Rapid death of adoptively transferred T cells in acquired immunodeficiency syndrome

Blood

Volumn 93, Issue 5, 1999, Pages 1506-1510

  Tan, Rusung ^b   Xu, Xiaoning ^b   Ogg, Graham S ^b   Hansasuta, Pokrath ^b   Dong, Tao ^b   Rostron, Tim ^b   Luzzi, Graz ^b   Conlon, Christopher P ^b   Screaton, Gavin R ^b   McMichael, Andrew J ^b   Rowland Jones, Sarah ^a  

^a JOHN RADCLIFFE HOSPITAL   (United Kingdom)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

CD4 ANTIGEN; CD8 ANTIGEN; GAG PROTEIN; POL PROTEIN; T LYMPHOCYTE RECEPTOR;

ACQUIRED IMMUNE DEFICIENCY SYNDROME; ADOPTIVE TRANSFER; ADULT; APOPTOSIS; ARTICLE; BONE MARROW TRANSPLANTATION; CASE REPORT; CYTOTOXIC T LYMPHOCYTE; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; LYMPHOCYTE COUNT; MAJOR HISTOCOMPATIBILITY COMPLEX; MALE; MONONUCLEAR CELL; PRIORITY JOURNAL; T LYMPHOCYTE; VIRUS LOAD;

EID: 0033105536     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood.v93.5.1506.405a38_1506_1510     Document Type: Article

References (33)

1. Koup RA, Safrit JT, Cao Y, Andrews CA, McLeod G, Borkowsky W, Farthing C, Ho DD: Temporal association of cellular immune responses with the initial control of viremia in primary human immunodeficiency virus type 1 syndrome. J Virol 68:4650, 1994
2. Borrow P, Lewicki H, Hahn BH, Shaw GM, Oldstone MB: Virus-specific CD8+ cytotoxic T-lymphocyte activity associated with control of viremia in primary human immunodeficiency virus type 1 infection. J Virol 68:6103, 1994
3. Borrow P, Lewicki H, Wei X, Horwitz MS, Peffer N, Meyers H, Nelson JA, Gairin JE, Hahn BH, Oldstone MB, Shaw GM: Antiviral pressure exerted by HIV-1-specific cytotoxic T lymphocytes (CTLs) during primary infection demonstrated by rapid selection of CTL escape virus. Nat Med 3:205, 1997
4. Price DA, Goulder PJ, Klenerman P, Sewell AK, Easterbrook PJ, Troop M, Bangham CR, Phillips RE: Positive selection of HIV-1 cytotoxic T lymphocyte escape variants during primary infection. Proc Natl Acad Sci USA 94:1890, 1997
5. Rowland-Jones SL, Nixon DF, Aldhous MC, Gotch F, Ariyoshi K, Hallam N, Kroll JS, Froebel K, McMichael AJ: HIV-specific CTL activity in an HIV-exposed but uninfected infant. Lancet 341:860, 1993
6. Rowland-Jones SL, Sutton J, Ariyoshi K, Dong T, Gotch FM, McAdam S, Whitby D, Sabally S, Gallimore A, Corrah T, Takiguchi M, Schultz T, McMichael AJ, Whittle H: HIV-specific cytotoxic T cells in HIV-exposed but uninfected Gambian women. Nat Med 1:59, 1995
7. Matano T, Shibata R, Siemon C, Connors M, Lane H, Martin M: Administration of an anti-CD8 monoclonal antibody interferes with the clearance of chimeric simian/human immunodeficiency virus during primary infections of rhesus macaques. J Virol 72:164, 1998
8. Ogg GS, Xin J, Bonhoeffer S, Dunbar PR, Nowak MA, Monard S, Segal JP, Cao Y, Rowland-Jones SL, Cerundolo V, Hurley A, Markowitz M, Ho DD, Nixon DF, McMichael AJ: Quantisation of HIV-1-specific cytotoxic T lymphocytes and plasma viral RNA load. Science 279:2103, 1998
9. Rowland-Jones SL, Tan R, McMichael AJ: The role of cellular immunity in protection against HIV infection. Adv Immunol 65:277, 1997
10. Riddell SR, Watanabe KS, Goodrich JM, Li CR, Agha ME, Greenberg PD: Restoration of viral immunity in immunodeficient humans by the adoptive transfer of T cell clones. Science 257:238, 1992
11. Rooney CM, Smith CA, Ng CYC, Loftin S, Li C, Krance RA, Brenner MK, Heslop HE: Use of gene-modified virus-specific T lymphocytes to control EBV-related lymphoproliferation. Lancet 345:9, 1995
12. Walter EA, Greenberg PD, Gilbert MJ, Finch RJ, Watanabe KS, Thomas ED, Riddell SR: Reconstitution of cellular immunity against cytomegalovirus in recipients of allogeneic bone marrow by transfer of T-cell clones from the donor, N Engl J Med 333:1038, 1995
13. Koenig S, Conley AJ, Brewah YA, Jones GM, Leath S, Boots LJ, Davey V, Pantaleo G, Demarest JF, Carter C, Wannebo C, Yannelli JR, Rosenberg SA, Lane HC: Transfer of HIV-1 specific cytotoxic T lymphocytes to an AIDS patient leads to selection for mutant HIV variants and subsequent disease progression. Nat Med 1:330, 1995
14. Riddell SR, Elliott M, Lewinsohn DA, Gilbert MJ, Wilson L, Manley SA, Lupton SD, Overell RW, Reynolds TC, Corey L, Greenberg PD: T-cell mediated rejection of gene-modified HIV-specific cytotoxic T lymphocytes in HIV-infected patient. Nat Med 2:216, 1996
15. Lieberman J, Skolnik PR, Parkerson Gr, Fabry JA, Landry B, Bethel J, Kagan J: Safety of autologous, ex vivo-expanded human immunodeficiency virus (HIV)-specific cytotoxic T-lymphocyte infusion in HIV-infected patients. Blood 90:2196, 1997
16. Loh EY, Elliott JF, Cwirla S, Lanier LL, Davis MM: Polymerase chain reaction with single-sided specificity: Analysis of T cell receptor delta chain. Science 243:217, 1989
17. Moss PAH, Rowland-Jones SL, Frodsham PM, McAdam S, Giangrande P, McMichael AJ, Bell JI: Persistent high frequency of human immunodeficiency virus-specific cytotoxic T cells in peripheral blood of infected donors. Proc Nat Acad Sci USA 92:5773, 1995
18. Altman J, Moss PAH, Goulder P, Barouch D, McHeyzer-Williams M, Bell JI, McMichael AJ, Davis MM: Direct visualization and phenotypic analysis of virus-specific T lymphocytes in HIV-infected individuals. Science 274:94, 1996
19. Goulder PJR, Sewell AK, Lalloo DG, Price DA, Whelan JA, Evans J, Taylor GP, Luzzi G, Giangrande P, Phillips RE, McMichael AJ: Patterns of immunodominance in HIV-1-specific cytotoxic T lymphocyte responses in two human histocompatibility leukocyte antigens (HLA)-identical siblings with HLA-A*0201 are influenced by epitope mutation. J Exp Med 185:1423, 1997
20. Harrer E, Harrer T, Barbosa P, Feinberg M, Johnson RP, Buchbinder S, Walker BD: Recognition of the highly conserved YMDD region in the human immunodeficiency virus type 1 reverse transcriptase by HLA-A2-restricted cytotoxic T lymphocytes from an asymptomatic long-term nonprogressor. J Infect Dis 173:476, 1996
21. Papadopoulos EB, Ladanyi M, Emanuel D, Mackinnon S, Boulad F, Carabisi MH, Castro-Malaspina H, Childs BH, Gillio AP, Small TN, Young JW, Kernan NA, O'Reilly RJ: Infusions of donor leukocytes to treat EBV-associated lymphoproliferative disorders after allogeneic bone marrow transplantation. N Engl J Med 330:1185, 1994
22. + T lymphocytes in patients with acquired immunodeficiency syndrome (AIDS)-related complex or AIDS. Blood 81:2093, 1993
23. Klimas N, Patarca R, Walling J, Garcia R, Mayer V, Moody D, Okarma T, Fletcher MA: Clinical and immunological changes in AIDS patients following adoptive therapy with activated autologous CD8 T cells and interleukin-2 infusion. AIDS 8:1073, 1994
24. Yap KL, Ada GL, McKenzie IFC: Transfer of specific cytotoxic T lymphocytes protects mice inoculated with influenza virus. Nature 273:238, 1978
25. Lukacher AE, Braciale VL, Braciale TJ: In vivo effector function of influenza virus-specific cytotoxic T lymphocyte clones is highly specific. J Exp Med 160:814, 1984
26. Baenziger J, Hengartner H, Zinkernagel RM, Cole GA: Induction or prevention of immunopathological disease by cloned cytotoxic T cell lines specific for lymphocytic choriomeningitis virus. Eur J Immunol 16:387, 1986
27. Bell E, Shand F: Changes in lymphocyte recirculation and liberation of the adoptive memory response from cellular regulation in irradiated recipients. Eur J Immunol 5:1, 1975
28. Hamann D, Baars PA, Rep MH, Hooibrink B, Kerkhof-Garde SR, Klein MR, Van Lier RA: Phenotypic and functional separation of memory and effector human CD8+ T cells. J Exp Med 186:1407, 1997
29. Battegay M, Moskophidis D, Rahemtulla A, Hengartner H, Mak TW, Zinkernagel RM: Enhanced establishment of a virus carrier state in adult CD4+ T-cell-deficient mice. J Virol 68:4700, 1994
30. Riddell SR, Greenberg PD: Principles for adoptive T cell therapy of human viral diseases. Annu Rev Immunol 13:545, 1995
31. Rosenberg ES, Billingsley JM, Caliendo A, Boswell SL, Sax PE, Kalams SA, Walker BD: Vigorous HIV-1-specific CD4+ T-cell responses associated with control of viraemia. Science 278:1447, 1997
32. Lynch D, Ramsdell F, Alderson M: Fas and FasL in the homeostatic regulation of immune responses. Immunol Today 16:569, 1995
33. Xu X-N, Screaton GR, Gotch FM, Dong T, Tan R, Almond N, Walker B, Stebbings R, Kent K, Nagata S, Stott JE, McMichael AJ: Evasion of CTL responses by nef-dependent induction of Fas ligand expression on SIV-infected cells. J Exp Med 186:7, 1997