T-cell mediated rejection of gene-modified HIV-specific cytotoxic T lymphocytes in HIV-infected patients

Nature Medicine

Volumn 2, Issue 2, 1996, Pages 216-223

  Riddell, Stanley R ^a,b   Elliott, Mark ^a   Lewinsohn, Deborah A ^a   Gilbert, Mark J ^a,b   Wilson, Linda ^c   Manley, Sara A ^c   Lupton, Stephen D ^c   Overell, Robert W ^c   Reynolds, Thomas C ^c   Corey, Lawrence ^b   Greenberg, Philip D ^a,b  

^a USA   (United States)

^b UNIVERSITY OF WASHINGTON   (United States)

^c Targeted Genetics Corporation   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACQUIRED IMMUNE DEFICIENCY SYNDROME; ARTICLE; CLINICAL ARTICLE; CLINICAL PROTOCOL; CLINICAL TRIAL; CYTOTOXIC T LYMPHOCYTE; GENE THERAPY; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; IMMUNE DEFICIENCY; PRIORITY JOURNAL;

ANTIGEN PRESENTATION; BASE SEQUENCE; CD8-POSITIVE T-LYMPHOCYTES; CYTOTOXICITY, IMMUNOLOGIC; HISTOCOMPATIBILITY ANTIGENS CLASS I; HIV ANTIGENS; HIV INFECTIONS; HUMANS; IMMUNOTHERAPY, ADOPTIVE; MOLECULAR SEQUENCE DATA;

EID: 13344261952     PISSN: 10788956     EISSN: None     Source Type: Journal    
DOI: 10.1038/nm0296-216     Document Type: Article

References (9)

1. Miller, A.D. Human gene therapy comes of age. Nature 357, 455-460 (1992).
2. Anderson, W.F. Human gene therapy. Science 256, 808-813 (1992).
3. Yang, Y. et al. Cellular immunity to viral antigens limits El-deleted adenoviruses for gene therapy. Proc. Natl. Acad. Sci. USA 91, 4407-4411 (1994).
4. Yang, Y. et al. Inactivation of E2a in recombinant adenoviruses improves the prospect for gene therapy in cystic fibrosis. Nature Genet. 7, 362-369 (1994).
5. Simon, R.H. et al. Adenovirus-mediated transfer of the CFTR gene to lung of nonhuman primates: Toxicity study. Hum. Gene Ther. 4, 771-780 (1993).
6. Yei, S.P., Mittereder, N., Tang, K., O'Sullivan, C. & Trapnell, B.C. Adenovirus-mediated gene transfer for cystic fibrosis - quantitative evaluation of repeated in vivo vector administration to the lung. Gene Ther. 1, 192-200 (1994).
7. Yang, Y., Li, Q., Ertl, H.C. & Wilson, J.M. Cellular and humoral immune responses to viral antigens create barriers to lung-directed gene therapy with recombinant adenoviruses. J. Virol. 69, 2004-2015 (1995).
8. Dai, Y. et al. Cellular and humoral immune responses to adenoviral vectors containing factor IX gene: Tolerization of factor IX and vector antigens allows for long-term expression. Proc. Natl. Acad. Sci. USA 92, 1401-1405 (1995).
9. Zsengeller, Z.K. et al. Persistence of replication-deficient adenovirus-mediated gene transfer in lungs of immune-deficient (nu/nu) mice. Hum. Gene Ther. 6, 457-467 (1995).