D, Forster R, et al. Two subsets of memory T lymphocytes with distinct homing potentials and effector functions. Nature 1999;401(6754):708-12
    • (1999) Nature , vol.401 , Issue.6754 , pp. 708-712
    • Sallusto, F.1    Lenig, D.2    Forster, R.3
  • 10
  • 12
    • 0031660446 scopus 로고    scopus 로고
    • - T cells in untreated hemato-oncological patients are expanded and display a Th1-type cytokine secretion profile, ex vivo cytolytic activity and enhanced tendency to apoptosis
    • - T cells in untreated hemato-oncological patients are expanded and display a Th1-type cytokine secretion profile, ex vivo cytolytic activity and enhanced tendency to apoptosis. Leukemia 1998;12(10):1573-82
    • (1998) Leukemia , vol.12 , Issue.10 , pp. 1573-1582
    • Van den Hove, L.E.1    Van Gool, S.W.2    Vandenberghe, P.3
  • 13
    • 0038128194 scopus 로고    scopus 로고
    • Cutting edge: Rapid in vivo killing by memory CD8 T cells
    • Barber DL, Wherry EJ, Ahmed R. Cutting edge: rapid in vivo killing by memory CD8 T cells. J Immunol 2003;171(1):27-31
    • (2003) J Immunol , vol.171 , Issue.1 , pp. 27-31
    • Barber, D.L.1    Wherry, E.J.2    Ahmed, R.3
  • 15
    • 3543099130 scopus 로고    scopus 로고
    • Helping the CD8(+) T-cell response
    • Bevan MJ. Helping the CD8(+) T-cell response. Nat Rev Immunol 2004;4(8):595-602
    • (2004) Nat Rev Immunol , vol.4 , Issue.8 , pp. 595-602
    • Bevan, M.J.1
  • 16
    • 0032473562 scopus 로고    scopus 로고
    • Specific T helper cell requirement for optimal induction of cytotoxic T lymphocytes against major histocompatibility complex class II negative tumors
    • Ossendorp F, Mengede E, Camps M, et al. Specific T helper cell requirement for optimal induction of cytotoxic T lymphocytes against major histocompatibility complex class II negative tumors. J Exp Med 1998;187(5):693-702
    • (1998) J Exp Med , vol.187 , Issue.5 , pp. 693-702
    • Ossendorp, F.1    Mengede, E.2    Camps, M.3
  • 17
    • 0032482474 scopus 로고    scopus 로고
    • Schoenberger SP, Toes RE, van d V, et al. T-cell help for cytotoxic T lymphocytes is mediated by CD40-CD40L interactions. Nature 1998;393(6684):480-3
    • Schoenberger SP, Toes RE, van d V, et al. T-cell help for cytotoxic T lymphocytes is mediated by CD40-CD40L interactions. Nature 1998;393(6684):480-3
  • 18
    • 0037058993 scopus 로고    scopus 로고
    • + T cell clones for the treatment of patients with metastatic melanoma: In vivo persistence, migration, and antitumor effect of transferred T cells
    • + clones persist at higher levels in peripheral blood when IL-2 is also infused, •
    • + clones persist at higher levels in peripheral blood when IL-2 is also infused.
    • (2002) Proc Natl Acad Sci USA , vol.99 , Issue.25 , pp. 16168-16173
    • Yee, C.1    Thompson, J.A.2    Byrd, D.3
  • 19
    • 0036624737 scopus 로고    scopus 로고
    • Infusion of cytomegalovirus (CMV)-specific T cells for the treatment of CMV infection not responding to antiviral chemotherapy
    • Einsele H, Roosnek E, Rufer N, et al. Infusion of cytomegalovirus (CMV)-specific T cells for the treatment of CMV infection not responding to antiviral chemotherapy. Blood 2002;99(11):3916-22
    • (2002) Blood , vol.99 , Issue.11 , pp. 3916-3922
    • Einsele, H.1    Roosnek, E.2    Rufer, N.3
  • 20
    • 30744454570 scopus 로고    scopus 로고
    • Restoration of immunity in lymphopenic individuals with cancer by vaccination and adoptive T-cell transfer
    • A randomized clinical trial showing the early reconstitution of lymphocytes and early induction of functional immunity to pneumococcus post stem cell transplantation following in vivo vaccine priming followed by the early infusion of primed and expanded T lymphocytes, ••
    • Rapoport AP, Stadtmauer EA, Aqui N, et al. Restoration of immunity in lymphopenic individuals with cancer by vaccination and adoptive T-cell transfer. Nat Med 2005;11(11):1230-7 •• A randomized clinical trial showing the early reconstitution of lymphocytes and early induction of functional immunity to pneumococcus post stem cell transplantation following in vivo vaccine priming followed by the early infusion of primed and expanded T lymphocytes.
    • (2005) Nat Med , vol.11 , Issue.11 , pp. 1230-1237
    • Rapoport, A.P.1    Stadtmauer, E.A.2    Aqui, N.3
  • 21
    • 85047690488 scopus 로고    scopus 로고
    • An integrated view of suppressor T cell subsets in immunoregulation
    • Jiang H, Chess L. An integrated view of suppressor T cell subsets in immunoregulation. J Clin Invest 2004;114(9):1198-208
    • (2004) J Clin Invest , vol.114 , Issue.9 , pp. 1198-1208
    • Jiang, H.1    Chess, L.2
  • 22
    • 0033571105 scopus 로고    scopus 로고
    • + T cells: A common basis between tumor immunity and autoimmunity
    • + cells or administration of anti-CD25 antibody can augment anti-tumor immunity, •
    • + cells or administration of anti-CD25 antibody can augment anti-tumor immunity.
    • (1999) J Immunol , vol.163 , Issue.10 , pp. 5211-5218
    • Shimizu, J.1    Yamazaki, S.2    Sakaguchi, S.3
  • 24
    • 42449101470 scopus 로고    scopus 로고
    • Adoptive immunotherapy with autologous CD25-depleted and CD3/CD28-costimulated T-cells (ACTC) enhances numeric and functional lymphocyte recovery after cyclophosphamide - fludarabine chemotherapy in patients with low-grade follicular lymphoma
    • Schuster SJ, Levine BL, Nasta S, et al. Adoptive immunotherapy with autologous CD25-depleted and CD3/CD28-costimulated T-cells (ACTC) enhances numeric and functional lymphocyte recovery after cyclophosphamide - fludarabine chemotherapy in patients with low-grade follicular lymphoma. Blood 2007;110(11):126
    • (2007) Blood , vol.110 , Issue.11 , pp. 126
    • Schuster, S.J.1    Levine, B.L.2    Nasta, S.3
  • 25
    • 0035874949 scopus 로고    scopus 로고
    • Woo EY, Chu CS, Goletz TJ, et al. Regulatory CD4(+)CD25(+) T cells in tumors from patients with early-stage non-small cell lung cancer and late-stage ovarian cancer. Cancer Res 2001;61(12):4766-72 • Evidence is presented that costimulation provided by triggering the CD28 receptor is able to increase CD25 expression and cytokine secretion in tumor-associated T cells.
    • Woo EY, Chu CS, Goletz TJ, et al. Regulatory CD4(+)CD25(+) T cells in tumors from patients with early-stage non-small cell lung cancer and late-stage ovarian cancer. Cancer Res 2001;61(12):4766-72 • Evidence is presented that costimulation provided by triggering the CD28 receptor is able to increase CD25 expression and cytokine secretion in tumor-associated T cells.
  • 26
    • 33745166296 scopus 로고    scopus 로고
    • Impact of donor and recipient sex and parity on outcomes of HLA-identical sibling allogeneic hematopoietic stem cell transplantation
    • Loren AW, Bunin GR, Boudreau C, et al. Impact of donor and recipient sex and parity on outcomes of HLA-identical sibling allogeneic hematopoietic stem cell transplantation. Biol Blood Marrow Transplant 2006;12(7):758-69
    • (2006) Biol Blood Marrow Transplant , vol.12 , Issue.7 , pp. 758-769
    • Loren, A.W.1    Bunin, G.R.2    Boudreau, C.3
  • 27
    • 33750511589 scopus 로고    scopus 로고
    • + T cells as augmentation of allogeneic hematopoietic cell transplantation
    • + T cells as augmentation of allogeneic hematopoietic cell transplantation. Biol Blood Marrow Transplant 2006;12(11):1150-60
    • (2006) Biol Blood Marrow Transplant , vol.12 , Issue.11 , pp. 1150-1160
    • Fowler, D.H.1    Odom, J.2    Steinberg, S.M.3
  • 28
    • 32644448488 scopus 로고    scopus 로고
    • A phase 1 trial of donor lymphocyte infusions expanded and activated ex vivo via CD3/CD28 costimulation
    • Porter DL, Levine BL, Bunin N, et al. A phase 1 trial of donor lymphocyte infusions expanded and activated ex vivo via CD3/CD28 costimulation. Blood 2006;107(4):1325-31
    • (2006) Blood , vol.107 , Issue.4 , pp. 1325-1331
    • Porter, D.L.1    Levine, B.L.2    Bunin, N.3
  • 30
    • 0036281441 scopus 로고    scopus 로고
    • Prognostic significance of adoptive immunotherapy with tumor-associated lymphocytes in patients with advanced gastric cancer: A randomized trial
    • Kono K, Takahashi A, Ichihara F, et al. Prognostic significance of adoptive immunotherapy with tumor-associated lymphocytes in patients with advanced gastric cancer: a randomized trial. Clin Cancer Res 2002;8(6):1767-71
    • (2002) Clin Cancer Res , vol.8 , Issue.6 , pp. 1767-1771
    • Kono, K.1    Takahashi, A.2    Ichihara, F.3
  • 31
    • 0037174674 scopus 로고    scopus 로고
    • Cancer regression and autoimmunity in patients after clonal repopulation with antitumor lymphocytes
    • Evidence is presented that the addition of a non-myeloblative, but lymphodepleting conditioning regimen, showed, in contrast to previous studies, a robust engraftment of ex vivo-expanded tumor infiltrating lymphocytes. In 6 of 13 patients regression of metastatic melanoma was observed, ••
    • Dudley ME, Wunderlich JR, Robbins PF, et al. Cancer regression and autoimmunity in patients after clonal repopulation with antitumor lymphocytes. Science 2002;298(5594):850-4 •• Evidence is presented that the addition of a non-myeloblative, but lymphodepleting conditioning regimen, showed, in contrast to previous studies, a robust engraftment of ex vivo-expanded tumor infiltrating lymphocytes. In 6 of 13 patients regression of metastatic melanoma was observed.
    • (2002) Science , vol.298 , Issue.5594 , pp. 850-854
    • Dudley, M.E.1    Wunderlich, J.R.2    Robbins, P.F.3
  • 32
    • 0031027417 scopus 로고    scopus 로고
    • Adoptive immunotherapy with vaccine-primed lymph node cells secondarily activated with anti-CD3 and interleukin-2
    • Chang AE, Aruga A, Cameron MJ, et al. Adoptive immunotherapy with vaccine-primed lymph node cells secondarily activated with anti-CD3 and interleukin-2. J Clin Oncol 1997;15(2):796-807
    • (1997) J Clin Oncol , vol.15 , Issue.2 , pp. 796-807
    • Chang, A.E.1    Aruga, A.2    Cameron, M.J.3
  • 33
    • 0034596475 scopus 로고    scopus 로고
    • Adoptive immunotherapy to lower postsurgical recurrence rates of hepatocellular carcinoma: A randomised trial
    • Takayama T, Sekine T, Makuuchi M, et al. Adoptive immunotherapy to lower postsurgical recurrence rates of hepatocellular carcinoma: a randomised trial. Lancet 2000;356(9232):802-7
    • (2000) Lancet , vol.356 , Issue.9232 , pp. 802-807
    • Takayama, T.1    Sekine, T.2    Makuuchi, M.3
  • 34
    • 0035048973 scopus 로고    scopus 로고
    • Therapy of human tumors in NOD/SCID mice with patient-derived reactivated memory T cells from bone marrow
    • Feuerer M, Beckhove P, Bai L, et al. Therapy of human tumors in NOD/SCID mice with patient-derived reactivated memory T cells from bone marrow. Nat Med 2001;7(4):452-8
    • (2001) Nat Med , vol.7 , Issue.4 , pp. 452-458
    • Feuerer, M.1    Beckhove, P.2    Bai, L.3
  • 35
    • 20144383847 scopus 로고    scopus 로고
    • Enrichment of functional CD8 memory T cells specific for MUC1 in bone marrow of patients with multiple myeloma
    • Choi C, Witzens M, Bucur M, et al. Enrichment of functional CD8 memory T cells specific for MUC1 in bone marrow of patients with multiple myeloma. Blood 2005;105(5):2132-4
    • (2005) Blood , vol.105 , Issue.5 , pp. 2132-2134
    • Choi, C.1    Witzens, M.2    Bucur, M.3
  • 36
    • 27544506907 scopus 로고    scopus 로고
    • High frequencies of functional tumor-reactive T cells in bone marrow and blood of pancreatic cancer patients
    • Schmitz-Winnenthal FH, Volk C, Z'graggen K, et al. High frequencies of functional tumor-reactive T cells in bone marrow and blood of pancreatic cancer patients. Cancer Res 2005;65(21):10079-87
    • (2005) Cancer Res , vol.65 , Issue.21 , pp. 10079-10087
    • Schmitz-Winnenthal, F.H.1    Volk, C.2    Z'graggen, K.3
  • 37
    • 20144389307 scopus 로고    scopus 로고
    • Activated marrow-infiltrating lymphocytes effectively target plasma cells and their clonogenic precursors
    • Noonan K, Matsui W, Serafini P, et al. Activated marrow-infiltrating lymphocytes effectively target plasma cells and their clonogenic precursors. Cancer Res 2005;65(5):2026-34
    • (2005) Cancer Res , vol.65 , Issue.5 , pp. 2026-2034
    • Noonan, K.1    Matsui, W.2    Serafini, P.3
  • 38
    • 0030586516 scopus 로고    scopus 로고
    • Safety and feasibility of harvesting cells for adoptive immunotherapy from patients with asymptomatic HIV infection
    • Trickett A, Dwyer J, Tedla N, Lam-Po-Tang R. Safety and feasibility of harvesting cells for adoptive immunotherapy from patients with asymptomatic HIV infection. J Acquir Immune Defic Syndr Hum Retrovirol 1996;12(5):523-4
    • (1996) J Acquir Immune Defic Syndr Hum Retrovirol , vol.12 , Issue.5 , pp. 523-524
    • Trickett, A.1    Dwyer, J.2    Tedla, N.3    Lam-Po-Tang, R.4
  • 39
    • 0034915851 scopus 로고    scopus 로고
    • Donor lymphocyte apheresis for adoptive immunotherapy compared with blood stem cell apheresis
    • Korbling M, Giralt S, Khouri I, et al. Donor lymphocyte apheresis for adoptive immunotherapy compared with blood stem cell apheresis. J Clin Apher 2001;16(2):82-7
    • (2001) J Clin Apher , vol.16 , Issue.2 , pp. 82-87
    • Korbling, M.1    Giralt, S.2    Khouri, I.3
  • 40
    • 0037448353 scopus 로고    scopus 로고
    • Intratumoral T cells, recurrence, and survival in epithelial ovarian cancer
    • Zhang L, Conejo-Garcia JR, Katsaros D, et al. Intratumoral T cells, recurrence, and survival in epithelial ovarian cancer. N Engl J Med 2003;348(3):203-13
    • (2003) N Engl J Med , vol.348 , Issue.3 , pp. 203-213
    • Zhang, L.1    Conejo-Garcia, J.R.2    Katsaros, D.3
  • 41
    • 19944434269 scopus 로고    scopus 로고
    • High frequency of antitumor T cells in the blood of melanoma patients before and after vaccination with tumor antigens
    • Germeau C, Ma W, Schiavetti F, et al. High frequency of antitumor T cells in the blood of melanoma patients before and after vaccination with tumor antigens. J Exp Med 2005;201(2):241-8
    • (2005) J Exp Med , vol.201 , Issue.2 , pp. 241-248
    • Germeau, C.1    Ma, W.2    Schiavetti, F.3
  • 42
    • 30744473195 scopus 로고    scopus 로고
    • Vaccinating transplant recipients
    • Molldrem JJ. Vaccinating transplant recipients. Nat Med 2005;11(11):1162-3
    • (2005) Nat Med , vol.11 , Issue.11 , pp. 1162-1163
    • Molldrem, J.J.1
  • 43
    • 33750343038 scopus 로고    scopus 로고
    • Adoptive transfer of vaccine-induced peripheral blood mononuclear cells to patients with metastatic melanoma following lymphodepletion
    • Powell DJ Jr, Dudley ME, Hogan KA, et al. Adoptive transfer of vaccine-induced peripheral blood mononuclear cells to patients with metastatic melanoma following lymphodepletion. J Immunol 2006;177(9):6527-39
    • (2006) J Immunol , vol.177 , Issue.9 , pp. 6527-6539
    • Powell Jr, D.J.1    Dudley, M.E.2    Hogan, K.A.3
  • 44
    • 33744788680 scopus 로고    scopus 로고
    • Safe adoptive transfer of virus-specific T-cell immunity for the treatment of systemic adenovirus infection after allogeneic stem cell transplantation
    • Feuchtinger T, Matthes-Martin S, Richard C, et al. Safe adoptive transfer of virus-specific T-cell immunity for the treatment of systemic adenovirus infection after allogeneic stem cell transplantation. Br J Haematol 2006;134(1):64-76
    • (2006) Br J Haematol , vol.134 , Issue.1 , pp. 64-76
    • Feuchtinger, T.1    Matthes-Martin, S.2    Richard, C.3
  • 45
    • 0031469361 scopus 로고    scopus 로고
    • CD40-activated human B cells: An alternative source of highly efficient antigen presenting cells to generate autologous antigen-specific T cells for adoptive immunotherapy
    • Schultze JL, Michalak S, Seamon MJ, et al. CD40-activated human B cells: an alternative source of highly efficient antigen presenting cells to generate autologous antigen-specific T cells for adoptive immunotherapy. J Clin Invest 1997;100(11):2757-65
    • (1997) J Clin Invest , vol.100 , Issue.11 , pp. 2757-2765
    • Schultze, J.L.1    Michalak, S.2    Seamon, M.J.3
  • 46
    • 0034606276 scopus 로고    scopus 로고
    • Melanocyte destruction after antigen-specific immunotherapy of melanoma: Direct evidence of T cell-mediated vitiligo
    • Yee C, Thompson JA, Roche P, et al. Melanocyte destruction after antigen-specific immunotherapy of melanoma: direct evidence of T cell-mediated vitiligo. J Exp Med 2000;192(11):1637-44
    • (2000) J Exp Med , vol.192 , Issue.11 , pp. 1637-1644
    • Yee, C.1    Thompson, J.A.2    Roche, P.3
  • 47
    • 33750940238 scopus 로고    scopus 로고
    • + T cells for the treatment of patients with metastatic melanoma
    • + T cells for the treatment of patients with metastatic melanoma. J Clin Oncol 2006;24(31):5060-9
    • (2006) J Clin Oncol , vol.24 , Issue.31 , pp. 5060-5069
    • Mackensen, A.1    Meidenbauer, N.2    Vogl, S.3
  • 48
    • 0028820386 scopus 로고
    • Reconstitution of cellular immunity against cytomegalovirus in recipients of allogeneic bone marrow by transfer of T-cell clones from the donor
    • Walter EA, Greenberg PD, Gilbert MJ, et al. Reconstitution of cellular immunity against cytomegalovirus in recipients of allogeneic bone marrow by transfer of T-cell clones from the donor. N Engl J Med 1995;333(16):1038-44
    • (1995) N Engl J Med , vol.333 , Issue.16 , pp. 1038-1044
    • Walter, E.A.1    Greenberg, P.D.2    Gilbert, M.J.3
  • 49
    • 0026648439 scopus 로고    scopus 로고
    • + cytotoxic T cell clones could establish anti-viral immunity in vivo.
    • + cytotoxic T cell clones could establish anti-viral immunity in vivo.
  • 50
    • 0028816546 scopus 로고
    • Use of gene-modified virus-specific T lymphocytes to control Epstein-Barr-virus-related lymphoproliferation
    • Ex vivo-expanded and genetically marked EBV-specific donor derived CTL were shown to engraft and persist and were associated with clinical benefit in patients with EBV lymphoproliferative disease, •
    • Rooney CM, Smith CA, Ng CY, et al. Use of gene-modified virus-specific T lymphocytes to control Epstein-Barr-virus-related lymphoproliferation. Lancet 1995;345(8941):9-13 • Ex vivo-expanded and genetically marked EBV-specific donor derived CTL were shown to engraft and persist and were associated with clinical benefit in patients with EBV lymphoproliferative disease.
    • (1995) Lancet , vol.345 , Issue.8941 , pp. 9-13
    • Rooney, C.M.1    Smith, C.A.2    Ng, C.Y.3
  • 51
    • 0029924619 scopus 로고    scopus 로고
    • Long-term restoration of immunity against Epstein-Barr virus infection by adoptive transfer of gene-modified virus-specific T lymphocytes
    • Heslop HE, Ng CY, Li C, et al. Long-term restoration of immunity against Epstein-Barr virus infection by adoptive transfer of gene-modified virus-specific T lymphocytes. Nat Med 1996;2(5):551-5
    • (1996) Nat Med , vol.2 , Issue.5 , pp. 551-555
    • Heslop, H.E.1    Ng, C.Y.2    Li, C.3
  • 52
    • 0242299672 scopus 로고    scopus 로고
    • Adoptive T-cell therapy for EBV-associated post-transplant lymphoproliferative disease
    • Bollard CM, Savoldo B, Rooney CM, Heslop HE. Adoptive T-cell therapy for EBV-associated post-transplant lymphoproliferative disease. Acta Haematol 2003;110(2-3):139-48
    • (2003) Acta Haematol , vol.110 , Issue.2-3 , pp. 139-148
    • Bollard, C.M.1    Savoldo, B.2    Rooney, C.M.3    Heslop, H.E.4
  • 53
    • 13044295992 scopus 로고    scopus 로고
    • Activation and adoptive transfer of Epstein-Barr virus-specific cytotoxic T cells in solid organ transplant patients with posttransplant lymphoproliferative disease
    • Khanna R, Bell S, Sherritt M, et al. Activation and adoptive transfer of Epstein-Barr virus-specific cytotoxic T cells in solid organ transplant patients with posttransplant lymphoproliferative disease. Proc Natl Acad Sci USA 1999;96(18):10391-6
    • (1999) Proc Natl Acad Sci USA , vol.96 , Issue.18 , pp. 10391-10396
    • Khanna, R.1    Bell, S.2    Sherritt, M.3
  • 54
    • 0036189723 scopus 로고    scopus 로고
    • Treatment of Epstein-Barr virus-associated malignancies with specific T cells
    • Gottschalk S, Heslop HE, Roon CM. Treatment of Epstein-Barr virus-associated malignancies with specific T cells. Adv Cancer Res 2002;84:175-201
    • (2002) Adv Cancer Res , vol.84 , pp. 175-201
    • Gottschalk, S.1    Heslop, H.E.2    Roon, C.M.3
  • 55
    • 33749514632 scopus 로고    scopus 로고
    • Monoculture-derived T lymphocytes specific for multiple viruses expand and produce clinically relevant effects in immunocompromised individuals
    • This paper describes a novel strategy for the simultaneous expansion of T cells specific for CMV, EBV and adenovirus. EBV-transformed antigen presenting cell lines were genetically modified with chimeric adenoviral vectors encoding CMV antigen, •
    • Leen AM, Myers GD, Sili U, et al. Monoculture-derived T lymphocytes specific for multiple viruses expand and produce clinically relevant effects in immunocompromised individuals. Nat Med 2006;12(10):1160-6 • This paper describes a novel strategy for the simultaneous expansion of T cells specific for CMV, EBV and adenovirus. EBV-transformed antigen presenting cell lines were genetically modified with chimeric adenoviral vectors encoding CMV antigen.
    • (2006) Nat Med , vol.12 , Issue.10 , pp. 1160-1166
    • Leen, A.M.1    Myers, G.D.2    Sili, U.3
  • 56
    • 0034028070 scopus 로고    scopus 로고
    • HIV-specific cytotoxic T lymphocytes traffic to lymph nodes and localize at sites of HIV replication and cell death
    • Brodie SJ, Patterson BK, Lewinsohn DA, et al. HIV-specific cytotoxic T lymphocytes traffic to lymph nodes and localize at sites of HIV replication and cell death. J Clin Invest 2000;105(10):1407-17
    • (2000) J Clin Invest , vol.105 , Issue.10 , pp. 1407-1417
    • Brodie, S.J.1    Patterson, B.K.2    Lewinsohn, D.A.3
  • 57
    • 0033105536 scopus 로고    scopus 로고
    • Rapid death of adoptively transferred T cells in acquired immunodeficiency syndrome
    • Tan R, Xu X, Ogg GS, et al. Rapid death of adoptively transferred T cells in acquired immunodeficiency syndrome. Blood 1999;93(5):1506-10
    • (1999) Blood , vol.93 , Issue.5 , pp. 1506-1510
    • Tan, R.1    Xu, X.2    Ogg, G.S.3
  • 58
    • 0028031582 scopus 로고
    • Treatment of patients with metastatic melanoma with autologous tumor-infiltrating lymphocytes and interleukin 2
    • Rosenberg SA, Yannelli JR, Yang JC, et al. Treatment of patients with metastatic melanoma with autologous tumor-infiltrating lymphocytes and interleukin 2. J Natl Cancer Inst 1994;86:1159-66
    • (1994) J Natl Cancer Inst , vol.86 , pp. 1159-1166
    • Rosenberg, S.A.1    Yannelli, J.R.2    Yang, J.C.3
  • 59
    • 0032784492 scopus 로고    scopus 로고
    • Multicenter, randomized, Phase III trial of CD8(+) tumor-infiltrating lymphocytes in combination with recombinant interleukin-2 in metastatic renal cell carcinoma
    • Figlin RA, Thompson JA, Bukowski RM, et al. Multicenter, randomized, Phase III trial of CD8(+) tumor-infiltrating lymphocytes in combination with recombinant interleukin-2 in metastatic renal cell carcinoma. J Clin Oncol 1999;17(8):2521-9
    • (1999) J Clin Oncol , vol.17 , Issue.8 , pp. 2521-2529
    • Figlin, R.A.1    Thompson, J.A.2    Bukowski, R.M.3
  • 60
    • 0036034859 scopus 로고    scopus 로고
    • Randomized trial of adoptive transfer of melanoma tumor-infiltrating lymphocytes as adjuvant therapy for stage III melanoma
    • Dreno B, Nguyen JM, Khammari A, et al. Randomized trial of adoptive transfer of melanoma tumor-infiltrating lymphocytes as adjuvant therapy for stage III melanoma. Cancer Immunol Immunother 2002;51(10):539-46
    • (2002) Cancer Immunol Immunother , vol.51 , Issue.10 , pp. 539-546
    • Dreno, B.1    Nguyen, J.M.2    Khammari, A.3
  • 61
    • 20244366111 scopus 로고    scopus 로고
    • Adoptive cell transfer therapy following non-myeloablative but lymphodepleting chemotherapy for the treatment of patients with refractory metastatic melanoma
    • Extension of the results first reported in reference 31 to a total of 35 patients with refractory metastatic melanoma using selected and expanded TIL cultures, •
    • Dudley ME, Wunderlich JR, Yang JC, et al. Adoptive cell transfer therapy following non-myeloablative but lymphodepleting chemotherapy for the treatment of patients with refractory metastatic melanoma. J Clin Oncol 2005;23(10):2346-57 • Extension of the results first reported in reference 31 to a total of 35 patients with refractory metastatic melanoma using selected and expanded TIL cultures.
    • (2005) J Clin Oncol , vol.23 , Issue.10 , pp. 2346-2357
    • Dudley, M.E.1    Wunderlich, J.R.2    Yang, J.C.3
  • 62
    • 29444442811 scopus 로고    scopus 로고
    • +/regulatory T cell ratio are associated with favorable prognosis in ovarian cancer
    • +/regulatory T cell ratio are associated with favorable prognosis in ovarian cancer. Proc Natl Acad Sci USA 2005;102(51):18538-43
    • (2005) Proc Natl Acad Sci USA , vol.102 , Issue.51 , pp. 18538-18543
    • Sato, E.1    Olson, S.H.2    Ahn, J.3
  • 63
    • 0037829421 scopus 로고    scopus 로고
    • Generation of tumor-infiltrating lymphocyte cultures for use in adoptive transfer therapy for melanoma patients
    • 1997
    • Dudley ME, Wunderlich JR, Shelton TE, et al. Generation of tumor-infiltrating lymphocyte cultures for use in adoptive transfer therapy for melanoma patients. J Immunother 2003;26(4):332-42 (1997)
    • (2003) J Immunother , vol.26 , Issue.4 , pp. 332-342
    • Dudley, M.E.1    Wunderlich, J.R.2    Shelton, T.E.3
  • 64
    • 0038446699 scopus 로고    scopus 로고
    • Muul LM, Tuschong LM, Soenen SL, et al. Persistence and expression of the adenosine deaminase gene for 12 years and immune reaction to gene transfer components: long-term results of the first clinical gene therapy trial. Blood 2003;101(7):2563-9 •• This follow up report on the first clinical trial of gene modified T cells shows the persistence of these cells for 12 years in a highly selective in vivo environment of congenital adenosine deaminase deficiency. Currently, genetically modified cells can be detected in each patient 16 years after infusion (L. Muul, pers. commun.).
    • Muul LM, Tuschong LM, Soenen SL, et al. Persistence and expression of the adenosine deaminase gene for 12 years and immune reaction to gene transfer components: long-term results of the first clinical gene therapy trial. Blood 2003;101(7):2563-9 •• This follow up report on the first clinical trial of gene modified T cells shows the persistence of these cells for 12 years in a highly selective in vivo environment of congenital adenosine deaminase deficiency. Currently, genetically modified cells can be detected in each patient 16 years after infusion (L. Muul, pers. commun.).
  • 65
    • 0034254611 scopus 로고    scopus 로고
    • Prolonged survival and tissue trafficking following adoptive transfer of CD4ζ gene-modified autologous CD4(+) and CD8(+) T cells in human immunodeficiency virus-infected subjects
    • Mitsuyasu RT, Anton PA, Deeks SG, et al. Prolonged survival and tissue trafficking following adoptive transfer of CD4ζ gene-modified autologous CD4(+) and CD8(+) T cells in human immunodeficiency virus-infected subjects. Blood 2000;96(3):785-93
    • (2000) Blood , vol.96 , Issue.3 , pp. 785-793
    • Mitsuyasu, R.T.1    Anton, P.A.2    Deeks, S.G.3
  • 66
    • 34247208235 scopus 로고    scopus 로고
    • Transfer of autologous gene-modified T cells in HIV-infected patients with advanced immunodeficiency and drug-resistant virus
    • van Lunzen J, Glaunsinger T, Stahmer I, er al. Transfer of autologous gene-modified T cells in HIV-infected patients with advanced immunodeficiency and drug-resistant virus. Mol Ther 2007;15(5):1024-33
    • (2007) Mol Ther , vol.15 , Issue.5 , pp. 1024-1033
    • van Lunzen, J.1    Glaunsinger, T.2    Stahmer, I.3    er al4
  • 67
    • 0034724857 scopus 로고    scopus 로고
    • Gene therapy of human severe combined immunodeficiency (SCID)-X1 disease
    • Cavazzana-Calvo M, Hacein-Bey S, de Saint BG, et al. Gene therapy of human severe combined immunodeficiency (SCID)-X1 disease. Science 2000;288(5466):669-72
    • (2000) Science , vol.288 , Issue.5466 , pp. 669-672
    • Cavazzana-Calvo, M.1    Hacein-Bey, S.2    de Saint, B.G.3
  • 68
    • 42449122923 scopus 로고    scopus 로고
    • Available from
    • Available from: www.esgct.org/upload/X-SCID_statement_AT.pdf
  • 69
    • 33748939587 scopus 로고    scopus 로고
    • Gene therapy: X-SCID transgene leukaemogenicity
    • Thrasher AJ, Gaspar HB, Baum C, et al. Gene therapy: X-SCID transgene leukaemogenicity. Nature 2006;443(7109):E5-6
    • (2006) Nature , vol.443 , Issue.7109
    • Thrasher, A.J.1    Gaspar, H.B.2    Baum, C.3
  • 70
    • 0142084745 scopus 로고    scopus 로고
    • Hacein-Bey-Abina S, von Kalle C, Schmidt M, et al. LMO2-associated clonal T cell proliferation in two patients after gene therapy for SCID-X1. Science 2003;302(5644):415-9 • Following the development of leukemia in patients with severe combined immunodeficiency who had received retrovirally transduced hematopoietic stem cells, clonal proliferation of T cells was detected by TCR Vβ analysis. Tracking TCR Vβ clonality and integration site analysis is an important part of long-term follow up in gene transfer studies.
    • Hacein-Bey-Abina S, von Kalle C, Schmidt M, et al. LMO2-associated clonal T cell proliferation in two patients after gene therapy for SCID-X1. Science 2003;302(5644):415-9 • Following the development of leukemia in patients with severe combined immunodeficiency who had received retrovirally transduced hematopoietic stem cells, clonal proliferation of T cells was detected by TCR Vβ analysis. Tracking TCR Vβ clonality and integration site analysis is an important part of long-term follow up in gene transfer studies.
  • 71
    • 33751251058 scopus 로고    scopus 로고
    • Gene transfer in humans using a conditionally replicating lentiviral vector
    • The first clinical use of a lentiviral vector, •
    • Levine BL, Humeau LM, Boyer J, et al. Gene transfer in humans using a conditionally replicating lentiviral vector. Proc Natl Acad Sci USA 2006;103(46):17372-7 • The first clinical use of a lentiviral vector.
    • (2006) Proc Natl Acad Sci USA , vol.103 , Issue.46 , pp. 17372-17377
    • Levine, B.L.1    Humeau, L.M.2    Boyer, J.3
  • 72
    • 33745108790 scopus 로고    scopus 로고
    • Hematopoietic stem cell gene transfer in a tumor-prone mouse model uncovers low genotoxicity of lentiviral vector integration
    • Montini E, Cesana D, Schmidt M, et al. Hematopoietic stem cell gene transfer in a tumor-prone mouse model uncovers low genotoxicity of lentiviral vector integration. Nat Biotechnol 2006;24(6):687-96
    • (2006) Nat Biotechnol , vol.24 , Issue.6 , pp. 687-696
    • Montini, E.1    Cesana, D.2    Schmidt, M.3
  • 73
    • 18944373328 scopus 로고    scopus 로고
    • Highly efficient endogenous human gene correction using designed zinc-finger nucleases
    • Urnov FD, Miller JC, Lee YL, et al. Highly efficient endogenous human gene correction using designed zinc-finger nucleases. Nature 2005;435(7042):646-51
    • (2005) Nature , vol.435 , Issue.7042 , pp. 646-651
    • Urnov, F.D.1    Miller, J.C.2    Lee, Y.L.3
  • 74
    • 42449158330 scopus 로고    scopus 로고
    • Towards gene knock out therapy for AIDS/HIV: Targeted disruption of CCR5 using engineered Zinc Finger Protein Nucleases (ZFNs)
    • Perez E, Jouvenot Y, Miller JC, et al. Towards gene knock out therapy for AIDS/HIV: targeted disruption of CCR5 using engineered Zinc Finger Protein Nucleases (ZFNs). Mol Ther 2007;13:S293
    • (2007) Mol Ther , vol.13
    • Perez, E.1    Jouvenot, Y.2    Miller, J.C.3
  • 75
    • 0035251532 scopus 로고    scopus 로고
    • Functional expression of chimeric receptor genes in human T cells
    • Eshhar Z, Waks T, Bendavid A, Schindler DG. Functional expression of chimeric receptor genes in human T cells. J Immunol Methods 2001;248(1-2):67-76
    • (2001) J Immunol Methods , vol.248 , Issue.1-2 , pp. 67-76
    • Eshhar, Z.1    Waks, T.2    Bendavid, A.3    Schindler, D.G.4
  • 76
    • 33750699642 scopus 로고    scopus 로고
    • Kershaw MH, Westwood JA, Parker LL, et al. A Phase I study on adoptive immunotherapy using gene-modified T cells for ovarian cancer. Clin Cancer Res 2006;12(20 Pr 1):6106-15
    • Kershaw MH, Westwood JA, Parker LL, et al. A Phase I study on adoptive immunotherapy using gene-modified T cells for ovarian cancer. Clin Cancer Res 2006;12(20 Pr 1):6106-15
  • 77
    • 33947265424 scopus 로고    scopus 로고
    • Adoptive transfer of chimeric antigen receptor re-directed cytolytic T lymphocyte clones in patients with neuroblastoma
    • Park JR, DiGiusto DL, Slovak M, et al. Adoptive transfer of chimeric antigen receptor re-directed cytolytic T lymphocyte clones in patients with neuroblastoma. Mol Ther 2007;15(4):825-33
    • (2007) Mol Ther , vol.15 , Issue.4 , pp. 825-833
    • Park, J.R.1    DiGiusto, D.L.2    Slovak, M.3
  • 78
    • 33646440024 scopus 로고    scopus 로고
    • Treatment of metastatic renal cell carcinoma with autologous T-lymphocytes genetically retargeted against carbonic anhydrase IX: First clinical experience
    • Lamers CH, Sleijfer S, Vulto AG, et al. Treatment of metastatic renal cell carcinoma with autologous T-lymphocytes genetically retargeted against carbonic anhydrase IX: first clinical experience. J Clin Oncol 2006;24(13):e20-2
    • (2006) J Clin Oncol , vol.24 , Issue.13
    • Lamers, C.H.1    Sleijfer, S.2    Vulto, A.G.3
  • 79
    • 33750061330 scopus 로고    scopus 로고
    • Loskog A, Giandomenico V, Rossig C, et al. Addition of the CD28 signaling domain to chimeric T-cell receptors enhances chimeric T-cell resistance to T regulatory cells. Leukemia 2006;20(10):1819-28 • Evidence is presented that the incorporation of the intracellular portion of the CD28 molecule fused to the CD3ζ-chain and CD19 single-chain Fv chimeric receptor shows that suppression induced by T regulatory cells can be overcome compared with chimeric receptor with CD3ζ alone in the intracellular portion.
    • Loskog A, Giandomenico V, Rossig C, et al. Addition of the CD28 signaling domain to chimeric T-cell receptors enhances chimeric T-cell resistance to T regulatory cells. Leukemia 2006;20(10):1819-28 • Evidence is presented that the incorporation of the intracellular portion of the CD28 molecule fused to the CD3ζ-chain and CD19 single-chain Fv chimeric receptor shows that suppression induced by T regulatory cells can be overcome compared with chimeric receptor with CD3ζ alone in the intracellular portion.
  • 80
    • 0037264471 scopus 로고    scopus 로고
    • Targeting tumours with genetically enhanced T lymphocytes
    • Sadelain M, Riviere I, Brentjens R. Targeting tumours with genetically enhanced T lymphocytes. Nat Rev Cancer 2003;3(1):35-45
    • (2003) Nat Rev Cancer , vol.3 , Issue.1 , pp. 35-45
    • Sadelain, M.1    Riviere, I.2    Brentjens, R.3
  • 81
    • 11144230063 scopus 로고    scopus 로고
    • The CD28 family: A T-cell rheostat for therapeutic control of T-cell activation
    • Riley JL, June CH. The CD28 family: a T-cell rheostat for therapeutic control of T-cell activation. Blood 2005;105(1):13-21
    • (2005) Blood , vol.105 , Issue.1 , pp. 13-21
    • Riley, J.L.1    June, C.H.2
  • 82
    • 33749624177 scopus 로고    scopus 로고
    • Cancer regression in patients after transfer of genetically engineered lymphocytes
    • A clinical trial of redirected TCR gene-modified T cells shows engraftment and persistence of the modified cells, although only 2 of 17 patients demonstrated a sustained objective regression, •
    • Morgan RA, Dudley ME, Wunderlich JR, et al. Cancer regression in patients after transfer of genetically engineered lymphocytes. Science 2006;314(5796):126-9 • A clinical trial of redirected TCR gene-modified T cells shows engraftment and persistence of the modified cells, although only 2 of 17 patients demonstrated a sustained objective regression.
    • (2006) Science , vol.314 , Issue.5796 , pp. 126-129
    • Morgan, R.A.1    Dudley, M.E.2    Wunderlich, J.R.3
  • 83
    • 33845985925 scopus 로고    scopus 로고
    • Efficiency of T-cell receptor expression in dual-specific T cells is controlled by the intrinsic qualities of the TCR chains within the TCR-CD3 complex
    • Heemskerk MH, Hagedoorn RS, van der Hoorn MA, et al. Efficiency of T-cell receptor expression in dual-specific T cells is controlled by the intrinsic qualities of the TCR chains within the TCR-CD3 complex. Blood 2007;109(1):235-43
    • (2007) Blood , vol.109 , Issue.1 , pp. 235-243
    • Heemskerk, M.H.1    Hagedoorn, R.S.2    van der Hoorn, M.A.3
  • 84
    • 34548151333 scopus 로고    scopus 로고
    • T-cell receptor gene therapy for cancer: The progress to date and future objectives
    • Thomas S, Hart DP Xue SA, et al. T-cell receptor gene therapy for cancer: the progress to date and future objectives. Expert Opin Biol Ther 2007;7(8):1207-18
    • (2007) Expert Opin Biol Ther , vol.7 , Issue.8 , pp. 1207-1218
    • Thomas, S.1    Hart, D.P.2    Xue, S.A.3
  • 86
    • 0033543128 scopus 로고    scopus 로고
    • Evans LS, Witte PR, Feldhaus AL, et al. Expression of chimeric granulocyte-macrophage colony-stimulating factor/interleukin 2 receptors in human cytotoxic T lymphocyte clones results in granulocyte-macrophage colony-stimulating factor-dependent growth. Hum Gene Ther 1999;10(12):1941-51 • Chimeric GM-CSFR/IL-2R receptors that deliver an IL-2 signal on binding GM-CSF, a novel design to address the issue of long-term survival of adoptively transferred CTLs, are described.
    • Evans LS, Witte PR, Feldhaus AL, et al. Expression of chimeric granulocyte-macrophage colony-stimulating factor/interleukin 2 receptors in human cytotoxic T lymphocyte clones results in granulocyte-macrophage colony-stimulating factor-dependent growth. Hum Gene Ther 1999;10(12):1941-51 • Chimeric GM-CSFR/IL-2R receptors that deliver an IL-2 signal on binding GM-CSF, a novel design to address the issue of long-term survival of adoptively transferred CTLs, are described.
  • 87
    • 0141449956 scopus 로고    scopus 로고
    • + memory effector T cells reconstitutes antigen-induced IL-2 production
    • + memory effector T cells reconstitutes antigen-induced IL-2 production. J Exp Med 2003;198(6):947-55
    • (2003) J Exp Med , vol.198 , Issue.6 , pp. 947-955
    • Topp, M.S.1    Riddell, S.R.2    Akatsuka, Y.3
  • 88
    • 0035437179 scopus 로고    scopus 로고
    • Transfer of the human telomerase reverse transcriptase (TERT) gene into T lymphocytes results in extension of replicative potential
    • Rufer N, Migliaccio M, Antonchuk J, et al. Transfer of the human telomerase reverse transcriptase (TERT) gene into T lymphocytes results in extension of replicative potential. Blood 2001;98(3):597-603
    • (2001) Blood , vol.98 , Issue.3 , pp. 597-603
    • Rufer, N.1    Migliaccio, M.2    Antonchuk, J.3
  • 89
    • 0030843493 scopus 로고    scopus 로고
    • HSV-TK gene transfer into donor lymphocytes for control of allogeneic graft-versus-leukemia
    • Bonini C, Ferrari G, Verzeletti S, et al. HSV-TK gene transfer into donor lymphocytes for control of allogeneic graft-versus-leukemia. Science 1997;276(5319):1719-24
    • (1997) Science , vol.276 , Issue.5319 , pp. 1719-1724
    • Bonini, C.1    Ferrari, G.2    Verzeletti, S.3
  • 90
    • 85117739334 scopus 로고    scopus 로고
    • Ciceri F, Bonini C, Marktel S, et al. Antitumor effects of HSV-TK-engineered donor lymphocytes after allogeneic stem-cell transplantation. Blood 2007;109(11):4698-707 • A clinical demonstration that immune suppression of the patient and kinetics of graft versus tumor effect mediated by thymidine kinase-transduced donor lymphocytes in the setting of stem cell transplantation may allow the full exploitation of TK-DLI.
    • Ciceri F, Bonini C, Marktel S, et al. Antitumor effects of HSV-TK-engineered donor lymphocytes after allogeneic stem-cell transplantation. Blood 2007;109(11):4698-707 • A clinical demonstration that immune suppression of the patient and kinetics of graft versus tumor effect mediated by thymidine kinase-transduced donor lymphocytes in the setting of stem cell transplantation may allow the full exploitation of TK-DLI.
  • 91
    • 13344261952 scopus 로고    scopus 로고
    • T-cell mediated rejection of gene-modified HIV-specific cytotoxic T lymphocytes in HIV-infected patients
    • Riddell SR, Elliott M, Lewinsohn DA, et al. T-cell mediated rejection of gene-modified HIV-specific cytotoxic T lymphocytes in HIV-infected patients. Nat Med 1996;2(2):216-23
    • (1996) Nat Med , vol.2 , Issue.2 , pp. 216-223
    • Riddell, S.R.1    Elliott, M.2    Lewinsohn, D.A.3
  • 92
    • 33644750264 scopus 로고    scopus 로고
    • Analysis of transgene-specific immune responses that limit the in vivo persistence of adoptively transferred HSV-TK-modified donor T cells after allogeneic hematopoietic cell transplantation
    • Berger C, Flowers ME, Warren EH, Riddell SR. Analysis of transgene-specific immune responses that limit the in vivo persistence of adoptively transferred HSV-TK-modified donor T cells after allogeneic hematopoietic cell transplantation. Blood 2006;107(6):2294-302
    • (2006) Blood , vol.107 , Issue.6 , pp. 2294-2302
    • Berger, C.1    Flowers, M.E.2    Warren, E.H.3    Riddell, S.R.4
  • 93
    • 13144276290 scopus 로고    scopus 로고
    • Redesigning an FKBP-ligand interface to generate chemical dimerizers with novel specificity
    • Clackson T, Yang W, Rozamus LW, et al. Redesigning an FKBP-ligand interface to generate chemical dimerizers with novel specificity. Proc Natl Acad Sci USA 1998;95(18):10437-42
    • (1998) Proc Natl Acad Sci USA , vol.95 , Issue.18 , pp. 10437-10442
    • Clackson, T.1    Yang, W.2    Rozamus, L.W.3
  • 95
    • 0029069364 scopus 로고
    • + T cells and induce similar patterns of cytokine secretion in vitro
    • + T cells and induce similar patterns of cytokine secretion in vitro. Int Immunol 1995;7(6):891-904
    • (1995) Int Immunol , vol.7 , Issue.6 , pp. 891-904
    • Levine, B.L.1    Ueda, Y.2    Craighead, N.3
  • 96
    • 0031573612 scopus 로고    scopus 로고
    • + T cells in the absence of exogenous feeder cells
    • + T cells in the absence of exogenous feeder cells. J Immunol 1997;159(12):5921-30
    • (1997) J Immunol , vol.159 , Issue.12 , pp. 5921-5930
    • Levine, B.L.1    Bernstein, W.B.2    Connors, M.3
  • 97
    • 8944232102 scopus 로고    scopus 로고
    • + T cell proliferation in HIV- positive patients as a result of CD28 costimulation
    • + T cell proliferation in HIV- positive patients as a result of CD28 costimulation. Science 1996;272(5270):1939-43
    • (1996) Science , vol.272 , Issue.5270 , pp. 1939-1943
    • Levine, B.L.1    Mosca, J.D.2    Riley, J.L.3
  • 99
    • 0029902054 scopus 로고    scopus 로고
    • T cells from patients with Hodgkin's disease have a defective T-cell receptor zeta chain expression that is reversible by T-cell stimulation with CD3 and CD28
    • Renner C, Ohnesorge S, Held G, et al. T cells from patients with Hodgkin's disease have a defective T-cell receptor zeta chain expression that is reversible by T-cell stimulation with CD3 and CD28. Blood 1996;88(1):236-41
    • (1996) Blood , vol.88 , Issue.1 , pp. 236-241
    • Renner, C.1    Ohnesorge, S.2    Held, G.3
  • 100
    • 13544256621 scopus 로고    scopus 로고
    • In vitro engagement of CD3 and CD28 corrects T cell defects in chronic lymphocytic leukemia
    • Bonyhadi M, Frohlich M, Rasmussen A, et al. In vitro engagement of CD3 and CD28 corrects T cell defects in chronic lymphocytic leukemia. J Immunol 2005;174(4):2366-75
    • (2005) J Immunol , vol.174 , Issue.4 , pp. 2366-2375
    • Bonyhadi, M.1    Frohlich, M.2    Rasmussen, A.3
  • 101
    • 0036171757 scopus 로고    scopus 로고
    • Ex vivo expansion of polyclonal and antigen-specific cytotoxic T lymphocytes by artificial APCs expressing ligands for the T-cell receptor, CD28 and 4-1BB
    • Maus MV, Thomas AK, Leonard DG, et al. Ex vivo expansion of polyclonal and antigen-specific cytotoxic T lymphocytes by artificial APCs expressing ligands for the T-cell receptor, CD28 and 4-1BB. Nat Biotechnol 2002;20(2):143-8
    • (2002) Nat Biotechnol , vol.20 , Issue.2 , pp. 143-148
    • Maus, M.V.1    Thomas, A.K.2    Leonard, D.G.3
  • 102
    • 0036909464 scopus 로고    scopus 로고
    • A cell-based artificial antigen-presenting cell coated with anti-CD3 and CD28 antibodies enables rapid expansion and long-rerm growth of CD4 T lymphocytes
    • Thomas AK, Maus MV, Shalaby WS, et al. A cell-based artificial antigen-presenting cell coated with anti-CD3 and CD28 antibodies enables rapid expansion and long-rerm growth of CD4 T lymphocytes. Clin Immunol 2002;105(3):259-72
    • (2002) Clin Immunol , vol.105 , Issue.3 , pp. 259-272
    • Thomas, A.K.1    Maus, M.V.2    Shalaby, W.S.3
  • 103
    • 34247212403 scopus 로고    scopus 로고
    • Engineering artificial antigen-presenting cells to express a diverse array of co-stimulatory molecules
    • Lentivirally transduced universal aAPCs for the activation and expansion of antigen-speficic and polyclonal T lymphocytes are described, •
    • Suhoski MM, Golovina TN, Aqui NA, et al. Engineering artificial antigen-presenting cells to express a diverse array of co-stimulatory molecules. Mol Ther 2007;15(5):981-8 • Lentivirally transduced universal aAPCs for the activation and expansion of antigen-speficic and polyclonal T lymphocytes are described.
    • (2007) Mol Ther , vol.15 , Issue.5 , pp. 981-988
    • Suhoski, M.M.1    Golovina, T.N.2    Aqui, N.A.3
  • 104
    • 33846866815 scopus 로고    scopus 로고
    • K562/GM-CSF vaccination reduces tumor burden, including achieving molecular remissions, in chronic myeloid leukemia (CML) patients (PTS) with residual disease on imatinib mesylate (IM)
    • Smith B, Kasamon YL, Miller CB, et al. K562/GM-CSF vaccination reduces tumor burden, including achieving molecular remissions, in chronic myeloid leukemia (CML) patients (PTS) with residual disease on imatinib mesylate (IM). J Clin Oncol 2006;24(18S):6509
    • (2006) J Clin Oncol , vol.24 , Issue.18 S , pp. 6509
    • Smith, B.1    Kasamon, Y.L.2    Miller, C.B.3
  • 105
    • 0034672064 scopus 로고    scopus 로고
    • + T cells with CD80 or CD86 rather than anti-CD28 leads to a Th2 cytokine profile
    • + T cells with CD80 or CD86 rather than anti-CD28 leads to a Th2 cytokine profile. J Immunol 2000;165(12):6908-14
    • (2000) J Immunol , vol.165 , Issue.12 , pp. 6908-6914
    • Broeren, C.P.1    Gray, G.S.2    Carreno, B.M.3    June, C.H.4
  • 106
    • 3142519564 scopus 로고    scopus 로고
    • In vitro-expanded human CD4(+)CD25(+) T-regulatory cells can markedly inhibit allogeneic dendritic cell-stimulated MLR cultures
    • Godfrey WR, Ge YG, Spoden DJ, et al. In vitro-expanded human CD4(+)CD25(+) T-regulatory cells can markedly inhibit allogeneic dendritic cell-stimulated MLR cultures. Blood 2004;104(2):453-61
    • (2004) Blood , vol.104 , Issue.2 , pp. 453-461
    • Godfrey, W.R.1    Ge, Y.G.2    Spoden, D.J.3
  • 107
    • 18344406935 scopus 로고    scopus 로고
    • Long-term in vivo survival of receptor-modified syngeneic T cells in patients with human immunodeficiency virus infection
    • Walker RE, Bechtel CM, Natarajan V, et al. Long-term in vivo survival of receptor-modified syngeneic T cells in patients with human immunodeficiency virus infection. Blood 2000;96(2):467-74
    • (2000) Blood , vol.96 , Issue.2 , pp. 467-474
    • Walker, R.E.1    Bechtel, C.M.2    Natarajan, V.3
  • 108
    • 0031737652 scopus 로고    scopus 로고
    • + T cells from HIV-1 infected donors following CD3/CD28 costimulation
    • + T cells from HIV-1 infected donors following CD3/CD28 costimulation. J Hematotherapy 1998;7:437-48
    • (1998) J Hematotherapy , vol.7 , pp. 437-448
    • Levine, B.L.1    Cotte, J.2    Small, C.C.3
  • 109
    • 0142094685 scopus 로고    scopus 로고
    • Current regulatory issues in cell and tissue therapy
    • Burger SR. Current regulatory issues in cell and tissue therapy. Cytotherapy 2003;5(4):289-98
    • (2003) Cytotherapy , vol.5 , Issue.4 , pp. 289-298
    • Burger, S.R.1
  • 110
    • 42449113207 scopus 로고    scopus 로고
    • Assays for the release of cellular gene therapy products
    • Dropulic B, Carter B, editors. Hoboken, NJ, John Wiley & Sons;
    • Cross P, Levine BL. Assays for the release of cellular gene therapy products. In: Concepts in Genetic Medicine. Dropulic B, Carter B, editors. Hoboken, NJ, John Wiley & Sons; 2008
    • (2008) Concepts in Genetic Medicine
    • Cross, P.1    Levine, B.L.2
  • 111
    • 10744233830 scopus 로고    scopus 로고
    • Molecular remission of CML after autotransplantation followed by adoptive transfer of costimulated autologous T cells
    • Rapoport AP, Levine BL, Badros A, et al. Molecular remission of CML after autotransplantation followed by adoptive transfer of costimulated autologous T cells. Bone Marrow Transplant 2004;33(1):53-60
    • (2004) Bone Marrow Transplant , vol.33 , Issue.1 , pp. 53-60
    • Rapoport, A.P.1    Levine, B.L.2    Badros, A.3
  • 112
    • 42449151098 scopus 로고    scopus 로고
    • Adaptive immunotherapy with autologous CD25-depleted and CD3/CD28-costimulated T-cells enhances lymphocyte recovery after cyclophosphamide - fludarabine chemotherapy in patients with low-grade follicular lymphoma
    • Andreadis C, Levine BL, Nasta SD, et al. Adaptive immunotherapy with autologous CD25-depleted and CD3/CD28-costimulated T-cells enhances lymphocyte recovery after cyclophosphamide - fludarabine chemotherapy in patients with low-grade follicular lymphoma. Blood 2006;108(11):2717
    • (2006) Blood , vol.108 , Issue.11 , pp. 2717
    • Andreadis, C.1    Levine, B.L.2    Nasta, S.D.3
  • 113
    • 0036157376 scopus 로고    scopus 로고
    • Adoptive transfer of costimulated CD4(+) T cells induces expansion of peripheral T cells and decreased CCR5 expression in HIV infection
    • Levine BL, Bernstein WB, Aronson NE, et al. Adoptive transfer of costimulated CD4(+) T cells induces expansion of peripheral T cells and decreased CCR5 expression in HIV infection. Nat Med 2002;8(1):47-53
    • (2002) Nat Med , vol.8 , Issue.1 , pp. 47-53
    • Levine, B.L.1    Bernstein, W.B.2    Aronson, N.E.3
  • 114
    • 33846160971 scopus 로고    scopus 로고
    • Lentiviral vectors ready for prime-time
    • Kohn DB. Lentiviral vectors ready for prime-time. Nat Biotechnol 2007;25(1):65-6
    • (2007) Nat Biotechnol , vol.25 , Issue.1 , pp. 65-66
    • Kohn, D.B.1


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